Clinical trials: Acute Medical Event
Venous Thromboembolism
A Comparison of Extended Versus Conventional Duration of Enoxaparin Prophylaxis (i.e., Preventive Treatment) for Venous Thromboembolism (VTE, i.e., Blood Clots in the Veins) and Bleeding Event Risk in a Population With Acute Medical Illness
Venous Thromboembolism (VTE), including deep vein thrombosis (DVT) and pulmonary embolism (PE), is associated with an increase in risk of mortality and long-term disability and is a major contributor to global disease burden.
- Trial name
- NCT05819112
- Where
- United States
- Volunteers
- 14,799 people
- Sponsor
- Sanofi
Acute Coronary Syndrome, Percutaneous Transluminal Coronary Angioplasty
Establish a Telecare Model of Acute Coronary Syndrome Patient With Heart Stent Implantation by a Non-invasive Wearable Device and Artificial Intelligence Cloud to Reducing Medical Adverse Events.
Heart disease is still one of the world's most important health problems, and it ranks second among the top ten causes of death among Taiwan.
- Trial name
- NCT04455568
- Testing
- use EKG Wisdom bracelet
- Volunteers
- 400 people
- Sponsor
- Taipei Medical University Shuang Ho Hospital
Influenza, Human, Respiratory Syncytial Virus Infections
Specific Respiratory Infections as Triggers of Acute Medical Events
This study will investigate whether there is a population-level association between circulating respiratory viruses and NHS hospital admissions for acute vascular events using data from national infection surveillance and…
- Conditions
- Influenza, Human, Respiratory Syncytial Virus Infections, Parainfluenza, Rhinovirus
- Trial name
- NCT02984280
- Where
- United Kingdom
- Volunteers
- 787,000 people
- Sponsor
- University College, London
Ischemic Stroke, Mild
ProUrokinase for Mild Ischemic Cerebrovascular Events (PUMICE)
The purpose of this study is to investigate the safety and efficacy of rhPro-UK (35mg) versus standard medical treatment in acute mild ischemic stroke within 4.5 hours of symptom onset.
- Conditions
- Ischemic Stroke, Mild, Thrombosis
- Trial name
- PUMICE (NCT05507645)
- Testing
- Recombinant Human Prourokinase for Injection (rhPro-UK), standard medical treatment
- Where
- 89 sites in China
- Volunteers
- 1,446 people
- Sponsor
- Beijing Tiantan Hospital
Venous Thrombosis, Pulmonary Embolism
Study of Apixaban for the Prevention of Thrombosis-related Events in Patients With Acute Medical Illness
The purpose of this study is to learn if apixaban can prevent blood clots in the leg (deep vein thrombosis [DVT]) and lung (pulmonary embolism [PE]) that sometimes occur within patients hospitalized for acute medical illness, and…
- Trial name
- ADOPT (NCT00457002)
- Testing
- Apixaban, Enoxaparin
- Where
- 296 sites in United States, Argentina and 33 more
- Volunteers
- 6,758 people
- Sponsor
- Bristol-Myers Squibb
Breast Cancer Female, Acute Coronary Events
Implications of MEDIcal Low Dose RADiation Exposure - BReast Cancer Acute Coronary Events
MEDIRAD-BRACE aims to determine the relationship between 3D dose distributions in cardiac structures and the risk of acute coronary events (ACE) and other cardiac complications in breast cancer (BC) patients to develop and…
- Conditions
- Breast Cancer Female, Acute Coronary Events, Cardiac Complications
- Trial name
- MEDIRAD-BRACE (NCT03211442)
- Testing
- Radiotherapy
- Where
- Netherlands
- Volunteers
- 7,000 people
- Sponsor
- University Medical Center Groningen
Stroke
Tenecteplase Reperfusion Therapy in Acute Ischemic Cerebrovascular Events-BEYOND
The benefit-risk profile of thrombolysis for acute ischemic strokes beyond 24 hours has never been investigated. We initiated a multicenter, prospective, randomized, open label, blinded-endpoint (PROBE) controlled trial to assess…
- Trial name
- TRACE-BEYOND (NCT06954155)
- Testing
- Tenecteplase (0.25mg/kg), Standard medical treatment
- Where
- China
- Volunteers
- 330 people
- Sponsor
- Beijing Tiantan Hospital
Acute Coronary Syndrome
Relationship of Helicobacter Pylori Eradication Therapy and Long-term Outcome in Acute Coronary Syndrome
Objective: To investigate the relationship between Helicobacter pylori (Hp) infection and the prognosis of acute coronary syndrome (ACS) in a Chinese population and to explore the significance of Hp eradication therapy in…
- Trial name
- NCT02317445
- Volunteers
- 472 people
- Sponsor
- Capital Medical University
Myocardial Infarction (MI), Acute Coronary Syndromes (ACS)
Prehospital Point-of-Care Hs-Troponin I for Rule-Out of Acute Myocardial Infarction in Patients Without ST-Segment Elevation
People who call emergency medical services (EMS) with chest pain or other possible heart-related symptoms are often taken to hospital for further testing.
