Clinical trials: Acute Post-surgical Pain
Acute Postoperative Pain, Dental Pain
A Study of CYT-1010 in Healthy Volunteers and Participants With Acute Pain After Third Molar Extraction
The primary objective of this trial is to assess the safety and tolerability of single, ascending doses of CYT-1010 in healthy male and female volunteers and in the treatment of acute postoperative pain after third molar…
- Trial name
- NCT07905105
- Testing
- CYT-1010
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Cytogel Pharma, LLC
Post Operative Pain, Ureteroscopy
Different Postoperative Analgesics Use After Ureteroscopy
In this study, we will see the feasibility of a non-opioid pain killers in management of acute post-operative period as well as on discharge from the hospital compared to opioid medications for postoperative pain following URS…
- Conditions
- Post Operative Pain, Ureteroscopy, Ureter Stone
- Trial name
- NCT05507554
- Testing
- Opioid, Non-Opioid Analgesic, Non-Opioid
- Where
- Pakistan
- Volunteers
- 176 people
- Sponsor
- Pakistan Kidney and Liver Institute and Research Center
Post Operative Pain, Midline Sternotomy Incision
Percutaneous Electrical Nerve Stimulation (PENS) of the Auricle for Post Operative Pain Solution(POPS) - Cardiac Surgery
Percutaneous Electrical Nerve Stimulation (PENS) of the auricle for acute pain management post cardiac surgery
- Trial name
- POPS (NCT03750357)
- Testing
- Primary Relief v 2.0
- Where
- India
- Volunteers
- 60 people
- Sponsor
- DyAnsys, Inc.
Cholecystitis, Cholecystitis, Acute
TAP Block vs External Oblique Plane Block for Laparoscopic Cholecystectomy Surgery
Ultrasound (US) guidedTransversus Abdominis Plane Block (TAPB) is performed by injecting a local anesthetic into the plane between the internal oblique and transverse abdominis muscles and provides analgesia in the anterolateral…
- Conditions
- Cholecystitis, Cholecystitis, Acute, Cholecystitis, Chronic
- Trial name
- NCT06178757
- Testing
- TAPB, EOIB
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Medipol University
Postoperative Pain, Acute, Postoperative Complications
Minimally Invasive Esophagectomy Pain Control Trial
A pilot randomized controlled trial comparing intercostal nerve blocks, cryo-ablation plus intercostal nerve blocks, and serratus plane catheter plus intercostal nerve blocks in patients undergoing esophagectomies with minimally…
- Trial name
- NCT05906134
- Testing
- Local intercostal nerve block, Cryo-analgesia and intercostal nerve block, Serratus plane catheter blocks and intercostal nerve blocks
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Swedish Medical Center
Pain, Postoperative, Pain, Acute
External Oblique Intercostal Block in Laparoscopic Cholecystectomy
Adequate postoperative pain management is essential for improving patient comfort and recovery after laparoscopic cholecystectomy.
- Conditions
- Pain, Postoperative, Pain, Acute, Opioid Use
- Trial name
- NCT07164664
- Testing
- External Oblique Intercostal Block, Port-Site Infiltration, ıv morphine PCA
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ondokuz Mayıs University
Postoperative Pain, Acute, Emergence Delirium
Comparing Ketamine and Fentanyl in Pediatric Tonsillectomy: Pain Control and Emergence Delirium Outcomes (KVFPT)
This study is designed to compare the effectiveness of two medications, ketamine and fentanyl, in managing pain and preventing delirium in children aged 3 to 8 years who are undergoing tonsillectomy and adenoidectomy surgery.
- Trial name
- KVFPT (NCT06630364)
- Testing
- ketamine, fentanyl
- Where
- Turkey (Türkiye)
- Volunteers
- 59 people
- Sponsor
- Medipol University
Pain, Acute Postoperative, Breast Disease
Suzetrigine for Non-Mastectomy Breast Surgery
This is a single-center clinical study to investigate the efficacy of a Food and Drug Administration-approved analgesic, suzetrigine, to treat pain following non-mastectomy breast surgery in concert with a single-injection…
- Trial name
- NCT07463430
- Testing
- suzetrigine
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of California, San Diego
Chronic Post-surgical Pain, Acute Postoperative Pain
CROPS Study: Chronification of Post-Surgical Pain and Risk Assessment
Chronic post-surgical pain (CPSP) represents a major clinical problem associated with impaired functional recovery, reduced quality of life, prolonged opioid use, and increased healthcare utilization.
- Conditions
- Chronic Post-surgical Pain, Acute Postoperative Pain, Cardiac Surgery
- Trial name
- CROPS (NCT07629453)
- Testing
- Standard Multimodal Opioid-Based Analgesia, Regional Anesthesia-Based Analgesia
- Volunteers
- 180 people
- Sponsor
- Kočan Ladislav
Pain, Postoperative, Chronic Pain
Online Mindfulness-based Intervention to Prevent Chronic Pain
Cardiac and orthopedic surgeries are frequent procedures. However, pain after a major surgery may become chronic (lasting >3 months) in adults.
