Clinical trials: Acute Ischemic Stroke Patients
Stroke, Acute
Telestroke at Comprehensive Stroke Center During the COVID-19 Pandemic
TELEstroke to CAre for STroke Patients at a Comprehensive Stroke Center (TELECAST-CSC) during the COVID-19 pandemic is a pre-post study evaluating guideline-based acute ischemic stroke care following the implementation of…
- Trial name
- TELECAST-CSC (NCT04761874)
- Testing
- Telestroke
- Where
- United States
- Volunteers
- 296 people
- Sponsor
- University of Minnesota
Stroke, Acute
Delay AvoIding Primary Evaluation for ThRombectomy of Acute StrokE Patients With Large Vessel OCclusion in the Angiography SuiTe
The purpose of this study is to compare two strategies for treating adults with suspected large vessel occlusion stroke within 7 hours of symptom onset.
- Trial name
- DIRECT (NCT06825897)
- Testing
- Conventional Triage for Mechanical Thrombectomy, Direct Transfer to Angiography Suite (DTAS
- Where
- 15 sites in United States
- Volunteers
- 2,039 people
- Sponsor
- Santiago Ortega Gutierrez
Acute Cerebral Ischemia
Study to Assess the Safety and Efficacy of Sovateltide in Patients With Acute Cerebral Ischemic Stroke
This is a prospective, multicenter, randomized, double-blind, parallel, phase IV study designed to evaluate the safety and efficacy of sovateltide (PMZ-1620, IRL-1620) as a potential treatment for cerebral ischemic stroke.
- Trial name
- NCT05955326
- Testing
- Sovateltide, Normal Saline
- Where
- 6 sites in India
- Volunteers
- 160 people
- Sponsor
- Pharmazz, Inc.
Ischemic Stroke
Head Position on Cerebral Haemodynamics in Acute Ischemic Stroke and Controls
Cerebral autoregulation is an important mechanism whereby cerebral perfusion is normally maintained at a constant level, over a relatively wide blood pressure range.
- Trial name
- NCT02932540
- Testing
- change of head position
- Where
- United Kingdom
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- University of Leicester
Dehydration, Ischemic Stroke
BUN/Cr-based Hydration Therapy to Improve Outcome of Patients With Acute Ischemic Stroke
English Synopsis I. Title of Study: A trial of BUN/Cr-based hydration therapy to reduce stroke-in-evolution and improve short-term functional outcomes for dehydrated patients with acute ischemic stroke-version 2. II.
- Trial name
- NCT05121389
- Testing
- normal saline
- Where
- Taiwan
- Volunteers
- 288 people
- Sponsor
- Chang Gung Memorial Hospital
Acute Ischemic Stroke
A Study to Test if Tenecteplase Helps People to Recover From an Acute Stroke When Given More Than 4.5 Hours After the Person Was Last Seen Well
This study is open to adults who had an acute stroke caused by a clot blocking a blood vessel in the brain (acute ischemic stroke).
- Trial name
- TENACITY (NCT07361302)
- Testing
- Tenecteplase, Standard of care treatment
- Where
- 257 sites in Argentina, Australia and 14 more
- Volunteers
- 1,325 people
- Sponsor
- Boehringer Ingelheim
Ischemic Stroke
Efficacy of Transcranial Direct Current Stimulation in Acute Ischemic Stroke
Non-invasive brain stimulation (tDCS) such as transcranial direct current stimulation (TDCS) has been reported to be effective in improving motor performance and safe in participants with cerebral infarction.
- Trial name
- DAS (NCT04938076)
- Testing
- Transcranial direct current stimulation
- Where
- South Korea
- Volunteers
- 172 people
- Sponsor
- Incheon St.Mary's Hospital
Stroke, Stroke Ischemic
Effects of Vojta Therapy on Posture and Trunk Control
Vojta therapy that is reflex locomotion therapy is a neurophysiological rehabilitation approach that stimulates specific "reflex zones" on the body to activate global, innate movement patterns.
- Trial name
- NCT07244952
- Testing
- Vojta therapy, Routine physical therapy
- Where
- Pakistan
- Volunteers
- 62 people
- Sponsor
- University of Lahore
Ischemic Stroke
Efficacy and Safety of SP-8203 in Patients With Ischemic Stroke Requiring rtPA
This clinical trial is designed to evaluate the efficacy and safety of the combination therapy of SP-8203 (Otaplimastat) and recombinant tissue Plasminogen Activator (rtPA) standard of care.
- Trial name
- SP-8203-2002 (NCT04479449)
- Testing
- SP-8203
- Where
- South Korea
- Volunteers
- 178 people
- Sponsor
- Shin Poong Pharmaceutical Co. Ltd.
Acute Ischemic Stroke
DLBS1033 for the Treatment of Acute Ischemic Stroke
This is a prospective, randomized, double-blind, and controlled clinical study to investigate the effects of DLBS1033 in conjunction with standard therapy compared to standard therapy alone in acute ischemic stroke patients.
- Trial name
- NCT02362984
- Testing
- DLBS1033
- Where
- Indonesia
- Volunteers
- 9 people
- Sponsor
- Dexa Medica Group
Stroke, Ischemic, Stroke, Acute
Efficacy of Intravenous Tissue-type Plasminogen Activator on Acute Ischemic Stroke Patients With Large Vessel Occlusions
This is an observational prospective study about the reperfusion rate of intravenous thrombolysis on ischemic stroke patients with large vessel occlusions and predictor factors of successful recanalization.
