Clinical trials: Acute Respiratory Distress Syndrome (ARDS)
Respiratory Distress Syndrome, Surfactant Administration by Aerosolization
Does The Surfactant Administration by Aerosolization Effective?
The present study was designed to evaluate, in premature babies with RDS breathing spontaneously, the efficacy of combined treatment with nasal continuous positive airway pressure (CPAP) and aerosolized surfactant.
- Trial name
- NCT02825953
- Testing
- surfactant, nasal continuous positive airway pressure, non-invasive intermittent positive-pressure ventilation
- Volunteers
- 75 people
- Sponsor
- nihat demir
Acute Respiratory Distress Syndrome, COVID-19
Predictors of Severe COVID-19 Outcomes
This is a longitudinal, multi-center, observational study collecting diverse biological measurements and clinical and epidemiological data for the purpose of enabling a greater understanding of the onset of severe outcomes…
- Trial name
- PRESCO (NCT04388813)
- Where
- 8 sites in United States
- Volunteers
- 494 people
- Sponsor
- Verily Life Sciences LLC
ARDS, Human
PET - PEEP by EIT for Acute Respiratory Distress Syndrome Trial
This study is a multicentric randomized controlled study.The objective of this study is to compare the prognosis of patients with ARDS between EIT-oriented individualized PEEP and traditional lower PEEP/FiO2 table-oriented PEEP…
- Trial name
- NCT05307913
- Testing
- EIT-guided PEEP, Table-guided PEEP
- Where
- China
- Volunteers
- 676 people
- Sponsor
- Peking Union Medical College Hospital
Acute Respiratory Distress Syndrome (ARDS), Post Intensive Care Syndrome (PICS)
An Observational Study to Identify New Health Problems Arising After an Intensive Care Unit Admission in People With Acute Respiratory Distress Syndrome in the United States
This is an observational study in which data already collected from people with acute respiratory distress syndrome (ARDS) admitted to an intensive care unit (ICU) are studied.
- Trial name
- SeeMe Tool (NCT06272942)
- Testing
- An ICU admission and a temporally related ARDS diagnosis
- Where
- United States
- Volunteers
- 640,058 people
- Sponsor
- Bayer
Acute Respiratory Distress Syndrome, Delirium
Cognitive Dysfunctions Associated With Delirium in Critically-ill ARDS Patients
Early cognitive assessment of critically-ill acute respiratory distress syndrome (ARDS) patients with delirium using a multidimensional electrophysiological evaluation battery (mEEG) to identify and characterize the neural…
- Trial name
- DeSign (NCT06206473)
- Testing
- mEEG assessment
- Sponsor
- University Hospital, Toulouse
nCPAP, BiPAP
Bi-level Positive Airway Pressure for Respiratory Distress Syndrome in Twins Infants
The investigators compared advantages and disadvantages of two forms of noninvasive respiratory support -bi-level positive airway pressure(BiPAP) or nasal continuous positive airway pressure (nCPAP) -as a primary mode of…
- Conditions
- nCPAP, BiPAP, Respiratory Distress Syndrome
- Trial name
- NCT03235661
- Testing
- BiPAP, nCPAP
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
COVID-19 Severe Pneumonia, Acute Lung Injury
Efficacy and Safety Study of IV Ravulizumab in Patients With COVID-19 Severe Pneumonia
This study evaluated the efficacy, safety, pharmacokinetics, and pharmacodynamics of ravulizumab administered in adult participants with coronavirus disease 2019 (COVID-19) severe pneumonia, acute lung injury, or acute…
- Conditions
- COVID-19 Severe Pneumonia, Acute Lung Injury, Acute Respiratory Distress Syndrome, Pneumonia, Viral
- Trial name
- NCT04369469
- Testing
- Ravulizumab, BSC
- Where
- 39 sites in United States, France and 3 more
- Volunteers
- 202 people
- Sponsor
- Alexion Pharmaceuticals, Inc.
Acute Respiratory Distress Syndrome
Early PP Monitored by EIT in Patients With ARDS
Acute Respiratory Distress Syndrome (ARDS) is a syndrome characterized by respiratory distress and refractory hypoxemia caused by pulmonary and extra-pulmonary factors.
- Trial name
- NCT05822869
- Testing
- EIT-guided mechanical ventilation strategy, Lung protective ventilation group
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Beijing Chao Yang Hospital
Cardiac Arrest, Respiratory Distress Syndrome
Pre Hospital Evaluation of Video Laryngoscopy
The objective of this work is to compare standard intubation with video laryngoscope (Glide scope Ranger ) in French pre hospital multicentric study.
- Conditions
- Cardiac Arrest, Respiratory Distress Syndrome, Shock, Acute Post-trauma Stress State
- Trial name
- EVE (NCT01374061)
- Testing
- Classical intubation, GLIDESCOPE
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Respiratory Distress Syndrome, Bronchopulmonary Dysplasia
Pilot Trial of Surfactant Booster Prophylaxis For Ventilated Preterm Neonates
A research study that will evaluate if giving surfactant medication to premature babies weighing < 1250 gm at birth during the second and third weeks of life will help their lungs.
- Trial name
- NCT00208039
- Testing
- Infasurf
- Volunteers
- 89 people
- Sponsor
- Children's Hospital of Philadelphia
Acute Hypoxemic Respiratory Failure
Physiological Effects of Continuous Negative External Pressure for Acute Hypoxemic Respiratory Failure
This study is being conducted to evaluate if wearing a non-invasive breathing support device over the chest/abdomen improves markers of breathing in patients with lung injury requiring high-flow oxygen.
