Clinical trials: Adenomas Serrated
Colon Polyp, Adenoma Colon
AmplifEYE Colonoscopy vs Standard Colonoscopy
Colonoscopy screening is proven to reduce mortality rates for colorectal cancer, which relies on early detection and removal of colonic polyps.
- Conditions
- Colon Polyp, Adenoma Colon, Serrated Polyp, Colonic Neoplasms
- Trial name
- NCT03814369
- Testing
- AmplifEYE
- Where
- Hong Kong
- Volunteers
- 355 people, healthy volunteers welcome
- Sponsor
- Queen Elizabeth Hospital, Hong Kong
Colorectal Cancer
Clinical Validation of PolyDeep: an Artificial Intelligence-based Computer-aided Polyp Detection (CADe) and Characterization (CADx) System. Polydeep Advance 3
This study is a clinical validation of PolyDeep, a computer-aided polyp detection (CADe) and characterization (CADx) system. PolyDeep Advance 3 is a multicentric randomized clinical trial comparing high definition colonoscopy…
- Trial name
- NCT05513261
- Testing
- High definition colonoscopy (standard colonoscopy) in Adenoma Detection Rate, PolyDeep assisted high definition colonoscopy (CAD system) in Adenoma Detection Rate
- Where
- 3 sites in Spain
- Volunteers
- 857 people
- Sponsor
- Fundacin Biomedica Galicia Sur
Artificial Intelligence
Artificial Intelligence (AI) Assisted Real-time Adenoma Detection and Classification During Colonoscopies
This is a pragmatic, double-blind, randomized, controlled trial, to evaluate the effect of implementing a Computer-assisted detection (CADe) system within the routine clinical practice of Canadian healthcare institutions.
- Trial name
- CAG-SIG-AI (NCT05244278)
- Testing
- Medtronic-GI genius (CADe system for detecting colorectal polyps)
- Where
- Canada
- Volunteers
- 1,596 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Colon Polyp, Adenoma
Six Versus Twelve Month Index Follow-up After Large Colon Polyp Resection
The study will compare the use of a 6-month follow-up vs a 12-month follow-up after the removal of a large non-pedunculated polyp 20-50mm in size and without high grade dysplasia.
- Conditions
- Colon Polyp, Adenoma, Serrated Polyp, Recurrence, Local Neoplasm
- Trial name
- STARLING (NCT07198945)
- Testing
- 6-month follow-up, 12-month follow-up
- Where
- 10 sites in United States, Canada and 1 more
- Volunteers
- 546 people
- Sponsor
- Indiana University
Sessile Serrated Adenoma
Use of a Distal Colonoscope Attachment to Increase Detection of Sessile Serrated Adenomas
This study evaluates whether the use of a disposable colonoscope attachment, Endocuff Vision, can increase the detection of sessile serrated adenomas.
- Trial name
- NCT03560037
- Testing
- Endocuff Vision Assisted Colonoscopy
- Where
- United States
- Volunteers
- 427 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Colorectal Neoplasms, Colorectal Polyp
MS Versus NICE for Colorectal Lesions
OBJECTIVE: Our study aimed to compare a recently-developed endoscopic classification with an established one for colorectal lesions in a randomised trial between 2013 and 2015.
- Trial name
- NCT02963207
- Testing
- Modified Sano's classification, NICE classification
- Volunteers
- 348 people, healthy volunteers welcome
- Sponsor
- Lyell McEwin Hospital
Colorectal Cancer, Adenoma
Cold Snare Polypectomy Versus Endoscopic Mucosal Resection for Colonic Sessile Serrated Polyps
Comparing the efficacy of cold snare polypectomy with endoscopic mucosal resection
- Trial name
- CSP-EMR (NCT02967107)
- Testing
- Cold snare polypectomy, Endoscopic mucosal resection
- Where
- Australia
- Volunteers
- 474 people
- Sponsor
- Western Sydney Local Health District
Serrated Polyp, Hyperplastic Polyp
Study of Gut Microbiome and Colorectal Tumors
Gut microbiota were assessed in 540 colonoscopy-screened adults by 16S rRNA gene sequencing of stool samples. Investigators compared gut microbiota diversity, overall composition, and normalized taxon abundance among these groups.
