Clinical trials: Acute Conditions
Autoimmune Diseases, Cardiovascular Disorders
Mesenchymal Stem Cells for the Treatment of Various Chronic and Acute Conditions
This multi-arm, multi-site study investigates the safety, tolerability, and efficacy of stem cell therapy for the treatment of various acute and chronic conditions.
- Conditions
- Autoimmune Diseases, Cardiovascular Disorders, Diabetes Complications, Integumentary Disease
- Trial name
- NCT04684602
- Testing
- PrimePro™/ PrimeMSK™
- Where
- United States
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Thomas Advanced Medical LLC
Acute Postoperative Pain, Dental Pain
A Study of CYT-1010 in Healthy Volunteers and Participants With Acute Pain After Third Molar Extraction
The primary objective of this trial is to assess the safety and tolerability of single, ascending doses of CYT-1010 in healthy male and female volunteers and in the treatment of acute postoperative pain after third molar…
- Trial name
- NCT07905105
- Testing
- CYT-1010
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Cytogel Pharma, LLC
Post-op Pain
Study to Assess Dopamine Receptor Modulation With Rotigotine to Enhance Morphine Analgesia in the Dental Model
Narcotics are widely used as the mainstay of pain treatment, although increasing doses are required over time as the individual becomes tolerant to their effects.
- Trial name
- NCT02123979
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- East Carolina University
COVID-19, Pain, Chronic
Pain-related Long Covid in Covid-19 Survivors
The exploratory project aims to investigate the presence of pain as a long Covid-19 symptom in previously hospitalised patients and in non-hospitalised persons previously tested positive in a PCR test.
- Trial name
- NCT05520931
- Testing
- Questionnaire and register-based data assessment
- Where
- Denmark
- Volunteers
- 600,000 people, healthy volunteers welcome
- Sponsor
- Aalborg University
Cirrhosis, Liver, Immune Suppression
S100A8/A9 and Innate Immunity in Liver Disease
This observational study evaluates the concentration of immune protein S100A8/A9 in different liver failure syndromes, its interaction with the immune system and validity as an immunotherapeutic target to improve survival in…
- Conditions
- Cirrhosis, Liver, Immune Suppression, Liver Failure, Acute on Chronic, Ascites Hepatic
- Trial name
- NCT05793983
- Where
- United Kingdom
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- St George's, University of London
Slow Breathing, Acute Myocardial Infarction
The Effect of Slow Breathing Exercise Applied to Patients on Pulse, Blood Pressure and Quality of Life
This study was designed as a randomized controlled experimental type in order to determine the effect of slow breathing exercise applied after the procedure on heart rate, blood pressure and quality of life in patients who…
- Trial name
- NCT06098222
- Testing
- Slow breathing exercise training
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
Travel-Related Illness, Malaria
Infection Tracking in Travellers. The Project Aims to Identify Profiles of Travel-associated Illness and to Follow up on Long-term Sequelae of Arboviral Infections and Malaria
The investigators hypothesize that sex, age, area of exposure and purpose of travel are associated with different travel-related infections. The investigators also hypothesize that certain infections will have long-term sequelae.
- Conditions
- Travel-Related Illness, Malaria, Dengue, Chikungunya
- Trial name
- ITIT (NCT04672577)
- Testing
- Observational study
- Where
- Switzerland
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Patricia Schlagenhauf
Healthy Male Volunteers Over 65
Assessing the Impact of a Leucine Enriched Whey Protein vs Isonitrogenous Whey on Muscle Protein Synthetic Responses in the Rested and Acute Post Exercise States in Older Adults
Occupying ~45-55% of body mass, skeletal muscle is the largest organ of the body and plays a pivotal role in locomotion, structural support and whole-body metabolic health.
- Trial name
- NCT06971822
- Testing
- Protein Supplementation
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
COVID-19, Post-COVID-19 Syndrome
The COVID HOME Study: Prospective Cohort Study of Non-hospitalised COVID-19 Patients
Background. Guidelines on COVID-19 management are developed as we learn from this pandemic. However, most research has been done on hospitalised patients and the impact of the disease on non-hospitalised and their role in…
- Trial name
- COVID-HOME (NCT06282627)
- Testing
- Observational study
- Where
- Netherlands
- Volunteers
- 256 people, healthy volunteers welcome
- Sponsor
- University Medical Center Groningen
Pneumonia, Diarrhea
Vitamin A and Zinc: Prevention of Pneumonia (VAZPOP) Study
Children with malnutrition are often low in some nutrients, like zinc or vitamin A, that could help them fight off infections like pneumonia.