- Trial name
- Pre-POCT TnI (NCT07563998)
- Testing
- Prehospital high-sensitivity cardiac troponin I measurement
- Where
- Denmark
- Volunteers
- 500 people
- Sponsor
- Central Denmark Region
Critical Illness, Acute Kidney Injury
Isotonic Solutions and Major Adverse Renal Events Trial in the Medical Intensive Care Unit
The administration of intravenous fluids is ubiquitous in the care of the critically ill. Commonly available isotonic crystalloid solutions contain a broad spectrum electrolyte compositions including a range chloride…
- Trial name
- SMART-MED (NCT02444988)
- Testing
- 0.9% Saline, Physiologically-balanced isotonic crystalloid
- Where
- United States
- Volunteers
- 5,381 people
- Sponsor
- Vanderbilt University
Dementia, Acute Medical Event
Implementation of Function Focused Care in Acute Care
Older adults with Alzheimer's Disease and Related Dementias (ADRD) comprise approximately 25% of hospitalized older adults. These individuals are at increased risk for functional decline, delirium, falls, behavioral symptoms…
- Conditions
- Dementia, Acute Medical Event, Hospitalization
- Trial name
- NCT04235374
- Testing
- FFC-AC-EIT
- Where
- 14 sites in United States
- Volunteers
- 455 people
- Sponsor
- University of Maryland, Baltimore
Ischemic Stroke, Acute
Teneteplase Reperfusion Therapy in Acute Ischemic Cerebrovascular Events-III
The trial is a phase 3, multicenter, prospective, randomized, open-label, blinded-endpoint (PROBE) controlled design. Patients with acute ischemic stroke due to anterior circulation large vessel occlusion within 4.5-24 hours from…
- Trial name
- TRACE III (NCT05141305)
- Testing
- tenecteplase (0.25 mg/kg, Max 25 mg), standard medical treatment
- Where
- China
- Volunteers
- 516 people
- Sponsor
- Beijing Tiantan Hospital
Acute Kidney Injury
AKI Prevention and Early Intervention in VAD Patients Admitted for Acute Medical Events.
The investigators are doing this research to investigate whether multifaceted preventive measures for newly hospitalized ventricular assist device (VAD) patients will reduce the Acute Kidney Injury (AKI) occurrence rate…
- Trial name
- NCT03236103
- Testing
- Clinical Recommendations
- Where
- 3 sites in United States
- Volunteers
- 900 people
- Sponsor
- Mayo Clinic
Critical Illness, Acute Kidney Injury
Isotonic Solutions and Major Adverse Renal Events Trial in the Non-Medical Intensive Care Unit (SMART-SURG)
The administration of intravenous fluids is ubiquitous in the care of the critically ill. Commonly available isotonic crystalloid solutions contain a broad spectrum electrolyte compositions including a range chloride…
- Trial name
- SMART-SURG (NCT02547779)
- Testing
- 0.9% Saline, Physiologically-balanced isotonic crystalloid
- Where
- United States
- Volunteers
- 10,421 people
- Sponsor
- Vanderbilt University
Venous Thromboembolism
Venous Thromboembolic Event (VTE) Prophylaxis in Medically Ill Patients
This study will evaluate if extended therapy with oral rivaroxaban can prevent blood clots in the leg and lung that can occur with patients hospitalized for acute medical illness, and compare these results with those of the…
- Trial name
- MAGELLAN (NCT00571649)
- Testing
- Rivaroxaban (Xarelto, BAY59-7939), Enoxaparin
- Where
- 676 sites in United States, Argentina and 51 more
- Volunteers
- 8,101 people
- Sponsor
- Bayer
Cardiogenic Shock, Renal Replacement Therapy
REnal reCOVery After ECMO for Cardiogenic Shock (RECOVECMO)
This retrospective study assesses long term renal outcome in patients having suffered medical or post cardiotomy refractory cardiogenic shock requiring renal replacement therapy (RRT) concomitant with veno-arterial extracorporeal…
- Conditions
- Cardiogenic Shock, Renal Replacement Therapy, Venoarterial Extracorporeal Membrane Oxygenation
- Trial name
- RECOVECMO (NCT05788211)
- Testing
- standard of care
- Where
- France
- Volunteers
- 93 people
- Sponsor
- University Hospital, Bordeaux