Clinical trials: Acute Gastrointestinal Injury
Hepatic Encephalopathy, Acute on Chronic Liver Failure (ACLF)
A Study to See if an Investigational Medicine Called VS-01 Can Help and How Safe it is in the Treatment of Patients With Overt Hepatic Encephalopathy
A Phase 2, Randomized, Controlled, Open-Label, Adaptive Dose Design, Proof-of-Concept Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of Two Different Dwell Times of VS-01 on Top of Standard of Care versus Standard…
- Conditions
- Hepatic Encephalopathy, Acute on Chronic Liver Failure (ACLF), Decompensated Cirrhosis
- Trial name
- NCT06987968
- Testing
- VS-01 on top of SOC (Active Treatment Group), SOC
- Where
- 6 sites in United States, France and 1 more
- Volunteers
- 3 people
- Sponsor
- Genfit
Hepato-Renal Syndrome
Nor-epinephrine Versus Midodrine/Octreotide in Patients With Hepatorenal Syndrome
Hepatorenal syndrome is a functional renal impairment occurring in cirrhotic patients . It develops secondary to splanchnic arterial vasodilatation which decreases the effective blood volume, activate the…
- Trial name
- NCT04522297
- Testing
- Midodrine/Octreotide, Nor-epinephrine
- Where
- Egypt
- Volunteers
- 91 people
- Sponsor
- National Hepatology & Tropical Medicine Research Institute
Drug-Induced Acute Liver Injury
Macrophage Markers, Soluble CD163 (sCD163) and Soluble CD206 (sCD206) in Paracetamol Overdose
Paracetamol (PCM) is a widely used over-the-counter analgesic, and overdose with PCM is a condition regularly seen in everyday clinical practice.
- Trial name
- NCT03679442
- Testing
- N-acetylcysteine
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Acute Lung Injury(ALI), Liver Cirrhosis
Digital Early Warning System for Acute Lung Injury in Liver Surgery
This study aims to develop an explainable machine learning model that takes into account the characteristics of cardiopulmonary interactions.
- Conditions
- Acute Lung Injury(ALI), Liver Cirrhosis, ARDS, Human, MASLD
- Trial name
- NCT07070362
- Where
- 4 sites in China
- Volunteers
- 3,000 people
- Sponsor
- Beijing Tsinghua Chang Gung Hospital
Variceal Hemorrhage, Cirrhosis, Liver
Terlipressin on Effect of Renal Function in Cirrhotic Patients With Acute Gastrointestinal Hemorrhage
Terlipressin and somatostatin/octreotide are the first-line choices for the treatment of acute variceal bleeding in liver cirrhosis. Acute kidney injury can develop in patients presenting with acute variceal bleeding.
- Conditions
- Variceal Hemorrhage, Cirrhosis, Liver, Kidney Injury
- Trial name
- NCT03846180
- Testing
- Terlipressin, Somatostatin, Octreotide
- Where
- 14 sites in China
- Volunteers
- 1,682 people
- Sponsor
- General Hospital of Shenyang Military Region
Acute Kidney Injury, Subclinical Acute Kidney Injury
Early Kidney Injury Biomarkers in Gynecologic Laparoscopic Surgery
This prospective observational study aims to evaluate early subclinical acute kidney injury associated with pneumoperitoneum and Trendelenburg positioning during gynecological laparoscopic surgery.
- Trial name
- NCT07704242
- Testing
- Pneumoperitoneum and Trendelenburg Positioning
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Medipol University
Drug Induced Liver Injury
Glucocorticoids for Acute Drug Induced Liver Injury With Hyperbilirubinemia
Drug-induced liver injury (DILI) can lead to potentially fatal complications, such as acute liver failure and even death. In clinical practice, glucocorticoids have been considered in some cases of DILI, especially patients with…
- Trial name
- NCT06922669
- Testing
- Methylprednisolone, Magnesium isoglycyrrhizinate, Glutathione
- Where
- China
- Volunteers
- 232 people
- Sponsor
- General Hospital of Shenyang Military Region
Acute Gastrointestinal Injury
Microbial Markers for AGI
AGI is very common in ICU and sometimes will trigger the development of gut derived sepsis. Thus, to find out the biomarker in early stage is very important to improve the overall prognosis of critically ill patients.