- Conditions
- Pain, Postoperative, Chronic Pain, Pain Catastrophizing, Pain, Acute
- Trial name
- NCT04848428
- Testing
- Online mindfulness-based cognitive therapy, Online standardized education
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Florida State University
Acute Pain, Postoperative Pain
Efficacy and Safety of Etoricoxib-tramadol Tablet in Acute Postoperative Pain
The goal of the present phase IIb clinical trial was to compare the safety and efficacy of the fixed-dose combination etoricoxib-tramadol 120mg/100mg tablet (once a day, for three days) versus naproxen 220mg tablet plus tramadol…
- Trial name
- NCT05995912
- Testing
- etoricoxib-tramadol, Naproxen, Tramadol
- Where
- Mexico
- Volunteers
- 58 people
- Sponsor
- Laboratorios Liomont
Acute Post-operative Pain, Cholecystectomy, Laparoscopic
Optimizing Pain Management Following Laparoscopic Cholecystectomy RCT
evaluating the two final steps we added to optimize post laparoscopic cholecystectomy pain management.
- Conditions
- Acute Post-operative Pain, Cholecystectomy, Laparoscopic, Pain Assessment Pain Intensity, Pain Intensity
- Trial name
- Pain (NCT05214157)
- Testing
- active gas aspiration
- Where
- Egypt
- Volunteers
- 804 people
- Sponsor
- Zagazig University
Acute Pain, Post Operative Pain
Study of MR-107A-02 in the Treatment of Post Surgical Dental Pain.
MR-107A-02 is being studied to investigate its efficacy, safety and dose-response after dental surgery.
- Conditions
- Acute Pain, Post Operative Pain, Pain
- Trial name
- NCT05317312
- Testing
- MR-107A-02
- Where
- United States
- Volunteers
- 111 people
- Sponsor
- Mylan Specialty, LP
Pain, Acute Post-Operative, Pilonidal Sinus
Effect of Sacral Erector Spinae Plane Block on Hemorrhoid and Pilonidal Sinus Surgery
Introduction: This study investigated the efficacy of sacral erector spinae plane block (ESPB) for managing postoperative pain and reducing opioid consumption in patients undergoing hemorrhoid and pilonidal sinus (PS) surgery.
- Conditions
- Pain, Acute Post-Operative, Pilonidal Sinus, Hemorrhoids, Anesthesia
- Trial name
- NCT06459739
- Testing
- sacral ESPB
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Erzincan Binali Yildirim Universitesi
Analgesia, Patient-Controlled, Postoperative Pain, Acute
Comparison of Two Different Approach TAP Block on Pain Management of Laparoscopic Nephrectomy
Primary aim is to compare the effectiveness of the posterior approach Transversus abdominis plane block (P-TAP) and the lateral approach Transversus abdominis plane block (L-TAP) technique on the pain management of the…
- Trial name
- NCT05188794
- Testing
- lateral tap block, posterior tap block
- Where
- Turkey (Türkiye)
- Volunteers
- 88 people
- Sponsor
- Ankara City Hospital Bilkent
Pain
A Study to Evaluate a Fixed Combination of Acetaminophen/Naproxen Sodium in Acute Postoperative Pain Following Bunionectomy
The purpose of this study is to evaluate effectiveness of a fixed combination of acetaminophen/naproxen sodium compared with placebo for reduction of pain when administered as multiple doses over a 48-hour period.
- Trial name
- NCT05868122
- Testing
- Acetaminophen/Naproxen Sodium Fixed Combination
- Where
- 4 sites in United States
- Volunteers
- 143 people
- Sponsor
- Johnson & Johnson Consumer Inc. (J&JCI)
Obesity, Morbid, Postoperative Pain
Study of the Effect of the Drug Gabapentin on Postoperative Pain and Incidence of Postoperative Nausea and Vomiting
The purpose of this research study is to evaluate the drug gabapentin (Neurontin®) for its ability to reduce postoperative pain, the need for morphine-like pain medication, and the severity and frequency of postoperative nausea…
- Conditions
- Obesity, Morbid, Postoperative Pain, Postoperative Nausea and Vomiting
- Trial name
- NCT00886236
- Testing
- Gabapentin
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Medical University of South Carolina
Postoperative Pain
Effects of Perioperative Administration of Intravenous Lidocaine in Children Operated on for Acute Generalized Peritonitis
Intravenous administration of lidocaine perioperatively after laparotomy for peritonitis could be an interesting alternative by reducing the duration of postoperative ileus, the intensity of pain and the patient's hospital stay…
- Trial name
- NCT06051630
- Testing
- Lidocaine intravenous, Serum saline intravenous
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Université NAZI BONI
Post Operative Pain, Acute
Pain After Laparoscopy Results From the Incision, Manipulation of the Abdominal Organs, and Retained CO2(Back Pain)
Postoperative pain after laparoscopy may be localized pain resulting from incision due to many (two or three) punctures (somatic pain) or due to manipulation of the intra-abdominal organs as ovaries, uterus, omentum, and…
- Trial name
- NCT05186467
- Testing
- intraperitoneal Magnesium sulfate, intravenous magnesium sulfate
- Where
- Egypt
- Volunteers
- 44 people
- Sponsor
- Sohag University
Pain, Postoperative, Pain, Acute
Dexmedetomidine and Morphine as Adjuvants to US Guided Erector Spinae Plane Blocks in Elective Thoracic Surgeries
The aim of this study will be to compare the effects of morphine versus dexmedetomidine when used as adjuvants to local anesthetic (Ropivacaine) in Erector Spinae Plane Block under ultrasound guidance.
- Conditions
- Pain, Postoperative, Pain, Acute, Pain, Chronic, Morphine
- Trial name
- NCT05843344
- Testing
- erector spinae plane block with a combination of ropivacaine and morphine, erector spinae plane block with a combination of ropivacaine and dexmedetomidine, erector spinae plane block with ropivacaine only
- Where
- 2 sites in Greece
- Volunteers
- 90 people
- Sponsor
- Dr Kassiani Theodoraki