- Conditions
- Pneumonia, Diarrhea, Acute Upper Respiratory Tract Infections
- Trial name
- NCT00228254
- Testing
- Zinc (12.5 mg/day), vitamin A 10,000 IU per week
- Where
- 2 sites in United States, Ecuador
- Volunteers
- 2,582 people, healthy volunteers welcome
- Sponsor
- Tufts University
COVID-19 Pneumonia, Bromelains Adverse Reaction
Nebulised BromAc in Healthy Volunteers
COVID-19 is a disease that has multiple facets including an inflammatory storm, it promotes blood clotting and causes kidney damage, mucinous secretions in the lung are of great importance to outcome.
- Conditions
- COVID-19 Pneumonia, Bromelains Adverse Reaction, Acetylcysteine Adverse Reaction, Mucus; Plug
- Trial name
- NCT05220605
- Testing
- BromAc
- Where
- Australia
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Mucpharm Pty Ltd
Pre B ALL, Regulatory T Cell
The Effect of Chemotherapy on Regulatory T Cells
The investigators aimed to study the effect of chemotherapy on regulatory T cells (Tregs) in children with precursor B (PreB) acute lymphoblastic leukemia (ALL) at 15 and 33 days of malignity directed therapy.
- Trial name
- NCT03413046
- Testing
- Peripheral and bone marrow sampling
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ankara Children's Health and Diseases Hematology and Oncology Training and Research Hospital
Anxiety, Acute Post Operative Pain
Gender-specific Preoperative Anxiety Level and Postoperative Opioid Requirement After ENT Surgery.
The study will be designed to investigate the impact of the preoperative anxiety level on postoperative opioid requirement during the PACU stay, in order to improve postoperative pain treatment in the long term after ENT surgery.
- Trial name
- NCT05141591
- Testing
- Anxiety level assessment
- Where
- Austria
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Acute Pain, Nursing Caries
Effects of Distraction Methods on Pain Perceptions and Anxiety Levels in Children During the Blood Collection
Aim:This study was conducted to investigate the effects of music, kaleidoscope and video watching methods on children's pain perception and anxiety level during the blood collection procedures.
- Trial name
- NCT04113980
- Testing
- music group, kaleidoscope group, video group
- Where
- Turkey (Türkiye)
- Volunteers
- 134 people, healthy volunteers welcome
- Sponsor
- Adiyaman University Research Hospital
Sleep Deprivation
Call- Associated Acute Fatigue in Surgical Residency
The study aimed to evaluate the effects of 24-Hour-Call-associated acute partial sleep deprivation on surgical residents' technical and cognitive performance in a virtual reality (VR) setting.
- Trial name
- CAFIS (NCT01284842)
- Testing
- 24-Hour-Call
- Where
- Germany
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Philipps University Marburg
Hearing Loss, Noise-Induced
Noise-Induced Hearing Loss-Acute Exposure Treatment (UA)
The purpose of this study is to assess the safety and efficacy of zonisamide (ZNS) for the treatment of noise-induced hearing loss in adults.
- Trial name
- PINIHL-AET (NCT04774250)
- Testing
- Zonisamide 100Mg Cap
- Where
- United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Postpartum Hemorrhage, Pregnancy
RCT of Misoprostol for Postpartum Hemorrhage in India
Death rates for pregnant women in rural India are approximately forty-five times higher than in the United States. Bleeding after the birth of a child and underlying anemia are the primary causes of mothers' deaths and sickness…
- Trial name
- NCT00097123
- Testing
- Misoprostol
- Where
- India
- Volunteers
- 1,600 people, healthy volunteers welcome
- Sponsor
- NICHD Global Network for Women's and Children's Health
Postoperative Pain
Impact of Gender on Perceived Postoperative Pain
Postoperative pain is a common problem after surgical procedures with many patients afflicted worldwide. Fundamental challenges are the complexity of measuring pain appropriately, and the many associated possible confounders.
- Trial name
- G-PAIN (NCT03968497)
- Testing
- Postoperative pain assessment with female investigator, Postoperative pain assessment with male investigator
- Where
- Sweden
- Volunteers
- 247 people, healthy volunteers welcome
- Sponsor
- Lund University
Scar, Trauma Injury
The Use of Fractional Ablative CO2 Laser vs Control on Acute Traumatic Injuries to Prevent Scar Formation
Surgical standard for treating traumatic burn injury scarring is to wait one year following the initial assault prior to beginning treatment.
- Conditions
- Scar, Trauma Injury, Burns, Wound Heal
- Trial name
- NCT03888703
- Testing
- Fractional ablative CO2 laser
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Miami Dermatology and Laser Institute
Gender, Postoperative Pain
Acute Postthoracotomy Pain - Impact of Gender
Adequate analgesia in thoracic surgery is essential to prevent severe postoperative complications, especially respiratory problems.
- Conditions
- Gender, Postoperative Pain, Thoracotomy, Analgesia
- Trial name
- NCT03281213
- Testing
- Thoracotomy
- Where
- Austria
- Volunteers
- 346 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
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