Clinical trials: Addiction, Alcohol
Cigarette Smoking
Tailored Tobacco Quitline for Rural Veterans
The proposed work is designed to help increase access to tobacco cessation services among rural veterans and to develop more effective treatment services that better address comorbid issues commonly experienced by rural smokers.
- Trial name
- NCT01592695
- Testing
- Nicotine replacement therapy - transdermal nicotine patch, Tailored behavioral intervention, Tobacco quit line referral
- Where
- United States
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Iowa City Veterans Affairs Medical Center
Alcohol Dependence
Glycine and Oral D-Cycloserine in Alcoholic Patients and Healthy Subjects
Question #1: Will glycine ameliorate cognitive deficits? Hypothesis #1: Based on positive findings conducted with glycine and milacemide, a glycine prodrug, in schizophrenia and dementia, we expect that glycine will ameliorate…
- Trial name
- NCT00635102
- Testing
- D-Cycloserine PO and Glycine IV
- Where
- United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Yale University
Tobacco Abstinence
Varenicline For Smokers In Recovery From Alcohol Dependence
The goal of this proposal is to explore the potential effectiveness of varenicline to treat tobacco dependence among recovering alcoholic smokers who, as a group, are at high risk for tobacco-caused morbidity and mortality.
- Trial name
- NCT01092702
- Testing
- Varenicline
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Cannabis Use, Alcohol Use Disorder
VRT as a Biomarker of Cerebellar Dysfunction in Chronic Cannabis Use
Chronic cannabis consumption has been associated with poor psychosocial functioning that could be associated to cerebellar dysfunction.
- Conditions
- Cannabis Use, Alcohol Use Disorder, Healthy
- Trial name
- NCT03662737
- Testing
- Visuomotor adaptation task
- Where
- Spain
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Hospital Clinic of Barcelona
Alcohol Use Disorder
Alcohol Use and Mental Health - Pilot Test of Video-assisted Drinking Topography
The overall goal is to pilot test and establish a procedure for video-assisted alcohol topography and explore its utility as an indicator of alcohol use disorder.
- Trial name
- NCT03314454
- Testing
- Beer, Videotaped drinking session
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- University of Florida
Loneliness, Depression
Isolated During COVID-19: Effects of COVID-19's Social Restrictions on Loneliness and Psychosocial Symptomatology
This study seeks to gather data and insight on epidemiologic trends of loneliness and other behaviors in the wake of the CDC recommended "social distancing" during the COVID-19 pandemic.
- Conditions
- Loneliness, Depression, Anxiety, Alcohol Abuse
- Trial name
- NCT04440098
- Where
- United States
- Volunteers
- 1,008 people, healthy volunteers welcome
- Sponsor
- University of Miami
Alcohol Use Disorder, Nicotine Use Disorder
Neurobiology of Alcohol and Nicotine Co-Addiction
This proposal addresses the critical absence of information about the neurobiology of recovery from Alcohol Use Disorder (AUD) in alcohol and nicotine users.
- Trial name
- NAUD (NCT03338933)
- Testing
- magnetic resonance imaging (MRI)
- Where
- United States
- Volunteers
- 109 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Alcohol-Related Disorders, Alcohol Dependence
Acamprosate to Reduce Symptoms of Alcohol Withdrawal
This study will examine whether a new drug called acamprosate can be helpful for alcohol withdrawal, a result of drinking high amounts of alcohol for long periods of time.
- Conditions
- Alcohol-Related Disorders, Alcohol Dependence, Alcoholism, Healthy Volunteer
- Trial name
- NCT00106106
- Testing
- NMR-spectroscopy, Oral acamprosate
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
Alcohol Consumption, Alcohol Abuse
Reducing Hazardous Alcohol Use in Social Networks Using Targeted Intervention
Alcohol use is almost ubiquitous on college campuses and first-year students are at particularly high risk of alcohol-related harm when they first make the transition to college.
- Trial name
- NCT02895984
- Testing
- Single-session alcohol intervention (BMI)
- Volunteers
- 1,424 people, healthy volunteers welcome
- Sponsor
- Brown University
Alcoholism
Effects of Alcohol on Simulated Driving
Previous studies have shown that alcohol significantly impairs driving performance. Acute alcohol administration also has a detrimental effect on secondary task performance during dual-tasks.
- Trial name
- NCT00477984
- Testing
- alcohol
- Where
- Netherlands
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Utrecht Institute for Pharmaceutical Sciences
Alcohol Drinking, Alcohol-Related Disorders
COVID-19 Pandemic Impact on Alcohol (PIA) - A Natural History Study
Background: The SARS-CoV-2 virus has caused a pandemic infection called COVID-19. It is a global threat to people, communities, and health systems. Researchers are concerned about the mental health effects of the pandemic.
