Clinical trials: Acute Exacerbation of Chronic Obstructive Pulmonary Disease
COPD, AECOPD
The CANadian EXAcerbation of COPD Trial
The natural history of Chronic Obstructive Pulmonary Disease (COPD) is marked by acute, episodic attacks known as exacerbations of COPD.
- Trial name
- CAN-EXACT (NCT07850648)
- Where
- Canada
- Volunteers
- 125 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Congestive Heart Failure, Copd
A Mobile Integrated Health Intervention to Manage Congestive Health Failure and Chronic Obstructive Pulmonary Disease
Episodic and disjointed medical care for older, community-dwelling adults with chronic obstructive pulmonary disease (COPD) and congestive heart failure (CHF) leave them vulnerable to adverse events such as worsening disease…
- Trial name
- NCT05540158
- Testing
- Mobile Integrated Health Intervention
- Sponsor
- University of Massachusetts, Worcester
Chronic Obstructive Pulmonary Disease
Bufei Yishen Prescription on Patients With Frequent AECOPD in Stable Stage
To evaluate the clinical efficacy and health economic advantages of Lung Replenishing and Kidney Enhancing Formula for the treatment of patients with frequent acute exacerbations in the stabilized phase.
- Trial name
- NCT06326658
- Testing
- Bufei Yishen Prescription Granule
- Volunteers
- 848 people
- Sponsor
- Henan University of Traditional Chinese Medicine
Pulmonary Disease, Chronic Obstructive
Inhaled Long-acting Bronchodilators With or Without Inhaled Glucocorticosteroids for Preventing Hospitalizations and Death in Elderly Patients With Chronic Obstructive Pulmonary Disease
This will be a phase IV, open label, multicenter, randomized pragmatic study in frail elderly patients with COPD. Participants will be treated with either inhaled LABD alone or LABD combined with inhaled glucocorticosteroids.
- Trial name
- NCT03662711
- Testing
- Bronchodilator Agents
- Where
- 39 sites in Italy
- Volunteers
- 843 people
- Sponsor
- Università degli Studi di Ferrara
COPD, COPD Exacerbation
Inhaled Amikacin in Preventing AECOPD
The underlying bacterial colonization in lower respiratory tract (LRT) of COPD patients may be related to acute exacerbation of COPD (AECOPD) and disease progression.
- Trial name
- NCT05213507
- Testing
- aerosol inhaled Amikacin Sulfate Injection, conventional therapy
- Where
- 5 sites in China
- Volunteers
- 136 people
- Sponsor
- Shanghai Zhongshan Hospital
Pulmonary Disease, Chronic Obstructive
Investigate the Impact of Early Treatment Initiation With Tiotropium in Patients Recovering From Hospitalization for an Acute COPD Exacerbation 1
A randomized, placebo-controlled, double-blind, parallel group, multi center study to assess the safety and efficacy of tiotropium bromide (18 µg) delivered via the HandiHaler® in Chronic Obstructive Pulmonary Disease (COPD)…
- Trial name
- NCT01663987
- Testing
- tiotropium bromide
- Where
- 50 sites in United States, Puerto Rico
- Volunteers
- 79 people
- Sponsor
- Boehringer Ingelheim
COPD
Early Supported Discharge and Enhanced Homecare After Emergency Department Admission for Acute Exacerbation of COPD
The prevalence of chronic obstructive pulmonary disease (COPD) is between 8 and 15% of the adult population in 2010. This prevalence is expected to increase over the coming decades as the population ages and exposure to the risk…
- Trial name
- EXADOM (NCT03474575)
- Testing
- Prevention
- Where
- France
- Volunteers
- 84 people
- Sponsor
- University Hospital, Grenoble
Acute Exacerbation Chronic Obstructive Pulmonary Disease
MxA and CRP-Guided Use of Antimicrobial Agents for AECOPD
This randomized controlled trial will investigate the clinical impact of Myxovirus Resistance A (MxA) and C-Reactive Protein (CRP)-guided antimicrobial treatment compared to usual care in outpatients with acute exacerbations of…
- Trial name
- NCT06779344
- Testing
- MxA and CRP tests, MxA and CRP feedback, Follow up
- Where
- China
- Volunteers
- 458 people
- Sponsor
- Capital Medical University
Chronic Obstructive Pulmonary Disease
PIFR-based Inhalation Therapy in Patients Recovering From AECOPD
This study is designed to determine whether the optimized inhalation therapy based on peak inspiratory flow rates (PIFR) measured against the simulated resistance can reduce the rate of treatment failure in patients recovering…
- Trial name
- NCT04000958
- Testing
- PIRF measured by InCheck DIAL, Regular treament
- Where
- China
- Volunteers
- 460 people
- Sponsor
- Shanghai Zhongshan Hospital
Chronic Obstructive Pulmonary Disease
Eosinophilic Cationic Protein as a Biomarker in Diagnosis of Acute Exacerbation of Chronic Obstructive Pulmonary Disease
Chronic obstructive pulmonary disease is a type of obstructive lung disease characterized by long-term breathing problems and poor airflow.
- Trial name
- NCT04008017
- Testing
- Eosinophilic Cationic Protein biomarker
- Where
- Egypt
- Volunteers
- 64 people
- Sponsor
- Assiut University
COPD, COPD Exacerbation Acute
Assessing Optimal Inhaler Strategies During Acute Exacerbations of COPD (AECOPDs) Using Oscillometry
Chronic Obstructive Pulmonary Disease (COPD) is a persistent lung disease that makes it very difficult to breathe. The airways and the normally 'spongy' lungs themselves are affected.
