Clinical trials: Addiction, Alcohol
Obesity, Alcohol Dependence
Imaging of Cannabinoid 1 Receptors Using [11C]OMAR and PET
The aim of the present study is to conduct a human trial of [C-11]OMAR, a new PET imaging agent for the brain cannabinoid type 1 receptors (CB1), to determine its pharmacokinetics and binding characteristics.
- Conditions
- Obesity, Alcohol Dependence, High Stress
- Trial name
- NCT01719497
- Testing
- [C-11]OMAR
- Where
- United States
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Yale University
Alcohol Drinking, Alcohol Use Disorder
Alcohol and the Social Brain: An Alcohol-Administration Hyperscanning Study
In this study, the investigators aim to capture inter- and intra-brain mechanisms underlying alcohol reward in novel social context.
- Conditions
- Alcohol Drinking, Alcohol Use Disorder, Alcohol Intoxication, Alcohol; Harmful Use
- Trial name
- NCT06687525
- Where
- United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Urbana-Champaign
Substance Abuse Problem, Alcohol Abuse
Designing a Mobile App for Veterans With Substance Use Problems
The purpose of this study is to increase access for rural Veterans to evidence-based, person-centered, individually tailored treatment for alcohol use problems.
- Conditions
- Substance Abuse Problem, Alcohol Abuse, Alcohol Dependence
- Trial name
- NCT01812187
- Testing
- SHIFT Cognitive Behavioral Therapy
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Michael E. DeBakey VA Medical Center
Alcoholism, Substance Abuse
Recognition and Early Intervention for Alcohol and Substance Abuse in Adolescence in Adolescent
ASSIST mini-intervention is applied in an electric form in adolescent outpatients to see if it
- Conditions
- Alcoholism, Substance Abuse, Alcohol Dependence, Alcohol-Related Disorders
- Trial name
- REAL-SMART (NCT06262958)
- Testing
- ASSIST, Treatment as usual
- Where
- Finland
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Kuopio University Hospital
Potential Treatment for Alcohol Dependence-Alcohol Interaction
Effects of Ethanol on the Pharmacokinetics of PT-150 (Formerly ORG34517) (PT150 PK Study)
The purpose of this clinical study is to assess pharmacokinetic interactions between ethanol (EtOH) and PT150 (900 mg qd) in non-treatment-seeking alcohol-experienced volunteers-(to include military service members, veterans…
- Trial name
- NCT04331288
- Testing
- PT150, Beverage
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Pop Test Oncology LLC
Alcohol Drinking, Alcohol Abuse
Using Counter Attitudinal Advocacy to Change Drinking Behavior
High volume drinking by young adults has proven resistant to change, so new approaches are needed. We adapt a theory-based attitude change strategy for use in alcohol prevention.
- Trial name
- NCT04042909
- Testing
- Counter Attitudinal Advocacy, Personalized Normative Feedback
- Where
- 2 sites in United States
- Volunteers
- 591 people, healthy volunteers welcome
- Sponsor
- Brown University
Alcohol Abuse, Alcohol Drinking
Substance Use Risk Education (SURE) Project
This project is designed to compare college drinking interventions on outcomes and cost-effectiveness. We plan to recruit 700 students with residence hall alcohol violations to participate in a randomized study to evaluate 3…
- Trial name
- NCT00289965
- Testing
- Counselor-administered Brief Motivational Intervention (BMI), Alcohol 101 Plus (interactive CD-ROM), AlcoholEdu (Internet-based tutorial)
- Where
- United States
- Volunteers
- 703 people, healthy volunteers welcome
- Sponsor
- Syracuse University
Alcohol Dependence
Cerebral Hemodynamics With rTMS in Alcohol Dependence
The present study measures the cerebral hemodynamic indices of alcohol dependent patients and observe the relative changes in these parameters with rTMS application.
- Trial name
- NCT02446067
- Testing
- Repetitive Transcranial Magnetic Stimulation (rTMS)
- Where
- India
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Central Institute of Psychiatry, Ranchi, India
Fear, Stress
Traits Associated With Early Life Stress Among Treatment-Seeking Alcoholics
Background: Researchers want to see if people with alcohol dependence have more trouble learning to feel calm, or learn to fear things more easily, than non-alcoholics and to study how early life stress (ELS) affects these…
- Conditions
- Fear, Stress, Alcohol Dependence
- Trial name
- NCT02181608
- Volunteers
- healthy volunteers welcome
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Mental Disorder, Depressive Disorder
Reducing Stigma Among Healthcare Providers (RESHAPE-cRCT)
A growing number of trials have demonstrated treatment effectiveness for mental illness by non-specialist providers, such as primary care providers, in low-resource settings.
