Clinical trials: Acute Malnutrition, Severe
Severe Acute Malnutrition
Rice Bran-based Supplemental Foods for the Treatment of Childhood Malnutrition
The purpose of this study is to assess the efficacy of treating children with severe acute malnutrition (SAM) with a locally produced ready-to-use therapeutic food (RUTF) with or without rice bran.
- Trial name
- NCT05319717
- Testing
- Ready-to-use therapeutic food with heat stabilized rice bran, Ready-to-use therapeutic food (no rice bran)
- Where
- Indonesia
- Volunteers
- 200 people
- Sponsor
- Colorado State University
Malaria, Severe Acute Malnutrition
Efficacy and Bio-availability of Artemether-Lumefantrine in Severely Malnourished Children
The general objective of the study is to answer to the question: "Is the current dose of AL less efficacious in the severely malnourished compared to the non-severely malnourished children, and is PK in cause?" We aim to assess…
- Trial name
- MAL-NUT (NCT01958905)
- Testing
- Artemether-lumefantrine fixed combination
- Where
- 2 sites in Mali, Niger
- Volunteers
- 399 people
- Sponsor
- Epicentre
Severe Acute Malnutrition
Gastrointestinal Tolerance of Under-five Children With Severe Acute Malnutrition to ONS Compared to F-75/F-100
The primary outcome of the study is to identify gastrointestinal tolerance of under-five children with severe acute malnutrition to ready-to-drink high energy (1.5 kcal/ml) and standard energy (1 kcal/ml) oral nutrition…
- Trial name
- NCT04715204
- Testing
- High Energy Oral Nutrition Supplement, Standard Energy Oral Nutrition Supplement, Formula-75/Formula-100
- Where
- 2 sites in Indonesia
- Volunteers
- 108 people
- Sponsor
- Universitas Indonesia
Severe Acute Malnutrition
SAM: Discharge Based on the Use of a MUAC-based Criterion to
Retrospective analysis of routine program data of children aged 6 to 59 months admitted to the MSF therapeutic feeding program with MUAC ≤ 118 mm in Yako and Titao districts of Burkina Faso from 2007-2011.
- Trial name
- NCT03303131
- Testing
- Discharge from community-based management
- Volunteers
- 50,841 people
- Sponsor
- Epicentre
Shock Hypovolemic, Shock, Septic
Management of Shock in Children With SAM or Severe Underweight and Diarrhea
Diarrhea is one of the leading causes of under-five childhood mortality and accounts for 8% of 5.4 million global under-5 deaths.
- Conditions
- Shock Hypovolemic, Shock, Septic, Blood Transfusion, Adrenaline
- Trial name
- NCT04750070
- Testing
- Blood and Dopamine, Blood and adrenaline
- Where
- Bangladesh
- Volunteers
- 135 people
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Tuberculosis, Pulmonary
Impact of Malnutrition on Pharmacokinetic of Rifampicin, Isoniazid, Pyrazinamide and Ethambutol in TB-HIV Co-infected Children (TB-Speed TB-PK)
TB-Speed TB-PK is a cross-sectional PK study of anti-TB treatment nested in the TB-Speed HIV and TB-Speed SAM studies aiming at assessing the impact of malnutrition on PK of rifampicin, isoniazid, pyrazinamide, and ethambutol in…
- Trial name
- NCT04972903
- Where
- 4 sites in Uganda, Zambia
- Volunteers
- 85 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Uncomplicated Severe Acute Malnutrition
Effects of Three Feeding Regimens on Recovery of Uncomplicated Severely Acute Malnourished Children
This project aims to assess the efficacy of three options under consideration in India for home management of Severe Acute Malnutrition (SAM).
