Clinical trials: Acute Respiratory Insufficiency
ARDS, Human, Respiratory Failure
Driving Pressure and Mortality: in the Pediatric Intensive Care Unit (PICU)
Respiratory failure is one of the most common causes of both hospitalization and mortality in patients in the pediatric intensive care unit (PICU).
- Trial name
- NCT04419376
- Testing
- driving pressure
- Where
- Turkey (Türkiye)
- Volunteers
- 116 people
- Sponsor
- Dr. Behcet Uz Children's Hospital
Acute Respiratory Failure
Prevention of Damage Induced by Facial Mask Ventilation
In patients with acute respiratory failure (ARF) undergoing noninvasive ventilation (NIV), the main complication of the use of the mask is the development of decubitus, sometimes so severe and painful as to force a suspension of…
- Trial name
- 3PROSNIV (NCT01351155)
- Testing
- Skin protective dressing device
- Where
- Italy
- Volunteers
- 252 people
- Sponsor
- Ospedale San Donato
Acute Respiratory Failure
Dexmedetomidine Versus Standard Clinical Practice During Non Invasive Mechanical Ventilation
This study compare the effectiveness of dexmedetomidine as a sedative drug during NIV and the different strategies routinely used in patients with ARF of different aetiologies.
- Trial name
- DEX-PCH-VMNI (NCT02958150)
- Testing
- Dexmedetomidine, Standard Clinical Practice
- Where
- Spain
- Volunteers
- 120 people
- Sponsor
- Basque Health Service
Acute Respiratory Failure (ARF), Hypertension
EIT Evaluation of Different Antihypertensive Agents on the Ventilation-Perfusion Ratio in Patients With Acute Respiratory Failure
This prospective, single-center interventional study aims to evaluate the effect of two commonly used intravenous antihypertensive agents - nicardipine and nitroglycerin - on lung ventilation-perfusion (V/Q) distribution in…
- Conditions
- Acute Respiratory Failure (ARF), Hypertension, Pulmonary Perfusion Imbalance, Aortic Dissection (Subset)
- Trial name
- NCT07603037
- Testing
- Nitroglycerin, Nicardipine
- Where
- China
- Volunteers
- 12 people
- Sponsor
- First Affiliated Hospital of Wannan Medical College
Slow Breathing
Assessing the Acute Effects of Virtual Reality Interventions on Stress
A Four-Arm RCT, testing the acute effects of a Virtual Reality (VR)- based slow-paced breathing intervention on subjective and physiological markers of stress.
- Trial name
- VR_Stress_25 (NCT07191288)
- Testing
- VR (VR-Breathing+Mystical), VR (VR-Mystical), Computer (Non-VR-Breathing)
- Where
- Switzerland
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Prof. Dominique de Quervain, MD
Acute Respiratory Failure, Heart Failure
Tracheostomy in ICU With a Double Lumen Endotracheal Tube
Percutaneous tracheostomy in Intensive care unit (ICU) is performed with the use of flexible fiberoptic bronchoscope inside the conventional single lumen endotracheal tube owned by the patients.
- Conditions
- Acute Respiratory Failure, Heart Failure, Neurological Disease
- Trial name
- NCT01691222
- Testing
- Double lumen endotracheal tube tracheostomy
- Where
- 2 sites in Italy
- Volunteers
- 30 people
- Sponsor
- University of Genova
COVID-19, Acute Kidney Injury
Kidney Disease After COVID-19
To understand the long-term epidemiology, develop effective risk-prediction and stratification tools, and understand the pathobiology of kidney disease in COVID-19 survivors.
- Conditions
- COVID-19, Acute Kidney Injury, Chronic Kidney Injury
- Trial name
- NCT05328986
- Where
- 5 sites in United States
- Volunteers
- 1,753 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Pediatric Respiratory Diseases, Respiratory Failure
Use of Lung Ultrasound to Diagnose the Etiology of Respiratory Failure in a PICU.
The purpose of this study is to determine the utility of point-of-care lung ultrasound (POC-LUS) in identifying the etiology of acute respiratory failure in pediatric patients admitted to the pediatric intensive care unit.
- Trial name
- NCT03744169
- Testing
- Lung ultrasound, Clinical exam, Chest x-ray
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- University of Wisconsin, Madison
Pneumonia, Diaphragm; Movement
Evaluation of the Relevance of Diaphragmatic Stroke Ultrasound for the Etiological Diagnosis of Acute Respiratory Distress in an Emergency Department.
The goal of this Prospective interventional multicenter diagnostic study is to investigate the use of diaphragmatic ultrasound (DE) as a diagnostic tool in an adult emergency department for patients in acute respiratory distress.
- Conditions
- Pneumonia, Diaphragm; Movement, Diaphragmatic Ultrasound, Emergency Medical Services
- Trial name
- EchoDiaph (NCT06650137)
- Testing
- diaphragmatic ultrasound
- Where
- 2 sites in France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Montpellier
Bradyarrhythmia, Dyspnea
The Safety and Efficacy of FFR Protocol in NTUH System
FFR-guided PCI has been performed in National Taiwan University Hospital(NTUH) for many years. Nevertheless, the method of FFR measurement in NTUH is different from that in literature.
