Clinical trials: Acute Hypoxemic Respiratory Failure
Acute Hypoxemic Respiratory Failure
Prediction of Duration of Mechanical Ventilation in Acute Hypoxemic Respiratoty Failure
Acute hypoxemic respiratory failure (AHRF) is a common cause of admission in intensive care units (ICUs) worldwide. We will assess machine learning (ML) techniques for prediction of prolonged duration (> or = to 7 days) of…
- Trial name
- PREMIER (NCT06815523)
- Testing
- Machine learning and logistic regression for the training/testing cohort and validation cohort
- Where
- 2 sites in Spain
- Volunteers
- 1,241 people
- Sponsor
- Jesus Villar
Acute Respiratory Distress Syndrome, Mechanical Ventilation Pressure High
Assessing Lung Inhomogeneity During Ventilation for Acute Hypoxemic Respiratory Failure
Mechanical ventilation can cause damage by overstretching the lungs, especially when the lungs are collapsed or edematous. Raising ventilator pressures can reduce lung collapse and this can prevent overstretching from mechanical…
- Conditions
- Acute Respiratory Distress Syndrome, Mechanical Ventilation Pressure High, Hypoxemic Respiratory Failure
- Trial name
- ALIVE (NCT03589482)
- Testing
- Electrical Impedance Tomography, ExPRESS-derived PEEP level
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University Health Network, Toronto
Respiratory Failure With Hypoxia
Helmet Noninvasive Ventilation vs. High-flow Nasal Cannula in Moderate-to-severe Acute Hypoxemic Respiratory Failure
Helmet noninvasive ventilation and high-flow nasal cannula are novel tools for the first-line treatment of acute hypoxemic respiratory failure.
- Trial name
- HENIVOTpilot (NCT04502576)
- Testing
- Noninvasive respiratory support
- Where
- 5 sites in Italy
- Volunteers
- 110 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Respiratory Failure With Hypoxia, Respiratory Failure Without Hypercapnia
PRone positioN in Patients With spontanEous ventiLation and Acute Hypoxemic respIratory FailurE
The proposed randomized controlled trial aims at comparing the application of the prone position in spontaneously breathing patients with acute hypoxemic respiratory failure from any cause versus standard treatment on the rate of…
- Trial name
- PRONELIFE (NCT04142736)
- Testing
- Prone Position
- Where
- Spain
- Volunteers
- 650 people
- Sponsor
- Corporacion Parc Tauli
Acute Hypoxemic Respiratory Failure, Acute Respiratory Distress Syndrome (ARDS)
EIT-Guided Ventilator Settings in AHRF
This exploratory study aims to investigate the effect of Electrical Impedance Tomography (EIT)-guided ventilator settings on mechanical power in patients with acute hypoxemic respiratory failure (AHRF), including both ARDS and…
- Conditions
- Acute Hypoxemic Respiratory Failure, Acute Respiratory Distress Syndrome (ARDS), Mechanical Power, Ventilator Induced Lung Injury
- Trial name
- NCT06936618
- Testing
- Electrical Impedance Tomography (EIT), Enlight 2100
- Where
- Thailand
- Volunteers
- 17 people
- Sponsor
- Mahidol University
Respiratory Failure, Acute Hypoxemic Respiratory Failure
Optimizing Care in Critically Ill at UCHealth by Liberalizing the Target O2 in Mechanically-ventilated ICU Patients
A multimodal educational intervention to target an oxygen saturation target range (SpO2 90-96%) will reduce ventilator length of stay and reduce occult hypoxemia by increased awareness and adherence to a designated oxygen…
- Conditions
- Respiratory Failure, Acute Hypoxemic Respiratory Failure, Acute Hypoxic Respiratory Failure, Hypoxemia
- Trial name
- NCT06501118
- Testing
- Education, Epic notification alert
- Where
- United States
- Volunteers
- 3,600 people
- Sponsor
- University of Colorado, Denver
Hypoxemic Respiratory Failure, Hypoxia
Automated Oxygen Control by O2matic to Patients Admitted With Acute Hypoxemia
The aim of this study is to examine if automated oxygen delivery with O2matic allows for faster weaning from oxygen supply and better oxygen control than manually controlled oxygen therapy for patients admitted to the emergency…
- Conditions
- Hypoxemic Respiratory Failure, Hypoxia, Hypoxemia, Respiratory Failure
- Trial name
- O2MATIC-ACUT (NCT04079465)
- Testing
- O2matic
- Where
- 2 sites in Denmark
- Volunteers
- 30 people
- Sponsor
- Hvidovre University Hospital
Acute Severe Respiratory Failure, Acute Respiratory Distress Syndrome
Impact of Arterial CO2 Tension on Management and Outcome in Patients With Acute Hypoxemic Respirator Failure and ARDS
There appears to be considerable variability in the approach physicians use to manage arterial carbon dioxide tensions, in patients in the early phases [first 48 hours] of ARDS (Acute hypoxemic respiratory failure and).
- Trial name
- CO2 LUNG SAFE (NCT03415529)
- Where
- Belgium
- Volunteers
- 4,500 people, healthy volunteers welcome
- Sponsor
- European Society of Intensive Care Medicine
Acute Respiratory Distress Syndrome, Hypoxemic Respiratory Failure
Identification and Treatment of Hypoxemic Respiratory Failure and ARDS With Protection, Paralysis, and Proning Pathway
Treatment of patients with Hypoxemic respiratory failure (HRF) and Acute Respiratory Distress Syndrome (ARDS) is complex. Therapies that have been shown to save the lives of patients with HRF and ARDS are available but they are…
- Conditions
- Acute Respiratory Distress Syndrome, Hypoxemic Respiratory Failure, ARDS, Human
- Trial name
- NCT04744298
- Testing
- TheraPPP
- Where
- 17 sites in Canada
- Volunteers
- 19,916 people
- Sponsor
- University of Calgary
Acute Hypoxemic Respiratory Failure
Benefits of Optiflow® Device for Preoxygenation Before Intubation in Acute Hypoxemic Respiratory Failure : The PREOXYFLOW Study
Oro-tracheal intubation in intensive unit care(ICU) in acute hypoxemic respiratory failure after crash induction remains a critical event.
- Trial name
- PREOXYFLOW (NCT01747109)
- Testing
- PREOXYFLOW, STANDARD FACE MASK
- Where
- 6 sites in France
- Volunteers
- 122 people
- Sponsor
- Nantes University Hospital
ARDS (Moderate or Severe), AHRF
STimulation to Activate RespIration
Multi-center, randomized, controlled, open-label Phase 2 feasibility trial. Subjects on mechanical ventilation (MV) for acute hypoxemic respiratory failure (AHRF) with lung injury (including subjects who meet criteria for acute…
- Conditions
- ARDS (Moderate or Severe), AHRF, Mechanically Ventilated ICU Patients
- Trial name
- STARI (NCT06832306)
- Testing
- Phrenic Nerve Stimulation
- Where
- 7 sites in United States, Canada
- Volunteers
- 30 people
- Sponsor
- Lungpacer Medical Inc.
SARS Pneumonia
Respiratory Mechanics and Gas Exchange in Patients With COVID-19 and Hypoxemic Acute Respiratory Failure
Data on respiratory mechanics and gas exchange in acute respiratory failure in COVID-19 patients is limited. Knowledge of respiratory mechanics and gas exchange in COVID-19 can lead to different selection of mechanical…
- Trial name
- COVID-VENT (NCT04445961)
- Testing
- Respiratory mechanics measurement, Gas exchange measurement
- Where
- 3 sites in Russia
- Volunteers
- 117 people
- Sponsor
- I.M. Sechenov First Moscow State Medical University
Post Operative Cardiac Surgery, ARDS
PEEP Levels Selected by PEEP Titration and PEEP Levels Routinely Used in Post-operative Cardiac Patients With Hypoxemic Respiratory Failure
The purpose of this study is to: Compare PEEP level selected by individualized PEEP titration by electrical impedance tomography and PEEP level routinely used in post-operative cardiac patients with Hypoxemic Respiratory Failure…
- Conditions
- Post Operative Cardiac Surgery, ARDS, Hypoxemic Respiratory Failure
- Trial name
- NCT02056977
- Testing
- Titration, control
- Where
- Brazil
- Volunteers
- 46 people
- Sponsor
- University of Sao Paulo General Hospital
Acute Viral Bronchitis, Hypoxemic Respiratory Failure
NHF vs. COT in Hypoxemic Pandemic Viral Illness
The study compares oxygen and NHF in patients with acute viral illness. The duration will be 72h. After them physiological parameters and the outcome will be evaluated.
