Clinical trials: Acute Myocardial Infarction With ST Elevation
STEMI, Acute Myocardial Infarction
Antiplatelets and Intramyocardial Hemorrhage in STEMI: Incidence and Outcomes
The MIRON-PLATELET study is a retrospective, observational multi-center analysis assessing the impact of different antiplatelet therapies on hemorrhagic myocardial infarction (HMI) incidence and outcomes in STEMI patients.
- Trial name
- MIRON-PLATELET (NCT06851325)
- Where
- United States
- Volunteers
- 6,180 people
- Sponsor
- Rohan Dharmakumar
Coronary Artery Disease, Stable Angina
BMX Alpha Registry: a Post-market Registry of the BioMatrix Alpha TM
Prospective, multi-center, registry designed to enrol up to 2,000 patients in up to 35 International centers. All patients will receive a BioMatrix AlphaTM stent as per clinical practice and will be followed for 2 years for data…
- Conditions
- Coronary Artery Disease, Stable Angina, Ischemia, Acute Coronary Syndrome
- Trial name
- NCT02871622
- Testing
- BioMatrix AlphaTM
- Where
- United Kingdom
- Volunteers
- 2,000 people
- Sponsor
- Biosensors Europe SA
STEMI
Smartphone Twelve Lead Electrocardiogram Utility In ST-Elevation Myocardial Infarction
Is the Smartphone ECG (electrocardiogram) an acceptable replacement for a standard ECG in the identification of STEMI (ST Elevation Myocardial Infarction).
- Trial name
- ST LEUIS (NCT03037229)
- Testing
- Smartphone ECG, Standard 12-lead ECG
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Mayo Clinic
STEMI - ST Elevation Myocardial Infarction (MI), Primary PCI - STEMI
Early Intracoronary N-Acetylcysteine During Primary PCI in STEMI: A Pilot Randomized Trial of Reperfusion Injury Biomarkers and Functional Recovery
Myocardial ischemia-reperfusion injury still poses a major therapeutic challenge in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PPCI).
- Trial name
- NCT06850831
- Testing
- Antipac
- Where
- Indonesia
- Volunteers
- 110 people
- Sponsor
- dr. Ahmad Yasa, Sp.JP, Subsp.K.I.(K), M.Kes, FIHA, FasCC, FA
Acute Coronary Syndrome
Fondaparinux Trial With Unfractionated Heparin (UFH) During Revascularization in Acute Coronary Syndromes (ACS)
The purpose of this study is to compare the safety of two different dose regimens of unfractionated heparin (UFH) during a percutaneous coronary intervention (PCI) procedure in patients with UA (unstable angina)/NSTEMI (non ST…
- Trial name
- FUTURA/OASIS 8 (NCT00790907)
- Testing
- fondaparinux background and standard dose UFH, Fondaparinux background and low dose heparin, Open label fondaparinux
- Where
- 203 sites in United States, Argentina and 16 more
- Volunteers
- 3,235 people
- Sponsor
- GlaxoSmithKline
Myocardial Infarction
Acute Balloon Angioplasty vs. Traditional Early Invasive Treatment of Non-ST-Elevation Myocardial Infarction
The purpose of this study is: A) To determine whether patients with a certain type of heart attack (NSTEMI) can be reliably diagnosed in an ambulance using telemedicine.
