Clinical trials: Acute Conditions
Healthy
Exercise-induced Effects on Immune Parameters in Healthy Participants
Exercise has been shown to influence the immune system and, for example, improve anti-viral immune response. However, knowledge of how exercise impacts the immune system is still lacking.
- Trial name
- INHALE (NCT05826496)
- Testing
- Exercise
- Where
- Denmark
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Per thor Straten
COVID Long-Haul
Long COVID-19 [11C]CPPC Study
The goal of this study is to evaluate the safety of using the [5-cyano-N-(4-(4-[11C]Methylpiperazin-1-yl)-2-(Piperidin-1-yl)Phenyl)Furan-2-carboxamide] ([11C]CPPC) radiotracer in positron emission tomography (PET) imaging of…
- Trial name
- NCT06223971
- Testing
- [11C]CPPC Injection
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Long-COVID, Post-COVID
ASAP - Assisted Immediate Augmented Post-/Long-COVID Plan for Patients Infected With COVID-19
Post-/long-COVID occurs in patients with severe, moderate, and even mild courses. The symptomatology is multi-layered and complex.
- Conditions
- Long-COVID, Post-COVID, Psychosomatic Disorder, Psychological Distress
- Trial name
- ASAP (NCT05238415)
- Testing
- Psychological and Physiological Assessments
- Where
- Germany
- Volunteers
- 192 people, healthy volunteers welcome
- Sponsor
- Prof. Dr. Sonia Lippke
Nursing Care, Pain Management
Comparison of the Effectiveness of Two Active Distraction Techniques During Venipuncture in Children
This study was conducted to compare the effects of two active distraction methods-bubble blowing and a material-free cognitive distraction/positive reinforcement technique-applied during venous blood sampling on pain, fear, and…
- Conditions
- Nursing Care, Pain Management, Anxiety, Children
- Trial name
- NCT07249723
- Testing
- Bubble Blowing Group, Positive Reinforcement Group
- Where
- Turkey (Türkiye)
- Volunteers
- 207 people, healthy volunteers welcome
- Sponsor
- Kocaeli University
Acute Pain, Pain, Acute
Double-blind, Placebo-control, Study to Evaluate the Safety and Pharmacokinetics of CT-044 HCl, in Healthy Volunteers
This study will be conducted to assess safety, tolerability, and PK of CT-044 HCl in normal healthy volunteers, in a traditional sequential multiple ascending dose paradigm.
- Conditions
- Acute Pain, Pain, Acute, Surgery, Neuropathy
- Trial name
- NCT04175743
- Testing
- CT-044 HCl
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Lotus Clinical Research, LLC
SARS (Disease)
Cyclosporine For The Treatment Of COVID-19(+)
Phase IIa clinical trial in which 75 non-ICU hospital inpatients will be randomized 2:1 to 7 days of an oral formulation of cyclosporine, Neoral (2.5mg/kg PO BID) + standard of care (SOC) or no Neoral + SOC.
- Trial name
- NCT04492891
- Testing
- Cyclosporine, Standard of Care Treatment
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Bryan Burt, MD
Acute Intermittent Porphyria
Dental Health, Diet, Inflammation and Biomarkers in Patients With Acute Intermittent Porphyria(AIP)
Acute intermittent porphyria (AIP) is an autosomal dominant inherited disease, which is relatively prevalent in northern Norway with a total of around 90 patients. This provides us with a special opportunity to study AIP.
- Trial name
- NCT01617642
- Where
- Norway
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Nordlandssykehuset HF
Stroke, Acute, Intracranial Hemorrhages
Safety, Tolerability and Pharmacokinetics of Y-2(Edaravone And Borneol) Sublingual Tablet
The primary objective is to evaluate the safety and tolerability of single ascending dose of Y-2 sublingual tablets in healthy male and female adult subjects.
- Trial name
- NCT03495206
- Testing
- Y-2(Edaravone And Borneol) Sublingual Tablet
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Yantai YenePharma Co., Ltd.
Lower Respiratory Tract Infection, Acute Bronchitis
Evaluating a Host-response Based Diagnostic for Distinguishing Between Bacterial and Viral Etiology in Patients With Lower Respiratory Tract Infection (LRTI)
The purpose of this study is to validate the diagnostic accuracy of a novel host-response based diagnostic tool for differentiating between bacterial and viral etiologies in adult patients aged 18 years and older with clinical…
- Conditions
- Lower Respiratory Tract Infection, Acute Bronchitis, Pneumonia, Chronic Obstructive Pulmonary Disease (COPD)
- Trial name
- OBSERVER (NCT03011515)
- Where
- Israel
- Volunteers
- 583 people, healthy volunteers welcome
- Sponsor
- MeMed Diagnostics Ltd.
Healthy, SIRS
A Prospective Validation Study of Albumin Kinetics With Tracer 123 I-HSA
This is a prospective, validation study of a extempore made tracer compared with a commercial. Studies with tracer have no medical effects but are used for studying human physiology, in this case pharmacokinetic variables of…
- Trial name
- NCT01686776
- Testing
- 123 I-HSA + 125 I HSA
- Where
- Sweden
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Ake Norberg
Atrial Fibrillation, Ischemic Heart Disease
Dynamic Changes in SDF-1α Levels in Acute and Stabilized Heart Disease
The aims of the present study are to measure dynamic changes over time in the plasma level of SDF-1α in patients with confirmed diagnoses of AMI, AF and CHF and in so doing: 1.
