Clinical trials: Acute Stress Reaction
Acute Stress Disorder, Post Traumatic Stress Disorder PTSD
Assessment of the Preventive Effect of Defusing on Traumatic Kindling
The exposure to a potential traumatic event (PTE) is common in the general population. This exposure may lead to psychiatric disorders such as acute stress disorder (ASD) and post-traumatic stress disorder (PTSD).
- Trial name
- PREDEKIT (NCT07850193)
- Testing
- Defusing, Psychological First Aid (PFA)
- Where
- 4 sites in France
- Volunteers
- 70 people
- Sponsor
- Hospices Civils de Lyon
Acute Stress Reaction, Acute Stress Disorder
BXCL501 After Stress to Increase Recovery Success
This study will examine the safety and efficacy of BXCL501 to reduce ASR symptoms and behavioral changes among patients presenting to the Emergency Department (ED) after Motor Vehicle Collision (MVC).
- Conditions
- Acute Stress Reaction, Acute Stress Disorder, Post-traumatic Stress Disorder
- Trial name
- RISE (NCT06943404)
- Testing
- BXCL501 (dexmedetomidine HCl)
- Where
- 3 sites in United States
- Volunteers
- 100 people
- Sponsor
- University of North Carolina, Chapel Hill
Stress Disorders, Post-Traumatic
Probabilistic Risk Modeling for Disorder Post Traumatic Stress (PTSD) After the Attacks in Paris In November 2015
The scientific approach of this project proposes to build a cohort of "psychological injuries" post-attack of 13 November 2015. This is called patients "involved", ie patients who directly witnessed the events and having the most…
- Trial name
- BV13 (NCT02853513)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Hospital, Tours
Suicide, Attempted
Pilot Trial of Inpatient Cognitive Therapy for the Prevention of Suicide in Military Personnel
The broad objective of this research is to effectively utilize a unique window of opportunity during the hospitalization period following a recent suicide attempt to deliver a brief and targeted intervention for traumatized…
- Trial name
- CDMRP (NCT01356186)
- Testing
- Post Admission Cognitive Therapy (PACT)
- Where
- 2 sites in United States
- Volunteers
- 36 people
- Sponsor
- Henry M. Jackson Foundation for the Advancement of Military Medicine
Depression, Depressive Disorder
Citalopram and Stress Reactivity
This study is investigating whether acute administration of citalopram is associated with a decrease in stress reactivity in healthy volunteers, compared to placebo administration.
- Conditions
- Depression, Depressive Disorder, Mental Disorder, Antidepressive Agents
- Trial name
- NCT04161209
- Testing
- Citalopram
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Benign Lesions in Left Liver
Laparoscopic Versus Open Left Hemihepatectomy for Liver Benign Lesions
The purpose of this study is to investigate the influence of the laparoscopic and open left hemihepatectomy on acute surgical trauma and stress response.
- Trial name
- NCT01768728
- Testing
- Laparoscopic left hemihepatectomy, Open left hemihepatectomy
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Sir Run Run Shaw Hospital
Trauma and Stressor Related Disorders, Post-traumatic Stress Disorders
Posttraumatic Stress Disorders in Police, Correctional Service Officers, and 911 Operators
Police officers, correctional service officers, and 911-operators are at increased risk for suffering from trauma-related disorders due to their direct and indirect exposure to life-threatening events, such as shootings, violent…
- Conditions
- Trauma and Stressor Related Disorders, Post-traumatic Stress Disorders, Adjustment Disorders, Acute Stress Disorder
- Trial name
- NCT03152175
- Testing
- Propranolol Hydrochloride
- Where
- Canada
- Volunteers
- 64 people
- Sponsor
- Douglas Mental Health University Institute
Healthy Participants
Influence of Dopaminergic Blockade on Stress Responses, Motivation and Emotional Reactivity in Humans.
The study aims to identify whether partial blockade of human dopamine signaling with antipsychotic drugs affects human stress responses, motivation and emotion.
- Trial name
- NCT03863691
- Testing
- Amisulpride 300 MG
- Where
- Germany
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Philipps University Marburg
Acute Stress Disorder, Anxiety
Safety & Efficacy of Intranasal Dexmedetomidine, Fentanyl & Midazolam in the Pediatric Emergency Room
The hypothesis is that intranasal dexmedetomidine will provide significantly more effective analgesia and anxiolysis for subjects undergoing a simple laceration repair when compared to either intranasal fentanyl or intranasal…
- Conditions
- Acute Stress Disorder, Anxiety, Pain
- Trial name
- NCT05057689
- Testing
- Intranasal Dexmedetomidine (4 mcg/kg), Intranasal Fentanyl (2 mcg/kg), Intranasal Midazolam (5 mg/kg)
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Nationwide Children's Hospital
Stress, Acute Stress Reaction
The Effect of Breathing on Cognitive Performance and Stress
The purpose of this study is to determine the effectiveness of different breathing techniques on biomarkers of stress and cognitive performance following the Trier Social Stress Test.
