Clinical trials: Acute Malnutrition
Diarrhea, Pneumonia
Effect of Zinc and Vitamin A Supplementation on Diarrhea, Physical Growth and Immune Response in Malnourished Children
Zinc deficiency is common in developing country children, as food intakes are often low, foods from animal sources are infrequently used, the bioavailability of zinc from staple cereal-based diets is limited and zinc losses occur…
- Conditions
- Diarrhea, Pneumonia, Acute Respiratory Tract Infection
- Trial name
- NCT00272116
- Testing
- Zinc and vitamin A single dose at enrollment
- Where
- India
- Volunteers
- 2,482 people, healthy volunteers welcome
- Sponsor
- Society for Applied Studies
Moderate Acute Malnutrition
Alternative Feeding Regimen on Recovery of Children Aged 6-59 Months With Moderate Acute Malnutrition in Bangladesh.
In spite of the large burden of acute malnutrition in the country, the Community-based Management of Acute Malnutrition (CMAM) protocol approved in Bangladesh highly deviates from the WHO normative guidance, in that it does not…
- Trial name
- NCT06045104
- Testing
- Wheat Soy Blend Plus Plus (WSB++) with nutrition counselling, 15 Micro Nutrient Powder (15 MNP) with improved nutrition counselling
- Where
- Bangladesh
- Volunteers
- 560 people
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Microbiota, Complementary Food
Community-based Clinical Trial With Microbiota-directed Complementary Foods (MDCFs) Made of Locally Available Food Ingredients for the Management of Children With Primary Moderate Acute Malnutrition
Background (brief): Burden: A total of 52 million children under 5 are suffering from acute malnutrition globally, of whom 33 million have moderate acute malnutrition (MAM).
- Conditions
- Microbiota, Complementary Food, Nutrition
- Trial name
- NCT04015999
- Testing
- Microbiota Directed Complementary Food (MDCF), Ready to Use Supplementary Food (RUSF)
- Where
- Bangladesh
- Volunteers
- 124 people
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Child, Malnutrition
Effectiveness of a Ready-to-Use-Food (RUF) Supplement to Prevent Acute Child Malnutrition
The overall objective of this project is to assess the effectiveness and cost-effectiveness of RUF (ready-to-Use Food, Plumpy Doz(r)) to prevent moderate acute malnutrition in children aged 6-36 months if embedded in a program of…
- Trial name
- PREAMA (NCT01154595)
- Testing
- Plumpy Doz(r) - Ready-to-Use Food, Food-for-Training
- Where
- Chad
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Action Contre la Faim
Severe Wasting, Severe Acute Malnutrition
High-protein Quantity and Quality RUTF in Improving Linear Growth Among Children With Severe Wasting
This is a proof-of-concept trial that aims to compare the efficacy of an 8-week treatment with higher-protein-Ready-to-Use Therapeutic Foods (RUTF) with standard RUTF in improving levels of markers of growths, height, nutritional…
- Trial name
- Protein+ (NCT05737472)
- Testing
- High-protein RUTF, Standard RUTF
- Where
- Malawi
- Volunteers
- 128 people
- Sponsor
- The Hospital for Sick Children
Undernutrition of Elderly Peopole
Personalized Dietary Advice After Discharge From Hospital in Geriatrics: Factors Associated With Improved Nutritional Status and Autonomy
The purpose of this study is to identify the factors associated with the effectiveness of home dietary management in these elderly people returning home (personal home or independent residence) after hospitalization in acute…
- Trial name
- DIETADOM (NCT04016532)
- Testing
- Personalized dietary management at home
- Where
- France
- Volunteers
- 353 people
- Sponsor
- Gérond'if
Acute Malnutrition in Infancy, Acute Malnutrition in Childhood
Optimization of the Simplified Protocol in Mali: a Cluster Randomised Pragmatic Trial
Acute malnutrition is a condition that affects more than 45 million children under the age of five at any time and requires specific treatment to ensure patient survival.
- Conditions
- Acute Malnutrition in Infancy, Acute Malnutrition in Childhood, Acute Malnutrition, Severe
- Trial name
- NCT06594341
- Testing
- Visit frequency, Suppression of the transition period, Simplified treatment
- Where
- Mali
- Volunteers
- 6,249 people
- Sponsor
- International Rescue Committee
Deficiency, Vitamin C
Hypovitaminosis C Prevalence and Risk Factors in an Acute Geriatric Unit
Vitamin C is essential for numerous biological processes as it acts as a cofactor in various hydroxylation reactions, but also as a powerful antioxidant.
- Trial name
- HYPO-VIT-C (NCT05668663)
- Testing
- Plasmatic Vitamin C concentrations (known as ascorbemia) on a single blood sample
- Where
- France
- Volunteers
- 434 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Malnutrition
Different Strategies for Preventing Severe Acute Malnutrition in Niger
Options for large-scale preventive distributions include fortified blended flours, ready-to-use foods and direct cash transfer either alone or in combination with family protective rations.
- Trial name
- NCT01828814
- Where
- Niger
- Volunteers
- 7,836 people, healthy volunteers welcome
- Sponsor
- Epicentre
Severe Acute Malnutrition
Therapeutic Approaches to Malnutrition Enteropathy
The TAME study will evaluate four new approaches which will be compared against the standard care currently in use in the treatment of malnutrition enteropathy in children with severe acute malnutrition.