- Conditions
- Atrial Fibrillation, Ischemic Heart Disease, Congestive Heart Failure
- Trial name
- DYNASDY (NCT02702752)
- Testing
- DYNASDY
- Where
- Denmark
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Hvidovre
Obstructive Sleep Apnea
Acute Effect of CPAP on Weight in Patients With Obstructive Sleep Apnea
The effect of CPAP on weight and fluid homeostasis will be assessed. Obstructive sleep apnea treatment-naive subjects will randomized to CPAP and control groups.
- Trial name
- NCT05253963
- Testing
- Continuous Positive Airway Pressure
- Where
- Brazil
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Necrotic Pulp, Acute Apical Periodontitis of Pulpal Origin
Clinical Efficacy of Novel Jasminum-based Calcium Hydroxide Medicament
A triple-blind, parallel group, randomized trial with an allocation ratio of 1:1. Participants randomly allocated into two groups A and B.
- Trial name
- NCT06653608
- Testing
- Nano-reinforced calcium hydroxide medicament, Calcium hydroxide without nanoparicles
- Where
- Pakistan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Pakistan Institute of Medical Sciences
Opioid-Related Disorders, Pain, Acute
A Comparison of Plasma Concentrations of Hydrocodone and Acetaminophen After Administration of Different Amounts of Tablets of a New and a Marketed Tablet Formulation in Healthy Adults
This clinical trial is being conducted to compare concentrations of hydrocodone and acetaminophen in the blood after administration of different amounts of tablets of a new and a marketed tablet formulation in healthy adults.
- Conditions
- Opioid-Related Disorders, Pain, Acute, Pain, Postoperative
- Trial name
- NCT03137030
- Testing
- GRT7014 - Abuse Deterrend Tablet, Norco 5Mg-325Mg Tablet
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Grünenthal GmbH
Acute Exercise, Caffeine Withdrawal
The Acute Effects of Exercise and Caffeine on Working Memory During Acute Caffeine Deprivation
To determine the effects of moderate intensity exercise and caffeine on working memory in deprived caffeine consumers.
- Conditions
- Acute Exercise, Caffeine Withdrawal, Memory Deficits
- Trial name
- NCT05170464
- Testing
- Acute Exercise, Caffeine Powder
- Where
- Canada
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Western University, Canada
Knee Arthroscopy, Acute Pain
"Comparison of Intra-articular of 0.2% Ropivacaine vs. 0.75% Ropivacaine in Postoperative of Knee Arthroscopy"
All patients with acute lesions that attend the orthopedic and trauma center of the ABC medical center are invited to participate in the study.
- Trial name
- ropivacaine (NCT05807945)
- Testing
- Ropivacaine 0.75% Injectable Solution, Ropivacaine 0.2% Injectable Solution
- Where
- Mexico
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Paola M Zamora Munoz
Acute Lung Injury (ALI), Acute Respiratory Distress Syndrome (ARDS)
Effect of R-spondin3 on Sepsis Induced Endothelial Dysfunction
Sepsis is the most frequent risk factor for ALI/ARDS. Meanwhile, Pulmonary is the most vulnerable organ to fail in response to sepsis, vascular endothelial dysfunction is a central event in the pathophysiology of sepsis.
- Trial name
- NCT04546919
- Testing
- sepsis
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Virtual Reality, Musculoskeletal Pain
Virtual Reality Analgesia In Trauma Rehab
This will be a pilot study utilizing Virtual Reality Analgesia (VRA) as a first line nonpharmacologic analgesic intervention on the Acute Rehabilitation Unit.
- Conditions
- Virtual Reality, Musculoskeletal Pain, Opioid Use, Anxiety
- Trial name
- NCT03894592
- Testing
- Virtual reality
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- New York City Health and Hospitals Corporation
Stretching, Control Condition
Hip Abduction and Adduction During Neurodynamic Stretching
Neurodynamic mobilization techniques are widely applied in rehabilitation and physiotherapy to enhance the mobility and function of peripheral nerves. Two main approaches are distinguished : Nerve tensioning and nerve flossing.
- Trial name
- HIPROT (NCT07350434)
- Testing
- Maximal neurodynamic flossing
- Where
- France
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Burgundy
Diabetes, Hypoglycemia
Acute Changes in Plasma Glucose and Cardiovascular Disease in Diabetes
Patients with diabetes have an increased risk of sudden cardiac death compared to the general population. Severe hypoglycemia is associated with an increased risk of cardiovascular (CV) disease (CVD) and events, including cardiac…
- Conditions
- Diabetes, Hypoglycemia, Hyperglycemia, Cardiovascular Diseases
- Trial name
- NCT05500352
- Testing
- Hyperglycemia with slow decline in plasma glucose in type 1 diabetes, Hyperglycemia with rapid decline in plasma glucose in type 1 diabetes, Rebound hyperglycemia in type 1 diabetes
- Where
- Denmark
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Steno Diabetes Center Copenhagen
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