Clinical trials: Acute Coronary Disease
Heart Failure
Dapa Acute Heart Failure Study
Heart failure (HF) is one of the most important reasons for hospital admission and is associated with high mortality and morbidity.
- Trial name
- NCT05759000
- Testing
- Dapagliflozin
- Where
- Hong Kong
- Volunteers
- 100 people
- Sponsor
- Chinese University of Hong Kong
Acute Coronary Syndrome, ST Elevation Myocardial Infarction
A Trial of Routine Aspiration Thrombectomy With Percutaneous Coronary Intervention (PCI) Versus PCI Alone in Patients With ST-Segment Elevation Myocardial Infarction (STEMI) Undergoing Primary PCI
This is an international, randomized, controlled, parallel group study in which patients with ST-Segment Elevation Myocardial Infarction (STEMI) will be allocated to one of the following: Manual aspiration thrombectomy with…
- Conditions
- Acute Coronary Syndrome, ST Elevation Myocardial Infarction, Percutaneous Coronary Intervention
- Trial name
- TOTAL (NCT01149044)
- Testing
- Percutaneous Coronary Intervention with or without manual aspiration thrombectomy
- Where
- 87 sites in United States, Australia and 18 more
- Volunteers
- 10,732 people
- Sponsor
- Population Health Research Institute
Acute Coronary Syndrome Comorbid With Cerebral Atherosclerosis
Tanhuo Decoction for Acute Coronary Syndrome With Cerebral Atherosclerosis in Elderly Patients
The goal of this clinical trial is to learn if Tanhuo decoction works to treat acute coronary syndrome combined with cerebral atherosclerosis in the elderly. It will also learn about the safety of Tanhuo decoction.
- Trial name
- NCT07445581
- Testing
- Tanhuo decoction, standard Western medicine
- Where
- China
- Volunteers
- 480 people
- Sponsor
- Jinggang Xia, MD
Chronic Kidney Diseases, Acute Coronary Syndrome
Study Comparing Treatment Effectiveness of Guideline Indicated APT for ACS in Patients With CKD
To compare clinical outcomes in patients with chronic kidney disease (CKD) presenting with an acute coronary syndrome (ACS) treated with clopidogrel or ticagrelor (both FDA approved and guideline indicated drugs for treating…
- Trial name
- CPRS-CKD (NCT03150667)
- Testing
- Ticagrelor, Clopidogrel
- Where
- 2 sites in United States
- Volunteers
- 220 people
- Sponsor
- North Texas Veterans Healthcare System
Ischemic Stroke, Paroxysmal Atrial Fibrillation
Paroxysmal Atrial Fibrillation in Patients With Acute Ischemic Stroke
The purpose of this study is to estimate the clinical relevance of monitoring patients with acute ischemic stroke with 48 hours' inpatient cardiac telemetry in relation to evaluate the presence of brief runs of premature atrial…
- Conditions
- Ischemic Stroke, Paroxysmal Atrial Fibrillation, Premature Atrial Complexes
- Trial name
- NCT02610803
- Where
- Denmark
- Volunteers
- 863 people
- Sponsor
- Odense University Hospital
Pulmonary Embolism, Acute Pulmonary Embolism
FlowTriever Pulmonary Embolectomy Clinical Study
Evaluate the safety and effectiveness of the FlowTriever System for use in the removal of emboli from the pulmonary arteries in the treatment of acute pulmonary embolism.