- Conditions
- Serrated Polyp, Hyperplastic Polyp, Sessile Serrated Adenoma, Colorectal Cancer
- Trial name
- NCT03297996
- Testing
- Mobio PowerSoil DNA Isolation Kit
- Where
- United States
- Volunteers
- 540 people
- Sponsor
- NYU Langone Health
Colorectal Serrated Adenomas, Colorectal Tubular Adenomas
Minimizing the Risk of Metachronous Adenomas of the Colorectum With Green Tea Extract -MIRACLE-
This is a randomized, placebo controlled, multicentric trial to investigate the effect of diet supplementation with green tea extract containing 300mg epigallocatechin gallate (EGCG), the major polyphenol of green tea, on the…
- Conditions
- Colorectal Serrated Adenomas, Colorectal Tubular Adenomas, Colorectal Villous Adenomas, Colorectal Tubulovillous Adenomas
- Trial name
- MIRACLE (NCT01360320)
- Testing
- Green tea extract of Camellia Sinensis
- Where
- 21 sites in Germany
- Volunteers
- 1,001 people
- Sponsor
- Martin-Luther-Universität Halle-Wittenberg
Colonic Polyps, Colon Neoplasms
Precision of Optical Diagnosis in Polyps Between 5-15 mm and Its Implications on Surveillance. A Prospective, Multicenter Study.
This study evaluates the ability of endoscopists to perform a complete optical diagnosis of colorectal polyps between 5 and 15 mm, and the impact of the only endoscopic diagnosis on the follow-up program for those patients.
- Conditions
- Colonic Polyps, Colon Neoplasms, Colon Cancer, Serrated Adenoma
- Trial name
- POPS (NCT04232176)
- Where
- Spain
- Volunteers
- 545 people
- Sponsor
- University Hospital Virgen de las Nieves
Colorectal Neoplasms, Colonic Polyps
Evaluation of Versatile Intelligent Staining Technology (VIST) and Spectral Flexible Imaging (SFI) for Detection and Optical Characterization of Colorectal Lesions: A Prospective Randomized Controlled Study
This prospective randomized controlled study aims to evaluate the diagnostic accuracy of Versatile Intelligent Staining Technology (VIST) and Spectral Flexible Imaging (SFI) for detection and optical characterization of…
- Conditions
- Colorectal Neoplasms, Colonic Polyps, Adenoma, Serrated Polyps
- Trial name
- INSIGHT (NCT07797361)
- Testing
- White Light Endoscopy, Versatile Intelligent Staining Technology, Spectral Flexible Imaging
- Where
- Brazil
- Volunteers
- 990 people
- Sponsor
- Alexandre Vontobel Padoin
Colon Adenomas, Colon Polyps
Impact of Computer-aided Detection System on the Right Colon Adenoma Miss Rate
This is a prospective, multicenter randomized controlled trial designed to determine whether the use of computer-aided detection system could reduce the miss rates of adenomas, SSLs, and polyps in the proximal colon during tandem…
- Conditions
- Colon Adenomas, Colon Polyps, Sessile Serrated Lesion
- Trial name
- NCT07308743
- Testing
- Computer-aided detection-assisted colonoscopy, Conventional white-light colonoscopy
- Where
- China
- Volunteers
- 686 people, healthy volunteers welcome
- Sponsor
- Nanfang Hospital, Southern Medical University
Adenomatous Polyps
Non-invasive Risk Stratification of CR AMN/SSP
The purpose of this study is to determine the clinical utility of stool and blood methylation tests for detection of advanced mucosal neoplasia (AMN) and sessile serrated polyps (SSP).
