Clinical trials: Acute Decompensated Heart Failure (ADHF)
Acute Decompensated Heart Failure
Low Level Tragus Stimulation in Acute Decompensated Heart Failure
Acute Decompensated Heart Failure (ADHF) is a major cause of morbidity and mortality. It is associated with increased systemic inflammation.
- Trial name
- TREAT-HF (NCT02898181)
- Testing
- Neuromodulation
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Oklahoma
Acute Decompensated Heart Failure
Impact of Hypertonic Saline Solution on Acute Decompensated Heart Failure
Acute decompensated heart failure (HF) is one of the most common cardiologic issues in emergency departments. Loop diuretics have long been recognized as the key for the treatment of Acute Decompensated Heart Failure…
- Trial name
- HSS (NCT05298098)
- Testing
- Hypertonic Saline Solution
- Where
- Tunisia
- Volunteers
- 600 people
- Sponsor
- University of Monastir
Acute Decompensated Heart Failure (ADHF), Cardiorenal Syndrome (CRS)
Clinical Outcomes of Levosimendan Versus Dobutamine Versus Milrinone in Cases With Acute Decompensated Heart Failure With Impaired Renal Function
This study aimed to assess and compare the cardiac, renal, and clinical efficacy of Levosimendan (LEV), Dobutamine (DOB), and milrinone (MIL) in cases with acute decompensated heart failure (ADHF) complicated by renal impairment…
- Trial name
- NCT07186062
- Testing
- Levosimendan, Dobutamine, Milrinone
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Heart Failure
Efficacy and Safety of Tolvaptan in Japanese Patients With Acute Heart Failure
The aims of the present study are to investigate prospectively the clinical course and outcome of the hospitalized heart failure patients treated with tolvaptan for management of fluid retention and serum sodium levels of less…
- Trial name
- MT FUJI (NCT01635517)
- Where
- Japan
- Volunteers
- 274 people
- Sponsor
- Translational Research Center for Medical Innovation, Kobe, Hyogo, Japan
Myocardial Infarction (MI), Heart Failure
Timing of Coronary Angiography in NSTEMI Complicated by Acute HF
Study objectives: To determine the optimal timing of coronary angiography (CAG) in patients with non-ST-segment elevation myocardial infarction (NSTEMI) complicated by acute decompensated heart failure (AHF).
- Trial name
- TIMING-AHF (NCT07002164)
- Testing
- Immediate coronary angiography, Delayed coronary angiography
- Where
- 20 sites in South Korea
- Volunteers
- 780 people
- Sponsor
- Chonnam National University Hospital
Congestive Heart Failure
Sub-Q Versus IV Furosemide in Acute Heart Failure
This study evaluates the clinical efficacy of subcutaneously administered Furosemide Injection Solution versus intravenous administration of Furosemide Injection, United States Pharmacopeia (USP) in adult patients presenting to a…
- Trial name
- NCT02579057
- Testing
- Furosemide Injection Solution (SCP-101), Furosemide Injection Solution, USP
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Johns Hopkins University
Acute Decompensated Heart Failure (ADHF)
Bedside Ultrasound-guided Volume Management and Discharge Timing for Patients With Heart Failure During Hospitalization: A Randomized Controlled Trial
Brief Summary of the POCUS-HF Study The goal of this clinical trial is to determine whether using bedside ultrasound (POCUS) to guide fluid management and discharge timing can improve outcomes for hospitalized heart failure (HF)…
- Trial name
- NCT07046169
- Testing
- Ultrasound-Guided Volume Assessment and Decongestion Strategy (UVADS), clinical assessment
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Pan He
Acute Heart Failure
Rivaroxaban Once Daily Versus Dose-adjusted Vitamin K Antagonist on the Biomarkers in Acute Decompensated Heart Failure and Atrial Fibrillation (ROAD HF-AF)
Vitamin K antagonists (VKAs) are used to reduce the risk of stroke (cerebral vascular dysfunction) in AF patients. However, VKAs interact with drugs/food and the drug level is influenced by worsening of renal function, liver…
- Trial name
- NCT03490994
- Testing
- Rivaroxaban, Warfarin + LMWH
- Where
- South Korea
- Volunteers
- 150 people
- Sponsor
- Yonsei University
Heart Failure, Decompensated Heart Failure
Strategies for Assessment of Fluid Overload in Acute Decompensated Heart Failure
Heart failure (HF) is the endstage of all heart disease, characterized by inability of either the left or right heart or both to maintain sufficient output of blood for the demands of the body at normal filling pressures.
- Trial name
- FLUID-AHF (NCT04901039)
- Testing
- Lung ultrasound, Echocardiography, Peripheral venous pressure
- Where
- 3 sites in Sweden
- Volunteers
- 21 people
- Sponsor
- Region Skane
Cardiogenic Shock, Acute Decompensated Heart Failure
Study of Patients Admitted to a Cardiac Intensive Care Unit With Acute CardioVascular Disease
This is a registry of the patients that are admitted to CICU and treated by the Scientific Staff of the 2nd Department of Cardiology, due to an acute cardiovascular disease (acute coronary syndrome, acute heart failure…
- Conditions
- Cardiogenic Shock, Acute Decompensated Heart Failure, Acute Pulmonary Embolism, Acute Myocardial Infarction
- Trial name
- NCT06081205
- Testing
- Admission in the Cardiac Intensive Care Unit (CICU)
- Where
- Greece
- Volunteers
- 1,000 people
- Sponsor
- University Hospital, Ioannina
Acute Decompensated Heart Failure, Fluid Overload
A Feasibility Study on Ultrafiltration and Blood Volume Measurements
The objective of this feasibility study is to characterize the performance of the Aquadex FlexFlow® System with the hematocrit (HCT) feature in conjunction with Daxor's blood volume analyzer (BVA-100).
- Trial name
- NCT04241718
- Testing
- Aquadex FlexFlow System and BVA-100
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Nuwellis, Inc.
Heart Failure Acute, Ventilator Lung
SGLT2 Inhibitors in Patients With ADHF During Ventilator Weaning
This study will explore the potential benefits of sodium-glucose cotransporter 2 (SGLT2) inhibitors in preventing cardiac ischemia and cardiopulmonary edema in patients with acute decompensated heart failure during weaning from…
- Trial name
- NCT06142474
- Testing
- SGLT2 inhibitor
- Where
- Taiwan
- Volunteers
- 450 people
- Sponsor
- National Taiwan University Hospital
Heart Failure
Evaluation of Circulating Levels of Adult Stem Cells in the Peripheral Blood of Patients With Acute Decompensated Heart Failure and Following Stabilization, in Comparison With Healthy Volunteers
Despite advances in medical technology, heart failure remains a major cause of illness on a global scale. Medical research, over recent years, has shown that adult stem cells (as opposed to embryonic stem cells) are present in…
- Trial name
- CIRCSTEM-HF (NCT01027403)
- Where
- Australia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Monash University
Acute Decompensated Heart Failure, Sleep Disordered Breathing
Adaptive Servo Ventilation (ASV) in Heart Failure
Up to 60% of patients with heart failure show abnormal patterns of breathing (sleep disordered breathing (SDB)) at night which can increase the risk of recurrent admissions and have important prognostic implications.
- Trial name
- NCT02440971
- Testing
- S9-Autoset CS-A
- Where
- Ireland
- Volunteers
- 40 people
- Sponsor
- St Vincent's University Hospital, Ireland
Acute Decompensated Heart Failure (ADHF), Acute Cardiogenic Pulmonary Edema (ACPE)
Acute Congestive Heart Failure
The aim of the study is to determine the feasibility of collecting respiratory parameters during recompensation following ADHF (Acute Decompensated Heart Failure)with non-invasive measurements.
- Trial name
- AcuteCHF (NCT01885403)
- Testing
- non-invasive respiratory parameter measurements
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- RWTH Aachen University
Acute Decompensated Heart Failure
The Hemodynamic Effects of SGLT2i in Acute Decompensated Heart Failure
The main purpose of this study is to observe hemodynamic effects of initiating sodium-glucose co-transporter 2 inhibitors (SGLT2i) in patients admitted to the intensive care unit (ICU) with acute decompensated heart failure.
- Trial name
- NCT05346653
- Testing
- SGLT2i, No SGLT2i
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of Chicago
Acute Decompensated Heart Failure
A Study Of Acute Decompensated Heart Failure
The purpose of this study is to examine shorter hospitalization length as well as a reduced rates of recurrent heart failure hospitalization compared to current standard of care in Acute Decompensated Heart Failure.
- Trial name
- NCT07572955
- Testing
- Lung Ultrasound
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Mayo Clinic
Acute Heart Failure, Decompensated Heart Failure
Subcutaneous Furosemide in Acute Decompensated Heart Failure: The SUBQ-HF Study
To determine if a strategy of early discharge using a novel subcutaneous delivery system for parenteral furosemide can improve clinical outcomes within 30 days of randomization (days alive and outside the hospital) compared to…
- Trial name
- SUBQ-HF (NCT03170219)
- Testing
- subcutaneous furosemide and sc2wear device
- Where
- 16 sites in United States
- Volunteers
- 11 people
- Sponsor
- Adrian Hernandez
Congestive Heart Failure
Ultrafiltration Versus Intravenous (IV) Diuretics for Patients Hospitalized for Acute Decompensated Heart Failure: (UNLOAD)
The purpose of this study is to compare patients who are suffering from heart failure and who are fluid overloaded to determine if ultrafiltration (UF) can remove more of the extra fluid as measured by weight loss while in the…
- Trial name
- NCT00124137
- Testing
- Aquadex system, IV diuretic
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Nuwellis, Inc.
Acute Decompensated Heart Failure
Neutrophil Gelatinase-Associated Lipcalin (NGAL) Evaluation Along With B-Type Natriuretic Peptide in Acutely Decompensated HF
This is a multi-center prospective pilot clinical study to assess the utility of the Triage NGAL Test - alone and in conjunction with the Triage BNP test - as an aid in the early risk assessment for heart-failure-related adverse…
- Trial name
- GALLANT (NCT00693745)
- Where
- 5 sites in United States, Netherlands and 1 more
- Volunteers
- 231 people
- Sponsor
- Abbott RDx Cardiometabolic