- Trial name
- DaNSTEMI2 (NCT00493584)
- Testing
- Primary Percutaneous Coronary Intervention, Coronary angiography / Percutaneous coronary intervention
- Where
- Denmark
- Volunteers
- 14 people
- Sponsor
- University of Aarhus
STEMI - ST Elevation Myocardial Infarction, Inflammation
Low-Level Transcutaneous Vagus Stimulation in ST Segment Elevation Myocardial Infarction: TREAT MI Study
This study will determine the impact of Transcutaneous Vagus Stimulation(TVNS) and autonomic modulation of inflammation in patients admitted with " acute heart attack." After admission for "acute heart attack" or "myocardial…
- Trial name
- TREATMI (NCT03284281)
- Testing
- Tragus stimulator
- Where
- United States
- Sponsor
- University of Oklahoma
Myocardial Infarction, ST Segment Elevation Myocardial Infarction (STEMI)
A Multicenter Trial to Assess the MIcrovascular Integrity and Left Ventricular Function Recovery After Clopidogrel or TicagrelOr Administration, in Patients With STEMI Treated With Thrombolysis - The 'MIRTOS' Study
This is a prospective randomized study, which investigates the coronary microvascular function as assessed by coronary angiography after administration of ticagrelor compared with clopidogrel in patients with myocardial…
- Trial name
- MIRTOS (NCT02429271)
- Testing
- Ticagrelor, Clopidogrel, Percutaneous Coronary Intervention (PCI)
- Where
- Greece
- Volunteers
- 336 people
- Sponsor
- Hellenic Cardiovascular Research Society
Acute Coronary Syndromes
Investigation of the Biomarker Copeptin in Patients With Acute Myocardial Infarction
While troponin is not detectable until several hours after an Acute Myocardial Infarction (AMI), copeptin is expected to be elevated very early after an AMI.
- Trial name
- CHOPIN (NCT00952744)
- Where
- 11 sites in United States
- Volunteers
- 2,071 people
- Sponsor
- Brahms AG
Acute Myocardial Infarction
Interleukin-1 (IL-1) Blockade in Acute Myocardial Infarction (VCU-ART3)
VCU-ART3 is a double-blind randomized clinical trial of anakinra high dose vs anakinra standard dose vs placebo in patients with ST-segment elevation myocardial infarction (STEMI) measuring the effects on the acute rise and fall…
- Trial name
- VCU-ART3 (NCT01950299)
- Testing
- Anakinra 100 mg
- Where
- 2 sites in United States
- Volunteers
- 99 people
- Sponsor
- Virginia Commonwealth University
ST-elevation Myocardial Infarction (STEMI)
Use of BVS in ST-segment Elevation Myocardial Infarction (STEMI): the BVS STEMI STRATEGY-IT Prospective Registry
BVS STEMI STRATEGY-IT is a spontaneous, prospective, non-randomized, single-arm multicenter registry on consecutive STEMI patients eligible to undergo primary percutaneous coronary intervention (PPCI) with BVS implantation on the…
- Trial name
- STRATEGY-IT (NCT02601781)
- Testing
- Primary percutaneous coronary intervention (PPCI), Bioresorbable Vascular Scaffold (BVS ABSORB)
- Where
- Italy
- Volunteers
- 500 people
- Sponsor
- Azienda Ospedaliera Bolognini di Seriate Bergamo
ST Elevation Myocardial Infarction, Multivessel Coronary Artery Disease
Validation of vFFR as Compared to FFR to Guide Revascularization of Non-culprit Lesions in STEMI Patients
This prospective multicenter observational cohort study is designed to study the diagnostic performance of acute-setting angiography-based FFR (e.g.
- Conditions
- ST Elevation Myocardial Infarction, Multivessel Coronary Artery Disease, Percutaneous Coronary Intervention
- Trial name
- NCT05698719
- Where
- 2 sites in Netherlands, Poland
- Volunteers
- 111 people
- Sponsor
- Erasmus Medical Center
ST Elevation Myocardial Infarction
Shanghai ST-segment Elevation Myocardial Infarction Cohort
ST-segment elevation myocardial infarction(STEMI) remains a major cause of morbidity and mortality worldwide, despite of the early reperfusion therapy, including fibrinolysis, primary percutaneous coronary intervention (PCI),and…
- Trial name
- NCT05450757
- Where
- 7 sites in China
- Volunteers
- 2,000 people
- Sponsor
- Ruijin Hospital
Acute Coronary Syndrome
STEMI Versus NSTEMI: Clinical and Angiographic Differences
The purpose of this study is to assess differences in the risk profile and in the coronary angiographic presentation between STEMI and NSTEMI.
