Clinical trials: Acute Conditions
Sepsis, AKI - Acute Kidney Injury
Mechanisms of Acute Kidney Injury in Severe Infections
Renal perfusion and neutrophil-mediated inflammation will be assessed in the kidney in sepsis patients with acute kidney injury using positron emission tomography.
- Conditions
- Sepsis, AKI - Acute Kidney Injury, Positron Emission Tomography (PET)
- Trial name
- PET-AKI (NCT06372444)
- Testing
- Positron emission tomography (PET)
- Where
- Sweden
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Uppsala University Hospital
SARS Virus
Investigating Severe Acute Respiratory Syndrome (SARS)
Severe Acute Respiratory Syndrome (SARS) is a newly recognized illness that can be fatal. The purpose of this study is to better understand SARS by collecting samples of blood and other body fluids of people who have been exposed…
- Trial name
- NCT00066209
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Acoustic Trauma
Study of Diagnostic Biomarkers of Acute Acoustic Trauma
Every year, more than two thousand acute acoustic trauma occur in France, equally between the military and the civilian environment.
- Trial name
- BIOTSA (NCT04832230)
- Testing
- Hearing test, Questionnaire about previous noise exposure, Otoacoustic emission measurement
- Where
- 14 sites in France
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Direction Centrale du Service de Santé des Armées
Pain, Acute, Pain, Neuropathic
Exercise and Pain in Non-Hispanic Blacks and Whites
Non-Hispanic Blacks tend to report higher levels of pain, experience pain more frequently, and be under-treated for pain compared to non-Hispanic Whites.
- Conditions
- Pain, Acute, Pain, Neuropathic, Analgesia, Aerobic Exercise
- Trial name
- NCT03609957
- Testing
- Aerobic Exercise Training, Interval Training
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Georgia State University
Pediatric Obesity
The Impact of an Acute Bout of Exercise on Children's Eating Behaviors
The purpose of this project is to examine the effects of an acute bout of exercise on children's energy intake over the course of a day.
- Trial name
- NCT02833051
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Penn State University
Hyperglucagonemia, Obesity
Effects of Glucagon Administration on Energy Expenditure
The purpose of this study is to collect data to help researchers better understand the effects of glucagon on the amount of calories burned.
- Trial name
- GLEE (NCT02237053)
- Testing
- Glucagon, Octreotide, Insulin
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- AdventHealth Translational Research Institute
Pain, Acute
The Effects of Auditory Interventions on Comfort and Mothers' Anxiety in Newborns
The heel blood procedure for newborn screening is done for almost all babies within the first 48 hours of birth. It is stated that non-pharmacological methods in reducing pain during the heel blood collection process are simple…
- Trial name
- NCT05079594
- Testing
- Mother voice, White noise
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Akdeniz University
Diarrhea
Impact of Home Zinc Treatment for Acute Diarrhea in Children
Background. Zinc deficiency is common in Africa. It has been shown in Asia that zinc as treatment for diarrhea can shorten the course of episodes of diarrhea, as well as prevent future episodes.
- Trial name
- NCT00530829
- Testing
- zinc
- Where
- Kenya
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Centers for Disease Control and Prevention
Appendicitis Acute, Appendicitis
Safety & Feasibility of PERIsign System in Demonstrating Involuntary Muscle Defense as a Sign of Peritonitis in Subjects With Appendicitis
This will be an explorative, proof-of-principle, open, multi-center investigation. The investigation aims to investigate the safety of the PERIsign system and the ability of physicians to differentiate between healthy individuals…
- Conditions
- Appendicitis Acute, Appendicitis, Abdominal Pain, Peritonitis
- Trial name
- PeriSaFe01 (NCT06296953)
- Testing
- PERIsign examination
- Where
- 2 sites in Sweden
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- STB INN AB
Nephropathy, Hypoxia
Acute Effects of SGLT2 Inhibition on Renal Oxygenation and Autonomic Function in Type 1 Diabetes
Background: Inhibiting the sodium-glucose cotransporter-2 (SGLT2) has been observed to reduce risk of cardiovascular events and kidney failure in type 2 diabetes.
- Conditions
- Nephropathy, Hypoxia, Mitochondrial Alteration, Type 1 Diabetes
- Trial name
- Astronaut (NCT04193566)
- Testing
- Forxiga
- Where
- Denmark
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Steno Diabetes Center Copenhagen
Bowel; Ischemic, Acute
FLuorescence Guided Assessment of Mesenteric Ischemia in Emergency Surgery
This is a prospective, multicentre, non-randomized cohort study using real-time intraoperative visualization of bowel perfusion by indocyanine green (ICG) in all-cause bowel ischemia.
