Clinical trials: Adipose Tissue
Perianal Fistula, Primary; Complex
Follow-up Study of Autologous Adipose-derived Stem Cells (ANTG-ASC) for the Complex Fistula (ANTG-ASC-211)
This is an open follow-up clinical trial to evaluate a sustained efficacy and safety of ANTG-ASC injection for 4 months (6 months after final dose injection) after Phase II clinical trial.
- Trial name
- ANTG (NCT01623453)
- Testing
- Autologous adipose derived stem cells(low dose group), Autologous adipose derived stem cells(high dose group)
- Where
- 2 sites in South Korea
- Volunteers
- 6 people
- Sponsor
- Anterogen Co., Ltd.
Traumatic Brain Injury
Autologous Adipose-Derived Mesenchymal Stem Cells for Chronic Traumatic Brain Injury
The global objective of this study is to establish the safety and investigate the potential treatment effect of an intravenous infusion of HB-adMSCs (Hope Biosciences adipose-derived mesenchymal stem cells) on brain structure…
- Trial name
- NCT05951777
- Testing
- Autologous HB-adMSCs, Normal Saline
- Where
- 2 sites in United States
- Volunteers
- 51 people
- Sponsor
- Hope Biosciences LLC
Insulin Resistance, Type 2 Diabetes Mellitus
(Mol-SHARE) Molecular Study of Health Assessment and Risk in Ethnic Groups
The purpose of this study is to directly compare the body composition, body fat distribution, and morphological and functional features of adipose tissue and skeletal muscle between South Asians and European Caucasians.
- Conditions
- Insulin Resistance, Type 2 Diabetes Mellitus, Cardiovascular Diseases
- Trial name
- NCT00249314
- Where
- Canada
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Hamilton Health Sciences Corporation
Crohn
Study of Allogenic Adipose-derived Stem Cells in Crohn's Fistula
Adipose-derived stem cells have properties of differentiation to various types of cells, immunomodulatory effects. adipose-derived stem cells (ASCs) show also low immunogenicity.
- Trial name
- ALLO-ASC (NCT01440699)
- Testing
- Allogenic human adipose-derived stem cells
- Where
- 3 sites in South Korea
- Volunteers
- 6 people
- Sponsor
- Anterogen Co., Ltd.
Myxofibrosarcoma, Recurrent Adult Soft Tissue Sarcoma
Alisertib in Treating Patients With Advanced or Metastatic Sarcoma
This phase II trial studies how well alisertib works in treating patients with sarcoma that has spread to other places in the body and usually cannot be cured or controlled with treatment (advanced) or has spread to other places…
- Conditions
- Myxofibrosarcoma, Recurrent Adult Soft Tissue Sarcoma, Recurrent Leiomyosarcoma, Recurrent Liposarcoma
- Trial name
- NCT01653028
- Testing
- Alisertib, Laboratory Biomarker Analysis
- Where
- 235 sites in United States
- Volunteers
- 72 people
- Sponsor
- National Cancer Institute (NCI)
Complex Perianal Fistula
Clinical Trials of Autologous Cultured Adipose-derived Stem Cells (ANTG-ASC) on Complex Fistula
Mesenchymal stem cells derived from adipose tissue are pluripotent to differentiate into myocytes, adipocytes or others. They have an immunosuppressive activity. Complex perianal fistula is difficult to cure and easy to relapse.
- Trial name
- ANTG-ASC-210 (NCT01314092)
- Testing
- Autologous cultured adipose derived stem cells(low dose group), Autologous cultured adipose derived stem cells(high dose group)
- Where
- 6 sites in South Korea
- Volunteers
- 15 people
- Sponsor
- Anterogen Co., Ltd.
Obesity, Exercise
Exercise Training and Insulin Sensitivity
Regular exercise participation is known to reduce cardiometabolic disease risk but the impact that exercise training has on adipose tissue (AT) metabolism is poorly understood, particularly in humans.
- Trial name
- NCT05930834
- Testing
- exercise
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Insulin Resistance, Obesity
Integrating the Genetic and Metabolic Faces of Obesity
The goal of this study is to determine why some obese individuals develop insulin resistance and others do not. We hypothesize that an impairment in differentiation of fat cells (adipocytes) is responsible for the development of…
- Conditions
- Insulin Resistance, Obesity, Metabolic Syndrome
- Trial name
- NCT00285844
- Testing
- weight loss, thiazolidinedione
- Where
- United States
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Stanford University
Leiomyosarcoma, Liposarcoma
Lenvatinib and Eribulin in Advanced Soft Tissue Sarcoma
This study is designed to test the safety and efficacy of the combination of lenvatinib, a drug that can inhibit the growth of supplying vessels around the tumors, and eribulin, a chemotherapy drug that targets the cancer cell…
- Conditions
- Leiomyosarcoma, Liposarcoma, Soft Tissue Sarcoma Adult, Advanced Cancer
- Trial name
- LEADER (NCT03526679)
- Testing
- Eribulin, Lenvatinib
- Where
- 2 sites in Taiwan
- Volunteers
- 30 people
- Sponsor
- National Taiwan University Hospital
CABG, Visceral Adipose Tissue
Impact of Visceral Adiposity on Postoperative Atrial Fibrillation After CABG
Obesity has become a major public health problem in both developed and developing countries, with a continuous increase particularly since the 1980s.
