Clinical trials: Adenosine
ST-elevation Myocardial Infarction (STEMI)
REperfusion Facilitated by LOcal Adjunctive Therapy in ST-elevation Myocardial Infarction
The purpose of this study is to determine whether intra-coronary adenosine or sodium nitroprusside (SNP) delivered selectively via a thrombus aspiration catheter (or if unsuccessful via a coronary microcatheter) following…
- Trial name
- REFLO-STEMI (NCT01747174)
- Testing
- IC Adenosine, IC Sodium nitroprusside (SNP), Standard PCI
- Where
- 4 sites in United Kingdom
- Volunteers
- 247 people
- Sponsor
- University Hospitals, Leicester
Sickle Cell Disease
Adenosine 2A Agonist Lexiscan in Children and Adults With Sickle Cell Disease
Sickle cell disease (SCD) is an inherited blood disorder that causes the red blood cells to change their shape from a round shape to a half-moon/crescent or sickled shape.
- Trial name
- NCT01085201
- Testing
- Lexiscan
- Where
- 7 sites in United States
- Volunteers
- 39 people
- Sponsor
- Dana-Farber Cancer Institute
Coronary Artery Disease
Myocardial Blood Flow by PET and N-13 Ammonia During Regadenoson vs Adenosine Stress
Blockage of the heart arteries (coronary artery disease) can lead to angina (chest pain), heart attacks, heart failure, and/or death.
- Trial name
- NCT01370265
- Testing
- Regadenoson, Adenosine, N-13 ammonia
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Chronic Cough, Bronchiectasis
ATP and Capsaicin Cough Provocation Test in Chronic Cough and Bronchiectasis
This is a randomized, cross-over, single-blind trial. Eligible patients will be randomly assigned to undergo either capsaicin or adenosine triphosphate (ATP) cough provocation test, followed by a washout period of 2 to 14 days.
- Trial name
- NCT03638063
- Testing
- Adenosine Triphosphate, capsaicin
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Guangzhou Institute of Respiratory Disease
Narcolepsy
The Effect of Caffeine on the Narcoleptic Patients
Caffeine may be playing a beneficial role in patients with narcolepsy. However, the relationship between caffeine and its effects on narcoleptic patients has not been examined, and it is also unclear whether caffeine provides a…
- Trial name
- NCT02832336
- Testing
- Vivarin, Fiber
- Where
- Saudi Arabia
- Volunteers
- 16 people
- Sponsor
- King Saud University
Hypotension Symptomatic, Ischemic Heart Disease
A Validation Study of Nitroglycerin Induced Acute Drop of Pd/Pa (NTG-Pd/Pa) in Clinical Practice
Hyperemia with adenosine was an elemental process in FFR examination. Adenosine injection will induce some discomfort, and increase cost expenditure.
- Trial name
- NCT04700397
- Testing
- Nitroglycerine
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- National Taiwan University Hospital Hsin-Chu Branch
Study Genetic Basis of Infantile Onset Diabetes Mellitus
Gene Study for Infantile Onset Diabetes
Diabetes mellitus is a group of metabolic diseases characterized by chronic hyperglycemia resulting from defects in insulin secretion, insulin action, or both.
- Trial name
- NCT03169413
- Testing
- Human Leucocytic antigen typing and mutation of adenosine triphosphate sensitive K channel gene in diabetic patients diagnosed under the age of one year.
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Assiut University
Coronary Artery Disease
Ticagrelor vs Clopidogrel Effect on MFR in CAD Population
Ticagrelor is one of 3 anti-platelet medications used in patients with acute coronary syndrome (ACS) to prevent further clot formation and further ischemic damage to myocardial tissue.
- Trial name
- PATH (NCT01894789)
- Testing
- Ticagrelor, Clopidogrel
- Where
- Canada
- Volunteers
- 36 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Prostate Cancer, Metastatic Castration-Resistant Prostate Cancer (mCRPC)
An Open-label, Phase II Study of AZD4635 in Patients With Prostate Cancer
This is an open-label Phase II modular study in participants with prostate cancer which will assess safety, efficacy, and tolerability of AZD4635 in combination with other therapeutic agents in different treatment arms (referred…
- Trial name
- NCT04089553
- Testing
- AZD4635, Oleclumab, Durvalumab
- Where
- 9 sites in United States
- Volunteers
- 59 people
- Sponsor
- AstraZeneca
Severe Combined Immunodeficiency Due to ADA Deficiency
Efficacy and Safety of the Cryopreserved Formulation of OTL-101 in Subjects With ADA-SCID
This is a prospective, non-randomized, single-cohort, longitudinal, single-center, clinical study designed to assess the efficacy and safety of a cryopreserved formulation of OTL-101 (autologous CD34+ hematopoietic…
- Trial name
- NCT02999984
- Testing
- Infusion of autologous cryopreserved EFS-ADA LV CD34+ cells (OTL-101), busulfan, PEG-ADA ERT
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of California, Los Angeles
Obstructive Sleep Apnea
Regulation of Vascular Thrombosis in Sleep Apnea
Sleep Apnea is a prevalent condition that has been increasingly diagnosed in the adult population and is now considered an independent risk factor for the development of cardiovascular disease.
