Clinical trials: Acute Lung Injury/Acute Respiratory Distress Syndrome (ARDS)
Acute Respiratory Distress Syndrome, Ventilator-Induced Lung Injury
Impact of the Depth of Neuromuscular Blockade on Respiratory Mechanics in Moderate to Severe ARDS Patients
Neuromuscular blockade (NMB) is proposed in patients with moderate to severe acute respiratory distress syndrome (ARDS). The supposed benefit of these muscle relaxants could be partly linked to their effects on respiratory…
- Trial name
- NCT05697666
- Testing
- Modulation of the depth of the neuromuscular blockade
- Where
- France
- Volunteers
- 33 people
- Sponsor
- Centre Hospitalier de Saint-Brieuc
Acute Respiratory Distress Syndrome, Respiratory Failure
Precision Ventilation vs Standard Care for Acute Respiratory Distress Syndrome
The goal of this interventional study is to compare standard mechanical ventilation to a lung-stress oriented ventilation strategy in patients with Acute Respiratory Distress Syndrome (ARDS).
- Trial name
- PREVENT VILI (NCT06066502)
- Testing
- Precision ventilation, Guided usual care ventilation
- Where
- 33 sites in United States
- Volunteers
- 1,100 people
- Sponsor
- Beth Israel Deaconess Medical Center
Ards
Duration of Prone Position in the Severe Acute Respiratory Syndrome Coronavirus 2 (COVID-19).
The OMELETTE study is a randomised, controlled, unicentric, open-label study to prove the noninferiority of reduced prone position (PP) sessions (more tan 16 hours) versus prolonged PP (48 hours).
- Trial name
- OmeLEtte (NCT05012267)
- Testing
- 16-hour PP
- Where
- Spain
- Volunteers
- 61 people
- Sponsor
- Ignacio Saez de la Fuente
Acute Respiratory Distress Syndrome
Assessment of Acute Respiratory Distress in Children Presenting to the Emergency Department: Clinical, Epidemiological, and Etiological Insights
This study investigates the clinical and epidemiological characteristics of children with acute respiratory distress presenting to the emergency unit at Assiut University Children Hospital.
- Trial name
- NCT07149389
- Volunteers
- 70 people
- Sponsor
- Assiut University
Acute Lung Injury
Exploratory Clinical Study of Neutrophil Activation Probe (NAP) for Optical Molecular Imaging in Human Lungs
Seriously ill patients may develop a complication called acute lung injury (ALI), a form of inflammation in which lung tissue is filled by fluid containing white blood cells called neutrophils.
- Trial name
- NAP (NCT01532024)
- Testing
- Microdose of NAP
- Where
- 3 sites in United Kingdom
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
ARDS, COVID-19 Acute Respiratory Distress Syndrome
Comparison of ARDS COVID-19 (WHO) vs ARDS Influenza in the ICU
Since the beginning of the SARS CoV 2 pandemia, the SARS CoV 2 was frequently compared with the seasonal influenza virus. However, few studies compared patients presenting acute respiratory distress syndrome (ARDS) induced by…
- Conditions
- ARDS, COVID-19 Acute Respiratory Distress Syndrome, Influenza
- Trial name
- NCT04941092
- Testing
- no intervention
- Where
- France
- Volunteers
- 157 people
- Sponsor
- Central Hospital, Nancy, France
ECMO Treatment, ARDS (Acute Respiratory Distress Syndrome)
Ciprofol's Impact on Oxygenator Function in Extracorporeal Membrane Oxygenation (ECMO) Patients
This study evaluates the safety and effectiveness of Ciprofol, a new sedative, in critically ill patients receiving Extracorporeal Membrane Oxygenation (ECMO), a life-support system for heart or lung failure.
