Clinical trials: Acute Coronary Disease
Heart Failure, Noninvasive Ventilation
High Flow Nasal Oxygen and Acute Left Heart Failure
Acute left heart failure (ALHF) is a sudden attack or deterioration of abnormal left heart function, which may impair myocardial contractility and increase cardiac loading, further result in decreased cardiac output, abrupt…
- Conditions
- Heart Failure, Noninvasive Ventilation, Oxygen Therapy
- Trial name
- HFNO (NCT03607357)
- Testing
- High Flow Nasal Oxygen, Non-invasive Ventilation
- Where
- China
- Volunteers
- 123 people
- Sponsor
- Nanjing Jiangbei People's Hospital
Acute Coronary Syndrome
Continuous Clopidogrel Dose Adjustment in Acute Coronary Syndrome Patients With High On-treatment Platelet Reactivity
The purpose of this study is to determine whether continuous clopidogrel dose adjustment targeted after platelet function testing improves outcomes during 12 months of follow-up in acute coronary syndrome patients treated with…
- Trial name
- NCT02096419
- Testing
- Clopidogrel dose adjustment
- Where
- Croatia
- Volunteers
- 87 people
- Sponsor
- University of Zagreb
Cardiac Disease, Diagnoses Disease
Diagnostic Value of CircRNA-Uck2 for Acute Myocardial Infarction
This is an observational diagnostic study that aims to evaluate the diagnostic value of circRNA-Uck2 in Acute Myocardial Infarction (AMI) in adults as compared to healthy and unstable angina controls.
- Conditions
- Cardiac Disease, Diagnoses Disease, Acute Myocardial Infarction
- Trial name
- NCT03170830
- Testing
- the diagnosis value of cUck2 in acute myocardial infarction.
- Where
- China
- Volunteers
- 178 people, healthy volunteers welcome
- Sponsor
- Beijing Haidian Hospital
Stroke Acute, Atrial Fibrillation
Stroke Alarm Efficacy Trial
The aim of this study is to test the efficacy of the CE-marked wearable system Stroke Alarm to identify the onset of a stroke with unilateral arm motor deficit within 3 hours of onset.
- Conditions
- Stroke Acute, Atrial Fibrillation, TIA
- Trial name
- StrokeAlarmEFF (NCT06315192)
- Testing
- Stroke Alarm
- Where
- 10 sites in Sweden
- Volunteers
- 500 people
- Sponsor
- Region Skane
Cardiovascular Diseases
Chronic and Acute Effects of Smoking on the Left and Right Ventricular Relaxation in Young Healthy Smokers
Impairment of relaxation, the early phase of ventricular diastole is the first stage of heart diastolic dysfunction. Left ventricular diastolic function can be determined noninvasively by Echo- Doppler - derived mitral valve flow…
- Trial name
- NCT00395928
- Where
- Poland
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Medical University of Warsaw
Heart Failure, Heart Failure Acute
Nitroglycerin vs. Furosemide Using Lung Ultrasound Pilot Trial
Nearly 80% of acute heart failure (AHF) patients admitted to the hospital are initially treated in the emergency department (ED). Once admitted, within 30 days post-discharge, 27% of patients are re-hospitalized or die.
- Conditions
- Heart Failure, Heart Failure Acute, Acute Cardiac Failure, Acute Cardiac Pulmonary Edema
- Trial name
- N-FURIOUS (NCT03259165)
- Testing
- Nitrates, Loop Diuretics
- Where
- 3 sites in United States
- Volunteers
- 52 people
- Sponsor
- Indiana University
Myocardial Infarction, STEMI
Cost-effectiveness of Genotype Guided Treatment With Antiplatelet Drugs in STEMI Patients: Optimization of Treatment (POPular Genetics)
Rationale: the use of antiplatelet drugs (i.e. clopidogrel, ticagrelor or prasugrel) is crucial in the treatment of patients undergoing percutaneous coronary intervention (PCI) with stent implantation to prevent atherothrombotic…
- Trial name
- NCT01761786
- Testing
- CYP2C19 genotyping
- Where
- 10 sites in Belgium, Italy and 1 more
- Volunteers
- 2,700 people
- Sponsor
- Vera HM Deneer
STEMI
Erectile Dysfunction After Percutaneous Coronary Intervention Versus the Thrombolytic Therapy in Acute ST Elevation Myocardial Infarction
Erectile dysfunction is a common sexual problem affecting up to one-third of men throughout their life. It is now well recognized that risk factors for erectile dysfunction (ED) include the same risk factors as coronary artery…
- Trial name
- NCT03328156
- Where
- Egypt
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Assiut University
End-stage Heart Failure
Acute Reno-Cardiac Action of Dapagliflozin In Advanced Heart Failure Patients on Heart Transplant Waiting List
In the DAPA-HF trial, the use of dapagliflozin, an inhibitor of sodium-glucose cotransporter 2 (SGLT2), reduced significantly the risk of worsening heart failure or death from cardiovascular causes compared to placebo among…
- Trial name
- ARCADIA-HF (NCT04782245)
- Testing
- Dapagliflozin 10mg
- Where
- France
- Sponsor
- Hospices Civils de Lyon
Atrial Fibrillation
This Study Uses the SITS Registry to Find Out When Patients With a Heart Rhythm Disorder (Atrial Fibrillation) Start Treatment With Dabigatran After They Had a Stroke
This is an observational study in patients with non-valvular atrial fibrillation (NVAF) presenting to the hospital with a first acute ischemic stroke based on existing data recorded in the SITS International Registry (located in…
- Trial name
- NCT03258645
- Testing
- Dabigatran
- Where
- Sweden
- Volunteers
- 1,489 people
- Sponsor
- Boehringer Ingelheim
Acute Ischemic Stroke
Heart Evaluation of Acute Ischemic Stroke With Reperfusion Therapy
Heart Evaluation of Acute ischemic stroke with Reperfusion Therapy (HEART) is a single-center observational registry evaluating the heart of patients hospitalized for acute ischemic stroke with reperfusion therapy.