- Conditions
- Stress, Acute Stress Reaction, Breathing Techniques, Cognitive Performance
- Trial name
- NCT06986135
- Testing
- Box Breathing, Prolonged Exhalation, Normal Breathing
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Texas State University
Healthy Adult Participants, Acute Stress Reaction
Breathwork and Stress: Investigating the Mechanisms of Action and Effectiveness of Breathing Interventions in Modulating the Psychophysiological Response to Acute Stress Test
This study investigates whether the psychophysiological benefits of breathing exercises are driven by a specific physiological rhythm (6 breaths per minute) or by the general psychological experience of performing a structured…
- Conditions
- Healthy Adult Participants, Acute Stress Reaction, Stress Biomarkers, Healthy
- Trial name
- NCT07529379
- Testing
- Coherent Breathing (6 bpm)
- Where
- Poland
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Medical University of Bialystok
Adults, Acute Stress Reaction
Impact of MetaCalm on Stress of Healthy People With Acute Stress
This Open-Label, Non-Randomized Clinical Study involving 280 participants who will undergo a total participation of 6 hours.
- Trial name
- NCT07507669
- Testing
- 2 chewable tablets of MetaCalm, 4 chewable tablets of MetaCalm
- Where
- Italy
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- Metagenics, Inc.
Acute Stress Disorder Symptoms
Movement Sonification as an add-on to Immediate Post-event Psychotherapeutic Intervention in the Management of Acute Stress Disorder: a Feasibility and Acceptability Study
Natural disasters, conflicts, persecution, population displacement, often traumatic migration experiences, and terrorist attacks are all factors that currently expose a significant proportion of the world's population to…
- Trial name
- SONICUMP (NCT07307937)
- Testing
- The sonification of movement is an act studied in this research.
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Healthy
Exercise-induced Effects on Immune Parameters in Healthy Participants
Exercise has been shown to influence the immune system and, for example, improve anti-viral immune response. However, knowledge of how exercise impacts the immune system is still lacking.
- Trial name
- INHALE (NCT05826496)
- Testing
- Exercise
- Where
- Denmark
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Per thor Straten
Hemodynamic Response, Acute Appendicitis
Lidocaine VS Hemodynamic, Metabolic and Hormonal Response
Intravenous lidocaine - a potent local anesthetic with analgesic and anti- inflammatory properties has been shown to be an effective adjunct that reduces intra and postoperative opioid consumption and facilitates pain management…
- Conditions
- Hemodynamic Response, Acute Appendicitis, Complication of Treatment, Opioid Consumption
- Trial name
- NCT05238506
- Testing
- Intravenous lidocaine, Normal saline infusion
- Where
- Poland
- Volunteers
- 132 people
- Sponsor
- Medical University of Warsaw
Alcohol Use Disorder (AUD), Alcoholism
Cue Effects in Human Addiction: Pavlovian to Instrumental Transfer
Individuals with substance use disorders (SUD) have to cope with drug-related cues and contexts, which can affect instrumental drug seeking as shown with Pavlovian to instrumental transfer (PIT) paradigms in animals and humans.
- Conditions
- Alcohol Use Disorder (AUD), Alcoholism, Substance Use Disorders, Smoking, Tobacco
- Trial name
- ReCoDe (NCT05992272)
- Testing
- fMRI imaging (BOLD), sMRI (structure), Trier Social Stress Test
- Where
- 2 sites in Germany
- Volunteers
- 300 people
- Sponsor
- Charite University, Berlin, Germany
Cardiovascular Reactivity to Stress
Effects of Yoga on Heart Rate and Heart Rate Variability Responses to Stress
Introduction: Yoga has been shown to reduce stress and have benefits for a number of stress-related disorders. However, the effects of an acute bout of yoga practice on cardiac autonomic response to and recovery from stress…
- Trial name
- NCT04897230
- Testing
- Hatha Yoga, Video Watching
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital
Post-traumatic Stress Disorder (PTSD), Acute Stress Disorder
EMDR Flash Group Protocol for Earthquake Survivors
This pilot randomized controlled trial evaluated the preliminary effects of the online EMDR Flash Group Protocol among adults affected by the 2023 Kahramanmaraş earthquakes in Türkiye.
- Conditions
- Post-traumatic Stress Disorder (PTSD), Acute Stress Disorder, Anxiety, Depression
- Trial name
- FlashGP-EQ (NCT07672613)
- Testing
- EMDR Flash Group Protocol
- Where
- Turkey (Türkiye)
- Volunteers
- 410 people, healthy volunteers welcome
- Sponsor
- Istanbul Galata University
Migraine Headache
Acute Stress Response in Migraine Sufferers
This study will examine the influence of stress and fasting on headache activity. Participants will receive both a control and stress session and be randomized to either fasting or not fasting for the visits.
- Trial name
- NCT03099070
- Testing
- Stress, Fasting
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Massachusetts General Hospital
Acute Stress Reaction
The Efficacy of Vitamin D Supplementation to Sustain Performance Outcomes
The goal of this clinical trial is to find out if vitamin D supplements help healthy adults maintain their cognitive and simple physical task performance and emotional state during highly stressful situations.
- Trial name
- NCT07654777
- Testing
- Vitamin D3 (Cholecalciferol)
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Walter Reed Army Institute of Research (WRAIR)