- Conditions
- CABG, Visceral Adipose Tissue, Atrial Fibrillation (AF)
- Trial name
- NCT07467941
- Testing
- Postoperative AF Group, Non-AF Group
- Volunteers
- 300 people
- Sponsor
- Kartal Kosuyolu Yuksek Ihtisas Education and Research Hospital
HIV Infections
PREventing Progression of Adipose Tissue Redistribution
The main objective of the study is to assess changes in fat distribution over 48 weeks of treatment in patients who currently successfully use zidovudine (AZT) and lamivudine (3TC) as part of their regimen and who will either…
- Trial name
- NCT00389194
- Testing
- continuing AZT+3TC or switching AZT+3TC to TDF+ FTC
- Where
- Netherlands
- Volunteers
- 120 people
- Sponsor
- International Antiviral Therapy Evaluation Center
Parkinson's Disease
Study to Assess the Safety and Effects of Autologous Adipose-Derived SVF Cells in Patients With Parkinson's Disease
The intent of this clinical study is to answer the questions: 1. Is the proposed treatment safe 2. Is treatment effective in improving the disease pathology of patients with Parkinson's Disease and clinical outcomes.
- Trial name
- NCT01453803
- Testing
- Harvesting and Implantation of Adipose-Derived Stem Cells
- Where
- United States
- Sponsor
- Ageless Regenerative Institute
Idiopathic Parkinson Disease, Parkinson's Disease and Parkinsonism
Adipose-derived Stromal Vascular Fraction Cells to Treat Parkinson
This is an interventional study to treat 10 patients with a diagnosis of Parkinson's disease with neurological assessment from the Oxford Parkinson's Disease Quotient-39 (PDQ-39) and Movement Disorders Society Universal…
- Trial name
- SVFP1 (NCT05699161)
- Testing
- Adipose-derived stromal vascular fraction cells
- Where
- Nicaragua
- Volunteers
- 10 people
- Sponsor
- Samuel Vilchez, PhD
Obesity, Visceral, Obesity
Genes Variability in Obesity and Normal Body Weight Patients.
The goal of this clinical trial is to learn about variability of gene SCD and MT-ATP6 in describe participant population and health conditions.
- Trial name
- NCT05789888
- Testing
- MT-ATP6 mtDNA gene variability in obesity and normal body weight patients., SCD gene variability in obesity and normal body weight patients., Finding TOFI and FOTI phenotypes in participants with obesity and normal weight.
- Where
- Poland
- Volunteers
- 116 people
- Sponsor
- Medical University of Bialystok
Kidney Neoplasms
MRI Functional Imaging Characteristics and Fat Quantification of CT-fat-free Renal Neoplasms: Relationships With Histological Classifications and Molecular Markers
The knowledge of the histological diagnosis and its subtype of a renal parenchymal tumor is important for determine whether the choice of a specific regimen of chemotherapy, target therapy and immunotherapy could be suitable and…
- Trial name
- NCT06126159
- Testing
- multiparametric and fat-detection magnetic resonance imaging (MRI)
- Where
- Taiwan
- Volunteers
- 44 people
- Sponsor
- Chang Gung Memorial Hospital
Systemic Sclerosis
EFFECTS OF THE MICRO REINJECTION OF AUTOLOGOUS ADIPOSE TISSUE IN THE FACE OF PATIENTS WITH SYSTEMIC SCLEROSIS
This prospective single-center study evaluates a current care procedure. It includes 14 patients diagnosed with SSc according to the ACR/EULAR criteria or the Leroy \& Medsger criteria of the disease.
- Trial name
- FACE (NCT02206672)
- Testing
- Micro reinjection of autologus adipose tissue
- Where
- France
- Volunteers
- 15 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Obesity
Body Heat Content and Dissipation in Obese and Normal Weight Adults
This study will investigate how different parts of the body lose body heat and will measure the heat released by specific areas such as the limbs and abdomen.
- Trial name
- NCT00266500
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Rheumatoid Arthritis
A Nutritional Intervention for Arthritis
The purpose of the study is to assess whether, in individuals with rheumatoid arthritis, a low-fat, vegan diet improves pain and other subjective symptoms more effectively than a control supplement or a placebo.
- Trial name
- NCT01544101
- Testing
- Vegan Diet, dietary supplement omega3 fatty acids aand vitamins
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Physicians Committee for Responsible Medicine
Obesity
Identification of Novel Targets for Regulation of Adipose Tissue Mass
The aim of this study is to understand the metabolic changes occurring in fat tissue both during controlled weight loss that lead to the improvement of type 2 diabetes and other obesity associated metabolic disorders.
- Trial name
- NCT00773565
- Testing
- Optifast
- Where
- Germany
- Volunteers
- 62 people
- Sponsor
- Gottfried Rudofsky
Fibrosis
Growth Hormone as a Model for Reversible Activation of Adipose Tissue Fibrosis
Background: Adipose tissue fibrosis denotes excessive pathological accumulation of extracellular matrix (ECM) in adipose tissue and is a marker of dysfunction.
- Trial name
- NCT04998500
- Testing
- Growth hormone, saline and GH receptor blockade (Pegvisomant)
- Where
- Denmark
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Aarhus