Clinical trials: Acute Injuries Knee
Knee Injury, Knee Osteoarthritis
Monitoring Of Helsingborg Acute Knee Injuries (MOHAK)
Using magnetic resonance imaging (MRI), laboratory analyses and patient reported outcomes, the overall aim of this study is to investigate structural injuries and biochemical alterations in the acutely injured knee and to relate…
- Trial name
- NCT01382173
- Where
- Sweden
- Volunteers
- 192 people
- Sponsor
- Lund University
Knee Injury
F18-Flouride PET/CT in Acute Knee Injury
18F-fluoride is a positron-emitting bone-seeking agent with favorable pharmacokinetic properties. Its uptake mechanism resembles that of 99mTc-MDP.
- Trial name
- NCT00687921
- Volunteers
- 50 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Patellar (or Kneecap) Instability and Mal-alignment, Patellar Dislocation
MPFL Reconstruction Versus Rehabilitation
This study involves patients between the ages of 16 and 25 and have been diagnosed with a first-time traumatic patellar dislocation within the past 3 months.
- Trial name
- ANTI-GLIDE (NCT06926699)
- Testing
- Medial Patellofemoral Ligament Reconstruction, Rehabilitation
- Sponsor
- McMaster University
Anterior Cruciate Ligament Injuries, Anterior Cruciate Ligament Rupture
Treatment of Acute ACL Injuries in Young Patients Using a Rebound ACL Brace
This study evaluates the use of a brace in acute anterior cruciate ligament (ACL) injuries in children and adolescents. Half of the participants will receive a so called rebound ACL brace together with a standardized rehab…
- Conditions
- Anterior Cruciate Ligament Injuries, Anterior Cruciate Ligament Rupture, Anterior Cruciate Ligament Tear
- Trial name
- NCT04185532
- Testing
- Rebound ACL brace and physioterapy, Physioterapy
- Where
- Sweden
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Frida Hansson, MD
Infection, Surgical Site Infection
Changing of Dressing for Periprosthetic Joint Infection in Total Knee Arthroplasty
The primary aim of the study is to compare two methods for a relationship with total knee infection: regular changing of dressings and not changing dressings.
- Conditions
- Infection, Surgical Site Infection, Prosthetic Infection, Wound Infection
- Trial name
- NCT04346875
- Testing
- Regularly changing of dressing, No application
- Volunteers
- 842 people
- Sponsor
- Bezmialem Vakif University
Acute Compartment Syndrome
The Research About Acute Compartment Syndrome
Acute compartment syndrome (ACS) is defined as a clinical entity originated from trauma or other conditions, and remains challenging to diagnose and treat effectively. Threre is the controversy in diagnosing, treating ACS.
- Trial name
- NCT04529330
- Testing
- fasciotomy
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Hebei Medical University Third Hospital
Knee Injuries
Acute Pain and Inflammation After Surgery
The purpose of this study is 1. to observe acute pain after surgery and measure the natural course of inflammatory mediators 2. study pain relieving effects and local anti-inflammatory effects of systemically administered…
- Trial name
- Knemikro01 (NCT00774540)
- Testing
- 1 Ketorolac intraarticular
- Where
- Norway
- Volunteers
- 40 people
- Sponsor
- Oslo University Hospital
Injuries, Injury Arm
Virtual Reality for Pain in Acute Orthopedic Injuries
The goal of this study is to pilot test a skills-based virtual reality (VR) for acute orthopedic injury. It will measure the feasibility, signals of improvement, exploratory pain mechanisms, and user experience of an established…
- Conditions
- Injuries, Injury Arm, Injury;Sports, Injury, Knee
- Trial name
- NCT05552430
- Testing
- RelieveVRx
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Massachusetts General Hospital
Pain, Acute, Knee Osteoarthritis
Comparison of the Analgesic Effect of Subsartorial Saphenous Block and Popliteal Sciatic vs Subsartorial Saphenous Block and IPACK in Total Knee Replacement Surgery.
Total knee replacement surgery is associated with significant pain in the immediate postoperative period, especially in movement. In turn, this is associated with more subsequent chronic pain.
- Conditions
- Pain, Acute, Knee Osteoarthritis, Anesthesia
- Trial name
- NCT06514365
- Testing
- IPACK block with Bupivacaine 0.25% with adrenaline
- Where
- Spain
- Volunteers
- 62 people
- Sponsor
- Germans Trias i Pujol Hospital
Anterior Cruciate Ligament Rupture
LIBRE (Ligamys, Internal Bracing, REconstruction) Study: Comparing Three Surgery Techniques After an Acute ACL Rupture.
Single-blind, multi-centre, prospective, randomized controlled trial comparing Ligamys Anterior Cruciate Ligament (ACL) repair, Internal Bracing ACL repair and conventional ACL reconstruction for relative clinical efficacy and…
- Trial name
- LIBRE (NCT03441295)
- Testing
- Dynamic Intraligamentary Stabilization, Internal Brace Ligament Augmentation, ACL Reconstruction
- Where
- 3 sites in Belgium
- Volunteers
- 95 people
- Sponsor
- University Hospital, Antwerp
Anterior Cruciate Ligament Injury, Osteoarthritis
Safety and Efficacy Study of MSB-CAR001 in Subjects 6 Weeks Post an Anterior Cruciate Ligament Reconstruction
The purpose of this study is to evaluate safety and preliminary efficacy of MSB-CAR001 in subjects who have recently undergone an Anterior Cruciate Ligament Reconstruction
- Trial name
- NCT01088191
- Testing
- MSB-CAR001 Combined With Hyaluronan, Hyaluronan
- Where
- Australia
- Volunteers
- 17 people
- Sponsor
- Mesoblast, Ltd.