- Trial name
- HEART (NCT06882577)
- Testing
- observational only- no intervention
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Soochow University
Atherosclerosis, Myocardial Ischemia
Trial to Assess the Effects of Vorapaxar (SCH 530348; MK-5348) in Preventing Heart Attack and Stroke in Particpants With Acute Coronary Syndrome (TRA•CER) (Study P04736)
The study is designed to determine whether vorapaxar, when added to the existing standard of care (eg, aspirin, clopidogrel) for preventing heart attack and stroke in patients with acute coronary syndrome, will yield additional…
- Conditions
- Atherosclerosis, Myocardial Ischemia, Myocardial Infarction
- Trial name
- NCT00527943
- Testing
- Vorapaxar
- Volunteers
- 12,944 people
- Sponsor
- Merck Sharp & Dohme LLC
Coronary Heart Disease, Acute Myocardial Infarction
Research on the Diagnostic Value of Machine Learning Model Based on Clinical Data in Patients With Coronary Heart Disease
Based on the clinical data of patients, a machine learning model for coronary heart disease diagnosis was established to evaluate whether the model could improve the accuracy of coronary heart disease diagnosis, and to evaluate…
- Conditions
- Coronary Heart Disease, Acute Myocardial Infarction, Angina
- Trial name
- NCT05018715
- Testing
- Machine learning model diagnosis
- Where
- China
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Xiang Ma
Acute Coronary Syndrome
Vascular Healing After Deployment of Titanium-nitride-oxide-coated OPTIMAX™ Stent and PROMUS-ELEMENT™ Everolimus-Eluting Stent
The purpose of this study is to compare vascular healing of the stented segment after deployment of titanium-nitride-oxide coated cobalt-chromium Optimax™-stent stent and Promus-Element™ everolimus-eluting stent in patients with…
- Trial name
- TIDES-OCT (NCT02280720)
- Testing
- Stenting using Optimax™, Stenting using PROMUS Element™ Plus
- Where
- 4 sites in Finland
- Volunteers
- 40 people
- Sponsor
- The Hospital District of Satakunta
Chronic Heart Failure
Acute Heart Failure Monitoring Via Inferior Vena Cava Ultrasound
Known before diagnosed heart failure and used diuretic therapy patients will be admitted in this study.The objective of this work is whether the Inferior Vena Cava Ultrasound can be used for management of Acute Heart failure…
- Trial name
- NCT02725151
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people
- Sponsor
- Haseki Training and Research Hospital
Acute Coronary Syndrome
Serum Concentration of Wnt2 and Wnt4 in Patients With Acute Coronary Syndrome
This study aims to find the change of serum wnt effectory moleculars and the association with Hs-CRP，cTnI and Prognosis in Patients with Acute Coronary Syndrome.
- Trial name
- NCT03342131
- Testing
- Circulating wnt 2 and wnt 4 concentration
- Where
- China
- Volunteers
- 450 people
- Sponsor
- The First Affiliated Hospital of Dalian Medical University
Coronary Arterial Disease (CAD), Vulnerable Coronary Plaques
Effectiveness of Interventional Therapy for Non-Flow-Limiting Vulnerable Plaques
The aim of this clinical trial is to explore the optimal preventative treatment strategy for non-flow-limiting vulnerable plaques.
- Conditions
- Coronary Arterial Disease (CAD), Vulnerable Coronary Plaques, Thin-cap fIbroatheroma, Acute Coronary Syndromes (ACS)
- Trial name
- NCT06855537
- Testing
- PCI strategy, OMT strategy
- Where
- China
- Volunteers
- 2,190 people
- Sponsor
- Beijing Anzhen Hospital
Aortic Dissection
Nordic Consortium for Acute Type A Aortic Dissection-2
The Nordic Consortium for Acute Type A Aortic Dissection-2 (NORCAAD-2) is a multicenter research collaboration involving up to 19 units in the Nordic countries and one in The Netherlands.
- Trial name
- NORCAAD-2 (NCT06862583)
- Testing
- surgery, endovascular intervention
- Where
- Sweden
- Volunteers
- 5,000 people
- Sponsor
- Karolinska Institutet
Acute Coronary Syndrome
Effect of Glucose-insulin-potassium Solution on Myocardial Protection During Off-pump Coronary Bypass Surgery in Patients With Acute Coronary Syndrome
Patients undergoing multivessel off-pump coronary bypass surgery (OPCAB) inevitably experience cumulative ischemia-reperfusion injury at myocardium.
- Trial name
- NCT01384656
- Testing
- GIK solution
- Where
- South Korea
- Volunteers
- 66 people
- Sponsor
- Yonsei University
Acute Kidney Injury
Remote Ischemic Preconditioning to Prevent Contrast Nephropathy
Contrast-medium induced nephropathy (CIN) is a frequent and devastating complication of coronary angiography, occurring in 10-50% of cases.
- Trial name
- RIPC-CIN (NCT02674451)
- Testing
- Remote ischemic preconditioning
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Johns Hopkins University