Clinical trials: Acute Respiratory Distress Syndrome (ARDS)
Acute Respiratory Distress Syndrome
Pilot Clinical Study of NOA-001 for ARDS (Acute Respiratory Distress Syndrome)
The primary object of this clinical study is to investigate the efficacy and the safety of NOA-001 in patients with ARDS (ARDS caused by Non-COVID-19 or COVID-19).
- Trial name
- NCT04804943
- Testing
- NOA-001
- Where
- Japan
- Volunteers
- 45 people
- Sponsor
- Toray Industries, Inc
Respiratory Distress Syndrome
Sustained Lung Inflation in the Delivery Room in Preterm Infants at High Risk of Respiratory Distress Syndrome
BACKGROUND. Sustained lung inflation (SLI) associated to an adequate PEEP may help the efficacy of the respiratory effort in lung of preterm infants at risk for respiratory distress syndrome (RDS) and reduce need of mechanical…
- Trial name
- SLIS (NCT01440868)
- Testing
- Sustained lung inflation
- Where
- Italy
- Volunteers
- 276 people
- Sponsor
- University of Florence
ACUTE RESPIRATORY DISTRESS SYNDROME
Veno-venous Extracorporeal CO2 Removal in ARDS-patients to Treat Respiratory Acidosis
Hypothesis: Extracorporeal removal of CO2 can treat hypercapnia and respiratory acidosis, which allows application of lung protective ventilation.
- Trial name
- NCT01911533
- Testing
- extracorporeal removal of CO2 (ECCO2-R), No extracorporeal CO2-removal
- Where
- Belgium
- Volunteers
- 4 people
- Sponsor
- University Hospital, Ghent
Acute Respiratory Distress Syndrome, Mechanical Ventilation
Echocardiographic Evaluation in ARDS Patients
The purpose of this study is to assess the left diastolic function at different levels of in patients affected by the acute respiratory distress syndrome (ARDS)
- Conditions
- Acute Respiratory Distress Syndrome, Mechanical Ventilation, Echocardiographic Ultrasound
- Trial name
- NCT03920189
- Testing
- echocariographic ultrasound
- Where
- Italy
- Volunteers
- 44 people
- Sponsor
- University of Milan
Infant, Newborn, Hypertension, Pulmonary
Inhaled Nitric Oxide Study for Respiratory Failure in Newborns
Respiratory failure in term newborns is associated with increased rates of death and long-term neurodevelopmental problems. This large international multicenter trial randomized newborns who had failed to respond to intensive…
- Conditions
- Infant, Newborn, Hypertension, Pulmonary, Persistent Fetal Circulation Syndrome, Pneumonia, Aspiration
- Trial name
- NINOS (NCT00005776)
- Testing
- Inhaled nitric oxide
- Where
- 20 sites in United States, Canada
- Volunteers
- 235 people
- Sponsor
- NICHD Neonatal Research Network
COVID-19 Acute Respiratory Distress Syndrome, Cognitive Decline
Cognitive Functions After COVID-19
This study was aimed to evaluate the post-infection cognitive functions of adult individuals with COVID-19. 50 individuals with COVID-19 and 50 healthy control groups were included in the study.
- Trial name
- NCT04978246
- Testing
- Neuropsychometric Test
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Medipol University
Acute Respiratory Distress Syndrome, Positive End Expiratory Pressure
Safety of Low PEEP Maneuvers During ARDS Management
Acute Respiratory distress syndrome (ARDS) is a severe condition in which protective ventilation is a critical point in its management.
- Trial name
- DEBAS (NCT05922969)
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Extracorporeal Membrane Oxygenation, Acute Respiratory Distress Syndrome
Reduction of Blood Recirculation in Veno-Venous ECMO
Blood which recirculates through the circuit of a veno-venous Extracorporeal Membrane Oxygenation (V-V ECMO) does not contribute to the systemic oxygenation of a patient on V-V ECMO and is called the recirculation fraction (Rf).
- Trial name
- NCT04754854
- Where
- Germany
- Volunteers
- 136 people
- Sponsor
- Charite University, Berlin, Germany
Acute Respiratory Distress Syndrome
Effect of Continuous Prolonged Prone Position Versus Intermittent Daily Prone Position in ARDS
Prone position (placing the patient on his abdomen) has been shown to be an effective intervention to decrease mortality in adults connected to mechanical ventilation for moderate to severe Acute Respiratory Distress Syndrome…
- Trial name
- ePRONE (NCT06854627)
- Testing
- Daily prone position sessions, Prolonged prone position sessions
- Where
- 38 sites in Argentina, Chile and 4 more
- Volunteers
- 780 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Acute Respiratory Distress Syndrome (ARDS), s100b
A Study of the Determinants of Neurological Outcomes in Patients With Acute Respiratory Distress Syndrome
Acute respiratory distress syndrome (ARDS) is characterized by pathological pulmonary edema caused by direct or indirect damage to the alveolar-capillary membrane.
- Conditions
- Acute Respiratory Distress Syndrome (ARDS), s100b, Mechanical Power, Ventilator Induced Lung Injury
- Trial name
- NEURDS (NCT07629973)
- Testing
- Blood test scores calculations
- Volunteers
- 150 people
- Sponsor
- University Hospital, Angers
ARDS (Moderate or Severe)
Effect of Inhaled Nitric Oxide Therapy in Adults With Moderate-to-Severe Acute Respiratory Distress Syndrome
The goal of this clinical trial is to evaluate whether inhaled nitric oxide (iNO), added to standard care, can reduce mortality in adults with moderate-to-severe Acute Respiratory Distress Syndrome (ARDS).