- Trial name
- FLAMES (NCT06322862)
- Testing
- Indocyanine green
- Where
- 5 sites in Denmark
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Acute on Chronic Liver Failure, Cirrhosis
Assessment of Coagulation Abnormalities in Acute on Chronic Liver Failure Patients Using Thromboelastography
Patients of acute \& chronic liver failure have long been assumed to have coagulopathy \& are given blood products prophylactically as well as during various interventions.
- Trial name
- NCT02757170
- Testing
- Thromboelastography
- Where
- India
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- All India Institute of Medical Sciences
Low Back Pain, Chronic Low-back Pain
Physical Exam, Static & Dynamic Ultrasound Assessment, & Treatment of Thoracolumbar Fascia (TLF) Mediated Low Back Pain
This Study is for our continued study of the Thoracolumbar Fascia (TFL) in patients with and without low back pain by our experienced multidisciplinary team: Vincent Wang PhD, VT Biomedical Engineering \& Mechanics (BEAM).
- Conditions
- Low Back Pain, Chronic Low-back Pain, Acute Low Back Pain
- Trial name
- NCT06818175
- Testing
- Ultrsound Guided Hydrodissection of the Thoracolumbar Fascia, Osteopathic Manipulative Treatment (OMT)
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Edward Via Virginia College of Osteopathic Medicine
Pain, Acute, Nausea
Enhanced Recovery Strategies in Elective Breast Surgery
Postoperative pain, nausea, and vomiting are frustrating sequelae of elective breast surgery. Poorly managed postoperative pain can lead to increased opioid use, increased postoperative nausea and vomiting (PONV), delayed return…
- Conditions
- Pain, Acute, Nausea, Vomiting, Postoperative, Opioid Use
- Trial name
- NCT03187080
- Testing
- Paravertebral block procedure using either local anesthetic (0.25% bupivacaine) or sterile saline, Enhanced recovery after breast surgery (ERABS) strategies, Paravertebral block using local anesthetic
- Where
- United States
- Volunteers
- 113 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Pain
Preoperative Gabapentin for Acute and Chronic Post-thoracotomy Analgesia
One dose of either gabapentin or placebo will be given to patients prior to thoracotomy. Patients will also receive an epidural infusion, intravenous patient-controlled analgesia with fentanyl, oral acetaminophen and intravenous…
- Trial name
- NCT00588159
- Testing
- Gabapentin, Diphenhydramine
- Where
- United States
- Volunteers
- 146 people, healthy volunteers welcome
- Sponsor
- Michelle Kinney
Extracorporeal Membrane Oxygenation Complication, ARDS (Acute Respiratory Distress Syndrome)
RECOMMEND Platform Trial
The goal of this platform trial is to determine the efficacy, safety and cost-effectiveness of various interventions in patients with acute cardiorespiratory failure requiring extracorporeal membrane oxygenation (ECMO) The main…
- Conditions
- Extracorporeal Membrane Oxygenation Complication, ARDS (Acute Respiratory Distress Syndrome), Intensive Care Medicine, Cardiac Arrest (CA)
- Trial name
- RECOMMEND (NCT06526533)
- Testing
- Liberal RBC Transfusion, Restrictive RBC Transfusion
- Where
- 3 sites in Australia
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Australian and New Zealand Intensive Care Research Centre
Preterm Birth, Pain, Acute
Reducing Pain During Heel Blood Collection in Preterm Newborns
Pharmacological and non-pharmacological methods are used to control interventional pain in preterm newborns. Non-pharmacological methods should be preferred in the management of pain, especially during painful minor invasive…
- Trial name
- NCT05431452
- Testing
- Pain management
- Where
- Turkey (Türkiye)
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Suleyman Demirel University
Pain
Effect of Acute Treatment With N2O on Inhibitory Pain Mechanisms in Healthy Subject
The purpose of this study is to determine whether N2O (laughing gas) has an antinociceptive effects in healthy volunteers.
- Trial name
- N2O (NCT01616004)
- Testing
- N2O, Air
- Where
- Israel
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Pain, Acute Pain
A Phase 1, Randomized, Placebo-Controlled Safety and Tolerability Study Of Intravenous SBS-1000 in Healthy Adults
This study will be a single-center, double-blind, randomized placebo-controlled, adaptive, single ascending dose study.
- Trial name
- NCT05721287
- Testing
- SBS-1000
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Sparian Biosciences, Inc
Aging, Inflammation
Effect of Age and Fitness on Vascular Function and Oxidative Stress During Acute Inflammation
This study focuses on whether high cardiorespiratory fitness in older adults has a protective effect on the vascular response to acute inflammation in comparison to low-fit older and young adults.
- Trial name
- NCT03889158
- Testing
- Typhoid Vaccine, Ascorbic Acid
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago