Clinical trials: Acute Infectious Diseases
Covid19
Screening of Health-care Workers in an University Hospital for SARS-CoV-2
This is an observational prospective study. The aim is to assess the prevalence of test positivity (swab or serological examination) to Coronavirus Disease-2019 (Covid-19) in relation to the duties and related occupational risk.
- Trial name
- STORM-HCW (NCT04567836)
- Testing
- Investigation of the prevalence of test positivity
- Where
- Italy
- Volunteers
- 260 people
- Sponsor
- University of Milano Bicocca
HIV-1-infection, Malnutrition, Child
Strategies to Reduce Mortality Among HIV-infected and HIV-exposed Children Admitted With Severe Acute Malnutrition
This study to investigate whether empiric use of an antibiotic with greater antimicrobial sensitivity (ceftriaxone) than standard-of-care (ampicillin plus gentamicin) will reduce mortality among HIV-infected/HEU children admitted…
- Trial name
- REDMOTHIV (NCT05051163)
- Testing
- Ceftriaxone Sodium, Ampicillin, Gentamicin
- Where
- Uganda
- Volunteers
- 300 people
- Sponsor
- Makerere University
COVID Long-Haul
Covid-19 Long Immunité IMagerie (CLIIM)
Covid-long pathology affects a large number of patients, and represents a major medical, economic and societal challenge. To date, we have no objective criterion for a definitive diagnosis, nor any predictive tool for monitoring…
- Trial name
- CLIIM (NCT06528171)
- Testing
- Brain MRI, Specific blood samples
- Where
- France
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nice
Acute Respiratory Tract Infections
Effects of Nasal-spraying LiveSpo Navax in Treatment of Acute Respiratory Infections in Children
Rationals: Infection with the Respiratory Syncytial Virus (RSV) is one of the most common causes of respiratory tract diseases. However, treatment for pediatric RSV infection remains supportive to prevent co-infection bacteria…
- Trial name
- NCT05164692
- Testing
- LiveSpo Navax, 0.9% NaCl physiological saline
- Where
- Vietnam
- Volunteers
- 100 people
- Sponsor
- National Children's Hospital, Vietnam
Covid19, COVID-19 Pneumonia
A Retrospective Study of COVID-19 Treatments
Surveys administered to subjects who have recovered from COVID-19 to assess how effective their treatment was.
- Conditions
- Covid19, COVID-19 Pneumonia, COVID-19 Respiratory Infection, COVID-19 Acute Bronchitis
- Trial name
- NCT04949230
- Testing
- No Intervention Used
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- ProgenaBiome
Acute Diarrheal Disease, Rotavirus Infection
Two-year Surveillance of Rotavirus Genotypes Causing Acute Diarrhea in Children Younger Than 5 Years Requiring Emergency Room (ER) and Hospital Admission in Chile
The purpose of this study is to prospectively determine the rotavirus VP7/VP4 genotypes associated with moderate to severe disease (requiring emergency room (ER) consult or hospitalization) in a large public hospital from…
- Trial name
- NCT00895492
- Where
- 2 sites in Chile
- Volunteers
- 967 people
- Sponsor
- University of Chile
Respiratory Tract Infections
PREDICATE Trial For Respiratory Tract Infections
Background The goal of this clinical trial is to learn if prednisolone works to treat moderate to severe respiratory tract infections in adults admitted to hospital.
- Trial name
- NCT06472219
- Testing
- Prednisolone 30 mg
- Where
- Hong Kong
- Volunteers
- 1,300 people
- Sponsor
- The University of Hong Kong
Wound Infection, Abscess
Oritavancin Versus IV Vancomycin for the Treatment of Participants With Acute Bacterial Skin and Skin Structure Infection (SOLO I)
The purpose of this Phase 3 trial was to evaluate the efficacy, safety, and tolerability of oritavancin in acute bacterial skin and skin structure infections (ABSSSIs), including those caused by methicillin-resistant…
- Conditions
- Wound Infection, Abscess, Systemic Inflammation, Cellulitis
- Trial name
- SOLO I (NCT01252719)
- Testing
- Single-Dose IV Oritavancin Diphosphate, IV Vancomycin
- Where
- United States
- Volunteers
- 968 people
- Sponsor
- Melinta Therapeutics, Inc.
Infection-Associated Acute Kidney Injury
Folate Treatment to Reduce Death Risk in the Year After Infection-Related Acute Kidney Injury
The goal of this clinical trial is to evaluate if taking folic acid (a form of vitamin B9) can help reduce the risk of death and improve kidney recovery in adults with acute kidney injury (AKI) caused by infections or sepsis.
- Trial name
- FOL-AKI (NCT07377071)
- Testing
- Folic Acid 5 MG
- Where
- Hong Kong
- Volunteers
- 382 people
- Sponsor
- The University of Hong Kong
Long Covid
SingStrong: Strong Lungs Through Song - Long COVID-19 Study
Evidence is emerging that many individuals who recover from Covid-19 are experiencing a range of residual problems. These include fatigue, pain, reduced exercise tolerance and breathing issues.
- Trial name
- ss (NCT04810065)
- Testing
- SingStrong: Strong lungs through Song
- Where
- Ireland
- Volunteers
- 30 people
- Sponsor
- University of Limerick
COVID-19, SARS-CoV-2 Infection
Lung Function, Exercise Capacity and Health-Related Quality of Life After Severe COVID-19
Coronavirus disease 2019 (COVID-19) is a respiratory tract infection caused by a newly emergent coronavirus (SARS-CoV-2) that can progress to severe disease requiring hospitalization and oxygen support in around14% of the cases…
- Trial name
- NCT04410107
- Testing
- Lung Function tests, Exercise capacity, Exercise physiology
- Where
- 5 sites in Brazil
- Volunteers
- 144 people
- Sponsor
- Federal University of Rio Grande do Sul
COVID-19, Post Acute Sequelae of COVID-19
COVID-19 Outcome Prediction Algorithm
Severe acute respiratory syndrome coronavirus 2-mediated coronavirus disease (COVID-19) is an evolutionarily unprecedented natural experiment that causes major changes to the host immune system.
- Conditions
- COVID-19, Post Acute Sequelae of COVID-19, Long COVID, Organ Dysfunction Syndrome, Multiple
- Trial name
- COPA (NCT05471011)
- Testing
- Blood and nasal swab sampling
- Where
- 7 sites in United States
- Volunteers
- 600 people
- Sponsor
- University of California, Los Angeles
COVID-19
COVID-19: A Prevalence Study of Two ART Centres After the Pandemic Lockdown in the USA (COVID-19 Free Clinics)
In late December 2019, a new coronavirus strain emerged causing coronavirus disease 2019 (COVID19). Since then, COVID19 has become a global pandemic outbreak being declared a "public health emergency of international concern" by…
- Trial name
- NCT04466644
- Testing
- ELISA, RT-PCR
- Where
- 2 sites in United States
- Volunteers
- 340 people, healthy volunteers welcome
- Sponsor
- Igenomix
COVID-19 Pneumonia, COVID-19
Cardiac Magnetic Resonance Tissue Characterization in COVID-19 Survivors
The purpose of this study is to test if visualizing the heart with cardiac MRI/echo will be important in the understanding cardiac function and prediction of cardiopulmonary symptoms, physical effort tolerance, and outcomes in…
- Conditions
- COVID-19 Pneumonia, COVID-19, COVID-19 Respiratory Infection, COVID-19 Acute Respiratory Distress Syndrome
- Trial name
- NCT05164744
- Testing
- Cardiac MRI, Echocardiogram, 6-minute walk test
- Where
- 3 sites in United States
- Volunteers
- 510 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Atelectasis, Acute Respiratory Distress Syndrome
Physiological Effects and Safety of Continuous High-frequency Oscillatory Ventilation in Mechanical Ventilation Patients
Mechanical ventilation is an important treatment modality for intensive care unit (ICU) patients, but it also brings a series of problems such as ventilator-associated pneumonia, ventilator-induced lung injury, and atelectasis.
- Conditions
- Atelectasis, Acute Respiratory Distress Syndrome, VAP - Ventilator Associated Pneumonia
- Trial name
- NCT06662630
- Testing
- High-Frequency Oscillatory Ventilation
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Shanghai Zhongshan Hospital
COVID-19, SARS-CoV 2
EXercise TRAining and Sedentary Lifestyle on Clinical Outcomes in Patients With COVID-19
The present study aims to assess the impact of exercise training, physical activity, and sedentary lifestyle on clinical outcomes in surviving patients infected with the severe acute respiratory syndrome coronavirus 2…
- Conditions
- COVID-19, SARS-CoV 2, Corona Virus Infection, Sedentary Behavior
- Trial name
- WHO (NCT04396353)
- Testing
- Electronic questionnaire
- Where
- Brazil
- Volunteers
- 1,574 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Acute Upper Respiratory Tract Infection and Acute Bacterial Rhinosinusitis
Acute Upper Respiratory Tract Infection - When is Bacteria Involved?
The purpose of this study is to find out if we can predict the progress of acute upper respiratory tract infection to acute bacterial rhinosinusitis in Finnish conscripts by symptoms, clinical, endoscopic or radiological…
- Trial name
- NCT01580137
- Where
- Finland
- Volunteers
- 48 people
- Sponsor
- Oulu University Hospital
Coronavirus, Coronavirus Infection
Natural Killer Cell (CYNK-001) Infusions in Adults With COVID-19
This study is a Phase 1 / 2 trial to determine the safety and efficacy of CYNK-001, an immunotherapy containing Natural Killer (NK) cells derived from human placental CD34+ cells and culture-expanded, in patients with moderate…
- Conditions
- Coronavirus, Coronavirus Infection, Severe Acute Respiratory Syndrome Coronavirus 2, Pneumonia
- Trial name
- CYNKCOVID (NCT04365101)
- Testing
- CYNK-001
- Where
- 4 sites in United States
- Volunteers
- 7 people
- Sponsor
- Celularity Incorporated
HIV/AIDS
Reducing HIV Persistence in Lymph Nodes by Interleukin-15 (IL-15) Receptor Super-agonist (N-803) in Acute HIV Infection
Reducing HIV persistence in lymph nodes by Interleukin-15 (IL-15) Receptor super-agonist (N-803) in Individuals with Acute HIV Infection
- Trial name
- NCT04505501
- Testing
- N-803
- Where
- Thailand
- Volunteers
- 14 people
- Sponsor
- Thai Red Cross AIDS Research Centre
Post-COVID19 Condition
Effect of Vitamin D Supplementation on Glutathione Peroxidase (GPx) Activity, Interleukin-6 (IL-6) Levels and Clinical Outcomes in Post-COVID-19 Patients
The goal of this clinical trial is to evaluate the effectiveness of vitamin D supplementation in treating neuropsychiatric symptoms and improving antioxidant levels in individuals diagnosed with post-COVID-19 condition, a state…
- Trial name
- VITDPOSTCOVID (NCT06419712)
- Testing
- vitamin D (cholecalciferol) supplementation
- Where
- Mexico
- Volunteers
- 54 people
- Sponsor
- Escuela Militar de Graduados de Sanidad, SEDENA
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