- Conditions
- ECMO Treatment, ARDS (Acute Respiratory Distress Syndrome), ECMO and Acute MI, Respiratory Failure Patients Treated With ECMO
- Trial name
- CIP-OXY (NCT06934811)
- Testing
- Ciprofol, Midazolam
- Volunteers
- 30 people
- Sponsor
- First Affiliated Hospital of Wannan Medical College
Acute Lung Injury/Acute Respiratory Distress Syndrome (ARDS), Pulmonary Complication
FSTL1 and PPCs on Pediatric Within LDLT:a Prospective Cohort Analysis
The goal of this observational study is to identify the association between FSTL1 elevation and acute lung injury (ALI) after pediatric liver transplantation.The main questions it aims to answer what the risk factors are for ALI…
- Conditions
- Acute Lung Injury/Acute Respiratory Distress Syndrome (ARDS), Pulmonary Complication, Liver Transplant; Complications
- Trial name
- NCT05807802
- Volunteers
- 400 people
- Sponsor
- Tianjin First Central Hospital
Acute Lung Injury, Acute Respiratory Distress Syndrome
Influence of Acute Respiratory Distress Syndrome (ARDS) and Severe Sepsis on sRAGE Levels in ICU Patients
sRAGE, the soluble form of the receptor for advanced glycation end products, is a novel marker of alveolar epithelial type I cell injury, but is also involved in acute systemic inflammation.
- Conditions
- Acute Lung Injury, Acute Respiratory Distress Syndrome, Severe Sepsis, Septic Shock
- Trial name
- NCT00811629
- Testing
- sRAGE
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Clermont-Ferrand
Lung Injury, Acute and Respiratory Distress Syndrome, Adult
Study of GSK2862277 in Subjects Undergoing Oesophagectomy Surgery
Lung injury in patients undergoing oesophagectomy may occur during surgery (peri-operatively) as a result of One Lung Ventilation (OLV) and/or during the immediate post-operative period when patients receive intensive care.
- Trial name
- NCT02221037
- Testing
- GSK2862277
- Where
- 6 sites in United Kingdom
- Volunteers
- 35 people
- Sponsor
- GlaxoSmithKline
Acute Respiratory Distress Syndrome (ARDS), s100b
A Study of the Determinants of Neurological Outcomes in Patients With Acute Respiratory Distress Syndrome
Acute respiratory distress syndrome (ARDS) is characterized by pathological pulmonary edema caused by direct or indirect damage to the alveolar-capillary membrane.
- Conditions
- Acute Respiratory Distress Syndrome (ARDS), s100b, Mechanical Power, Ventilator Induced Lung Injury
- Trial name
- NEURDS (NCT07629973)
- Testing
- Blood test scores calculations
- Volunteers
- 150 people
- Sponsor
- University Hospital, Angers
Respiratory Distress Syndrome, Adult, Pneumonia
Comparison Study of High Frequency Percussive Ventilation With Conventional Ventilation
This study is designed to exam the effects of early management with high frequency percussive ventilation (HFPV) on patients with lung injury.
- Conditions
- Respiratory Distress Syndrome, Adult, Pneumonia, Mechanical Ventilation
- Trial name
- NCT00308022
- Testing
- High Frequency Percussive Ventilation
- Where
- United States
- Sponsor
- University of Texas Southwestern Medical Center
COVID-19, Acute Respiratory Distress Syndrome
Treatment of Lung Injury From COVID-19 Infection With Intravenous Sodium Nitrite
This multicenter, randomized, double-blind, placebo-controlled clinical trial will evaluate the efficacy and safety of intravenous Sodium Nitrite Injection for treatment of patients infected with COVID-19 who develop lung injury…
- Conditions
- COVID-19, Acute Respiratory Distress Syndrome, Acute Respiratory Failure
- Trial name
- NCT04401527
- Testing
- Sodium Nitrite, Normal Saline
- Where
- 2 sites in United States
- Sponsor
- Hope Pharmaceuticals
Critically Ill, Acute Lung Injury
Respiratory Mechanics and Pleural Effusion
The investigators aim to compare the respiratory mechanics in acute lung injury (ALI)/acute respiratory diseases syndrome (ARDS) patients with and without pleural effusion.
