Clinical trials: Acute Stress Disorder Symptoms, open to volunteers
PTSD and Trauma-related Symptoms, Cognitive Decline in Older Adults
Acute Effects of Estradiol Administration on Brain Function During Fear Learning
The goal of current study is to better understand how fear is processed in the brain and how these processes are influenced by cognition and hormones.
- Conditions
- PTSD and Trauma-related Symptoms, Cognitive Decline in Older Adults, Post Menopausal Women
- Trial name
- EstroFearGen (NCT07737613)
- Testing
- estradiol
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Arizona
Acute Respiratory Distress Syndrome, Respiratory Failure
Precision Ventilation vs Standard Care for Acute Respiratory Distress Syndrome
The goal of this interventional study is to compare standard mechanical ventilation to a lung-stress oriented ventilation strategy in patients with Acute Respiratory Distress Syndrome (ARDS).
- Trial name
- PREVENT VILI (NCT06066502)
- Testing
- Precision ventilation, Guided usual care ventilation
- Where
- 33 sites in United States
- Volunteers
- 1,100 people
- Sponsor
- Beth Israel Deaconess Medical Center
Stress Incontinence Female, Urinary Incontinence
TENS Analgesia During Outpatient Urethral Bulking for Stress Urinary Incontinence.
This will be a double-blind randomized control trial in women with stress urinary incontinence who are undergoing an outpatient transurethral bulking procedure for stress urinary incontinence.
- Conditions
- Stress Incontinence Female, Urinary Incontinence, Urinary Incontinence,Stress, Pain
- Trial name
- TENSUB (NCT06369922)
- Testing
- TENS, Control TENS
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Rochester
Atherosclerosis, Cardiovascular Diseases
Carotid Intraplaque Neovascularization Combined With Stress Echo
The root cause of heart attacks and strokes is atherosclerosis, the hardening and thickening of blood vessels due to the presence of "plaque" which is a build-up of fat and cholesterol in the walls of vessels.
- Conditions
- Atherosclerosis, Cardiovascular Diseases, Acute Coronary Syndrome, Ischemic Heart Disease
- Trial name
- CIRCE (NCT05416385)
- Testing
- Carotid Contrast Enhanced Ultrasound
- Where
- 6 sites in Canada
- Volunteers
- 1,500 people
- Sponsor
- Dr. Amer Johri
Abdominal Pain, Isolated Extremity Fracture
Morphine or Ketamine for Analgesia
Pain is common in children presenting to the emergency department but is frequently undertreated, leading to both short- and long-term consequences.
- Conditions
- Abdominal Pain, Isolated Extremity Fracture, Pain, Pediatrics
- Trial name
- MoKA (NCT06835504)
- Testing
- Ketamine hydrochloride, Morphine sulphate
- Where
- 8 sites in United States
- Volunteers
- 1,010 people
- Sponsor
- Columbia University
Acute Myeloid Leukemia
ONC-LEUK-2406: The Impact of Systematic Financial Navigation in Acute Myeloid Leukemia
The purpose of this research is to see how personal financial burden (financial toxicity) related to cancer affects the overall health and quality of life by evaluating the impact of systematic financial navigation in addition to…
- Trial name
- NCT06945042
- Testing
- Arm A, Arm B
- Where
- 2 sites in United States
- Volunteers
- 120 people
- Sponsor
- Wake Forest University Health Sciences
Type 1 Diabetes, T1D
DASH-Obesity: Explainable AI for Family-Centric Personalized Weight Control in Adolescents and Young Adults With Obesity and Chronic Conditions
This prospective single-arm feasibility study evaluates the Adhera Caring Digital Program for Obesity (ACDP-O), a family-centered digital health intervention designed to support adolescents and young adults with…
- Conditions
- Type 1 Diabetes, T1D, Obesity & Overweight, Obesity Type 2 Diabetes Mellitus
- Trial name
- DASH-Obesity (NCT07638345)
- Testing
- Adhera Caring Digital Program-Obesity (ACDP-O)
- Where
- Spain
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- Adhera Health, Inc.
Acute Myocardial Infarction (AMI), ST Elevation (STEMI) Myocardial Infarction
Combined Antioxidant Therapy for Acute Myocardial Infarction
The goal of this clinical trial is to learn if a combined antioxidant therapy (CAT) can reduce heart damage caused by the return of blood flow after blocked arteries are reopened in adults with ST-elevation myocardial infarction…
- Conditions
- Acute Myocardial Infarction (AMI), ST Elevation (STEMI) Myocardial Infarction, Reperfusion Injuries, Myocardial
- Trial name
- CAT-AMI (NCT07776288)
- Testing
- Combined antioxidant therapy
- Where
- Chile
- Volunteers
- 46 people
- Sponsor
- University of Chile
Acute Stress Disorder Symptoms
Movement Sonification as an add-on to Immediate Post-event Psychotherapeutic Intervention in the Management of Acute Stress Disorder: a Feasibility and Acceptability Study
Natural disasters, conflicts, persecution, population displacement, often traumatic migration experiences, and terrorist attacks are all factors that currently expose a significant proportion of the world's population to…
- Trial name
- SONICUMP (NCT07307937)
- Testing
- The sonification of movement is an act studied in this research.