- Trial name
- NCT04957888
- Testing
- none intervention
- Where
- China
- Volunteers
- 584 people
- Sponsor
- Peking University Third Hospital
Caustic Esophageal Injury, Esophageal Stenosis
Corticosteroid Treatment in the Acute Phase of Caustic Ingestion Management
The management of patients who have ingested a caustic product has changed since 2007. Whereas previously the lesion assessment and surgical indication were based on endoscopic data, the therapeutic algorithm is currently based…
- Conditions
- Caustic Esophageal Injury, Esophageal Stenosis, Pharyngeal Stenosis
- Trial name
- CORTICAU (NCT03760354)
- Testing
- Methylprednisolone
- Volunteers
- 30 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Critically Ill Patients, Nutritional Support
Impact of Comprehensive Rehabilitation Nursing Combined With Refined Airway Management and Nutritional Support on Prognosis and Care Delivery Models in Critically Ill Patients
This combined intervention protocol effectively improves the prognosis of critically ill patients and optimizes nursing management models
- Conditions
- Critically Ill Patients, Nutritional Support, Pulmonary Infections, Gastrointestinal Bleeding
- Trial name
- NCT07025941
- Testing
- Standard Critical Care Nursing Protocol, ICU-PRO Nursing Protocol (Integrated Critical Care Protocol for Rehabilitation Outcomes)
- Where
- China
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- Taizhou Hospital of Traditional Chinese Medicine
Drug-Induced Acute Liver Injury
The Multi-Center, Randomized, Double-blind, Positive Controlled Clinical Trial of Bicyclol in the Treatment of Acute DILI
The study adopted the design of multi-center, randomized, double-blind, positive control drug, superiority test, using the double-blind double-simulating skills.
- Trial name
- NCT05063500
- Testing
- bicyclol, 25mg/ tablet, polyene phosphatidylcholine capsules, 228mg/ particle.
- Where
- 2 sites in China
- Volunteers
- 360 people
- Sponsor
- Drug Induced Liver Disease Study Group
Transfusion, Feeding During Transfusion
Withholding Feeds During Red Blood Cell Transfusion and TRAGI
Necrotising enterocolitis (NEC) is a devastating picture that all the neonatologists are afraid of facing during the follow up of newborns.
- Conditions
- Transfusion, Feeding During Transfusion, Transfusion Related Acute Gut Injury, Necrotising Enterocolitis
- Trial name
- Tx-TRAGI (NCT02132819)
- Testing
- Withholding feeds, feeding during transfusion
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people
- Sponsor
- Zekai Tahir Burak Women's Health Research and Education Hospital
Acute Liver Failure
13C-Methacetin Breath Test for the Prediction of Outcome in in ALI or ALF
The ALFSG-MBT protocol is for a multicenter, open label, non-randomized study to determine the value of Breath Identification® (BreathID®) N-(4-Methoxy-13C-phenyl)acetamide (13C-Methacetin) Breath Test System in predicting the…
- Trial name
- ALFSG-MBT (NCT02786836)
- Testing
- 13C-Methacetin
- Where
- 11 sites in United States
- Volunteers
- 76 people
- Sponsor
- University of Texas Southwestern Medical Center
Acute Kidney Injury, Hepatorenal Syndrome
The Selective Cytopheretic Device (SCD) for Acute Kidney Injury (AKI) and Hepatorenal Syndrome (HRS) Type I
This research study is being done to learn what effect 7 days of treatment with the Selective Cytopheretic Device (SCD) will have on these white blood cells in the bloodstream of patients with hepatorenal syndrome and to learn…
- Trial name
- NCT04898010
- Testing
- Selective Cytopheretic Device
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Lenar Yessayan
Appendicitis Acute, Pediatrics
TAP Block Versus Local Anesthesia Wound Infiltration for Postoperative Pain Relief After Appendicectomy in Children
When performing laparoscopic appendectomy in children, regional anesthetic techniques are rou-tinely used concomitantly with general anesthesia.