- Trial name
- SAMPOORNA (NCT01705769)
- Testing
- Ready to Use Therapeutic Food-Centrally produced, Ready to Use Therapeutic Food-Locally produced, High energy and micronutrient rich foods
- Where
- 3 sites in India
- Volunteers
- 911 people
- Sponsor
- Society for Applied Studies
Diarrhea, Pneumonia
Effect of Zinc and Vitamin A Supplementation on Diarrhea, Physical Growth and Immune Response in Malnourished Children
Zinc deficiency is common in developing country children, as food intakes are often low, foods from animal sources are infrequently used, the bioavailability of zinc from staple cereal-based diets is limited and zinc losses occur…
- Conditions
- Diarrhea, Pneumonia, Acute Respiratory Tract Infection
- Trial name
- NCT00272116
- Testing
- Zinc and vitamin A single dose at enrollment
- Where
- India
- Volunteers
- 2,482 people, healthy volunteers welcome
- Sponsor
- Society for Applied Studies
Severe Acute Malnutrition in Childhood
Severe Acute Malnutrition and Child Development Clinical Trial in Mwanza
This is a randomized clinical trial to learn whether ready-to-use therapeutic foods enriched with choline and docosahexaenoic acid (DHA) together with psychosocial stimulating activities work well to improve child development in…
- Trial name
- BRIGHTSAM (NCT06781918)
- Testing
- Ready to Use Therapeutic Food (RUTF), Psychosocial stimulation
- Where
- Tanzania
- Volunteers
- 800 people
- Sponsor
- National Institute for Medical Research, Tanzania
Covid19, Vitamin D Deficiency
High Dose Vitamin-D Substitution in Patients With COVID-19: a Randomized Controlled, Multi Center Study
The world is currently facing a pandemic with the coronavirus (SARS-CoV-2) which leads to the disease of COVID-19. Risk factors for a poor outcome of COVID-19 have so far been identified as older age and co-morbidity including…
- Conditions
- Covid19, Vitamin D Deficiency, Corona Virus Infection, ARDS
- Trial name
- VitCov (NCT04525820)
- Testing
- Single high dose vitamin D, Treatment as usual vitamin D
- Where
- 2 sites in Switzerland
- Volunteers
- 80 people
- Sponsor
- Prof. Dr. Jörg Leuppi
Malnutrition; Protein
True Ileal Amino Acid Digestibility of Tenebrio Molitor Larvae in Women
Dietary protein intake of adequate quality is essential for human health. Traditional animal source foods play a key role in providing high quality protein but are associated with a high burden on the environment.
- Trial name
- NCT05885191
- Testing
- 2H intrinsically-labeled T.molitor with 13-C labeled amino acid mixture
- Where
- Switzerland
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Diego Moretti
Malnutrition Severe, Antibiotic Resistance
First Line Antimicrobials in Children With Complicated Severe Acute Malnutrition
Children with severe malnutrition who are admitted sick to hospitals have a high mortality(death rate), usually because of infection.
- Conditions
- Malnutrition Severe, Antibiotic Resistance, Antibiotic Toxicity
- Trial name
- FLACSAM (NCT03174236)
- Testing
- Ceftriaxone, Benzyl penicillin, Metronidazole
- Where
- 8 sites in Kenya, Uganda
- Volunteers
- 2,000 people
- Sponsor
- University of Oxford
Malnutrition, HIV/AIDS
Nutritional Rehabilitation in Senegalese HIV-infected Children and Adolescents
Severe (SAM, Body Mass Index-z < -3) and moderate (MAM, -3 ≤ BMI-z < -2) acute malnutrition, highly prevalent in HIV-infected children and adolescents, is an independent risk factor of death, even when antiretroviral treatment…
- Trial name
- SNAC'S (NCT03101852)
- Testing
- Plumpy Nut, Plumpy Sup
- Volunteers
- 185 people
- Sponsor
- Institut de Recherche pour le Developpement
Severe Acute Malnutrition, Kwashiorkor
Effectiveness of Alternative Diets During the Stabilization Phase on Children With Complicated SAM
Severe acute malnutrition (SAM) is a life threatening condition and is defined by 1) a weight-for-height Z-score more than three standard deviations (SD) below the median based on the 2006 World Health Organization (WHO) growth…
