Clinical trials: Acute Uncomplicated Diverticulitis
Diverticulitis
Combination of Curcumin and Berberine Therapy in the Treatment of Post Acute Diverticulitis (SUDD)
Curcumin (Cur), an active ingredient of the Indian herb Rhizoma Curcuma Longa, has been extensively studied in the context of inflammatory diseases.
- Trial name
- NCT05596214
- Testing
- Curcumin-Berberine (coptis)
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- Dr. Adi Lahat
Acute Uncomplicated Diverticulitis
APLAUD Trial (Antibiotics vs PLacebo for Acute Uncomplicated Diverticulitis)
The goal of this clinical trial is to determine whether antibiotics improve recovery from acute uncomplicated diverticulitis (AUD) in racially and ethnically diverse United States clinical practice.
- Trial name
- NCT07492134
- Testing
- Amoxicillin-Clavulanate 875 Mg-125 Mg Oral Tablet, Metronidazole, Cefuroxime
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Vanderbilt University Medical Center
Acute Uncomplicated Diverticulitis
Acute Uncomplicated Diverticulitis and Conservative Treatment: Accuracy of Inflammatory Indexes for Failure Prediction: Observational Prospective Cohort Study. (AUDRIP Trial)
This is an observational multicenter study that will analyse the accuracy of inflammatory indexes as neutrophil-lymphocyte ratio and platelet-lymphocyte ratio, to predict the failure of conservative treatment of patients…
- Trial name
- AUDRIP (NCT05833698)
- Testing
- Elevation of NLR
- Where
- Spain
- Volunteers
- 2,160 people, healthy volunteers welcome
- Sponsor
- Fundación de Investigación Biomédica - Hospital Universitario de La Princesa
Acute Diverticulitis
Validation of Actigraph Measured Sleep During Acute Diverticulitis
The purpose of this study is to investigate the accuracy of actigraph measured sleep compared to the golden standard (polysomnography) during Acute uncomplicated diverticulitis.
- Trial name
- NCT01840878
- Where
- Denmark
- Volunteers
- 13 people
- Sponsor
- Herlev Hospital
Diverticulitis
Diverticulitis: Antibiotics or Close Observation?
Rationale The prevalence of colonic diverticular disease is increasing in Western countries. Approximately 10 to 25% of patients with diverticular disease will eventually develop an episode of acute diverticulitis.
- Trial name
- DIABOLO (NCT01111253)
- Testing
- Amoxicillin-clavulanate
- Where
- 24 sites in Netherlands
- Volunteers
- 533 people, healthy volunteers welcome
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Diverticulitis, Acute Diverticulitis
Randomized Multicentric Trial to Evaluate a Free Diet With a Progressive Diet in the Treatment of Acute Diverticulitis (DIVERDIET)
Phase III trial is designed to demonstrate the non-inferiority of a free diet versus a progressive diet in the treatment of acute diverticulitis (AD) without complications.
- Conditions
- Diverticulitis, Acute Diverticulitis, Diverticulitis, Colonic, Uncomplicated Diverticular Disease
- Trial name
- NCT03496090
- Testing
- Free diet, Progressive diet
- Where
- Spain
- Volunteers
- 134 people
- Sponsor
- Hospital General Universitario Reina Sofía de Murcia
Colonic Diverticulitis
The Out-patient, Non Antibiotic Management of Patients With Acute Uncomplicated Colonic Diverticulitis
Previous multicentre study NCT 01008488 indicates that a patient with CT-proven uncomplicated diverticulitis has a very low risk (1.4%) of developing severe complications such as perforations or abscesses.
- Trial name
- P-VOD (NCT01515150)
- Where
- Sweden
- Volunteers
- 161 people
- Sponsor
- Uppsala University
Acute Uncomplicated Diverticulitis
Non-antibiotic Management in Acute Uncomplicated Diverticulitis
Diverticulitis is a common condition that causes swelling and pain in part of the colon (the large intestine). Doctors classify it as "mild" when there are no serious complications.
- Trial name
- NAMAD (NCT07625267)
- Testing
- Symptomatic treatment (ibuprofen and acetaminophen), Amoxicillin-clavulanate, Ciprofloxacin plus metronidazole
- Sponsor
- Montefiore Medical Center
Diverticulitis
Symptomatic Treatment of Acute Uncomplicated Diverticulitis
The purpose of this study is to determine the safety and efficacy of symptomatic treatment (i.e. without antimicrobial drugs) of acute uncomplicated diverticulitis.
- Trial name
- NCT02219698
- Testing
- Ibuprofen, Paracetamol
- Where
- Finland
- Volunteers
- 158 people
- Sponsor
- Helsinki University Central Hospital
Acute Diverticulitis
Supplementation With Lacobacillus Reuteri ATCC PTA 4659 in Patients Affected by Acute Uncomplicated Diverticulitis
Acute Uncomplicated Diverticulitis (AUD) is defined as inflammation of the colon diverticulum, often involving the colic wall and pericolic fat.