- Conditions
- Appendicitis Acute, Pediatrics, Analgesia
- Trial name
- PABLO (NCT04969133)
- Testing
- Levobupivacaine Hydrochloride 2.5 MG/ML
- Where
- France
- Volunteers
- 110 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Abdominal Injury, Pelvic Fracture
Developing a Decision Instrument to Guide Abdominal-pelvic CT Imaging of Blunt Trauma Patients
Unrecognized abdominal and pelvic injuries can result in catastrophic disability and death. Sporadic reports of "occult" injuries have generated concern, and physicians, fearing that they may miss such an injury, have adopted the…
- Conditions
- Abdominal Injury, Pelvic Fracture, Genital Hemorrhage, Lumbar Spine Injury
- Trial name
- NEXUS AP CT (NCT04937868)
- Testing
- There are no interventions associated with this study
- Where
- United States
- Volunteers
- 12,000 people
- Sponsor
- University of California, Los Angeles
Sepsis, Septic Shock
Central Venous Catheter Colonisation Among Critically Ill Patients in Intensive Care Units
Background: Central Venous catheter insertion technique and indwelling time are major risk factors for CVC colonisation. Colonisation occurs through microbial migration and biofilm formation along the catheter insertion tract.
- Conditions
- Sepsis, Septic Shock, Post-cardiac Surgery, Post-Cardiorespiratory Arrest Coma
- Trial name
- NCT03270774
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Makerere University
Liver Cirrhosis, Kidney Failure, Acute
Intermittent ADVOS vs. Hemodialysis in Non-intensive Care Patients With Liver Dysfunction
In the planned randomized controlled prospective pilot study, we aim to evaluate ADVOS compared with conventional hemodialysis regarding the elimination of protein-bound toxins in patients with therapy-refractory hepatorenal…
- Conditions
- Liver Cirrhosis, Kidney Failure, Acute, Kidney Replacement, Multi Organ Failure
- Trial name
- ADVOMITTENT (NCT06129617)
- Testing
- Hemodialysis, ADVOS
- Where
- Germany
- Volunteers
- 14 people
- Sponsor
- University Medical Center Mainz
Liver Neoplasm, Kidney Injury, Acute
Perioperative Myocardial and Renal Injury in Patients Undergoing Hepatic Resection
Liver surgeries are high risk surgeries that might result in injuries in kidneys and heart. This study was planned to investigate the frequency of these injuries as well as the risk factors for their devolopment and its effect on…
- Conditions
- Liver Neoplasm, Kidney Injury, Acute, Myocardial Injury After Non-Cardiac Surgery
- Trial name
- NCT06775158
- Where
- Turkey (Türkiye)
- Volunteers
- 128 people
- Sponsor
- Istanbul Saglik Bilimleri University
Cholecystitis, Cholecystitis, Acute
EOIB for Laparoscopic Cholecystectomy
Laparoscopic cholecystectomy, while less painful compared to conventional methods, is still a surgery that can cause significant pain for patients.
- Conditions
- Cholecystitis, Cholecystitis, Acute, Cholecystitis, Chronic, Cholecystitis; Gallstone
- Trial name
- NCT06656299
- Testing
- ultrasound guided external oblique intercostal plane block, Bupivacaine injection, paracetamol, tramadol, and ondansetron
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Sehit Prof. Dr. Ilhan Varank Sancaktepe Training and Research Hospital