- Trial name
- FIT (NCT02476682)
- Testing
- blood or stool samples will be collected
- Where
- Australia
- Volunteers
- 205 people, healthy volunteers welcome
- Sponsor
- Professor Michael Bourke
Colonic Neoplasms, Adenomas Serrated
Detection in Tandem Endocuff Cap Trial
A randomised back to back study comparing cap and Endocuff to detect adenomas during colonoscopy
- Conditions
- Colonic Neoplasms, Adenomas Serrated, Colo-rectal Cancer, Colon Adenoma
- Trial name
- DETECT (NCT03254498)
- Testing
- Endocuff, cap assisted colonoscopy (CAC)
- Where
- United Kingdom
- Volunteers
- 154 people
- Sponsor
- London North West Healthcare NHS Trust
Colorectal Cancer, Serrated Adenomas
Acetic Acid Colonoscopy Enhancement Study
The purpose of this study is to compare the additional diagnostic yield obtained by using the acetic acid as vital substance to improve the detection of serrated lesions at colonoscopy.
- Conditions
- Colorectal Cancer, Serrated Adenomas, Colon Nos Polypectomy Tubular Adenoma
- Trial name
- NCT02231385
- Testing
- Acetic Acid
- Where
- 2 sites in Italy
- Volunteers
- 500 people
- Sponsor
- Istituto Clinico Humanitas
Colorectal Cancer, Colon Adenoma
Risk of Metachronous Findings After Detection of Serrated Lesions and High-grade Dysplasia With Surveillance Delay
The primary aim of this study is to determine the rate of total metachronous advanced neoplasia (TMAN) detection after index detection of serrated lesions (SL) [sessile serrated polyps (SSPs), traditional serrated adenomas…
- Trial name
- SSL follow-up (NCT05355363)
- Testing
- Standard Colonoscopy
- Where
- Canada
- Volunteers
- 727 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Colorectal Cancer, Colorectal Neoplasms
Early Detection of Advanced Adenomas and Colorectal Cancer
This study aims to develop a highly sensitive, specific, and cost-effective blood assay for early detection of colorectal adenomas and cancer, using advanced machine learning and state-of-the-art biological analyses.
- Conditions
- Colorectal Cancer, Colorectal Neoplasms, Colorectal Polyp, Colorectal Adenocarcinoma
- Trial name
- AACRC (NCT06342440)
- Testing
- DENEB
- Where
- 6 sites in United States, China and 3 more
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- City of Hope Medical Center
Colorectal Adenoma, Sessile Serrated Lesion
Evaluation of 'WAYMED Endo CL CS' for Automated Detection and Diagnosis of Colorectal Adenoma and Non-Adenoma Lesions
The purpose of this clinical trial is to evaluate the effectiveness of the computer-aided diagnosis (CADx) software, 'WAYMED endo CL CS', which assists medical specialists by automatically analyzing colorectal endoscopic images…
- Conditions
- Colorectal Adenoma, Sessile Serrated Lesion, Hyperplastic Polyp, Carcinoma
- Trial name
- NCT07470827
- Testing
- WAYMED endo CL CS, Reference standard review
- Where
- South Korea
- Volunteers
- 1,178 people
- Sponsor
- WAYCEN Inc
Polyposis
Endocuff for Surveillance of Serrated Polyposis Syndrome
Serrated Polyposis Syndrome (SPS) is a high-risk condition for colorectal cancer (CRC). SPS patients have a cumulative CRC risk of 1.9% in 5 years despite a strict endoscopic surveillance in specialized centers.
- Trial name
- NCT02592603
- Testing
- Endocuff-assisted Colonoscopy
- Where
- Spain
- Volunteers
- 125 people
- Sponsor
- Hospital Clinic of Barcelona
Colon Polyps
Prospective Study of Colon Serrated Polyps
With this study, the investigators plan to review the clinical, epidemiology, pathology, and endoscopic features of colon serrated lesions as well as outcome of endoscopic resection of these lesions.
- Trial name
- NCT02332785
- Testing
- Data Collection
- Where
- United States
- Volunteers
- 10,000 people
- Sponsor
- M.D. Anderson Cancer Center