Clinical trials: Acute Exacerbation Chronic Pulmonary Disease
COPD Exacerbation Acute
The Use of Medical Devices to Monitor Chronic Obstructive Pulmonary Disease Patients Study BREATH-TRACHER 2
The proposed study will explore whether remote monitoring of a COPD patient can be undertaken using a wearable medical device.
- Trial name
- BREATH-TRACHER (NCT06419062)
- Testing
- Frontier X2
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- University of Strathclyde
Chronic Obstructive Pulmonary Disease
Short Compared With Standard Duration of Antibiotic Treatment for AECOPD
Chronic obstructive pulmonary disease (COPD) is one of the most common diseases in the world. Acute exacerbation of COPD (AECOPD) refers to an exaggeration of the symptoms of the disease.
- Trial name
- AECOPD (NCT03698682)
- Testing
- Levofloxacin 500mg
- Where
- Tunisia
- Volunteers
- 310 people
- Sponsor
- University of Monastir
Chronic Obstructive Pulmonary Disease
Acute Exacerbation of Chronic Obstructive Pulmonary Disease Inpatient Registry Study
The purpose of this study is to investigate the demographic characteristics, clinical features, diagnoses and treatments of AECOPD hospitalized patients in China, and disease prognosis and its economic burden.
- Trial name
- AECOPD-IRS (NCT02657525)
- Volunteers
- 7,600 people
- Sponsor
- China-Japan Friendship Hospital
Chronic Obstructive Lung Disease
COPD-EXA-REHAB. Early Pulmonary Rehabilitation of Patients With Acute Exacerbation of COPD
Purpose: In a randomized controlled trial we will assess the effect of early pulmonary rehabilitation in patient with an acute exacerbation of chronic obstructive lung disease (AECOPD).
- Trial name
- NCT02987439
- Testing
- Pulmonary rehabilitation
- Where
- Denmark
- Volunteers
- 150 people
- Sponsor
- University Hospital, Gentofte, Copenhagen
Chronic Obstructive Pulmonary Disease With (Acute) Exacerbation
Comparison of HFNC With NIV in Weaning COPD
High flow nasal cannula (HFNC) has been shown to improve oxygenation and facilitate weaning in hypoxemia patients. Some clinical studies show the benefits of using HFNC in COPD patients, including reducing dead space and work of…
- Trial name
- NCT03458364
- Testing
- High flow nasal cannula, Noninvasive ventilation
- Where
- China
- Volunteers
- 42 people
- Sponsor
- Jie Li
Pulmonary Disease, Chronic Obstructive
Evaluate the Efficacy of Xuebijing Injection in Acute Exacerbations of COPD
Objective: A prospective multicenter randomized controlled trial to assess the efficacy and safety of Xuebijing injection for acute exacerbation of chronic obstructive pulmonary disease(AECOPD).
- Trial name
- NCT02937974
- Testing
- Xuebijing
- Where
- China
- Volunteers
- 254 people
- Sponsor
- Chinese PLA General Hospital
Pulmonary Disease, Chronic Obstructive, Respiratory Tract Diseases
Post-hospitalisation Nutritional Support and Gait Speed in COPD
To determine the feasibility of delivering different community nutritional interventions to chronic obstructive pulmonary disease (COPD) patients at moderate or severe risk of malnutrition following a hospitalisation for an acute…
- Conditions
- Pulmonary Disease, Chronic Obstructive, Respiratory Tract Diseases, Lung Diseases, Obstructive, Bronchitis, Chronic
- Trial name
- NCT02261350
- Testing
- Food fortification, Oral Nutritional Supplements
- Where
- United Kingdom
- Volunteers
- 22 people
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Chronic Obstructive Pulmonary Disease (COPD)
Study to Demonstrate That Antibiotics Are Not Needed in Moderate Acute Exacerbations of COPD
The ultimate goal is to reduce unnecessary antibiotic prescriptions which drive the development of antibiotic resistance in the community.
- Trial name
- NCT01892488
- Testing
- Sultamicillin
- Where
- 32 sites in Germany
- Volunteers
- 295 people
- Sponsor
- Hannover Medical School
Chronic Obstructive Pulmonary Disease
Comparative Effects of Different Noninvasive Ventilation Mode on Neural Respiratory Drive in Recovering AECOPD Patients
Background: The efficiency of Neural respiratory drive (NRD)expressed by a ratio of ventilation to the diaphragm electromyogram (EMGdi) decreases in patients with COPD .Improving the neural respiratory drive efficiency of COPD…
- Trial name
- NCT01782768
- Testing
- noninvasive positive pressure ventilation
- Where
- China
- Volunteers
- 20 people
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University
Chronic Obstructive Pulmonary Disease
Hyaluronic Acid in Acute Exacerbation of COPD - Duration Of Noninvasive Assistance
The objective of this study is to test the effect of High Molecular Weight Hyaluronic Acid (HMW-HA) on Non Invasive Ventilation (NIV) effectiveness in patients admitted to a sub-intensive care unit for respiratory failure due to…
- Trial name
- HAEC-DONA (NCT02674880)
- Testing
- HMW-HA
- Where
- Italy
- Volunteers
- 41 people
- Sponsor
- Campus Bio-Medico University
Chronic Obstructive Pulmonary Disease
An Evaluation of Post Discharge Utilization Among Patients With an Acute Exacerbation of COPD
Patients who are hospitalized at select Carolinas Healthcare System (CHS) sites with Chronic Obstructive Pulmonary Disorder (COPD) acute exacerbation symptoms will be treated per the CHS COPD Clinical Pathway.