- Trial name
- NCT03656328
- Testing
- Lactobacillus Reuteri 4659
- Where
- Italy
- Volunteers
- 90 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Acute Diverticulitis
Heart Rate Variability During Acute Diverticulitis
The purpose of this study is to investigate heart rate variability during Acute uncomplicated diverticulitis by ECG-monitor (Holter), the investigators hypothesis is the inflammation causes a decrease of High Frequency(HF)-power…
- Trial name
- NCT01840917
- Where
- Denmark
- Volunteers
- 13 people
- Sponsor
- Herlev Hospital
Acute Uncomplicated Diverticulitis
Multicenter Survey About Acute Uncomplicated Diverticulitis Management
Acute uncomplicated diverticulitis is a quite prevalent situation and consultation in the emergency department. Its management has progresively changed towards a more conservative one and it is currently recommended in several…
- Trial name
- NCT05784064
- Testing
- Survey
- Where
- Spain
- Volunteers
- 56 people
- Sponsor
- Fundación de Investigación Biomédica - Hospital Universitario de La Princesa
Colonic Diverticulitis
Antibiotic Therapy of Acute Uncomplicated Colonic Diverticulitis
The purpose of this study is to evaluate if antibiotic therapy is necessary for treatment of uncomplicated colonic diverticulitis.
- Trial name
- NCT01008488
- Testing
- Antibiotic
- Where
- Sweden
- Volunteers
- 600 people
- Sponsor
- Uppsala University
Acute Diverticulitis
Subjective Sleep and Fatigue During and After Acute Diverticulitis
The purpose of this study is to investigate subjective sleep quality and fatigue during and after Acute uncomplicated diverticulitis assessed by questionnaires and a sleep-diary.
- Trial name
- NCT01840904
- Where
- Denmark
- Volunteers
- 13 people
- Sponsor
- Herlev Hospital
Uncomplicated Diverticulitis
Rifamycin SV-MMX® 400 mg b.i.d. vs. Rifamycin SV-MMX® 600 mg t.i.d. vs. Placebo in Acute Uncomplicated Diverticulitis
The purpose of the trial is to compare the efficacy of Rifamycin SV-MMX® 400 mg b.i.d. vs. Rifamycin SV-MMX® 600 mg t.i.d. vs. placebo in patients with acute uncomplicated diverticulitis.
- Trial name
- NCT01847664
- Testing
- Rifamycin SV-MMX® 400 mg b.i.d., Rifamycin SV-MMX® 600 mg t.i.d.
- Where
- Germany
- Volunteers
- 204 people
- Sponsor
- Dr. Falk Pharma GmbH
Diverticulitis
Improving the Treatment of Acute Uncomplicated Diverticulitis in Routine Care
Acute uncomplicated diverticulitis is often treated with antibiotics, although current evidence shows that antibiotics are not always necessary.
- Trial name
- AUD (NCT07824180)
- Testing
- standardized treatment algorithm
- Volunteers
- 800 people
- Sponsor
- Ente Ospedaliero Cantonale, Bellinzona
Diverticulitis
Trial Assessing the Efficacy of a Short Course of Intravenous Antibiotic Followed by Oral Antibiotic in Uncomplicated Acute Diverticulitis
Medical treatment of uncomplicated acute diverticulitis is not standardized and there is an enormous diversity in clinical practice.
- Trial name
- DANC-05 (NCT00917592)
- Testing
- amoxicillin plus clavulanic acid
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Consorci Sanitari de Terrassa
Diverticulitis, Colonic, Colonic Neoplasms
Acute Diverticulitis and Advanced Colonic Neoplasia. When to Perform Colonoscopy (ADACOLON Study)
This study evaluate the prevalence of advanced colonic neoplasia (ACN) in acute diverticulitis. A sub-analysis of complicated and uncomplicated acute diverticulitis will be made in order to determinate whether there are…
- Trial name
- ADACOLON (NCT03557216)
- Testing
- Colonoscopy, Fecal immunochemical and occult blood test, Fecal calprotectin test
- Where
- Spain
- Volunteers
- 313 people
- Sponsor
- Parc de Salut Mar
Diverticulitis, Colonic
Effectiveness and Safety of Outpatient Treatment of Uncomplicated Acute Diverticulitis Without Antibiotics
The objective of this clinical trial to evaluate the effectiveness and safety of outpatient treatment without antibiotics compared to outpatient treatment with antibiotics in patients with acute uncomplicated diverticulitis.
- Trial name
- ADIANA (NCT06517264)
- Testing
- Antibiotic, Non antibiotic
- Where
- Spain
- Volunteers
- 282 people
- Sponsor
- Monica Mengual Ballester