- Trial name
- ENARCT-ARDS (NCT07334873)
- Testing
- Inhaled Nitric Oxide Therapy
- Where
- China
- Volunteers
- 536 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Respiratory Failure, Acute Respiratory Distress Syndrome
Respiratory System Compliance Guided VT in Moderate to Severe ARDS Patients
The Acute Respiratory Distress Syndrome (ARDS) is one of common clinical critically diseases. In the United States, the incidence of ARDS reaches 31%, which is one of the main causes of death in patients.
- Trial name
- NCT02814994
- Testing
- tidal volume guided by respiratory system compliance, low tidal volume
- Where
- China
- Volunteers
- 242 people
- Sponsor
- Southeast University, China
Acute Respiratory Distress Syndrome, Viral or Bacterial Infections
Phase 2a Multiple Ascending Dose Study in Hospitalized Patients With Pneumonia.
A Phase 2a, randomized, double-blind, placebo-controlled, multiple ascending dose study in patients who are hospitalized with presumed pneumonia requiring supplemental oxygen therapy.
- Conditions
- Acute Respiratory Distress Syndrome, Viral or Bacterial Infections, Pneumonia, Pneumonia, Viral
- Trial name
- NCT05123755
- Testing
- AV-001 Injection
- Where
- 6 sites in United States
- Volunteers
- 60 people
- Sponsor
- Vasomune Therapeutics, Inc.
Acute Respiratory Distress Syndrome
Titration of PEEP During Mechanical Ventilation in Patients With ARDS Using Electrical Impedance Tomography.
Lung units that participate in gas exchange are known as 'recruited' lung. Patients with lung injury suffer from a proportion of units that do not participate in gas exchange (i.e.
- Trial name
- NCT02596178
- Testing
- Electrical Impedance Tomography
- Where
- United States
- Sponsor
- Boston Children's Hospital
COVID-19, Organ Dysfunction Syndrome Sepsis
Mechanisms for Organ Dysfunction in Covid-19
The study aims to investigate organ dysfunction and biomarkers in patients with suspected or verified COVID-19 during intensive care at Uppsala University Hospital.
- Conditions
- COVID-19, Organ Dysfunction Syndrome Sepsis, Organ Dysfunction Syndrome, Multiple, Septic Shock
- Trial name
- UMODCOVID19 (NCT04316884)
- Where
- Sweden
- Volunteers
- 380 people
- Sponsor
- Uppsala University
Acute Respiratory Distress Syndrome, Acute Lung Injury
Role and Molecular Mechanism of Farnesoid X Receptor(FXR) and RIPK3 in the Formation of Acute Respiratory Distress Syndrome in Neonates
In the clinical data, the changes of RIPK3 and FXR were monitored in the lung lavage fluid and blood from the patients. In vivo experiments to find high risk factors to induce AEC necrosis and further lead to ARDS evidence, can…
- Conditions
- Acute Respiratory Distress Syndrome, Acute Lung Injury, FXR, RIPK3
- Trial name
- NCT02598648
- Testing
- FXR, RIPK3
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
Sepsis Related Acute Lung Injury/Acute Respiratory Distress Syndrome
EVLWI Exhibits Pulmonary and Systemic Permeability in Sepsis Related ALI/ARDS
To investigate the possible mechanisms of pulmonary and systemic permeability change including cytokine, extravascular lung water index (EVLWI), and oxygenation parameters in patients with sepsis related acute lung injury…
- Trial name
- NCT01694147
- Testing
- PiCCO monitoring system
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Chang Gung Memorial Hospital
Respiratory Distress Syndrome, Newborn
Ventilatory Management of the Preterm Neonate in the Delivery Room
The purpose of this study is to evaluate sustained lung inflation followed by early nCPAP as delivery room ventilatory management for preterm neonates at risk of respiratory distress syndrome in reducing their need for mechanical…
- Trial name
- NCT01255826
- Testing
- Resuscitation of preterm neonates by sustained lung inflation through T piece device followed by CPAP, Resuscitation of preterm neonates by intermittent bag and mask ventilation using self inflating bag.
- Where
- Egypt
- Volunteers
- 112 people
- Sponsor
- Ain Shams University
Preterm Infants
LISA vs INSURE in the Treatment of Respiratory Distress Syndrome in Preterm Infants
To evaluate the efficacy of less invasive surfactant administration（LISA ）technique in the treatment of neonatal respiratory distress syndrome（NRDS） by comparing with the traditional Intubate-Surfactant-Extubate（INSURE） technique.
- Trial name
- NCT04126382
- Testing
- Intubate-Surfactant-Extubate(INSURE), less invasive surfactant administration(LISA)
- Volunteers
- 200 people
- Sponsor
- Anhui Provincial Hospital
COVID-19
A Study to Assess the Efficacy and Safety of Gimsilumab in Subjects With Lung Injury or Acute Respiratory Distress Syndrome Secondary to COVID-19 (BREATHE)
Study KIN-1901-2001 is a multi-center, adaptive, randomized, double-blind, placebo-controlled study to assess the efficacy and safety of gimsilumab in subjects with lung injury or acute respiratory distress syndrome (ARDS)…
- Trial name
- NCT04351243
- Testing
- Gimsilumab
- Where
- 33 sites in United States
- Volunteers
- 227 people
- Sponsor
- Kinevant Sciences GmbH
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