- Conditions
- Alcohol Drinking, Alcohol-Related Disorders, Pandemic, Psychological Stress
- Trial name
- NCT04391816
- Where
- United States
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Tobacco Dependence, Alcohol Dependence
Effect of Varenicline on Reactivity to Smoking and Drinking Cues
Alcohol and nicotine dependence are often co-morbid, with 85% of alcoholics also smoking. However, very little research has been conducted into the nature of this co-occurrence.
- Trial name
- NCT00873535
- Testing
- Varenicline
- Where
- Canada
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health
Alcohol Use Disorder, Opioid Use Disorder
Developing e-Covery, an App-based Intervention to Support Individuals With Co-occurring Problem Alcohol and Opioid Use
This project aims to improve the health of individuals engaged in co-occurring alcohol and opioid use by supporting the maintenance of behavior change initiated in substance use treatment.
- Trial name
- NCT05325788
- Testing
- e-Covery, Comparator Condition
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Yale University
Asperger's Disorder, Asperger Disorder
QAIAx - SGI/SI Smart Health Cities: Microcity Enclave Program (Quantum SI/AGI Agency a/k/a AI City Hall Project - UPSTO App Nos. 64/074,526, 64/063,557, 64/105,164, 63/903,181, 63/729,428, 64/125,360; USPTO EO 9424 Assignment ID: 2101042 / ARN: REEL/FRAME: 76481/0026 - OUSD-R&E, Department of War)
BRIEF SUMMARY A. "What is the purpose of this study?" BACKGROUND. The QAIAx clinical trial (Quantum SI/SGI Public Health Agency), known operationally as the "AI City Hall Project," represents a landmark intergovernmental research…
- Conditions
- Asperger's Disorder, Asperger Disorder, Autism Disorder, Autism
- Trial name
- QAIAx (NCT07661823)
- Testing
- AI City Hall Project (AIhealth4u - Public Health Central), AI City Hall Project (QAIAx Microcity A - AI Public Health Central)
- Where
- United States
- Volunteers
- 1,000,000 people, healthy volunteers welcome
- Sponsor
- Veterans Recovery Network Inc.
Alcohol Abuse, Impulsive Behavior
Effects of Tolcapone on Decision Making and Alcohol Intake in Alcohol Users
The purpose of this study is to determine the effects of tolcapone on decision making and alcohol intake using a laboratory bar (on-site alcohol self-administration) in alcohol drinkers.
- Trial name
- NCT02740582
- Testing
- Tolcapone
- Where
- 2 sites in United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Jennifer Mitchell
Alcohol Use Disorder
Pilot Trial to Evaluate PROblem Solving Therapy and APPLE Watch for College Students
The goals of this Pilot Trial are to test the preliminary efficacy of Problom-Solving Therapy (PST)-APPLE Watch in a 2-arm pilot Randomized Control Trial (RCT), vs education only-control to reduce alcohol use disorder symptoms…
- Trial name
- NCT06333288
- Testing
- PST-APPLE Watch group, Education-only control group
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
Social Skills, Self-Criticism
Development and Pilot Trial of an Intervention to Reduce Disclosure Recipients Negative Social Reactions and Victims Psychological Distress and Problem Drinking
The purpose of this randomized controlled trial is to evaluate an intervention, Supporting Survivors and Self: An Intervention for Social Supports of Survivors of Partner Abuse and Sexual Aggression (SSS).
- Conditions
- Social Skills, Self-Criticism, Post-traumatic Stress Disorder, Depression
- Trial name
- NCT03488927
- Testing
- Supporting Survivors and Self: An Intervention for Social Supports of Survivors of Partner Abuse and Sexual Aggression (SSS)
- Where
- United States
- Volunteers
- 1,268 people, healthy volunteers welcome
- Sponsor
- University of New Hampshire
Alcoholism
The Effects of Topiramate on Alcohol Use in Alcohol Dependent Subjects
This investigation will assess the effectiveness of topiramate in reducing ethanol consumption by alcohol dependent subjects. It also will seek to establish whether topiramate can be safely used in this population including…
- Trial name
- NCT00329407
- Testing
- Topiramate (Topamax)
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Boston University
Alcohol Use Disorder
Testing the Efficacy of an Online Integrated Treatment for Comorbid Alcohol Misuse and Emotional Problems
Considering the high comorbidity between alcohol use disorders and emotional problems, there is currently a need for accessible, integrated treatments designed to target both disorders simultaneously.
- Trial name
- NCT03406039
- Testing
- Integrated Online CBT and MI
- Where
- Canada
- Volunteers
- 273 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Alcohol Use Disorder
Learning and Relapse Risk in Alcohol Dependence (FP2)
The investigators will examine clinical alterations in learning and automated approach behaviour and their neurobiological correlates in alcohol-dependent patients and healthy social drinkers and assess whether they are affected…
- Trial name
- LeAD_FP2 (NCT02615977)
- Testing
- Zooming Joystick Task
- Where
- 3 sites in Germany
- Volunteers
- 258 people, healthy volunteers welcome
- Sponsor
- Technische Universität Dresden