- Conditions
- Pulmonary Embolism, Acute Pulmonary Embolism, Submassive Pulmonary Embolism, Massive Pulmonary Embolism
- Trial name
- FLARE (NCT02692586)
- Testing
- FlowTriever System
- Where
- 18 sites in United States
- Volunteers
- 106 people
- Sponsor
- Inari Medical
Acute Coronary Syndrome, STEMI - ST-segment Elevation Myocardial Infarction
Kitasato PCI Registry
The Kitasato PCI Registry is a single-center, observational, prospective study. This study aims to investigate the impact of characteristics in clinical manifestation, patients' background, procedure of percutaneous coronary…
- Conditions
- Acute Coronary Syndrome, STEMI - ST-segment Elevation Myocardial Infarction, NSTEMI - Non-ST-Segment Elevation Myocardial Infarction, Atherosclerosis
- Trial name
- NCT05308329
- Testing
- Intra-coronary imaging device, PCI procedural characteristics
- Where
- Japan
- Volunteers
- 4,500 people
- Sponsor
- Kitasato University
Acute Coronary Syndrome
Prediction of Cardiovascular Events in Vulnerable Patients Following Acute Coronary Syndrome
The purpose of this study is to determine if testing patients for endothelial dysfunction will help identify which patients are more likely at risk to have another heart attack in the future.
- Trial name
- NCT01500902
- Testing
- EndoPAT testing (non invasive device), WatchPAT testing (non-invasive device)
- Where
- United States
- Volunteers
- 101 people
- Sponsor
- Mayo Clinic
Coronary Artery Disease
PCSK9 inhibitoRs for Early Passivation of coRonary athEroSclerotic plaqueS in Acute Coronary Syndromes (REPRESS)
In this prospective, multicenter, open-label trial, 212 ACS patients will be randomized 1:1 to either the "PCSK9i early" intensified therapy group (initial addition of PCSK9i to moderate-intensity statin) or the…
- Trial name
- NCT06791031
- Testing
- PCSK9 inhibitor (PCSK9i)
- Volunteers
- 212 people
- Sponsor
- West China Hospital
Acute Myocardial Infarction (AMI), Asystole
SPIKE FLOW Endocardial Lead Safety and Performance Study
The objective of this study is to assess the safety and performance of the SPIKE FLOW endocardial lead. Primary objectives are to assess: safety in terms of freedom from Serious Adverse Events(SADEs); performance in terms of Mean…
- Conditions
- Acute Myocardial Infarction (AMI), Asystole, Bradycardia, AV Block
- Trial name
- SPIKE FLOW (NCT07820072)
- Testing
- Lead insertion, lead removal
- Where
- 3 sites in Italy
- Volunteers
- 131 people
- Sponsor
- FIAB SpA
Heart Failure Acute, Heart Failure
Strain for Risk Assessment and Therapeutic Strategies in Patients With Acute Heart Failure (STRATS-AHF) Registry
STRATS-AHF (STrain for Risk Assessment and Therapeutic Strategies in patients with Acute Heart Failure) registry enrolled 4,312 patients hospitalized for acute HF from 3 tertiary university hospitals (Seoul National University…
- Conditions
- Heart Failure Acute, Heart Failure, Echocardiography
- Trial name
- STRATS-AHF (NCT03513653)
- Testing
- Echocardiography with speckle-tracking imaging
- Where
- 3 sites in South Korea
- Volunteers
- 4,312 people
- Sponsor
- Seoul National University Hospital
Acute Pulmonary Embolism
Epoprostenol in Pulmonary Embolism
You are admitted to hospital because of pulmonary embolism. You are treated with anticoagulants. The investigators know that, despite this treatment, pulmonary embolism can be a threat especially if heart function is compromized.
- Trial name
- NCT01014156
- Testing
- epoprostenol
- Where
- Netherlands
- Volunteers
- 14 people
- Sponsor
- Universitair Ziekenhuis Brussel
COVID-19, SARS-CoV 2
Canakinumab in Covid-19 Cardiac Injury (The Three C Study)
TThe purpose of this prospective, Phase 2, single center, blinded, randomized controlled study is to demonstrate as a proof of concept that early treatment with canakinumab prevents progressive heart and respiratory failure in…
- Trial name
- NCT04365153
- Testing
- Canakinumab Injection 600mg, Canakinumab Injection 300mg
- Where
- 2 sites in United States
- Volunteers
- 45 people
- Sponsor
- The Cleveland Clinic
Acute Kidney Injury, Cardiac Surgery
Kidney Oxygen Saturation and Neutrophil Gelatinase-associated Lipocalin (NGAL) for Detecting Acute Kidney Injury (AKI) After Cardiac Surgery
Acute kidney injury (AKI) is an important complication following cardiac surgery with cardiopulmonary bypass (CPB). Early identification of patients at risk of AKI may facilitate timely clinical management.