- Conditions
- Severe Acute Malnutrition, Kwashiorkor, Nutritional Edema, Marasmus
- Trial name
- NCT05020847
- Testing
- Standard F75, Alternative F75 with CMV, Alternative F75 without CMV
- Where
- Burkina Faso
- Volunteers
- 297 people
- Sponsor
- University Ghent
Growth Disorders, Infant Malnutrition
Effect of a Complementary Food Supplement on Growth and Morbidity of Ghanaian Infants
Prevention of malnutrition in infants and children requires access and intake of nutritious food starting at birth with exclusive breastfeeding for the first 6 months of life, breastfeeding in combination with complementary foods…
- Conditions
- Growth Disorders, Infant Malnutrition, Micronutrient Deficiency, Protein Malnutrition
- Trial name
- TRIUMF (NCT03181178)
- Testing
- Macro-micronutrient complementary food supplement, A micronutrient powder, Nutrition education
- Volunteers
- 1,204 people, healthy volunteers welcome
- Sponsor
- Nevin Scrimshaw International Nutrition Foundation
Sarcopenia, Skeletal Muscle Atrophy
Plant Protein Blend and Milk Protein Supplements in Older Individuals
Background Protein intake is important for skeletal muscle mass maintenance with aging and the ingestion of specifically-timed protein supplements could increase overall protein intake and thereby contribute to skeletal muscle…
- Conditions
- Sarcopenia, Skeletal Muscle Atrophy, Protein Malnutrition
- Trial name
- Blend-D2O (NCT06403137)
- Testing
- Resistance exercise, Standardized diet, Plant protein supplement
- Where
- Netherlands
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Severe Acute Malnutrition
A Trial of n-3 PUFA-Enriched Ready to Use Therapeutic Food for Childhood Severe Malnutrition
The investigators will perform a randomised controlled trial of the provision of food designed for rehabilitation of malnourished children that is supplemented with n-3 fatty acids compared to usual composition.
- Trial name
- Njugu Plus (NCT01593969)
- Testing
- RUTF/Flax Oil, RUTF/Flax Oil plus additional Fish Oil, Standard RUTF
- Where
- Kenya
- Volunteers
- 60 people
- Sponsor
- University of Oxford
Severe Malnutrition
Benefits of a Household WASH Package to Community-based Management of Acute Malnutrition (CMAM) Program, Chad
The objective of the research is to assess the effectiveness of adding a Household WASH component to the standard outpatient treatment of severe acute malnutrition.
- Trial name
- OUADINUT (NCT02486523)
- Testing
- Hygiene promotion sessions, Household WASH package, Household visit
- Where
- Chad
- Volunteers
- 1,572 people
- Sponsor
- Action Contre la Faim
Old Age; Cachexia, Dietary Habits
The Nutritionist's Educational Intervention on the Protein Intake in Hospitalized Elderly People
The food intake is often compromised in the elderly, and during hospitalization, dietary restrictions may be imposed, making them more susceptible to the risk of malnutrition and sarcopenia.
- Conditions
- Old Age; Cachexia, Dietary Habits, Sarcopenia, Protein Malnutrition
- Trial name
- NCT05502445
- Testing
- educational intervention
- Where
- Brazil
- Volunteers
- 58 people
- Sponsor
- Hospital Israelita Albert Einstein
Malnutrition, Child, Malnutrition, Infant
Mother Screening for Relapse Using Mid-upper Arm Circumference Among Children Recovered From Severe Acute Malnutrition (Full Scale Trial)
A 1:1:1 individually randomized unmasked controlled trial is proposed in which caregivers will be trained to screen their children who have recovered from an episode of SAM (severe acute malnutrition) using MUAC (mid-upper arm…
- Conditions
- Malnutrition, Child, Malnutrition, Infant, Malnutrition or Risk of Malnutrition, Hemoglobin Level Measurement
- Trial name
- MAMAN (NCT06599580)
- Testing
- Training caregivers to screen children for malnutrition relapse, Reduced follow-up schedule
- Where
- Burkina Faso
- Volunteers
- 2,400 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco