Clinical trials: Addiction, Drug
Induced Pluripotent Stem Cells
Stem Cell Study of Genetics and Drug Addiction
Background: Researchers are interested in studying the roles that genes play in drug and alcohol addiction. Genes seem to account for about half of the differences between people who become addicted to drugs and people who do…
- Trial name
- NCT01534624
- Where
- United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Substance Use Disorders, Adolescent Behavior
Addiction in Adolescence - Pathomechanisms and Treatment Evaluation
This study aims to investigate the sociodemographic background as well as psychiatric comorbidities of adolescent substance users with substance use disorders.
- Trial name
- MATRIX-A (NCT03444974)
- Testing
- adapted treatment according to the MATRIX-A therapy
- Where
- Germany
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Technische Universität Dresden
Addictive Behavior, Alcohol Use Disorder
90-Day Online Substance Use Program
Individuals indicating risky substance use are randomly assigned either to a three-month online intervention on the Workit Health platform or a waitlist/treatment as usual.
- Conditions
- Addictive Behavior, Alcohol Use Disorder, Alcohol Abuse, Drug Abuse
- Trial name
- NCT03069118
- Testing
- Treatment - Workit Health Online Program, Control - Resource List
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Workit Health
Substance-Related Disorders
Brief Intervention in Primary Care for Problem Drug Use and Abuse
This study will examine the effectiveness of a brief intervention in a primary care setting to reduce drug use or abuse compared to enhanced care as usual.
- Trial name
- NCT00877331
- Testing
- Brief intervention using motivational interviewing
- Where
- United States
- Volunteers
- 868 people, healthy volunteers welcome
- Sponsor
- University of Washington
Cocaine-Related Disorders, Cocaine Addiction
Effects of Corticorelin Administration on Dopamine Transmission, Craving, and Mood in Cocaine Dependence
This study will, in a sample of cocaine-dependent and healthy control subjects, administer corticorelin and compare dopamine release between groups.
- Conditions
- Cocaine-Related Disorders, Cocaine Addiction, Substance-Related Disorders
- Trial name
- NCT01984177
- Testing
- Corticotropin-Releasing Hormone
- Where
- Canada
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health
Substance Use Disorder (SUD), Alcohol Use Disorder (AUD)
Metabolome and Gut Microbiome Changes During Smoking Cessation in Long-term Drug Therapy in a Therapeutic Community
Theoretical Framework: Cigarette smoking is the leading preventable cause of death worldwide, with nicotine dependence notably common among individuals with Substance Use Disorders (SUD).
- Conditions
- Substance Use Disorder (SUD), Alcohol Use Disorder (AUD), Nicotine Addiction, Healthy Adult Participants
- Trial name
- NCT06803706
- Testing
- 6-weeks CBT smoking cessation programme, Long-term drug therapy within a therapeutic community
- Where
- 3 sites in Austria
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- Sigmund Freud PrivatUniversitat
Substance Withdrawal Syndrome, Drug Withdrawal Symptoms
Therapeutic Massage to Manage Withdrawal Related Anxiety
In Canada, Addiction Prevention and Treatment Service's (APTS) offer programs specifically designed to help people withdrawal from psychoactive drugs.
- Conditions
- Substance Withdrawal Syndrome, Drug Withdrawal Symptoms, Anxiety
- Trial name
- NCT00992979
- Testing
- Therapeutic Massage, Relaxation Control
- Where
- Canada
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Dalhousie University
Drug Addiction, Executive Dysfunction
Bilateral Prefrontal Modulation in Alcoholism
In this study, eligible alcoholic inpatients recruited from a specialized clinic for addiction treatment, filling inclusion criteria and not showing any exclusion criteria, were randomized to receive the repetitive (10 sessions…
- Trial name
- tDCS_ALCOHOL (NCT02091284)
- Testing
- transcranial Direct Current Stimulation
- Where
- Brazil
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Federal University of Espirito Santo
HIV Infections, Opioid-Related Disorders
Drug Treatment Combined With Drug and Risk Reduction Counseling to Prevent of HIV Infection and Death Among Injection Drug Users
Drug abuse and HIV/AIDS are serious global health problems. Injection drug use is currently the major mode of transmission of HIV in many countries.
- Trial name
- NCT00270257
- Testing
- Buprenorphine/Naloxone
- Where
- 4 sites in China, Thailand
- Volunteers
- 1,251 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Substance-related Disorders, Alcohol-Related Disorders
LaunchPad: Supporting Healthy Decisions and Preventing Drug Use After High School
LaunchPad is an online substance use prevention program for high school seniors. The program is designed to help seniors develop skills and make informed decisions as they transition from high school to young adulthood.
- Conditions
- Substance-related Disorders, Alcohol-Related Disorders, Tobacco Use Disorder, Marijuana Use
- Trial name
- NCT07655609
- Testing
- Introduction, Norms re: Protective Behavior Strategies (PBS), Life Skills
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Prevention Strategies, LLC
Drug Misuse, Addiction
Construction of a Risk Screening Tool for New Psychoactive Substance Misuse Among Adolescents and Young Adults
The goal of this observational study is to construct a risk tool available for screening young adults and adolescents at high risk of drug misuse and provides a chance for early intervention to young adults and adolescents at…
- Trial name
- NCT06714578
- Testing
- Questionnaire and Physical Exam
- Where
- China
- Volunteers
- 1,035 people, healthy volunteers welcome
- Sponsor
- Wei XIA, PhD
Smoking Cessation, Smoking, Tobacco
Helping Poor Smokers Quit
Using a 2x2 randomized factorial design, we will conduct a statewide field trial in Missouri to compare the relative and combined effects of these two strategies for augmenting an existing, evidence-based tobacco quitline…
- Conditions
- Smoking Cessation, Smoking, Tobacco, Smoking, Cigarette, Smoking, Pipe
- Trial name
- NCT03194958
- Testing
- Specialized Quitline, Basic Needs Navigator
- Where
- United States
- Volunteers
- 1,944 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Drug Addiction, Smoking Cessation
Examining the Effect of the Nicotine Patch in Male and Female Smokers - 3
Treatment studies have demonstrated that current smoking cessation techniques are less effective for women. The purpose of this study is to determine the role that gender plays in the effectiveness of nicotine replacement…
- Trial name
- NCT00390559
- Testing
- nicotine transdermal system, Nicotine containing cigarette
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Opioid Use, Unspecified, Prescription Drug Abuse (Not Dependent)
An Opioid Prescribing Nudge
Analyze baseline concurrent opioid prescribing metrics at the individual prescriber level in the Duke Health System on the identified three main outcome measures.
- Conditions
- Opioid Use, Unspecified, Prescription Drug Abuse (Not Dependent), Prescription Drug Abuse and Dependency, Health Behavior
- Trial name
- OHS (NCT04069403)
- Testing
- Automated Reports on prescription patterns for their patients
- Where
- United States
- Volunteers
- 427 people, healthy volunteers welcome
- Sponsor
- Duke University
Tobacco Use Disorder
The Effects of Memantine and Bupropion on Acute, Reinforcing, and Conditioned Effects of Cigarettes - 1
One of nicotine's effects on the body is at the level of the NMDA receptors in the brain. Memantine is a drug that also affects NMDA receptors, making it a candidate for the treatment of nicotine addiction.
- Trial name
- NCT00136747
- Testing
- Memantine, bupropion
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Amphetamine Addiction
The Novel Addiction Assessment Study in Synthetic Drugs Addiction
The purpose of this research is to develop an objective assessment based on the virtual reality techniques which is used for evaluate addiction severity.
- Trial name
- NCT02950376
- Testing
- DSM-5 +Virtual reality-based addiction assessment system, Virtual reality-based addiction assessment system
- Where
- China
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Shanghai Mental Health Center
Opioid Addiction
Integrating Support Persons Into Recovery
INtegrated Support Persons Into Recovery (INSPIRE) is a 4-year research project that tests whether integrating a patient's support person into a patient's treatment with Buprenorphine/Naloxone can improve outcomes.
- Trial name
- INSPIRE (NCT04239235)
- Testing
- CRAFT
- Where
- 6 sites in United States
- Volunteers
- 439 people, healthy volunteers welcome
- Sponsor
- Stanford University
Drug Addiction
Project on tDCS Intervention to Enhance Advanced Social Cognitive Functions in Drug Rehabilitation Individuals
This project aims to explore key brain functional and biochemical indicators associated with impaired advanced social cognition through an integrated approach encompassing unconscious control, conscious control, cognitive…
- Trial name
- NCT06888700
- Testing
- Transcranial direct current stimulation
- Where
- China
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Shaanxi Normal University
Internet Addiction Disorder, Health Promotion
The Effect of Health Education on Digital Game Addiction and Health Promotion Behavior in Adolescents
This study aimed to evaluate the effectiveness of a school nurse-led health education program in reducing digital game addiction and improving health-promoting behaviors among adolescents.
- Conditions
- Internet Addiction Disorder, Health Promotion, Digital Game Addiction, Adolescent
- Trial name
- NCT07002515
- Testing
- Health Education Program
- Where
- Turkey (Türkiye)
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi Gulhane Tip Fakultesi
PTSD, Psychiatric Illness
Killing Pain - Use of Analgesic, Sedative and Anxiolytic Medication and the Development of Psychiatric Illness in Adolescents
Prescription of analgesic, sedative, and anxiolytic medication for children and adolescents is increasing in Western countries. In recent decades, rates have also increased in Norway, despite a relatively restrictive prescription…
- Conditions
- PTSD, Psychiatric Illness, Prescription Drug Dependence, Addiction
- Trial name
- NCT04336605
- Testing
- Age & Development, Socioeconomy, Traumatic Events
- Where
- Norway
- Volunteers
- 25,000 people, healthy volunteers welcome
- Sponsor
- Norwegian Center for Violence and Traumatic Stress Studies