- Trial name
- NCT03207776
- Testing
- Usual Care, COPD Clinical Pathway
- Where
- 8 sites in United States
- Volunteers
- 4,832 people
- Sponsor
- Wake Forest University Health Sciences
Pulmonary Disease, Chronic Obstructive, Respiratory Tract Infections
Viral Infections in Chronic Obstructive Pulmonary Disease (COPD) Exacerbations
The objectives of the study are to determine the prevalence of respiratory virus infections in COPD patients, during and outside acute exacerbation to explore the impact of these viral infections on the outcome of these patients…
- Conditions
- Pulmonary Disease, Chronic Obstructive, Respiratory Tract Infections, Virus Diseases, Lung Diseases, Obstructive
- Trial name
- VICE (NCT00448604)
- Where
- Switzerland
- Volunteers
- 86 people
- Sponsor
- University Hospital, Geneva
Chronic Obstructive Pulmonary Disease
Treatment of Acute Exacerbation of Chronic Obstructive Pulmonary Disease With Qingkepingchuan Granules Clinical Observation of Phlegm-Heat and Lung Depletion
Through the clinical observation of Qingcheng Pingxian Granules in the treatment of acute exacerbation of chronic obstructive pulmonary disease (phlegm-heat lung syndrome), (1) to evaluate the safety of Qingcheng Pingxian…
- Trial name
- NCT06143358
- Testing
- Qingkepingchuan Granules, conventional treatment
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Zhang Zhijie
COPD Exacerbation
Magnesium Sulfate Versus Ipratropuim Bromide in Acute Exacerbation of Chronic Obstructive Pulmonary Disease
Treatment with short acting β2 agonists for exacerbations of COPD results in clinical improvement. It has not been established whether combining short acting β2 agonists to other bronchodilators is more effective than β2 agonists…
- Trial name
- NCT01136421
- Testing
- Ipratropium bromide, Magnesium Sulfate
- Where
- 2 sites in Tunisia
- Volunteers
- 124 people
- Sponsor
- University of Monastir
Chronic Obstructive Pulmonary Disease
High Flow Nasal Oxygen Versus Usual Care in COPD Pulmonary Rehabiliation
To compare the effects of high flow nasal oxygen with usual care during an outpatient 6-week pulmonary rehabilitation program after hospitalization for COPD exacerbation.
- Trial name
- NCT03940040
- Testing
- Usual care, High flow nasal oxygen
- Where
- Singapore
- Volunteers
- 22 people
- Sponsor
- Changi General Hospital
Chronic Obstructive Pulmonary Disease
The Doses of Systemic Steroid in Acute Exacerbation of Chronic Obstructive Pulmonary Disease (AECOPD)
It is well established that steroid use is a benefit in the treatment of chronic obstructive pulmonary disease (COPD) with acute exacerbation (AE). But it is still debated about the regimen and dosage of steroid use.
- Trial name
- NCT01215825
- Where
- Taiwan
- Volunteers
- 164 people
- Sponsor
- Far Eastern Memorial Hospital
Procalcitonin, Chronic Obstructive Pulmonary Disease
A Trial of Procalcitonin in Patients With Acute Exacerbation of Chronic Obstructive Pulmonary Disease
Current antibiotic prescription for patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is generally based on the Anthonisen criteria in The Global Initiative for Chronic Obstructive Pulmonary…
- Trial name
- NCT04682899
- Testing
- procalcitonin-guided antibiotic therapy, guideline-guided antibiotic therapy
- Volunteers
- 500 people
- Sponsor
- Capital Medical University
COPD
Early Pulmonary Rehabilitation Following Acute COPD Exacerbation
The principal aim of the study is to evaluate whether attendance at an exercise training and education programme (known as pulmonary rehabilitation) shortly following hospital discharge can lead to a reduction in exacerbations…
- Trial name
- NCT00557115
- Testing
- Early pulmonary rehabilitation (EPR)
- Where
- 3 sites in United Kingdom
- Volunteers
- 60 people
- Sponsor
- King's College Hospital NHS Trust
Pulmonary Disease, Chronic Obstructive
Personalized Prediction Strategy for Acute Exacerbation of Chronic Obstructive Pulmonary Disease
This is a 3-year longitudinal study designed to establish a personalized prediction and prevention system for acute exacerbations of chronic obstructive pulmonary disease (AECOPD).
- Trial name
- NCT03240315
- Where
- China
- Volunteers
- 442 people
- Sponsor
- Guangzhou Institute of Respiratory Disease
Chronic Obstructive Pulmonary Disease Exacerbation, Pneumonia
Improved Diagnostics, Treatment and Follow-up of Acute Exacerbation of Chronic Obstructive Pulmonary Disease
Chronic obstructive pulmonary disease (COPD) is a chronic and often progressive pulmonary disease, where inflammation and recurrent infections are key pathophysiological contibutors in disease progression.
- Conditions
- Chronic Obstructive Pulmonary Disease Exacerbation, Pneumonia, Respiratory Tract Infections
- Trial name
- COPEXNOR (NCT06105814)
- Testing
- Rapid diagnostics
- Volunteers
- 200 people
- Sponsor
- Vestre Viken Hospital Trust