- Conditions
- Mental Disorder, Depressive Disorder, Anxiety Disorder, Alcohol Use Disorder
- Trial name
- RESHAPE-cRCT (NCT04282915)
- Testing
- Reducing Stigma among Healthcare Providers (RESHAPE), mental health Gap Action Programme
- Where
- Nepal
- Volunteers
- 8,705 people, healthy volunteers welcome
- Sponsor
- George Washington University
Stress, Alcoholism
Chronic Alcohol and Brain Stress Circuit Response
Alcoholism is among the top three causes of preventable death and disease in the US (Mokdad et al., 2004; Room et al., 2005). Stress plays an important role in the development of alcoholism and in high vulnerability to alcohol…
- Trial name
- NCT01031264
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Yale University
Alcohol Abuse, Drug Abuse
Personality-targeted Interventions for Adolescent Alcohol Misuse
Personality targeted cognitive behavioural interventions have been shown to be effective in reducing alcohol and drug misuse in adult substance abusers (Conrod et al., 2000) and adolescent drinkers (Conrod et al, in press).
- Conditions
- Alcohol Abuse, Drug Abuse, Depression, Panic Disorder
- Trial name
- Preventure (NCT00344474)
- Testing
- PRE-Venture: Personality Risk Education
- Where
- United Kingdom
- Volunteers
- 710 people, healthy volunteers welcome
- Sponsor
- King's College London
Alcohol Abuse, Alcohol Use Disorder
A SMART Evaluation of an Adaptive Web-based AUD Treatment for Service Members and Their Partners
The purpose of this study is to evaluate the efficacy of an adaptive web intervention (Partners Connect) on military spouse drinking behaviors (CPs) and service member help-seeking (SMs).
- Conditions
- Alcohol Abuse, Alcohol Use Disorder, Alcohol Drinking, Relations, Interpersonal
- Trial name
- NCT05619185
- Testing
- CRAFT Web-Based Intervention, Phone-Based CRAFT, CRAFT Workbook
- Where
- United States
- Volunteers
- 744 people, healthy volunteers welcome
- Sponsor
- Stanford University
Alcohol Abuse
Health Explorer - Optimizing Alcohol Brief Interventions
The aims of the study are to develop and refine tailored motivational brief interventions that are parallel in structure but have varied delivery modalities (computer vs.
- Trial name
- NCT01370226
- Testing
- CBI, TBI
- Where
- United States
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Tobacco Use, Alcohol Abuse
Tobacco, Alcohol, Prescription Drug, and Illicit Substance Use- Electronic Spanish Platform
The goal of this study is to validate the TAPS-ESP as a screen and assessment that can be used in primary care for the screening and treatment of substance use.
- Conditions
- Tobacco Use, Alcohol Abuse, Prescription Drug Abuse, Substance Use
- Trial name
- TAPS-ESP (NCT05476588)
- Testing
- Screening
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Baylor Research Institute
Substance Abuse
Integrated Care (iCare) at Mount Sinai to Improve Substance Use Diagnosis and Treatment Practices in HIV Clinic Settings
Substance abuse and dependence is highly prevalent among people living with HIV and significantly exacerbates morbidity and mortality and accelerates HIV disease progression.
- Trial name
- NCT03092596
- Testing
- Patient-administered screening tool, Patient health navigator-administered screening tool, Patient health navigator-assisted linkage to treatment
- Where
- United States
- Volunteers
- 3,358 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Alcoholism, Child Abuse, Sexual
Group Therapies for Reducing HIV-risk Behavior in Women Who Have Survived Childhood Sexual Abuse
This study will evaluate the effectiveness of trauma-focused group therapy for reducing HIV-risk behavior and revictimization among adult women survivors of childhood sexual abuse (CSA).
- Conditions
- Alcoholism, Child Abuse, Sexual, Sexual Abuse, Sexual Behavior
- Trial name
- NCT00220597
- Testing
- Trauma-focused group therapy
- Where
- United States
- Volunteers
- 171 people, healthy volunteers welcome
- Sponsor
- Stanford University
College Drinking
Text-based Alcohol Prevention for First Year College Students
This project aims to combat excessive perceived norms that contribute to high volume drinking by young adults, which adversely affects health and academic achievement.
- Trial name
- NCT03864237
- Testing
- Alcohol texts, Attention control
- Where
- United States
- Volunteers
- 121 people, healthy volunteers welcome
- Sponsor
- Brown University
Alcohol Abuse
Alcohol Early Intervention for Freshmen
Alcohol abuse among college students is a significant and long-standing public health issue. The transition into college is marked by substantial increases in alcohol abuse and problems, suggesting the importance of interventions…
- Trial name
- Transitions (NCT00852033)
- Testing
- Brief Motivational Intervention (BMI), Parent Based Intervention plus booster, Combined brief motivational intervention and parent based intervention plus boosters for both interventions
- Where
- United States
- Volunteers
- 1,014 people, healthy volunteers welcome
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Alcohol Use Disorder (AUD), Healthy Controls Group - Age and Sex-matched
Imaging Mitochondrial Complex-I in Alcohol Use Disorder
Studies proposed in this application will image mitochondrial Complex-I (MCI-I) and cerebral glucose metabolism (CGM) in alcohol use disorder (AUD) and matched healthy controls
- Trial name
- NCT07825818
- Testing
- [F-18]BCPP-EF, [F-18]FDG
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Rajesh Narendran