Clinical trials: Acute Coronary Disease
Acute Coronary Syndrome
Gastrointestinal Ulceration in Patients on Dual Antiplatelet Therapy After Percutaneous Coronary Intervention
To determine the rate of symptomatic and asymptomatic gastrointestinal erosions and ulcerations in patients on dual antiplatelet (aspirin and clopidogrel) therapy after percutaneous coronary intervention (PCI).
- Trial name
- NCT00413309
- Testing
- Video Capsule Endoscopy
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Brigham and Women's Hospital
Acute Kidney Injury
Effect of Nitric Oxide in Cardiac Surgery Patients With Endothelial Dysfunction.
The purpose of this study is to determine whether nitric oxide is effective in the treatment of acute kidney injury in cardiac surgical patients with sign and laboratory data suggesting endothelial dysfunction undergoing…
- Trial name
- MGHK23 (NCT02836899)
- Testing
- Nitric Oxide
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- Massachusetts General Hospital
Smoking Cessation, Acute Coronary Syndrome
Post Acute Coronary Event Smoking Study
Smoking and depressed mood are both predictive of mortality following Acute Coronary Syndrome. However, to date, no counseling treatment has been designed to target smoking cessation and manage mood in this population.
- Trial name
- PACES (NCT01964898)
- Testing
- Behavioral Activation (BA), Standard Smoking Cessation Counseling, Nicotine patch
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- The Miriam Hospital
Acute Coronary Syndrome
Effect of Colchicine on Coronary Reperfusion in Patients With Acute Coronary Syndrome
This randomized clinical trial will determine the treatment effect of colchicine (1.5 mg loading dose and 0.5 mg daily thereafter) for 6 weeks on microvascular coronary reperfusion and infarct size in patients with acute coronary…
- Trial name
- NCT05472337
- Testing
- Colchicine
- Where
- Chile
- Volunteers
- 50 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Chronic Obstructive Pulmonary Disease (COPD), Acute Coronary Syndrome
Feasibility Study of a Digital Interactive Life-style Platform for Individuals After Rehabilitation
The goal of this clinical trial is to evaluate the feasibility and usability of a digital lifestyle platform designed to support patients after discharge from inpatient rehabilitation.
- Conditions
- Chronic Obstructive Pulmonary Disease (COPD), Acute Coronary Syndrome, Fragility Fracture, Minor Stroke
- Trial name
- Feas Platf (NCT07597031)
- Testing
- Digital Lifestyle Platform, Usual Care (Standard Post-Rehabilitation Care)
- Where
- 2 sites in Switzerland
- Volunteers
- 240 people
- Sponsor
- Matthias Wilhelm, MD
Coronary Syndrome
Determinants of Cognitive Impairment After Acute Coronary Syndrome
The general purpose of the present pathophysiological study is to investigate the relation between cognitive impairment observed after an acute coronary syndrome and the presence of cerebral anatomo-functional abnormalities.
- Trial name
- COSCA (NCT00982176)
- Testing
- Brain MRI and cerebral perfusion scintigraphy
- Where
- 2 sites in France
- Volunteers
- 49 people
- Sponsor
- University Hospital, Bordeaux
Myocardial Infarction, Cardiogenic Shock
Aortic Balloon Counterpulastion in Myocardial Infarction Related Shock
The role of intra aortic balloon counterpulsation in patients experiencing acute myocardial infarction with shock is not established. We hypothesised that use of such a device would lead to improved outcomes in these patients.
- Trial name
- IABPSHOCK (NCT00469248)
- Testing
- Intra-aortic balloon pump counterpulsation
- Where
- Germany
- Volunteers
- 45 people
- Sponsor
- Martin-Luther-Universität Halle-Wittenberg
Heart Failure
Slow Continuous Ultrafiltration Using Central vs Peripheral Line: Feasibility of Implementation, Safety and Efficacy in Acute Heart Failure Syndromes.
Slow continuous ultrafiltration using central vs peripheral line: feasibility of implementation, safety and efficacy in acute heart failure syndromes.
- Trial name
- NCT01630317
- Testing
- Peripheral line, Central line vein
- Where
- Spain
- Volunteers
- 33 people
- Sponsor
- Parc de Salut Mar
Coronary Artery Disease, Myocardial Ischemia
BIOFLOW-III All-comers Orsiro Safety and Performance Registry
This registry is a clinical post-market evaluation of the Orsiro LESS in subjects requiring coronary revascularization with Drug Eluting Stents (DES).
- Trial name
- BIOFLOW-III (NCT01553526)
- Where
- 43 sites in Austria, Chile and 11 more
- Volunteers
- 1,356 people
- Sponsor
- Biotronik AG
Acute Coronary Syndrome
Lipid Profile in Acute Coronary Syndrome
This study aims to assess the TG/Hdl-c ratio in patients with acute coronary syndrome as a novel marker of atherosclerosis.
- Trial name
- NCT05126043
- Testing
- Triglycerides/high density lipoprotein ratio
- Where
- Egypt
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Sohag University
Chest Pain, Acute Coronary Syndrome
Shared Decision Making in the Emergency Department: Chest Pain Choice Trial
Our long-term goal is to promote evidence-based patient-centered evaluation in the acute setting to more closely tailor testing to disease risk.