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Post-Acute COVID-19 Syndrome, ME/CFS
Unhide® Project: A Digital Health Platform to Collect Lifestyle Data for Brain Inflammation Research
The unhide® Project is a non-interventional, longitudinal research study designed to establish a secure data repository of demographic, health, and lifestyle information from individuals with brain inflammation and related…
- Conditions
- Post-Acute COVID-19 Syndrome, ME/CFS, Rheumatic Arthritis, Juvenile Rheumatoid Arthritis (JRA)
- Trial name
- NCT04806620
- Where
- United States
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Brain Inflammation Collaborative
End-Stage Renal Disease, Renal Dialysis
Effects of Horticultural Therapy on Acute Stress and Salivary Cortisol Levels in Hemodialysis Patients
The purpose of this study is to evaluate the acute psychological and physiological effects of a single-session structured horticultural therapy program on patients undergoing routine hemodialysis.
- Conditions
- End-Stage Renal Disease, Renal Dialysis, Acute Stress
- Trial name
- NCT07845214
- Testing
- Horticultural Therapy
- Volunteers
- 80 people
- Sponsor
- Ataturk University
Trauma (Including Fractures)
Stress in Trauma Patients in Triage Categories 3-5
The aim of this study is to better understand what causes patients the most concern immediately after an injury. We would like to find out how stressed patients are and whether the main causes of stress are pain, fear regarding…
- Trial name
- NCT07811830
- Testing
- Questionnaire and Physical Exam
- Where
- Croatia
- Volunteers
- 300 people
- Sponsor
- Gabriela Katharina Pomper
Pancreatitis, Acute, Hyperglycaemia
Glucose Levels in Acute Pancreatitis and the Impact of Insulin Depletion and Bacterial Endotoxaemia
There are currently no early predictive biomarkers for severity of acute pancreatitis (AP) that would allow stratification of patients for potential early interventional therapies.
- Trial name
- GLIDE (NCT06972238)
- Volunteers
- 30 people
- Sponsor
- Manchester University NHS Foundation Trust
Mild Cognitive Impairment, Alzheimer Disease
Trial of CORT108297 to Attenuate the Effects of Acute Stress in the Allocortex (CORT-X)
CORT-X will examine if mitigation of stress-mediated pathogenesis of Alzheimer's disease (AD) is a feasible target for intervention in individuals at risk for this disease.
- Conditions
- Mild Cognitive Impairment, Alzheimer Disease, Memory Impairment
- Trial name
- CORT-X (NCT04601038)
- Testing
- CORT108297
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Obesity & Overweight
Acute Sauna Session and Glucose Control
The goal of this clinical trial is to examine the effect of a single 40-minute sauna session on glucose control in individuals at risk for metabolic impairments.
- Trial name
- NCT07520929
- Testing
- Infrared sauna session, Resting condition
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- University of Prince Edward Island
Slow Breathing
Assessing the Acute Effects of Virtual Reality Interventions on Stress
A Four-Arm RCT, testing the acute effects of a Virtual Reality (VR)- based slow-paced breathing intervention on subjective and physiological markers of stress.
- Trial name
- VR_Stress_25 (NCT07191288)
- Testing
- VR (VR-Breathing+Mystical), VR (VR-Mystical), Computer (Non-VR-Breathing)
- Where
- Switzerland
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Prof. Dominique de Quervain, MD
Trauma Injury, Trauma
The Role of Brain-Bone Marrow-Gut Interaction Following Major Trauma
Traumatic injury followed by critical illness provokes pathophysiologic changes in the bone marrow and the gut that contribute to persistent anemia and changes in the microbiome which significantly impact long-term recovery.
- Conditions
- Trauma Injury, Trauma, Critical Illness, Microbiome
- Trial name
- NCT06606119
- Testing
- Data and tissue collection
- Where
- 3 sites in United States
- Volunteers
- 275 people
- Sponsor
- University of Florida
Coronary Artery Disease, Chest Syndrome
CT Stress Myocardial Perfusion, Fractional Flow Reserve and Angiography in Patients With Stable Chest Pain Syndromes
The purpose of the DYNAMITE trial (Dynamic CT stress myocardial perfusion, CT fractional flow reserve (FFR-CT) and coronary CT angiography for optimized treatment strategy in patients with chest pain syndromes) is to determine…
- Conditions
- Coronary Artery Disease, Chest Syndrome, Acute Myocardial Infarction, Heart Failure
- Trial name
- DYNAMITE (NCT04709900)
- Testing
- CT angiography, FFR-CT and stress CT myocardial perfusion
- Where
- Denmark
- Volunteers
- 2,000 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Acute Pain
Rebooting Infant Pain Care: Using Machine Learning and Skin-to-Skin Contact to Exponentially Improve Neonatal Intensive Care Unit Practice
To address the current limitations related to infant pain assessment in the NICU, our international team of knowledge users and health/natural science/engineering/social science researchers have come together to build a machine…
- Trial name
- BabyAIBabyCalm (NCT05579496)
- Where
- 2 sites in Canada, United Kingdom
- Volunteers
- 400 people
- Sponsor
- York University
Caregiver Distress, Emotional Distress
The Coma Family Program (COMA-F): A Resilience Program for Caregivers of Patients With Severe Acute Brain Injury
The purpose of this research study is to determine whether COMA-F is more efficacious at reducing emotional distress in caregivers of patients with severe acute brain injuries, compared to health education control.
- Conditions
- Caregiver Distress, Emotional Distress, Caregivers, Resilience
- Trial name
- COMA-F (NCT07331324)
- Testing
- Coma Family Program 1, Coma Family Program 2
- Where
- 4 sites in United States
- Volunteers
- 150 people
- Sponsor
- Icahn School of Medicine at Mount Sinai