Clinical trials: Acute HIV Infection
HIV Infections
Safety and Virologic Effect of a Human Monoclonal Antibody (VRC01) Administered Intravenously to Adults During Early Acute HIV Infection
This study will evaluate the safety and virologic effect of an experimental human monoclonal antibody (mAb), VRC-HIVMAB060-00-AB (VRC01), alone or in combination with antiretroviral therapy (ART), in adults during early acute HIV…
- Trial name
- NCT02591420
- Testing
- VRC01, Antiretroviral therapy (ART) (regimen will vary within countries and by patient)
- Where
- 5 sites in Kenya, Tanzania and 2 more
- Volunteers
- 24 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV Infections
Structured Treatment Interruption (STI) in Acute/Primary HIV
Although the introduction of Highly Active Anti-Retroviral Therapy - HAART - has dramatically altered the course of HIV/AIDS, true cure is still unattainable and patients are required to take these medications for the rest of…
- Trial name
- NCT01293513
- Testing
- Gradual anti-HIV treatment interruption
- Volunteers
- 10 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
HIV Infections
Safety of and Immune Response to a DNA HIV Vaccine (VRC-HIVDNA009-00-VP) in HIV Infected Individuals With Acute HIV Infection
The purpose of this study is to evaluate whether the HIV vaccine VRC-HIVDNA009-00-VP will be safe in individuals who started antiretroviral therapy during acute HIV-1 infection.
- Trial name
- NCT00125099
- Testing
- VRC-HIVDNA009-00-VP
- Where
- 5 sites in United States
- Volunteers
- 21 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV
Phase I Study of HIV 1 Antigen Expanded Specific T Cell Therapy
This is a phase 1, single-site study is to evaluate the safety and immunologic and virologic efficacy of ex vivo expanded HIV-1 multi-antigen specific T-cell (HXTC) therapy in HIV-infected individuals with viral suppression on…
- Trial name
- HXTC (NCT02208167)
- Testing
- HXTC infusion
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- University of North Carolina, Chapel Hill
Meningitis, Cryptococcal, HIV Infections
A Multicenter Comparison of Fluconazole (UK-49,858) and Amphotericin B as Treatment for Acute Cryptococcal Meningitis
To compare the safety and effectiveness of fluconazole and amphotericin B, alone or in combination with flucytosine, as treatment for acute cryptococcal meningitis.
- Trial name
- NCT00002068
- Testing
- Fluconazole, Amphotericin B
- Where
- 8 sites in United States, Canada
- Sponsor
- Pfizer
Cancer
Ketamine Hydrochloride and Best Pain Management in Treating Cancer Patients With Neuropathic Pain
RATIONALE: Ketamine hydrochloride may lessen neuropathic pain in patients with cancer. It is not yet known whether ketamine hydrochloride given together with the best pain management is more effective than a placebo given…
- Trial name
- NCT01316744
- Testing
- ketamine hydrochloride, pharmacogenomic studies, questionnaire administration
- Where
- 3 sites in United Kingdom
- Volunteers
- 214 people
- Sponsor
- University of Glasgow
HIV Infection
A Novel Method to Determine HIV Incidence Among Youth
Identifying young people with early HIV-1 infection is important for increasing linkage to care, for behavioral counseling, and for enrolling individuals into programs that can provide effective interventions to disease…
- Trial name
- NCT00103883
- Where
- 15 sites in United States, Puerto Rico
- Volunteers
- 440 people
- Sponsor
- University of North Carolina, Chapel Hill
Meningitis, Cryptococcal, HIV Infections
Multi-center Comparison of Fluconazole (UK-49,858) and Amphotericin B as Treatment for Acute Cryptococcal Meningitis
To compare the safety and effectiveness of fluconazole (FCZ) and amphotericin B (AMB), alone or in combination with flucytosine (FLC), as treatment for acute cryptococcal meningitis in patients who have not been treated…
- Trial name
- NCT00000708
- Testing
- Flucytosine, Fluconazole, Amphotericin B
- Where
- 6 sites in United States
- Volunteers
- 120 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Acute Febrile Illnesses
Etiologies of Fever Among Adults in Dar es Salaam
Following the decline of malaria in Sub-Saharan Africa, clinicians face febrile patients in whom an alternative diagnosis has to be made. This situation has led to an overuse of antibiotics by clinicians.
- Trial name
- NCT01947075
- Where
- Tanzania
- Volunteers
- 538 people
- Sponsor
- Swiss Tropical & Public Health Institute
HIV-1-infection, Acute HIV Infection
Specimen Repository for HIV Immunopathogenesis
Specimen Repository for HIV Immunopathogenesis Studies
- Trial name
- NCT03579381
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- AIDS Healthcare Foundation
Acute HIV Infection
A Clinical Trial of Combination HIV-Specific Broadly Neutralizing Monoclonal Antibodies Combined With ART Initiation During Acute HIV Infection to Induce HIV Remission
A5388 is a phase II, two-arm, randomized, double-blind, placebo-controlled study that will enroll 48 antiretroviral therapy (ART)-naïve adults with acute HIV infection (AHI) in order to determine whether: Administration of…
- Trial name
- NCT05719441
- Testing
- VRC07-523LS, PGT121.414.LS, ART
- Where
- 12 sites in United States, Brazil and 1 more
- Volunteers
- 48 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Acute HIV Infection
Establish and Characterize an Acute HIV Infection Cohort in a High Risk Population
To describe clinical, immunological, and virological characteristics of persons with acute HIV infection 1. To describe demographics and behavioral risk factors for those identified with acute HIV infection 2.