- Trial name
- CPC (NCT01969240)
- Testing
- Chest Pain Choice Decision Aid
- Where
- 5 sites in United States
- Volunteers
- 898 people
- Sponsor
- Mayo Clinic
Acute Coronary Syndromes
Targeted Feedback Reports to Improve Acute Coronary Syndromes (ACS) Care
This project is designed to examine the impact of tailored feedback on site performance. The investigators' objective is to evaluate whether a 'personalized and targeted' feedback, education and performance improvement…
- Trial name
- NCT00952250
- Testing
- Targeted Feedback Reports, Targeted Feedback Report
- Where
- United States
- Volunteers
- 149 people
- Sponsor
- Duke University
Acute Decompensated Heart Failure
Does Ultrasound Assessment for Extravascular Lung Water and IVC Measurement Affect Outcomes in Inpatient Heart Failure Management?
This study evaluates daily POCUS/FCU exams on patients admitted for acute decompensated heart failure with primary end point of acute kidney injury while in hospital.
- Trial name
- NCT04436718
- Testing
- Daily pocus exam
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Riverside University Health System Medical Center
Cardiac Surgery
Individualized Blood Pressure Management in Patients Undergoing Cardiac Surgery
This pilot randomized-controlled study will determine the feasibility of large study comparing individualized versus standard blood pressure (BP) management in patients undergoing cardiac surgery under cardiopulmonary bypass…
- Trial name
- PRECISE (NCT03784690)
- Testing
- Individualized intraoperative BP management, Standard intraoperative BP management
- Where
- Russia
- Sponsor
- Meshalkin Research Institute of Pathology of Circulation
Acute Respiratory Failure, Heart Failure
Tracheostomy in ICU With a Double Lumen Endotracheal Tube
Percutaneous tracheostomy in Intensive care unit (ICU) is performed with the use of flexible fiberoptic bronchoscope inside the conventional single lumen endotracheal tube owned by the patients.
- Conditions
- Acute Respiratory Failure, Heart Failure, Neurological Disease
- Trial name
- NCT01691222
- Testing
- Double lumen endotracheal tube tracheostomy
- Where
- 2 sites in Italy
- Volunteers
- 30 people
- Sponsor
- University of Genova
Infarction, Myocardial
Efficacy Of Eptifibatide Compared To Abciximab In Primary Percutaneous Coronary Intervention (PCI) For Acute ST Elevation Myocardial Infarction (STEMI)
Multinational, multicentre, randomised, prospective, open, parallel group study directly comparing two glycoprotein-IIb/IIIa inhibitors, abciximab and eptifibatide, added early to standard treatment before primary PCI of STEMI…
- Trial name
- NCT00426751
- Testing
- Abciximab, Eptifibatide
- Where
- 24 sites in France, Germany
- Volunteers
- 429 people
- Sponsor
- GlaxoSmithKline
Chest Pain, Coronary Artery Disease
ARgentinean Risk Assessment Registry in ACS; the ARRA-RACS Study
The first aim of this trial is to assess the long-term prognostic value of Omega-3 index, which is a measure of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) relative to other fatty acids in the erythrocyte membrane…
- Conditions
- Chest Pain, Coronary Artery Disease, Unstable Angina Pectoris, Myocardial Infarction
- Trial name
- ARRA-RACS (NCT01377402)
- Where
- 10 sites in Argentina, Norway
- Volunteers
- 982 people
- Sponsor
- Helse Stavanger HF
Acute Coronary Syndrome
Rivaroxaban ACS Specialist Cohort Event Monitoring Study
Rivaroxaban is a medicine which reduces the formation of blood clots. Acute coronary syndrome (ACS) comprises a range of disorders, including heart attack and unstable angina, caused by a sudden reduction in blood flow to part of…
- Trial name
- ROSE ACS (NCT02673437)
- Testing
- This is a non-interventional study
- Where
- 2 sites in United Kingdom
- Volunteers
- 701 people
- Sponsor
- Drug Safety Research Unit, Southampton, UK
Magnesium Disorder
The Relationship Between Preoperative Levels of Ionized Magnesium and Risk of Acute Kidney Injury After Cardiac Surgery
Detection the relationship between preoperative ionized magnesium levels and the risk of acute kidney injury after cardiac surgery.
- Trial name
- NCT05903677
- Testing
- magnesium levels
- Volunteers
- 50 people
- Sponsor
- Assiut University
Acute Coronary Syndrome, Renal Insufficiency
Remote Ischemic Preconditioning in ACS Patients
Remote ischemic preconditioning is a process of serial blood pressure cuff inflations and deflations that are performed prior to a procedure and have been shown in various other areas (coronary bypass surgery, vascular surgery…
- Conditions
- Acute Coronary Syndrome, Renal Insufficiency, Ischemia, Myocardial
- Trial name
- NCT03329612
- Testing
- Remote Ischemic Preconditioning
- Where
- United States
- Sponsor
- Henry Ford Health System
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