- Conditions
- Critically Ill, Acute Lung Injury, ARDS
- Trial name
- NCT00258518
- Testing
- mechanical ventilation/CT Scan
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Policlinico Hospital
Sepsis, Acute Kidney Injury Due to Sepsis
Presepsin:Gelsolin Ratio in Sepsis-related Organ Dysfunction
In the present study, 126 patients were enrolled (23 control, 38 non-septic and 65 septic patients). Blood samples were collected from septic patients at the intensive care unit (ICU) at three time points (T1-3): T1: within 12h…
- Conditions
- Sepsis, Acute Kidney Injury Due to Sepsis, Septic Shock, Acute Respiratory Distress Syndrome
- Trial name
- NCT05060679
- Testing
- Supportive therapy at the ICU, Sepsis therapy, Sepsis-related organ dysfunction therapy
- Where
- Hungary
- Volunteers
- 126 people
- Sponsor
- University of Pecs
Trauma Injury, Brain Injuries
The Effect of Supraglottic and Oropharyngeal Decontamination on the Incidence of Ventilator-associated Pneumonia
Oropharynx is the main source of pathogen microorganisms for the ventilator - associated pneumoniae. As known bacteriophages can eliminate different pathogen microorganisms or reduce a degree of a pathogen's colonization.
- Conditions
- Trauma Injury, Brain Injuries, Abdominal Sepsis, Pancreatitis
- Trial name
- SGDC-VAP (NCT04325685)
- Testing
- Control, Antiseptic Solution, Bacteriophage
- Where
- Russia
- Volunteers
- 60 people
- Sponsor
- Northern State Medical University
Acute Respiratory Distress Syndrome
Measurement of Airway Opening Pressure (AOP) in Patients With Acute Respiratory Distress Syndrom and With or Without Covid 19.
Mechanical ventilation in ARDS requires protective ventilation and PEEP. Airway closer has to be overcome to reduce lung heterogeneity, AOP is measured globally with a ventilator PV curve without PEEP.
- Trial name
- POVA-TIE (NCT04386720)
- Where
- France
- Volunteers
- 26 people
- Sponsor
- University Hospital, Bordeaux
COVID-19, Acute Lung Injury/Acute Respiratory Distress Syndrome (ARDS)
The Safety and Preliminary Tolerability of Lyophilized Lucinactant in Adults With Coronavirus Disease 2019 (COVID-19)
This is a multicenter, single-treatment study. Subjects will consist of adults with COVID-19 associated acute lung injury who are being cared for in a critical care environment.
- Trial name
- NCT04389671
- Testing
- Lucinactant
- Where
- 11 sites in United States, Argentina
- Volunteers
- 20 people
- Sponsor
- Windtree Therapeutics
Multi-organ Failure After Severe Trauma
Metabolic Reprogramming in Renal Tubular Cells in Acute Kidney Injury Following Severe Trauma
Severe trauma remains the leading cause of death in people under 50, and is associated with high morbidity, including severe disability, with a substantial socio-economic impact.
- Trial name
- METAKIT (NCT06167512)
- Where
- 2 sites in France
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
COPD (Chronic Obstructive Pulmonary Disease), ARDS (Acute Respiratory Distress Syndrome)
Can Total Mechanical Power Be a Determinant of Weaning Failure in Chronic Obstructive Pulmonary Disease (COPD)?
A Comparison of Ventilator Parameters (TV, DP, Total Mechanical Power, etc.) Between Successfully and unsuccessfully Weaned Patients with COPD Undergoing Mechanical Ventilation Due to Respiratory Failure, and Diagnosed with…
- Conditions
- COPD (Chronic Obstructive Pulmonary Disease), ARDS (Acute Respiratory Distress Syndrome), Mechanical Power, Pneumonia
- Trial name
- NCT06751654
- Where
- Turkey (Türkiye)
- Volunteers
- 1,000 people
- Sponsor
- Bakirkoy Dr. Sadi Konuk Research and Training Hospital