Orthopedic, Rupture
Clinical Screening of Acute Ruptures of the Anterior Cruciate Ligament of the Knee
This study develops the construction and validation of a reliable functional screening score in LCA ruptures in the immediate post-traumatic period.
- Trial name
- ACL-TS (NCT03113734)
- Testing
- Construction and validation of a functional score
- Where
- France
- Volunteers
- 355 people
- Sponsor
- French Arthroscopic Society
Acute Injury of Anterior Cruciate Ligament
Feasibility Trial Using Imaging and Biochemical Technologies to Measure Knee Cartilage Composition in Acute ACL Injury
This study will evaluate the bio-mechanical and biochemical abnormalities in acute ACL-injured knees over time. Data will be collected through advanced quantitative MR imaging, functional testing, and bio-specimen collection.
- Trial name
- NCT02010125
- Where
- United States
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Knee Osteoarthritis
Exploring Factors Linked to Worsening Over Time in People With Early-stage Knee Osteoarthritis and Those With Prior Proven Acute Knee Injury.
The goal of this observational, non-interventional cohort study is to identify tests or markers in blood or knee fluid, or any genetic risk factors that might contribute to worsening or improvement of knee osteoarthritis.
- Trial name
- KNEE (NCT07833488)
- Where
- United Kingdom
- Volunteers
- 200 people
- Sponsor
- Imperial College London
Tibial Shaft Fracture, Tibial Plateau Fracture
Gene Expression in Lower Extremity Acute Traumatic Compartment Syndrome
The purpose of this study is to evaluate both genotypic differences and differences in local gene expression in individuals who develop acute traumatic compartment syndrome relative to control patients with at-risk lower…
- Trial name
- NCT05521958
- Testing
- Acute injury without compartment syndrome, Acute injury with compartment syndrome, Exertional compartment syndrome
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Utah
Anterior Cruciate Ligament Tear, Anterior Cruciate Ligament Rupture
Altering Bone Microarchitecture and Mechanics by Off-label Pharmaceutical Intervention Following an Acute Knee Injury
The purpose of this study is to assess if a zoledronic acid injection can alter the trajectory of joint degeneration following an acute anterior cruciate ligament (ACL) injury.
- Conditions
- Anterior Cruciate Ligament Tear, Anterior Cruciate Ligament Rupture, Anterior Cruciate Ligament Injuries, Osteo Arthritis Knee
- Trial name
- ZAPOA (NCT05204836)
- Testing
- Zoledronic Acid Injection
- Where
- Canada
- Volunteers
- 4 people
- Sponsor
- University of Calgary
Orthopedic Surgery, Opioid Use
Post-op Crowd Sourcing Health Data Via Text-messaging
The Center for Disease Control has labeled the opioid prescription drug crisis an "epidemic" in the United States and recently this epidemic has been named a public health emergency.
- Conditions
- Orthopedic Surgery, Opioid Use, Acute Injuries Knee, Neurosurgery
- Trial name
- NCT03532256
- Testing
- Observation, Text to online survey, Bi-directional text script
- Where
- United States
- Volunteers
- 127 people
- Sponsor
- University of Pennsylvania
Osteoarthritis, Knee
MR Imaging of Knee Osteoarthritis and Acute Knee Injuries
The purpose of this study is to use better magnetic resonance imaging (MRI) techniques to examine the knee and the bony and soft tissue changes so as to better predict the progression of osteoarthritis and acute knee injuries.
- Trial name
- NCT00504114
- Testing
- ACL Reconstruction Surgery, Cartilage Resurfacing Surgery, Total Knee Replacement
- Where
- United States
- Volunteers
- 139 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Acute Knee Cartilage Injury, Tear of Articular Cartilage of Knee, Current
EAGLE European Post Market Study
Prospective, multi-center, non-randomized, historical controlled, post-market study of patients requiring surgical repair of a focal articular cartilage lesion or osteochondral defect in the knee.
- Trial name
- EAGLE (NCT02309957)
- Testing
- BioMatrix CRD
- Where
- 6 sites in Germany, Italy and 2 more
- Volunteers
- 33 people
- Sponsor
- Kensey Nash Corporation
Anterior Cruciate Ligament Injury
Preemptive Analgesia in Cruciate Reconstruction
The aims of this study was to compare analgesic efficacy of preoperative administration of etoricoxib versus celecoxib for post-operative pain relief after arthroscopic anterior cruciate ligament reconstruction.
- Trial name
- NCT01017380
- Testing
- Celecoxib, etoricoxib
- Where
- Thailand
- Volunteers
- 30 people
- Sponsor
- Prince of Songkla University