Clinical trials: Adenosine
Venoarteriolar Reflex
Adenosine Activity in Producing Venoarteriolar Reflexes
Veno-arteriolar and veno- arteriolar-myogenic reflexes (VAR and VMR, respectively) are of the most important contributors to local vasoregulation.
- Trial name
- NCT01280071
- Testing
- aminophylline
- Sponsor
- Tel-Aviv Sourasky Medical Center
Atrial Fibrillation
Safety and Efficacy Study of an A1-Adenosine Receptor Agonist to Slow Heart Rate in Atrial Fibrillation
This study is designed to evaluate the safety of DTI-0009 in patients with atrial fibrillation and to find the dose of DTI-0009 that lowers heart rates in patients with atrial fibrillation with rapid ventricular response.
- Trial name
- NCT00040001
- Testing
- DTI-0009
- Where
- United States
- Sponsor
- Aderis Pharmaceuticals
Coronary Artery Disease, Myocardial Ischemia
Comparison of Hyperemic Efficacy Between Nicorandil and Adenosine for Fractional Flow Reserve (FFR) Measurement
The purpose of this study is to evaluate the efficacy of nicorandil in the achievement of maximal coronary hyperemia compared with adenosine.
- Trial name
- NCT01331902
- Testing
- Maximal Hyperemia with Adenosine Followed by Nicorandil, Maximal Hyperemia with Nicorandil Followed by Adenosine
- Where
- South Korea
- Volunteers
- 200 people
- Sponsor
- Seoul National University Hospital
Inflammation
Role of Adenosine in the Release of VEGF and Cytokines
The purpose of this study is to extend previous observations in animal models regarding the effects of adenosine in the release of cytokines to human subjects. We intend to accomplish this in two study protocols.
- Trial name
- NCT00580905
- Testing
- Adenosine, Sodium Nitroprusside
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Bronchial Hyperreactivity
Different End Points for Bronchial Hyperactivity (BHR) Tests.
Bronchial challenge tests (BCT) are being used to diagnose bronchial hyperactivity (BHR) and quantify its severity.In older children and adults, BCT is done using spirometry to measure the value of 20% fall in FEV1 as an…
- Trial name
- NCT01654588
- Where
- Israel
- Volunteers
- 501 people
- Sponsor
- Wolfson Medical Center
Patent Ductus Arteriosus
AMPLATZER Duct Occluder II Additional Sizes
The ADO II AS Study is a single arm, prospective, multicenter, nonrandomized clinical investigation to characterize the safety and effectiveness of the ADO II AS device in patients with a patent ductus arteriosus (PDA).
- Trial name
- ADO II AS (NCT03055858)
- Testing
- ADO II AS (PDA closure)
- Where
- 9 sites in United States
- Volunteers
- 200 people
- Sponsor
- Abbott Medical Devices
Coronary Angioplasty
Intracoronary Adenosine Administration to Prevent Periprocedural Myonecrosis in Elective Coronary Angioplasty
Aim of the study is to evaluate the benefits from adjunctive intracoronary administration of adenosin in elective patients undergoing coronary angioplasty.
- Trial name
- PREVENT-ICARUS (NCT01148147)
- Testing
- Adenosine
- Where
- Italy
- Volunteers
- 260 people
- Sponsor
- Azienda Ospedaliero Universitaria Maggiore della Carita
Angina Pectoris
Adenosine Cardioplegia; Improved Cardioprotection?
60 elective patients for CABG will be included to receive either standard hyperkalemic cardioplegia (St.Thomas Hospital Solution No I) or cardioplegia where supranormal potassium is replaced with 1.2 mM adenosine.
- Trial name
- NCT01123525
- Testing
- Adenosine
- Where
- Norway
- Volunteers
- 60 people
- Sponsor
- University Hospital of North Norway
Rheumatoid Arthritis
Oral CF101 Tablets Treatment in Patients With Rheumatoid Arthritis
This trial will test the hypothesis that the administration of CF101, a novel anti-inflammatory agent, to patients with rheumatoid arthritis and high A3AR expression at baseline will relieve signs and symptoms of the disease.
- Trial name
- NCT01034306
- Testing
- CF101
- Where
- 5 sites in Bulgaria, Israel
- Volunteers
- 79 people
- Sponsor
- Can-Fite BioPharma
Chronic Spontaneous Urticaria
Assessment of Serum Levels of Adenosine Deaminase and Immunoglobulin E in Patients With Chronic Spontaneous Urticaria
adenosine deaminase activity (ADA) has been reported to be elevated in various diseases such as psoriasis, acne and juvenile idiopathic arthritis.