- Conditions
- Bradyarrhythmia, Dyspnea, Acute Respiratory Failure
- Trial name
- NCT03693157
- Where
- Taiwan
- Volunteers
- 250 people
- Sponsor
- National Taiwan University Hospital Hsin-Chu Branch
Acute Hypoxemic Respiratory Failure
Respiratory Mechanics Assessment During Assisted Mechanical Ventilation
To verify the association between respiratory system mechanical properties (ΔP, ΔPL,dyn, Pmus, Pplat and CRS and CL,dyn) assessed during assisted modes of ventilation (as average over the first three days since enrollment) and…
- Trial name
- ICEBERG (NCT05203536)
- Where
- 8 sites in Canada, Germany and 3 more
- Volunteers
- 298 people
- Sponsor
- University of Milano Bicocca
Acute Hypoxemic Respiratory Failure, High-Flow Nasal Cannula Therapy
Protocolized Weaning of High-Flow Nasal Cannula in Adult Patients
High-flow nasal cannula (HFNC) is a type of oxygen therapy commonly used in adults with breathing problems. While HFNC can help patients avoid breathing tubes and improve oxygen levels, there is no standard method for deciding…
- Trial name
- PRO-WEAN HFNC (NCT07452406)
- Testing
- Protocolized HFNC Weaning Strategy, Usual Care HFNC Weaning
- Where
- United States
- Volunteers
- 2,000 people
- Sponsor
- Rush University Medical Center
Chronic Obstructive Pulmonary Disease, Respiratory Failure
NHF vs NIV in Patients With Acute Exacerbation of COPD
Although non-invasive ventilation (NIV) usage has increased significantly over time in COPD exacerbation, a great percentage of patients (~30%) present contraindications to NIV or cannot tolerate it.
- Conditions
- Chronic Obstructive Pulmonary Disease, Respiratory Failure, Acute Exacerbation Copd
- Trial name
- NCT03466385
- Testing
- Nasal High Flow, Non-Invasive Ventilation
- Where
- 3 sites in Greece
- Volunteers
- 498 people
- Sponsor
- Evangelismos Hospital
Acute Respiratory Distress Syndrome, Acute Lung Injury
Effects of PEEP and FIO2 in ALI and ARDS
Current American-European Consensus Conference (AECC) definitions for ALI and ARDS are inadequate for inclusion into clinical trials due to the lack of standardization for measuring the oxygenation defect.
- Conditions
- Acute Respiratory Distress Syndrome, Acute Lung Injury, Acute Respiratory Failure
- Trial name
- HELP (NCT00435110)
- Testing
- standard ventilatory settings, PEEP and FiO2
- Where
- Spain
- Volunteers
- 178 people
- Sponsor
- Instituto Canario de Investigacion Biomedica
Obstructive Sleep Apnea, Acute Kidney Failure
Effect of Obstructive Sleep Apnea on Central Blood Pressure and Kidney and Endothelial Function
Obstructive sleep apnea (OSA) is a frequently underdiagnosed condition that has emerged as an increasing medical problem with important social and financial implications worldwide.
- Conditions
- Obstructive Sleep Apnea, Acute Kidney Failure, Chronic Kidney Disease
- Trial name
- OSA-AKI (NCT00947479)
- Testing
- continuous positive airway pressure (CPAP)
- Where
- Poland
- Volunteers
- 50 people
- Sponsor
- Medical University of Lodz
Respiratory Distress Syndrome, Adult
The Role of Morphological Phenotype in ARDS
Although most of the information focuses on understanding how the ventilator produces lung damage, the pulmonary factors that predispose to ventilator-induced lung injury (VILI) have been less studied.
- Trial name
- MPARDS (NCT04157946)
- Testing
- CT
- Where
- Argentina
- Volunteers
- 12 people
- Sponsor
- Hospital El Cruce
Cardiogenic Shock, Cardiac Arrest
Outcome of Patients Treated With ECLS
Extracorporeal life support (ECLS), also called extracorporeal membrane oxygenation (ECMO), is an extracorporeal technique of providing effective circulatory and (or) respiratory failure, with a growing number of critically ill…
- Conditions
- Cardiogenic Shock, Cardiac Arrest, Heart Failure, Acute Respiratory Failure
- Trial name
- NCT04405817
- Testing
- ECMO
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Nanjing Medical University
Pneumonia
HFNO in Pneumonia Patients Presenting With Acute Hypoxemic Respiratory Failure
High-flow nasal oxygen (HFNO) therapy is an upcoming and beneficial modality for patients with acute hypoxemic respiratory failure (AHRF).
- Trial name
- NCT05809089
- Testing
- High flow nasal cannula (HFNC), Noninvasive ventilation (NIV)
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Assiut University
End Stage Liver Diseases
Analysis of Respiratory System Mechanics and Inflammatory Response During Orthotopic Liver Transplantation (SPPLIT Trial)
During orthotopic liver transplantation (OLT), respiratory system function may be severely impaired for several reasons including anaesthesia effects, hyperdynamic volume state with fluid overload and ischemia reperfusion injury.
- Trial name
- SPPLIT (NCT02119585)
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- University of Turin, Italy
Acute Respiratory Failure, Hypoxemic Respiratory Failure
Standard Oxygen Versus High Flow Nasal Cannula Oxygen Therapy in Patients With Acute Hypoxemic Respiratory Failure
First-line therapy of patients with acute respiratory failure consists in oxygen delivery through standard oxygen, high-flow nasal oxygen therapy through cannula or non-invasive ventilation.
- Trial name
- SOHO (NCT04468126)
- Testing
- Standard oxygen, High-flow nasal oxygen therapy
- Where
- France
- Volunteers
- 1,504 people
- Sponsor
- Poitiers University Hospital
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.