- Trial name
- NCT00859690
- Volunteers
- 14 people
- Sponsor
- Weill Medical College of Cornell University
Severe Combined Immunodeficiency Due to ADA Deficiency
Evaluating the Effectiveness of STRIMVELIS Risk Minimization Measures (RMMs)
STRIMVELIS is a medicinal product that restores adenosine deaminase (ADA) function in hematopoietic cell lineages, thereby preventing impaired immune function.
- Trial name
- NCT03232203
- Testing
- STRIMVELIS
- Where
- Italy
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Fondazione Telethon
Hyperlipidemia
A Study Of Pharmacokinetics, Pharmacodynamics And Safety Of Adding ETC-1002 To Atorvastatin 80 mg
The purpose of this research study is to measure the amount of atorvastatin and ETC-1002 in the blood, to determine how ETC-1002 affects the level of LDL-cholesterol (bad cholesterol) and other markers of health and disease in…
- Trial name
- NCT02659397
- Testing
- ETC-1002, Atorvastatin
- Where
- 19 sites in United States
- Volunteers
- 68 people
- Sponsor
- Esperion Therapeutics, Inc.
Ovarian Neoplasms
A Study of Niraparib Combined With Bevacizumab Maintenance Treatment in Participants With Advanced Ovarian Cancer Following Response on Front-Line Platinum-Based Chemotherapy
Niraparib is an oral inhibitor of poly adenosine diphosphate-ribose polymerase (PARP)-1 and PARP-2. This study will evaluate safety and efficacy of niraparib combined with bevacizumab as maintenance treatment in participants with…
- Trial name
- NCT03326193
- Testing
- Niraparib, Bevacizumab
- Where
- 29 sites in United States
- Volunteers
- 105 people
- Sponsor
- Tesaro, Inc.
Healthy Volunteer/DDI Study
A Study to Assess the Effect of Fluvoxamine and Smoking on Pharmacokinetics ( the Movement of Drugs Within the Body) of AZD4635 in Healthy Volunteers
This study is a Phase I, open-label, non-randomized, 2-period, fixed-sequence study in healthy volunteers who are either smokers or non-smokers, performed at a single Clinical Unit.
- Trial name
- NCT04478513
- Testing
- AZD4635, Fluvoxamine
- Where
- United Kingdom
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Amyotrophic Lateral Sclerosis, Adenosine Triphosphate Activities
Effect of Terazosin on ATP Levels in People With Amyotrophic Lateral Sclerosis
This will be a single center, randomized, double-blind, placebo-controlled pilot study to assess the safety and tolerability of terazosin (TZ) at a dose of 5 milligrams (mg) per os (PO) daily for patients with amyotrophic lateral…
- Trial name
- TZ-ALS (NCT07224269)
- Testing
- Terazosine
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Iowa
Supraventricular Tachycardia
Simulation of Adenosine Push Methods for Treatment of SVT Using Agitated Saline Visualized by Ultrasound
Supraventricular tachycardia (SVT) is an abnormally fast heart rhythm arising from improper electrical activity in the upper part of the heart.
- Trial name
- NCT04051541
- Testing
- Agitated saline push
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- HealthPartners Institute
Cardiovascular Disease, Ischemia-Reperfusion Injury
Does Caffeine Reduce Dipyridamole-Induced Protection Against Ischemia-Reperfusion Injury?
The purpose of this project is to explore the interaction between caffeine and dipyridamole on ischemia-reperfusion injury in the forearm.
- Trial name
- NCT00430170
- Testing
- Dipyridamole, caffeine
- Where
- Netherlands
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Renal Cell Carcinoma
Phase 1b/2 Trial of Ipilimumab, Nivolumab, and Ciforadenant (Adenosine A2a Receptor Antagonist) in First-line Advanced Renal Cell Carcinoma.
To learn if the combination of ciforadenant, ipilimumab, and nivolumab can help to control advanced renal cell carcinoma
- Trial name
- NCT05501054
- Testing
- Ipilimumab, Nivolumab, Ciforadenant
- Where
- 3 sites in United States
- Volunteers
- 50 people
- Sponsor
- M.D. Anderson Cancer Center
Chronic Stable Angina
Capadenoson in Angina Pectoris
This is a multi-center and multi-national,randomized, double blind, placebo-controlled, 28-day treatment study with BAY 68-4986 taken orally or a matching placebo.
- Trial name
- NCT00518921
- Testing
- Capadenoson (BAY 68-4986)
- Where
- 36 sites in Czechia, Hungary and 4 more
- Sponsor
- Bayer