- Conditions
- Acute Kidney Injury, Cardiac Surgery, Cardiopulmonary Bypass
- Trial name
- NCT07837037
- Testing
- Renal Near-Infrared Spectroscopy Monitoring, Neutrophil Gelatinase-Associated Lipocalin (NGAL) Measurement
- Where
- Turkey (Türkiye)
- Volunteers
- 85 people
- Sponsor
- Haseki Training and Research Hospital
Myocardial Infarction
A Structuralised Sick-leave Program Compared to Usual Care Sick Leave Management in Patients After an Acute Myocardial Infarction
In this study the investigators aim at comparing the effect on quality of life and the cost-effectiveness of a structuralised sick-leave program compared to usual care sick leave management in patients after an acute non ST…
- Trial name
- NCT01108653
- Testing
- Usual care sick-leave management, Structuralised sick-leave program
- Where
- Norway
- Volunteers
- 120 people
- Sponsor
- Oslo University Hospital
Acute Coronary Syndrome, Atherosclerosis
Change in Plaque Characteristics With Atorvastatin
To examine effects of intensive lipid lowering therapy with atorvastatin on stabilization of coronary plaque by using optical coherence tomography (OCT) in patients with acute coronary syndrome.
- Conditions
- Acute Coronary Syndrome, Atherosclerosis, Dyslipidemia
- Trial name
- EASY-FIT (NCT00700037)
- Testing
- high-dose atorvastatin, low-dose atorvastatin
- Where
- Japan
- Volunteers
- 70 people
- Sponsor
- Wakayama Medical University
STEMI - ST Elevation Myocardial Infarction, Thrombi
Pan-Cardio-Genetics Clot Assessment in Acute Coronary Syndromes
Acute myocardial infarction with ST elevation (STEMI) is one of the leading causes of mortality. Although the presence of thrombus in STEMI patients has been linked to adverse outcomes, routine thrombus aspiration has not been…
- Conditions
- STEMI - ST Elevation Myocardial Infarction, Thrombi, MicroRNA
- Trial name
- PGCA-ACS (NCT03832153)
- Testing
- thrombus aspiration
- Where
- Greece
- Sponsor
- Aristotle University Of Thessaloniki
Coronary Disease
RE-DEEM Dose Finding Study for Dabigatran Etexilate in Patients With Acute Coronary Syndrome
The purpose of this trial is to evaluate the safety and indicators of efficacy of up to 4 doses of orally administered dabigatran etexilate, administered twice daily, compared to placebo when given in addition to dual…
- Trial name
- NCT00621855
- Testing
- dabigatran etexilate
- Where
- 167 sites in United States, Belgium and 22 more
- Volunteers
- 1,878 people
- Sponsor
- Boehringer Ingelheim
Coronary Artery Disease, Acute Coronary Syndrome
Τicagrelor Versus Prasugrel in Diabetic Patients: a Pharmacodynamic Study
This is a prospective, randomized, single-center, single blind, investigator initiated, two period study of crossover design. Diabetic patients with Acute Coronary Syndrome (ACS), treated with oral and/or parenteral hypoglycaemic…
- Trial name
- NCT01642940
- Testing
- Prasugrel, Ticagrelor
- Where
- Greece
- Volunteers
- 30 people
- Sponsor
- University of Patras
Cardiac Surgery, Pain
Development and Evaluation of a Nursing Virtual Intervention Tailored for Pain After Cardiac Surgery
The purpose of this project is to develop and evaluate the effects of a computer-tailored intervention targeting pain barriers and catastrophizing in adults having cardiac surgery.
- Conditions
- Cardiac Surgery, Pain, Adult, Pain Management
- Trial name
- SOULAGETAVIE (NCT01084018)
- Testing
- soulageTAVIE
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
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