- Conditions
- Acute Viral Bronchitis, Hypoxemic Respiratory Failure, Hypercapnic Respiratory Failure
- Trial name
- HIVI (NCT04750408)
- Testing
- Standard oxygen, Nasal high-flow
- Where
- Germany
- Volunteers
- 52 people
- Sponsor
- Jens Bräunlich
Acute Hypoxemic Respiratory Failure
Impact of Current Volume Under High-rate Nasal Oxygen Therapy During Acute Hypoxemic Respiratory Failure de Novo
De novo acute hypoxemic respiratory failure (AHRF) is associated with high overall mortality, which increases significantly with the use of orotracheal intubation.
- Trial name
- IVOXY (NCT03919331)
- Testing
- Assessment of tidal volume using Electrical Impedance Tomography (EIT) during high flow nasal canula(HFNC)
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Acute Hypoxemic Respiratory Failure
Lucinactant for Treatment of Acute Hypoxemic Respiratory Failure in Children up to Two Years Old
Treatment with lucinactant, a peptide-containing synthetic lung surfactant, will be evaluated in young children with acute respiratory failure who require mechanical ventilation (life support), to determine if it is safe and if…
- Trial name
- KL4-AHRF-01 (NCT00578734)
- Testing
- Lucinactant
- Where
- 3 sites in United States, Chile
- Volunteers
- 165 people
- Sponsor
- Windtree Therapeutics
Respiratory Failure, Hypoxemic Respiratory Failure
Helmet NIV vs. CPAP vs. High-flow Nasal Oxygen in Hypoxemic Respiratory Failure
Multicenter, open label, three-arm randomized trial to assess the effect of helmet noninvasive ventilation vs. helmet continuous positive airway pressure vs.
- Trial name
- HENIVOT2 (NCT05089695)
- Testing
- Noninvasive respiratory support
- Where
- Italy
- Volunteers
- 1,200 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
HFNO vs BIPAP, Preeclamptic Acute Hypoxaemic Respiratory Failure
HFNO VERSUS BIPAP IN PREECLAMPTIC PATIENTS WITH ACUTE HYPOXAEMIC RESPIRATORY FAILURE
The aim of this study was to evaluate the use of HFNO to support oxygenation in acute hypoxemic respiratory failure in postpartum pre-eclamptic patients, compared with non-invasive intermittent bilevel positive airway pressure…
- Trial name
- HFNO BIPAP (NCT07084870)
- Testing
- High flow nasal oxygen, non invasive BIPAP
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Alexandria University
Acute Respiratory Insufficiency
Respiratory Variability in Patients With Acute Hypoxemic Respiratory Failure and Placed on High Flow Oxygen Therapy
Recommendations from the European Respiratory Society are to use high-flow oxygen therapy rather than conventional oxygen therapy and non-invasive ventilation (NIV) in cases of acute hypoxaemic respiratory failure.
- Trial name
- HYPOXEVARIA (NCT06675045)
- Testing
- Respiratory variability monitoring
- Where
- France
- Volunteers
- 60 people
- Sponsor
- GCS Ramsay Santé pour l'Enseignement et la Recherche
Pneumonia
HFNO in Pneumonia Patients Presenting With Acute Hypoxemic Respiratory Failure
High-flow nasal oxygen (HFNO) therapy is an upcoming and beneficial modality for patients with acute hypoxemic respiratory failure (AHRF).
- Trial name
- NCT05809089
- Testing
- High flow nasal cannula (HFNC), Noninvasive ventilation (NIV)
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Assiut University