- Trial name
- TAME (NCT03716115)
- Testing
- Colostrum high protein powder (Neovite), N-Acetyl Glucosamine (GInNAC), Teduglutide
- Where
- 3 sites in Zambia, Zimbabwe
- Volunteers
- 125 people
- Sponsor
- Queen Mary University of London
Malnutrition, Child
Improving the Quality of Care for Children With Acute Malnutrition in Uganda
This is a cluster RCT in 6 health centres in Uganda, testing supportive supervision to improve health outcomes and quality of care of children with malnutrition
- Trial name
- NCT03044548
- Testing
- Supportive supervision
- Where
- Uganda
- Volunteers
- 700 people
- Sponsor
- WHO Collaborating Centre for Maternal and Child Health, Trieste
Marasmus, Kwashiorkor
Mothers Understand And Can do it - Mid Upper Arm Circumference Screening for Malnutrition Performed by Mothers
PRIMARY OBJECTIVE : To determine whether mothers, given minimal group training, are capable of using a MUAC (mid-upper arm circumference) bracelet to screen their children for malnutrition and categorise them into one of three…
- Conditions
- Marasmus, Kwashiorkor, Malnutrition; Degree, Moderate, Malnutrition
- Trial name
- MUAC (NCT01790815)
- Where
- Niger
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Alliance for International Medical Action
Moderate Acute Malnutrition
Supplementary Food for Moderate Acute Malnutrition in Children
Children with moderate acute malnutrition will be recruited in order to receive an intervention which consists in the consumption of a single serving of SF-cookies daily, 7-days a week for 12 months and 12 educational sessions on…
- Trial name
- NCT02571764
- Testing
- Nutritional Oats Cookie
- Where
- Mexico
- Volunteers
- 248 people
- Sponsor
- PepsiCo Global R&D
Wasting, Moderate Acute Malnutrition
Effectiveness of Nutritional Products to Treat Moderate Acute Malnutrition
The purpose of this study is to determine whether an improved corn-soya blend (CSB+) and a new formulated ready-to-use supplementary food (RUSF) are effective in the treatment of moderate acute malnutrition in children.
- Trial name
- NCT01898871
- Testing
- A daily ration of 40 kcal/kg of body weight during 56 days
- Where
- 2 sites in Cameroon
- Volunteers
- 81 people
- Sponsor
- Centre for Food and Nutrition Research, Yaounde
Uncomplicated Severe Acute Malnutrition
Effects of Three Feeding Regimens on Recovery of Uncomplicated Severely Acute Malnourished Children
This project aims to assess the efficacy of three options under consideration in India for home management of Severe Acute Malnutrition (SAM).
- Trial name
- SAMPOORNA (NCT01705769)
- Testing
- Ready to Use Therapeutic Food-Centrally produced, Ready to Use Therapeutic Food-Locally produced, High energy and micronutrient rich foods
- Where
- 3 sites in India
- Volunteers
- 911 people
- Sponsor
- Society for Applied Studies
Malnutrition
Whey Permeate Study
This is a prospective, randomized, double-blinded, controlled clinical effectiveness trial of two supplementary foods in the treatment of MAM.
- Trial name
- NCT01790048
- Testing
- Whey permeate RUSF, Soy Protein RUSF
- Where
- Malawi
- Volunteers
- 2,259 people
- Sponsor
- Washington University School of Medicine
Moderate Acute Malnutrition
Comparing Several Strategies to Manage Moderate Acute Malnutrition Among Children From 6 to 24 Months Old
The aim of this open-label randomized controlled trial conducted in four African countries (Madagascar, Niger, Central African Republic and Senegal) is to compare three strategies of renutrition for moderate acute malnutrition…
- Trial name
- MALINEA (NCT03474276)
- Testing
- Azythromycin, Inuline and fructo-oligosaccharides, Albendazole
- Where
- 4 sites in Central African Republic, Madagascar and 2 more
- Volunteers
- 1,357 people, healthy volunteers welcome
- Sponsor
- Institut Pasteur
Malnutrition
Comparison of an Alternative Therapeutic Food for the International Food Aid Market to a Standard Ready-to-use Therapeutic Food (RUTF) for the Treatment of Severe Acute Malnutrition in Children
In this clinical non-inferiority trial, two foods will be compared for the treatment of SAM, testing the hypothesis that the difference in recovery rates and growth between the two test groups will be no greater than 5 percent.
- Trial name
- NCT03407326
- Testing
- Alternative RUTF, Standard RUTF
- Where
- Sierra Leone
- Volunteers
- 1,568 people
- Sponsor
- Washington University School of Medicine
Old Age; Cachexia, Dietary Habits
The Nutritionist's Educational Intervention on the Protein Intake in Hospitalized Elderly People
The food intake is often compromised in the elderly, and during hospitalization, dietary restrictions may be imposed, making them more susceptible to the risk of malnutrition and sarcopenia.
- Conditions
- Old Age; Cachexia, Dietary Habits, Sarcopenia, Protein Malnutrition
- Trial name
- NCT05502445
- Testing
- educational intervention
- Where
- Brazil
- Volunteers
- 58 people
- Sponsor
- Hospital Israelita Albert Einstein
Child Nutrition Disorders, Malnutrition
Community Based Management of Severe Malnutrition in Tribal Area of Melghat- Cluster Randomized Control Field Trial
Provision of community based health care to severely malnourished children (Age group: 6 months through 5 years) in 16 tribal villages by trained semi-literate village health workers. 1.
- Trial name
- SAMMAN (NCT02671786)
- Testing
- MAHAN RUTF & MAHAN Vit-Min mix
- Where
- India
- Volunteers
- 824 people
- Sponsor
- MAHAN Trust