Clinical trials: Acute Exacerbation Chronic Obstructive Pulmonary Disease
Pneumonia, Acute Exacerbation of Chronic Obstructive Airways Disease
Procalcitonin as a Marker of Antibiotic Therapy in Patients With Lower Respiratory Tract Infections
The purpose of this study is to investigate weather or not the use of a procalcitonin(PCT)-based treatment in the daily clinical work could lower the consumption of antibiotics in patients with lower respiratory tract infections.
- Trial name
- NCT02171338
- Testing
- PCT-level, Antibiotic treatment based on PCT-level
- Where
- Denmark
- Volunteers
- 55 people
- Sponsor
- Holbaek Sygehus
COPD Exacerbation (AECOPD), Pulmonary Hypertension
Dynamic Changes in Right Ventricle and Pulmonary Artery Coupling Among COPD Patients With Acute Exacerbation
Chronic obstructive pulmonary disease (COPD) is a common, preventable, and manageable disease characterized by persistent respiratory symptoms and airflow limitation.
- Trial name
- NCT07694713
- Testing
- Echocardiography assessment
- Where
- Egypt
- Volunteers
- 115 people
- Sponsor
- Assiut University
Chronic Obstructive Pulmonary Disease
Short Antibiotic Treatment Versus Duration Guided by Markers of Inflammation in the Treatment of AECOPD
Chronic obstructive pulmonary disease (COPD) is one of the most common diseases in the world. In a recent study, we showed that administration of levofloxacin is superior to placebo in the treatment of decompensation of COPD; it…
- Trial name
- AECOPD (NCT02067780)
- Testing
- Levofloxacin 500mg
- Where
- Tunisia
- Volunteers
- 310 people
- Sponsor
- University of Monastir
COPD Exacerbation Acute
Extracorporeal CO2 Removal in Acute Exacerbation of COPD Not Responding to Non-Invasive Ventilation
Background: Acute exacerbation of chronic obstructive pulmonary disease (ae-COPD) has a gold standard treatment: non-invasive ventilation (NIV).
- Trial name
- NCT04882410
- Volunteers
- 56 people
- Sponsor
- Centre Hospitalier de Saint-Denis
Chronic Obstructive Pulmonary Disease (COPD)
Clinical Evaluation of SenseGuard™ to Detect Respiratory Changes, During Home Monitoring of Subjects With High Risk of AECOPD.
This is an observational, open labeled study. The study aims to evaluate the capability of SenseGuard™ (SG) non-invasive wearable device, to detect, post-hoc, early respiratory changes due to exacerbation by daily monitoring of…
- Trial name
- NCT05119374
- Testing
- SenseGuard Investigational Device
- Where
- 6 sites in Israel
- Volunteers
- 57 people
- Sponsor
- NanoVation
Chronic Obstructive Pulmonary Disease
Early Pulmonary Rehabilitation for Hospitalized Patients With Exacerbations of Chronic Obstructive Pulmonary Disease (COPD)
Chronic obstructive pulmonary disease (COPD) is a disease state characterized by airflow limitation that is not fully reversible.
- Trial name
- NCT00287625
- Testing
- Pulmonary rehabilitation
- Where
- Hong Kong
- Volunteers
- 60 people
- Sponsor
- Chinese University of Hong Kong
COPD Exacerbation Acute
The Effect of Airway and Chest Wall Oscillation on Respiratory Functions in COPD Patients in Acute Exacerbation
Chronic obstructive pulmonary disease (COPD); It is a common, treatable and preventable disease characterized by progressive and irreversible airflow limitation and has systemic effects with respiratory system involvement.
- Trial name
- NCT06274957
- Testing
- CONTROL, PEP DEVICE, HFCWO DEVICE
- Where
- Turkey (Türkiye)
- Volunteers
- 33 people
- Sponsor
- Saglik Bilimleri Universitesi
Bronchitis, Chronic
A Study of the Safety and Effectiveness of Oral Levofloxacin Compared With Cefuroxime Axetil in the Treatment of Adults With Persistent Bronchitis Experiencing Rapid Onset of Severe Worsening of Symptoms Caused by Bacteria
The purpose of this study is to evaluate the safety and effectiveness of levofloxacin, an antibiotic, compared with cefuroxime axetil, another antibiotic, in the treatment of adults with chronic bronchitis experiencing rapid…
- Trial name
- NCT00269932
- Testing
- levofloxacin
- Volunteers
- 485 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Chronic Obstructive Pulmonary Disease
Myotrace: An Evaluation of a Novel Critical Illness Monitoring System
There are 24,000 admissions each year to Intensive Care Units (ICU) in the United Kingdom due to pneumonia, asthma and a common condition called chronic obstructive pulmonary disease (COPD), with rates of death of 10%, 40% and…
- Trial name
- NCT01361451
- Where
- United Kingdom
- Volunteers
- 120 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Chronic Obstructive Pulmonary Disease (COPD)
Examining Pulmonary Rehabilitation on Discharged COPD Patients
Chronic obstructive pulmonary disease (COPD) is a chronic lung disease primarily caused by smoking. COPD creates a tremendous burden to the healthcare system, as disease exacerbations result in frequent, prolonged…
- Trial name
- NCT02426437
- Testing
- Pulmonary Rehabilitation (PR), Usual Care
- Where
- Canada
- Volunteers
- 87 people
- Sponsor
- University of Alberta
Chronic Obstructive Pulmonary Disease
Placebo Versus Antibiotics in Acute Exacerbations of Chronic Obstructive Pulmonary Disease (COPD)
The role of antibiotic therapy in patients with COPD remains controversial. While the outcome of several clinical trials is in favour of antibiotics, the quality of these studies in insufficient.
- Trial name
- NCT00170222
- Testing
- doxycycline
- Where
- Netherlands
- Volunteers
- 258 people
- Sponsor
- Medical Center Alkmaar
Chronic Obstructive Pulmonary Disease, COPD
Do Blood Tests Help to Decide Which Patients With Flares of Chronic Obstructive Pulmonary Disease (COPD) Need Antibiotics and Steroids?
The goal of this clinical trial is to see if the use of two simple blood tests: C reactive protein and eosinophils, can reduce the use of steroids and antibiotics in patients with flares of chronic obstructive pulmonary disease…
- Conditions
- Chronic Obstructive Pulmonary Disease, COPD, Exacerbation of COPD, AECOPD
- Trial name
- Bidex (NCT06929767)
- Testing
- biomarker-guided decision making, GOLD recommendations
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- Ottawa Hospital Research Institute
Acute Exacerbation of Chronic Obstructive Pulmonary Disease, Acute Exacerbation of COPD
Functional Strength Training and Neuromuscular Electrical Stimulation in Severe Acute Exacerbations of COPD
Chronic obstructive pulmonary disease (COPD) is highly prevalent and frequently punctuated by severe acute exacerbations (AECOPD), defined as a temporary worsening of symptoms which leads to hospitalisation.
- Trial name
- NCT05480566
- Testing
- Functional strength training, NMES, Daily medical treatment (e.g., oxygen, medrol, duovent, azitromycine)
- Where
- Belgium
- Volunteers
- 35 people
- Sponsor
- Hasselt University
COPD, COPD Exacerbation
Using Mobile Health to Respond Early to Acute Exacerbations of COPD in HIV
Investigators propose to develop methods to improve early identification of acute exacerbations of COPD (AECOPD) among HIV-infected individuals.
- Trial name
- mReach (NCT01892566)
- Testing
- mHealth Intervention
- Where
- United States
- Volunteers
- 133 people
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
COPD (Chronic Obstructive Pulmonary Disease)
COPD Exacerbation Follow Up
The goal of this study is to evaluate the impact of implementing an AI-enabled clinical workflow tool (Viz COPD) on respiratory specialist follow up and clinical outcomes after an acute exacerbation.
- Trial name
- NCT07118306
- Where
- 5 sites in United States
- Volunteers
- 485 people
- Sponsor
- Viz.ai, Inc.
Pulmonary Disease, Chronic Obstructive
Compliance With Clinical Guidelines and Effect on Patient Outcome of Treatment of Hospitalised Exacerbations of COPD
Rationale. Currently there are well-established guidelines for the management of stable COPD. However, recommendations on the treatment of COPD exacerbations (E-COPD) are based on observational studies and low-quality clinical…
- Trial name
- ADEG-EPOC (NCT04237896)
- Where
- Spain
- Volunteers
- 400 people
- Sponsor
- Sociedad Española De Medicina Interna
Chronic Obstructive Pulmonary Disease, Acute Exacerbation of Chronic Obstructive Pulmonary Disease
Nebulized Verapamil in COPD Exacerbations
This clinical trial evaluated whether adding nebulized verapamil to conventional treatment could improve oxygenation and clinical status in patients hospitalized with an acute exacerbation of chronic obstructive pulmonary disease…
- Trial name
- NCT07866989
- Testing
- Verapamil hydrochloride, Conventional treatment
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
COPD (Chronic Obstructive Pulmonary Disease), COPD Exacerbation
A Repeat Ascending Dosing Study of the Safety and Clinical Activity of R-3750 in Patients With Mild to Moderate COPD
The goal of this study is to determine the safety and tolerability of orally taken probiotic (R-3750) in patients with mild to moderate chronic obstructive pulmonary disease (COPD)
- Conditions
- COPD (Chronic Obstructive Pulmonary Disease), COPD Exacerbation, COPD Exacerbation Acute
- Trial name
- R-3750-01-LU (NCT07076290)
- Testing
- R-3750
- Volunteers
- 27 people
- Sponsor
- Rise Therapeutics LLC
Acute Exacerbation of Chronic Obstructive Pulmonary Disease
High-Intensity vs Low-Intensity NPPV in Patients With an AECOPD: The HAPPEN Trial
To determine whether high-intensity NPPV, compared with low-intensity NPPV, could reduce the need for endotracheal intubation during hospitalization in patients with an AECOPD and hypercapnia.
- Trial name
- NCT02985918
- Testing
- High-intensity NPPV, Low-intensity NPPV
- Where
- 31 sites in China
- Volunteers
- 300 people
- Sponsor
- Beijing Chao Yang Hospital
Acute Exacerbation Chronic Obstructive Pulmonary Disease
Effect of Low-Dose Versus High-Dose Alpha-Lipoic Acid on Oxidative Stress, Inflammation, and Clinical Outcomes in Acute Exacerbations of Chronic Obstructive Pulmonary Disease
Chronic Obstructive Pulmonary Disease (COPD) is a progressive inflammatory lung disease characterized by persistent airflow limitation and enhanced oxidative stress.
- Trial name
- NCT07456176
- Testing
- Alpha Lipoic Acid 600 MG Oral Tablets, Alpha Lipoic Acid
- Where
- Egypt
- Volunteers
- 75 people
- Sponsor
- Ain Shams University