Clinical trials: Acute Pain, completed
Dental Pain
Evaluation of the Efficacy and Safety of Diclofenac HPBCD 75mg/ml in Treatment of Pain Following Dental Surgery
The present study is aimed at demonstrating the therapeutic equivalence of diclofenac HPBCD 75mg/1ml s.c. with the marketed reference product, Voltarol® 75mg/3ml i.m.
- Trial name
- NCT00943098
- Testing
- Diclofenac HPBCD s.c. 75mg/ml, Voltarol 75mg/3ml i.m.
- Where
- 3 sites in United Kingdom
- Volunteers
- 142 people
- Sponsor
- IBSA Institut Biochimique SA
Acute Pain
Pain Relief in the Emergency Department Waiting Room: a Prevalence Study
Pain in the emergency room is under documented and pain relief suboptimal. Data on nurse driven analgesia in emergency department waiting rooms is lacking.
- Trial name
- NCT03115684
- Volunteers
- 2,371 people
- Sponsor
- University Hospital, Geneva
Healthy Subjects (HS)
Effects of Foam Rolling, Foam Rolling with Dynamic Movement, and Static Stretching on Plantar Flexor Range of Motion and Tissue Properties in Healthy Participants
Each voluntary participant will be invited and tested at the Functional Assessment Laboratory. After reading and completing the informed consent document regarding our research and data processing, participants will be invited…
- Trial name
- NCT06877832
- Testing
- Static Stretching (SS), Foam Rolling (FR), Foam rolling with dynamic movement (FR-DM)
- Where
- Italy
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Ewan Thomas
Pharyngitis
Testing The Effectiveness Of Celecoxib In Patients With Painful Sore Throat
We are proposing a study in which we utilize and augment the sore throat pain model to assess the analgesic effectiveness of celecoxib compared to placebo in patients with painful pharyngitis under randomized, double-blind…
- Trial name
- NCT00402987
- Testing
- Celecoxib
- Where
- United States
- Volunteers
- 269 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Local Anesthetic, Ultrasound
TAP Block With Methyl-prednisolone as a Pain Treatment Modality After Total Abdominal Hysterectomy Procedures
The aim of this work to compare between the efficacy of ultrasound guided TAP block with dexamethasone as an adjuvant versus ultrasound guided TAPB with methyl prednisolone as an adjuvant to local anesthetic for postoperative…
- Conditions
- Local Anesthetic, Ultrasound, Pain, Acute
- Trial name
- NCT06131593
- Testing
- TAPB with dexamethasone as an adjuvant to local anesthetics, TAPB with methylprednisolone as an adjuvant to local anesthetics
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Kasr El Aini Hospital
Acute Pain, Virtual Reality
Effects of Virtual Reality Glasses, Kaleidoscope and Distraction Cards on Pain and Anxiety During Blood Draw in Children
The study was designed as a randomized controlled experimental research with the purpose of determining the effect of distraction by using Virtual Reality Glasses, Kaleidoscope and Distraction Cards in reducing pain and anxiety…
- Conditions
- Acute Pain, Virtual Reality, Kaleidoscope, Distraction Cards
- Trial name
- NCT06192498
- Testing
- Virtual Reality Glasses, Kaleidoscope, Distraction Cards
- Where
- Turkey (Türkiye)
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Burdur Mehmet Akif Ersoy University
Anesthetics, Local Anesthetics
Lidocaine Versus ESP - After Bariatric Surgery
The Erector Spinal Block (ESP) is based on the deposition of the local anesthetic in the inter-fascial space between the dorsal extensor muscle and the intercostal muscles at the height of the transverse processes.
- Trial name
- NCT05700214
- Testing
- Ropivacaine injection, Lidocaine IV
- Where
- Poland
- Volunteers
- 279 people, healthy volunteers welcome
- Sponsor
- Jagiellonian University
Postoperative Pain
Impact of Gender on Perceived Postoperative Pain
Postoperative pain is a common problem after surgical procedures with many patients afflicted worldwide. Fundamental challenges are the complexity of measuring pain appropriately, and the many associated possible confounders.
- Trial name
- G-PAIN (NCT03968497)
- Testing
- Postoperative pain assessment with female investigator, Postoperative pain assessment with male investigator
- Where
- Sweden
- Volunteers
- 247 people, healthy volunteers welcome
- Sponsor
- Lund University
Pain, Postoperative, Pain, Chronic
Pain and Impact of Chronic Pain on Function After Total Knee Replacements
After Institutional Review Board approval, adult patients scheduled for total knee arthroplasty (TKA) will be enrolled into the study after obtaining informed consent over a 24 month period.
- Conditions
- Pain, Postoperative, Pain, Chronic, Osteogenic Sarcoma, Knee Arthropathy
- Trial name
- NCT03032679
- Testing
- Non interventional study
- Where
- India
- Volunteers
- 139 people
- Sponsor
- Tata Memorial Centre
Appendicitis Acute
Wound Infiltration With Local Anesthetic Agent for Laparoscopic Appendectomy in Adult
Acute appendicitis is one of the most common acute abdomens that need surgical intervention. Laparoscopic surgery much decreases postoperative pain of wound, however, pain remains an important determinant of recovery after…
- Trial name
- NCT03481517
- Testing
- Bupivacaine
- Where
- Taiwan
- Volunteers
- 47 people
- Sponsor
- National Taiwan University Hospital
Pain, Sprains and Strains
A Multi-Center, Randomized, Double-Blind, Parallel Group Study To Compare The Efficacy And Tolerability Of Valdecoxib And Diclofenac In Patients With A Sprained Ankle
To determine whether valdecoxib 40 mg twice a day the first day and then 40mg once a day until Day 7, was at least as effective as diclofenac 75 mg twice a day for 7 days, in treating acute first or second degree ankle sprain.