- Trial name
- NCT04170647
- Testing
- Plasminogen Activators
- Where
- Vietnam
- Volunteers
- 81 people
- Sponsor
- University of Medicine and Pharmacy at Ho Chi Minh City
Acute Ischemic Stroke, Contrast-induced Nephropathy
Serum Electrolytes and Contrast-Induced Nephropathy in Acute Ischemic Stroke Patients Undergoing Endovascular Treatment
This study aims to evaluate the relationship between serum electrolyte levels and the development of contrast-induced acute kidney injury (CI-AKI) in patients with acute ischemic stroke undergoing endovascular therapy (EVT).
- Conditions
- Acute Ischemic Stroke, Contrast-induced Nephropathy, Acute Kidney Injury
- Trial name
- NCT07546448
- Testing
- No intervention (observational cohort study)
- Where
- Turkey (Türkiye)
- Volunteers
- 250 people
- Sponsor
- Saglik Bilimleri Universitesi Gazi Yasargil Training and Research Hospital
Acute Ischemic Stroke
Thrombolysis Treated With TNK-tPA in Acute Ischemic Stroke Patients （3T Stroke-Ⅲ）
The trial is prospective, randomized, open-label, blinded endpoint (PROBE) design. Patients with acute ischemic stroke, who are eligible for standard intravenous thrombolysis within 4.5 hours of stroke onset will be randomized…
- Trial name
- NCT05745259
- Testing
- Alteplase, Tenecteplase
- Where
- 63 sites in China
- Volunteers
- 1,630 people
- Sponsor
- Beijing Tiantan Hospital
Ischemic Stroke, Cardioembolic Stroke
Diagnostic Yield of Cardiac CT to Detect Cardiac Thrombi in Acute Ischemic Stroke: an Individual Patient Data Meta-Analysis
The aim of the AIS of HEARTS registry is to establish a database to collect, maintain and provide accessible individual patient data from international cohorts and to provide pooled analyses about the yield and value of cardiac…
- Conditions
- Ischemic Stroke, Cardioembolic Stroke, Thrombus, Cardiac CT
- Trial name
- AIS of HEARTS (NCT07165093)
- Where
- Netherlands
- Volunteers
- 3,940 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Stroke, Acute, Thromboses, Intracranial
Alteplase Compared to Tenecteplase in Patients With Acute Ischemic Stroke
The proposed trial is a pragmatic, registry linked, prospective, randomized (1:1) controlled, open-label parallel group clinical trial with blinded endpoint assessment of 1600 patients to test if intravenous tenecteplase (0.25…
- Trial name
- AcT (NCT03889249)
- Testing
- Tenecteplase, Alteplase
- Where
- 22 sites in Canada
- Volunteers
- 1,600 people
- Sponsor
- University of Calgary
Ischemic Stroke, Acute
Thrombolysis and Deferoxamine in Middle Cerebral Artery Occlusion
Iron overload has been associated with greater brain injury in ischemia/reperfusion experimental stroke models and ischemic stroke patients, especially in those treated with thrombolytic treatment.
- Trial name
- TANDEM-1 (NCT00777140)
- Testing
- Deferoxamine
- Where
- 4 sites in Spain
- Volunteers
- 62 people
- Sponsor
- Germans Trias i Pujol Hospital
Acute Ischemic Stroke
Early Administration of Edoxaban After Acute Ischemic Stroke in Patients With Non-valvular Atrial Fibrillation
The investigators hypothesize that earlier initiation of edoxaban in AF-related stroke patients may significantly reduce the early recurrence of ischemic stroke, compared with conventional strategy of anticoagulation following…
- Trial name
- NCT03433235
- Testing
- Edoxaban
- Where
- South Korea
- Volunteers
- 68 people
- Sponsor
- Jong Sung Kim
Ischemic Stroke
Evaluation of the Safety and Performance of Magneto Microcatheter
A prospective, open label single arm feasibility study to evaluate the safety and performance of the Magneto Microcatheter in patients diagnosed with acute ischemic stroke and planned for thrombectomy procedure.
- Trial name
- NCT04466033
- Testing
- Magneto Microcatheter
- Where
- 3 sites in Hungary, Israel
- Volunteers
- 4 people
- Sponsor
- Magneto Thrombectomy Solutions
Acute Ischemic Stroke
Evaluate Endovascular Treatment of Large Ischemic Stroke With Substantial Penumbra.
Large cerebral infarctions are frequent and associated with a poor outcome. Previous cohort studies results suggest that patients with an acute ischemic stroke with large core and substantial penumbra on perfusion imaging benefit…
- Trial name
- FrameLP (NCT05539404)
- Testing
- Endovascular treatment in addition of best medical treatment.
- Where
- 9 sites in France
- Volunteers
- 2 people
- Sponsor
- University Hospital, Toulouse
Ischemic Stroke, Acute, Myocardial Injury
Safety and Efficacy of Remote Ischemic Conditioning in Patients With Acute Myocardial Injury Following Acute Ischemic Stroke
Introduction: The management of acute myocardial injury following acute ischemic stroke (AMI-AIS), a frequent complication that severely worsens prognosis, is challenging.
- Trial name
- NCT07531394
- Testing
- Remote Ischemic Conditioning
- Volunteers
- 580 people
- Sponsor
- Capital Medical University