- Trial name
- NCT06495047
- Testing
- Long-acting bronchodilator therapy (LABD), Short-acting bronchodilator therapy (SABD)
- Where
- Canada
- Volunteers
- 37 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Chronic Obstructive Pulmonary Disease, COPD
Effectiveness of Vibrating Mesh Versus Small Volume Nebuliser in Chronic Obstructive Pulmonary Disease (COPD)
When patients get an attack of COPD, one of the main treatments is regular nebulised medications called bronchodilators. These medications act by opening up the airways allowing patients to breathe easier and to reduce shortness…
- Conditions
- Chronic Obstructive Pulmonary Disease, COPD, Copd Exacerbation Acute, COPD Exacerbation
- Trial name
- NCT03286855
- Testing
- Vibrating Mesh Nebuliser, Standard Hospital Care
- Where
- Ireland
- Volunteers
- 62 people
- Sponsor
- Beaumont Hospital
Chronic Obstructive Pulmonary Disease, COPD Exacerbation
Efficacy of Varenicline on Smoking Cessation at the Acute Phase of an Exacerbation of Chronic Obstructive Pulmonary Disease
Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory disease of the bronchi with an increasing prevalence. By 2020, the mortality related to COPD is expected to become the 3rd leading death worldwide.
- Conditions
- Chronic Obstructive Pulmonary Disease, COPD Exacerbation, Smoking
- Trial name
- SAVE (NCT01694732)
- Testing
- Varenicline
- Where
- 13 sites in France
- Volunteers
- 83 people
- Sponsor
- University Hospital, Brest
Acute Exacerbation of COPD
Use of MULTIplex PCR, Procalcitonin, and Sputum Appearance to Reduce Duration of Antibiotic Therapy During Severe COPD EXAcerbation: A Controlled, Randomized, Open-label, Parallel-Group, Multicenter Trial
COPD is a common chronic disease. Its natural course is characterized by Acute exacerbations (AE). This may require hospitalization or even ICU/RESUSCITATION admission.
- Trial name
- MULTI-EXA (NCT05280132)
- Testing
- Personalized antibiotic treatment, Usual antibiotic treatment
- Where
- France
- Volunteers
- 204 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Chronic Obstructive Pulmonary Disease, Acute Exacerbation of Chronic Obstructive Airways Disease
Home Non Invasive Ventilation (NIV) Treatment for COPD-patients After a NIV-treated Exacerbation
Background: In chronic obstructive pulmonary disease, the prognosis for patients who have survived an episode of acute hypercapnic respiratory failure due to an exacerbation is poor.
- Conditions
- Chronic Obstructive Pulmonary Disease, Acute Exacerbation of Chronic Obstructive Airways Disease, Chronic Hypercapnic Respiratory Failure
- Trial name
- NCT01513655
- Testing
- LTNIV
- Where
- 4 sites in Denmark
- Volunteers
- 150 people
- Sponsor
- University Hospital, Gentofte, Copenhagen
COPD, COPD Exacerbation
Weight Training With VR in Out-Patients With Acute Exacerbation of Chronic Obstructive Pulmonary Disease
Using weight training with virtual reality can help after discharge patients of acute exacerbation of chronic obstructive pulmonary disease, which maintained their quality of life, and improved their exercise capacity, pulmonary…
- Conditions
- COPD, COPD Exacerbation, Pulmonary Rehabilitation, Weight Training
- Trial name
- NCT04880486
- Testing
- Education, Supervision upper limb weight training exercise with VR
- Where
- Taiwan
- Volunteers
- 22 people
- Sponsor
- National Cheng-Kung University Hospital
COPD Exacerbation
Early Extubation by ECCO2R Compared to IMV in Patients with Severe Acute Exacerbation of COPD
The study aims to investigate if veno-venous (vv)-extracorporeal carbon dioxide Removal (ECCO2R) is capable of reducing mortality and/or severe disability at day 60 after randomisation in patients with severe acute exacerbation…
- Trial name
- X-COPD (NCT03584295)
- Testing
- Extracorporeal carbon dioxide removal, Conventional Care
- Where
- Germany
- Volunteers
- 18 people
- Sponsor
- Xenios AG
COPD Exacerbation Acute
Airway Inflammation, Small Airways Dysfunction, and Frequency of Exacerbations in COPD
Chronic Obstructive Pulmonary Disease (COPD) is a common, preventable, and treatable disease that is characterized by persistent respiratory symptoms and airflow limitation that is due to airway and/or alveolar abnormalities…
- Trial name
- NCT06040931
- Testing
- Bronchoscopy
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Mansoura University Hospital
COPD Exacerbation, Hypoxia
Automated Oxygen Delivery by O2matic to Patients Admitted With an Exacerbation in COPD
The aim of the study is to examine if automated oxygen delivery with O2matic is better than manually controlled oxygen therapy for patients admitted to hospital with an exacerbation in Chronic Obstructive Pulmonary Disease…
- Conditions
- COPD Exacerbation, Hypoxia, Hyperoxia, Respiratory Failure
- Trial name
- O2MATIC (NCT03464695)
- Testing
- O2matic
- Where
- 2 sites in Denmark
- Volunteers
- 20 people
- Sponsor
- Hvidovre University Hospital
COPD
Prevalence of Respiratory Aspiration in Patients With COPD
The aim of the study is to estimate the prevalence of respiratory aspiration in patients with COPD, in a tertiary hospital of Buenos Aires.
- Trial name
- NCT02722629
- Testing
- FEESST
- Where
- Argentina
- Volunteers
- 330 people
- Sponsor
- Hospital Italiano de Buenos Aires