- Trial name
- NCT05675345
- Testing
- HFNC only, HFNC + CNEP10, HFNC + CNEP20
- Where
- 4 sites in United States
- Volunteers
- 20 people
- Sponsor
- NYU Langone Health
Acute Respiratory Distress Syndrome, Lung Diseases
Extracorporeal Carbon Dioxide Removal for Acute Respiratory Distress Syndrome
To compare conventional therapy using low frequency positive pressure ventilation with extracorporeal CO2 removal for the treatment of adult respiratory distress syndrome (ARDS).
- Trial name
- NCT00000572
- Testing
- positive-pressure ventilation, extracorporeal membrane oxygenation (CO2 removal)
- Volunteers
- 40 people
- Sponsor
- Intermountain Health Care, Inc.
Acute Respiratory Distress Syndrome (ARDS), Acute Brain Injury
Contribution of Transthoracic and Transcranial Ultrasonography to the Titration of PEEP in Patients With ARDS and ABI
The present study will investigate whether the combined use of lung and brain ultrasonography is useful in selecting the optimal positive end-expiratory pressure in mechanically ventilated critically ill patients with acute…
- Trial name
- NCT07248995
- Testing
- Stepwise Positive End-Expiratory Pressure (PEEP) Increase Protocol
- Where
- Greece
- Volunteers
- 30 people
- Sponsor
- Theodoros Schizodimos
Respiratory Distress Syndrome, Adult, Multi-antibiotic Resistance
Multi-drug Resistant Gram-negative Bacteria and Veno-venous Extracorporeal Membrane Oxygenation (ECMO)
Veno-venous extracorporeal membrane oxygenation (VV-ECMO) is a life-support technique used in patients with most severe acute respiratory distress syndrome (ARDS).
- Trial name
- MDR-ECMO (NCT06199141)
- Where
- Italy
- Volunteers
- 279 people
- Sponsor
- University of Padova
Respiratory Distress Syndrome, Pneumonia
Telemedicine in the Generals Practitioners Office
Pediatrician does physical examination through telemedicine and in real life to see whether the telemedicine consultation corresponds with the real life examination. Goal is to determine: 1. Check practical feasability 2.
- Conditions
- Respiratory Distress Syndrome, Pneumonia, Bronchiolitis, Croup
- Trial name
- NCT04168554
- Testing
- Telemedicine
- Volunteers
- 40 people
- Sponsor
- Rijnstate Hospital
Respiratory Distress Syndrome (Neonatal), Intubation Complication
InfasurfAero™ Versus Sham Treatment in Preterm Newborns With RDS
The purpose of this clinical study is to determine the effectiveness and safety of Infasurf® administered through the InfasurfAero™, a novel oral airway delivery device specifically designed to give Infasurf in a less complicated…
- Conditions
- Respiratory Distress Syndrome (Neonatal), Intubation Complication, Death; Neonatal
- Trial name
- Aero-05 (NCT05960929)
- Testing
- Infasurf Aero™
- Where
- 10 sites in United States
- Volunteers
- 220 people
- Sponsor
- ONY
Respiratory Distress Syndrome of Prematurity (Surfactant Dysfunction), Bronchopulmonary Dysplasia
Trial of Late Surfactant to Prevent BPD: A Pilot Study in Ventilated Preterm Neonates Receiving Inhaled Nitric Oxide
The purpose of this study is to determine if the combination of late doses of Infasurf with inhaled nitric oxide will interact to improve the surfactant function and thus the respiratory status and outcome of treated infants.
- Trial name
- TOLSURFPilot (NCT00569530)
- Testing
- Infasurf (ONY Inc.)
- Where
- 9 sites in United States
- Volunteers
- 85 people
- Sponsor
- Roberta Ballard
ARDS, Human, Mechanical Ventilation Complication
Awake Prone Positioning to Reduce Invasive VEntilation in COVID-19 Induced Acute Respiratory failurE
Prone positioning (PP) is an effective first-line intervention to treat moderate-severe acute respiratory distress syndrome (ARDS) patients receiving invasive mechanical ventilation, as it improves gas exchanges and lowers…
- Conditions
- ARDS, Human, Mechanical Ventilation Complication, COVID19
- Trial name
- APPROVE-CARE (NCT04347941)
- Testing
- Prone Positioning, Standard of care.
- Where
- Ireland
- Volunteers
- 24 people
- Sponsor
- University College Hospital Galway
COVID-19 Acute Respiratory Distress Syndrome
T-Cell Mitochondrial Respiration Response to Ketone Monoester Supplement in Healthy Volunteers and COVID-19
T-Cell Mitochondrial Respiration Response to Ketone monoester (Ketoneaid) in Healthy Volunteers and COVID-19
- Trial name
- NCT05798260
- Testing
- Agilent Seahorse XF Cell Mito Stress Test
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Duke University
Infant, Newborn, Infant, Low Birth Weight
Vitamin A Supplementation for Extremely-Low-Birth-Weight Infants
This multi-site, randomized trial was conducted to determine the safety and effectiveness of a higher dose of vitamin A and determine if this would increase the rate of survival without bronchopulmonary dysplasia (BPD) and reduce…
- Conditions
- Infant, Newborn, Infant, Low Birth Weight, Infant, Small for Gestational Age, Infant, Premature
- Trial name
- Vitamin A (NCT01203488)
- Testing
- Vitamin A
- Where
- 11 sites in United States
- Volunteers
- 807 people
- Sponsor
- NICHD Neonatal Research Network