- Trial name
- NCT00796146
- Where
- Thailand
- Volunteers
- 777 people
- Sponsor
- SEARCH Research Foundation
HIV Infections
Three Month Course of Anti-HIV Medications for People Recently Infected With HIV
Short-term therapy may reduce the amount of HIV in the blood of adults recently infected with HIV. The purpose of this study is to see whether it is better for people to take a short course of anti-HIV drugs when they are first…
- Trial name
- NCT00087464
- Testing
- Emtricitabine, Nevirapine, Tenofovir disoproxil fumarate
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Acute HIV Infection, HIV Seropositive
Acute Partner and Social Contact Referral: iKnow
The primary purpose of this research is to assess the benefit of an "unaware intervention package" for identifying high risk persons who are unaware of their HIV infection status.
- Conditions
- Acute HIV Infection, HIV Seropositive, Sexually Transmitted Infections
- Trial name
- NCT02467439
- Testing
- Notification cards
- Where
- United States
- Volunteers
- 15,310 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
AIDS-related Diffuse Large Cell Lymphoma, AIDS-related Diffuse Mixed Cell Lymphoma
Topotecan Hydrochloride in Treating Children With Meningeal Cancer That Has Not Responded to Previous Treatment
Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. This phase II trial is studying how well topotecan hydrochloride works in treating children with meningeal cancer that…
- Conditions
- AIDS-related Diffuse Large Cell Lymphoma, AIDS-related Diffuse Mixed Cell Lymphoma, AIDS-related Diffuse Small Cleaved Cell Lymphoma, AIDS-related Immunoblastic Large Cell Lymphoma
- Trial name
- NCT00005811
- Testing
- topotecan hydrochloride, laboratory biomarker analysis
- Where
- United States
- Volunteers
- 77 people
- Sponsor
- National Cancer Institute (NCI)
Hepatitis C, HIV Infections
Pegylated Interferon Therapy for Acute Hepatitis C Infection in HIV-infected Patients
The purpose of this study is to determine whether pegylated interferon therapy is effective to treat acute hepatitis C infection in HIV-coinfected individuals.
- Trial name
- NCT00132210
- Testing
- pegylated interferon
- Where
- 14 sites in Germany
- Volunteers
- 200 people
- Sponsor
- University Hospital, Bonn
Malaria, HIV Infections
Interactions Between HIV and Malaria in African Children
This is a prospective cohort study where HIV-infected and uninfected children will be enrolled between 6 weeks and 9 months of age and followed to the age of 21 months.
- Trial name
- TCC (NCT00527800)
- Testing
- Dihydroartemisinin-piperaquine, Artemether-lumefantrine, Trimethoprim-sulfamethoxazole
- Where
- Uganda
- Volunteers
- 351 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Acute HIV Infection, HIV CNS Involvement
Assessment of the HIV CNS Reservoir, Neurological and Neuro-cognitive Effects, and Source of Rebound HIV in CNS
This study aims to describe in depth the CNS, CNS HIV reservoir and CNS viral rebound in consenting SEARCH 019 subjects prior to, during and after the SEARCH 019 study intervention (VHM + ART or ART only), at 1) baseline, 2) end…
- Trial name
- NCT02470351
- Where
- Thailand
- Volunteers
- 9 people
- Sponsor
- SEARCH Research Foundation
HIV Infections
Safety and Effectiveness of a Three-Drug Combination Treatment for Recently Infected or Converted HIV Patients
The purpose of this study is to determine the safety and effectiveness of stavudine (d4T), didanosine (ddI), and BMS-232632 when given early in the course of HIV infection.
- Trial name
- NCT00007202
- Testing
- Atazanavir, Stavudine, Didanosine
- Where
- 5 sites in United States, Brazil
- Volunteers
- 55 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV Infections
Controlling Acute or Early HIV Infection With Antiretroviral Drugs, Without a Candidate Vaccine.As Reported Previously, the Candidate Vaccie Was Not Provided by the Maufacturer as Promised
The purpose of this study is to determine the role of HIV-specific CD4 T cell responses and immune responses dependent upon these CD4 responses that develop when antiretroviral drugs are started during acute or recent HIV…
- Trial name
- NCT00238459
- Testing
- Patients elected to take licensed drugs. The vaccine was not provided for evaluation, multiple licensed drugs not randomized, multiple licensed antiretroviral drugs; not randomized
- Where
- 2 sites in United States, Canada
- Volunteers
- 58 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)