- Trial name
- NCT01636427
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- Federico II University
Coronary Stenosis, Periodontal Diseases
Periodontal Disease, Inflammation and Acute Coronary Syndromes
Recent studies have shown that the systemic inflammation caused by periodontal disease (PD) can determine important changes in the coronary arteries, favoring atherosclerosis progression and development of acute coronary…
- Conditions
- Coronary Stenosis, Periodontal Diseases, Acute Coronary Syndrome, Non-ST Elevation Myocardial Infarction
- Trial name
- ATHERODENT (NCT03395041)
- Testing
- cardiac imaging tests
- Where
- Romania
- Volunteers
- 149 people
- Sponsor
- Cardio Med Medical Center
Myocardial Infarction
Post Conditioning in PCI for Acute ST Elevation Myocardial Infarction
The purpose of this trial is to compare post-conditioning to standard angioplasty (50/50 chance) in patients who present with an acute heart attack and are taken directly for an angioplasty procedure.
- Trial name
- NCT00334373
- Testing
- Post conditioning
- Where
- Canada
- Volunteers
- 102 people
- Sponsor
- University of Calgary
STEMI - ST Elevation Myocardial Infarction, Thrombosis Cardiac
Efficacy of Using 50 ml Syringe Manual Thrombectomy Catheter in Primary PCI With Heavy Thrombus Burden
In high thrombus burden subgroup of Acute STEMI, manual aspiration thrombectomy was associated with reduced cardiovascular death but increased stroke or transient ischemic attack.
- Trial name
- NCT06327659
- Testing
- 30 mL syringe manual thrombectomy catheter, 50 mL syringe manual thrombectomy catheter
- Where
- Egypt
- Volunteers
- 88 people
- Sponsor
- Helwan University
Coronary Artery Disease, Acute Coronary Syndromes
CRAGS (Coronary aRtery diseAse in younG adultS)
Young patients requiring myocardial revascularization are generally considered at low operative risk, but data on their immediate and late outcome are scarce.
- Conditions
- Coronary Artery Disease, Acute Coronary Syndromes, Young Patient, Percutaneous Coronary Intervention
- Trial name
- CRAGS (NCT01838746)
- Where
- 9 sites in Finland, Iceland and 2 more
- Volunteers
- 2,000 people
- Sponsor
- University of Turku
Acute ST Segment Elevation Myocardial Infarction, Acute Myocardial Infarction
FLOW Evaluation to Guide Revascularization in Multi-vessel ST-elevation Myocardial Infarction
Although current guidelines recommend fractional flow reserve (FFR) to identify haemodynamically relevant coronary lesion(s) in stable patients when evidence of ischaemia is not available (Class I, Level of Evidence: A), no…
- Conditions
- Acute ST Segment Elevation Myocardial Infarction, Acute Myocardial Infarction, Multi Vessel Coronary Artery Disease
- Trial name
- FLOWER-MI (NCT02943954)
- Testing
- Angiography guided PCI, Fractional Flow Reserve (FFR)
- Where
- France
- Volunteers
- 1,170 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
ST Elevated Myocardial Infarction, Dual Antiplatelet Therapy
Comparison Of Reduced DAPT Followed by P2Y12 Inhibitor Monotherapy With Prasugrel vs stAndard Regimen in STEMI Patients
The study is a multi-centre, Open-label, Randomized Controlled, 1:1 trial comparing Prasugrel-based short DAPT (30-45 days) followed by Prasugrel monotherapy versus standard DAPT regimen in STEMI patients in terms of safety and…
- Trial name
- NCT05491200
- Testing
- Prasugrel based short DAPT, Prasugrel based standard DAPT, OCT guided revascularization
- Where
- 27 sites in Belgium, Czechia and 4 more
- Volunteers
- 1,656 people
- Sponsor
- Research Maatschap Cardiologen Rotterdam Zuid