- Trial name
- NCT05992987
- Testing
- Adenosine deaminase serum level, IgE antibodies serum level
- Volunteers
- 90 people
- Sponsor
- Sohag University
Breast Cancer
HKI-272 for HER2-Positive Breast Cancer and Brain Metastases
The purpose of this research study is to determine how well neratinib works in treating breast cancer that has spread to the brain.
- Trial name
- NCT01494662
- Testing
- HKI-272, Surgical Resection, Capecitabine
- Where
- 18 sites in United States
- Volunteers
- 140 people
- Sponsor
- Dana-Farber Cancer Institute
Validation Studies, Magnetic Resonance Spectroscopy
Magnetic Resonance & Optical Spectroscopy Validation
The purpose of this study is to develop and refine techniques for using magnetic resonance and optical spectroscopy to investigate how your body uses energy.
- Trial name
- NCT01827527
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- AdventHealth Translational Research Institute
Dental Caries, Dental Plaque
Effect of Xylitol- Versus Erythritol-Sweetened Mints on Plaque ATP-Bioluminescence Readings
This study will assess the effectiveness of erythritol and xylitol in suppressing biofilm activity, using both within-subject and between-group comparisons.
- Trial name
- NCT07902323
- Testing
- Xylitol, Erythritol
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Loma Linda University
Coronary Artery Disease, Cardiac Perfusion
Stress Adenosine Cardiac Magnetic Resonance (MR) Comparison With Single Photon Emission Computed Tomography (SPECT) Imaging
This study is designed to determine the diagnostic value of adenosine cardiac magnetic resonance (CMR) when compared with SPECT.
- Trial name
- NCT00864591
- Testing
- SPECT Imaging, Stress Adenosine CMR
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Sheba Medical Center
Atrial Fibrillation
Adenosine to Assess Complete Conduction Block During Catheter Ablation of Paroxysmal Atrial Fibrillation
The purpose of this study is to determine if additional ablation during the first procedure as the result of the ability to medically induce quiet atrial arrhythmias will improve clinical outcome in patients with atrial…
- Trial name
- NCT03032965
- Testing
- Adenosine, Isoproterenol
- Where
- United States
- Volunteers
- 131 people
- Sponsor
- University of Michigan
Acute Myeloid Leukemia, Recurrent Acute Myeloid Leukemia
8-Chloroadenosine in Combination With Venetoclax for the Treatment of Patients With Relapsed/Refractory Acute Myeloid Leukemia
This phase I trial tests the safety, side effects, and best dose of a new 8-chloroadenosine in combination with venetoclax in treating patients with acute myeloid leukemia that has come back (relapsed) or does not respond to…
- Conditions
- Acute Myeloid Leukemia, Recurrent Acute Myeloid Leukemia, Refractory Acute Myeloid Leukemia
- Trial name
- NCT05263284
- Testing
- 8-Chloroadenosine, Venetoclax
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- City of Hope Medical Center
Supra-ventricular Tachycardia
A Trial to Compare American Heart Association (AHA) and Simple (SIM)Method to Give Adenosine to Treat Supra-ventricular Tachycardia (SVT)
Study to compare non inferiority of giving adenosine with the simplified method vs the AHA method
- Trial name
- AHAvsSIM (NCT04392362)
- Testing
- Adenosine
- Where
- South Africa
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Pretoria
Acute Coronary Syndrome (ACS), High On-treatment Platelet Reactivity (HTPR)
The Effect of IV Cangrelor and Oral Ticagrelor Study
Major heart attacks are caused by a number of factors, the two major of which are furring up of a coronary artery with atheroma and then sudden clot formation on this area leading to a blockage and interruption of blood flow.
- Conditions
- Acute Coronary Syndrome (ACS), High On-treatment Platelet Reactivity (HTPR), Microvascular Obstruction (MVO), ST-segment Elevation Myocardial Infarction (STEMI)
- Trial name
- NCT02733341
- Testing
- Cangrelor, Ticagrelor
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- The Royal Wolverhampton Hospitals NHS Trust
Caffeine
Does Caffeine Facilitate Human Reward Learning Behaviors?
"Learning from the rewards" is underlying the formulation of knowledge and habits in daily life. Caffeine is the most commonly used "psychoactive" substance that could change one's mind state by affecting the brain and nervous…
- Trial name
- ADoRe (NCT05325502)
- Testing
- caffeine, mannitol
- Where
- Switzerland
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Yu-Shiuan Lin
ALS
Adenosine 2A Receptor Antagonism and AIH in ALS
The purpose of this research study is to determine the effects of a medication, istradefylline, in conjunction with breathing air with reduced oxygen for short periods of time (called acute intermittent hypoxia, or AIH), on…
- Trial name
- NCT05377424
- Testing
- Consume 20mg of istradefylline, Low Oxygen therapy
- Where
- 2 sites in United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Florida