- Conditions
- Pain, Sprains and Strains, Sprain
- Trial name
- NCT00671320
- Testing
- valdecoxib, diclofenac
- Where
- 15 sites in Argentina, Chile and 3 more
- Volunteers
- 202 people
- Sponsor
- Pfizer
Postoperative Pain
Safety and Efficacy of Tapentadol Immediate Release (IR) and Oxycodone IR for Treatment of Acute Post-op Pain Following Elective Arthroscopic (Surgery Using a Thin Flexible Scope) Shoulder Surgery
The purpose of this study is to evaluate how tapentadol immediate release (IR) and oxycodone IR treat moderate to severe post-operative pain after elective arthroscopic shoulder surgery.
- Trial name
- NCT00814580
- Testing
- Tapentadol IR, Oxycodone IR
- Volunteers
- 382 people
- Sponsor
- Ortho-McNeil Janssen Scientific Affairs, LLC
Low Back Pain
Diazepam Use With Standard Management for Acute Low Back Pain
Given the poor pain and functional outcomes that persist beyond an Emergency Department (ED) visit for musculoskeletal low back pain (LBP), we propose a clinical trial to evaluate whether combining a benzodiazepine with an NSAID…
- Trial name
- NCT02646124
- Testing
- Naproxen, Diazepam
- Where
- United States
- Volunteers
- 114 people
- Sponsor
- Montefiore Medical Center
Regional Anesthesia, Postoperative Pain, Acute
Caudal Block and Transversus Abdominis Plane Block in Pediatric Inguinal Hernia Repair
Pediatric inguinal hernia repair (IHR) candidates experiences ordinarily mild to moderate pain, rarely severe pain in the postoperative period.
- Trial name
- NCT05286190
- Testing
- Bupivacaine 0.25% Injectable Solution
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Istanbul University
Training, Exercise
Hypoalgesic Effects of Exercise and Training of Different Modalities
Further research is needed to explore the analgesic effects of post-acute and chronic exercise and if effects are partially dependent on lower H-reflex/V-wave inhibition by group III and IV muscle afferents desensitization.
- Conditions
- Training, Exercise, Fatigue, Occlusion
- Trial name
- NCT07105410
- Testing
- Aim #1: The effect of post-exercise circulatory occlusion on H-reflex and V-wave, Aim #2: The hypoalgesic effects of acute exercise of different modalities, Aim #3: The hypoalgesic effects of chronic training of different modalities
- Where
- Portugal
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Faculdade de Motricidade Humana
Acute Pain
A Study Evaluating Efficacy and Safety of VX-548 for Acute Pain After a Bunionectomy
The purpose of this study is to evaluate the efficacy and safety of VX-548 doses in treating acute pain after a bunionectomy.
- Trial name
- NCT04977336
- Testing
- VX-548, HB/APAP
- Where
- 12 sites in United States
- Volunteers
- 274 people
- Sponsor
- Vertex Pharmaceuticals Incorporated
Pain
A Phase Ⅱ Study to Evaluate the Efficacy and Safety of YZJ-4729 in Patients With Moderate to Severe Acute Pain After Abdominal Surgery
Primary Objective： To explore the analgesic efficacy of YZJ-4729 compared with placebo in patients with acute postoperative pain following abdominal surgery.
- Trial name
- NCT06680466
- Testing
- YZJ-4729, morphine
- Where
- China
- Volunteers
- 179 people
- Sponsor
- Shanghai Haiyan Pharmaceutical Technology Co., Ltd.
Acute Pain
Pain Response to Open Label Placebo in Induced Acute Pain in Healthy Male Adults
Open Label Placebo application has been shown to be effective in treatment of chronic pain (low back pain) and disease like the irritable bowel Syndrome. Data about effects on acute pain are spare.
- Trial name
- POLAP (NCT03361579)
- Testing
- Education
- Where
- Switzerland
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Pain and Hysteroscopy
Virtual Reality Effects on Pain During Hysteroscopy Hysteroscopy: A Randomized Control Trial
The Objective of this study is to compare pain levels in women undergoing office-based hysteroscopies using Virtual Reality versus control in a randomized control prospective trial.
- Trial name
- VR (NCT04802460)
- Testing
- Virtual reality headset (The Guided Meditation VR App through Oculus Go headset)
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Medstar Health Research Institute
Unstable Angina
MMP Polymorphisms and Acute Coronary Syndromes
Some Matrix Metalloproteases, proteases degrading the extracellular matrix, play a relevant role in structure and stability of atherosclerotic plaques.
- Trial name
- NCT00484406
- Where
- 2 sites in Italy
- Sponsor
- University of Trieste
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