Clinical trials: Adipose Tissue Inflammation
Knee Osteoarthritis
Circuit Training on Knee Osteoarthritis Patients
Introduction: The increase in intermuscular adipose tissue (IMAT) can contribute to muscle weakness and consequently on progression of knee OA.
- Trial name
- NCT02761590
- Testing
- Circuit training protocol
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- Universidade Federal de Sao Carlos
Obesity
Celecoxib Inhibition of Aromatase Expression and Inflammation in Adipose Tissue of Obese Postmenopausal Women
The study plans to find out whether Celebrex may be potentially useful to decrease inflammation in fat tissues and thereby lower the production of substances such as estrogens that may increase the risk of developing breast…
- Trial name
- NCT01901679
- Testing
- Celebrex
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Rockefeller University
Obesity, Morbid, NASH - Nonalcoholic Steatohepatitis
Investigating the Link Between Type 2 Immunity and NAFLD in Human Obesity
This study is being done to better understand the relationship between inflammation in adipose tissue (AT), abnormal deposition of fat around the liver and how this affects its appearance and function and ultimately insulin…
- Conditions
- Obesity, Morbid, NASH - Nonalcoholic Steatohepatitis, Chronic Inflammation
- Trial name
- NCT04232566
- Testing
- Bariatric surgery
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Overweight, Obese
Angiotensin II Blockade and Inflammation in Obesity
Overweight and obesity, which afflicts ~65% of the U.S. population and more than 1 billion people worldwide, increases the risk of developing hypertension.
- Conditions
- Overweight, Obese, Prehypertension, Hypertension
- Trial name
- ARB (NCT01684748)
- Testing
- Olmesartan medoxomil
- Volunteers
- 20 people
- Sponsor
- Virginia Polytechnic Institute and State University
Growth Hormone Deficiency
Effects of Growth Hormone Supplementation to Adults With Growth Hormone Deficient on Metabolism and Adipose Tissue Molecular Phenotype
This study is designed as a follow up study to that performed in 2005. In the Baseline study (2005) extensive clinical whole body metabolic phenotyping was combined with in depth molecular and cellular biology analyses aimed at…
- Trial name
- GHAT (NCT01616095)
- Where
- 3 sites in Slovakia
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Slovak Academy of Sciences
Cardiovascular Risk Factor
Peri-vascular Adipose Tissue Inflammation Evaluated Using Coronary CT Angiography
The P-VECT Study proposes to test the use of CCTA-derived FAI measurements in a group of patients with coronary artery inflammation, who will receive routinely-used statin and aspirin treatment.
- Trial name
- P-VECT (NCT04181749)
- Testing
- aspirin and atorvastatin
- Where
- 3 sites in United Kingdom
- Volunteers
- 200 people
- Sponsor
- University of Leicester
Body Fat Distribution, Cellulitis
Effect of Vibro-oscillatory Therapy for Improvement of Body Contour and Appearance of Cellulite.
OBJECTIVE: To evaluate the efficacy of vibro-oscillatory therapy through an electromedical equipment in improving body contour and appearance of cellulite.
- Trial name
- NCT03312946
- Testing
- Modellata
- Where
- Brazil
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Indústria Brasileira Equipamentos Médicos - IBRAMED
Cardiac Arrest, Inflammation
Immunoinflammatory Response in Post Cardiac Arrest Syndrome (PCAS)
This is a prospective, observational study to investigate molecular mechanisms mediating the systemic inflammatory process, and changes to metabolism, and their impact on brain injury, survival, and functional outcomes after…
- Conditions
- Cardiac Arrest, Inflammation, Obesity, Hypoxic Ischemic Encephalopathy (HIE)
- Trial name
- PCAS (NCT02664831)
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- MaineHealth
Obesity
Effect of Nicotinic Acid on Adipose Tissue Inflammation in Obese Subjects
Our working hypothesis postulates that lipolysis is a determinant of inflammation in adipose tissue (AT). Inhibition of lipolysis, e.g.
- Trial name
- ANITA (NCT01083329)
- Testing
- training, nicotinic acid
- Where
- France
- Volunteers
- 24 people
- Sponsor
- University Hospital, Toulouse
Obesity, Aging
Obesity, Inflammation and Aging: Effects of Physical Exercise and Omega-3 Fatty Acids.
Dysfunction of adipose tissue in obesity, inflammation and aging: mechanisms and effects of physical exercise and omega-3 fatty acids.
- Conditions
- Obesity, Aging, Inflammation
- Trial name
- OBELEX (NCT03300388)
- Testing
- Omega-3 (DHA-rich dietary supplement), Resistance training
- Where
- Spain
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Clinica Universidad de Navarra, Universidad de Navarra
Inflammation
Metabolic and Immune System Responses to a Mixed Meal
Overweight and obesity are major problems and their complications such as cardiovascular disease and type 2 diabetes mellitus pose great burdens on healthcare systems.
- Trial name
- NCT02416843
- Testing
- Consumption of a mixed meal
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Bath
Obesity & Overweight, Obesity (Disorder)
Weight Loss and Adipose Tissue Metabolism During Conservative Treatment of Obesity
This prospective observational study investigates weight loss and metabolic changes in adults with obesity undergoing standard clinical diet-induced lifestyle treatment and counseling.
- Trial name
- 4FAT (NCT07456124)
- Testing
- Diet-Induced Weight Loss Program
- Volunteers
- 22 people
- Sponsor
- University of Helsinki
Inflammation, Obesity
Impact of High-fat Meals Varying in Fatty Acid Composition on Adipose and Systemic Metabolic-inflammatory Responses
Cardiometabolic disorders are a leading cause of death worldwide. Replacing saturated fatty acids (SFA) with unsaturated fatty acids is recommended as a way of lowering cardiometabolic disease risk.
- Conditions
- Inflammation, Obesity, Inflammatory Response, Cardiovascular Diseases
- Trial name
- NCT03712579
- Testing
- SFA-Rich Meal, MUFA-Rich Meal
- Where
- United Kingdom
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Loughborough University
Metabolism Disorder, Adiposity
Effect of Exercise and Omega-3 on Metabolic Health in Elderly
The aim of this project is to investigate in elderly women, the effect of combined aerobic and resistive training and concomitant supplementation with omega-3 fatty acids on adipogenesis, metabolic functions and pro-inflammatory…
- Conditions
- Metabolism Disorder, Adiposity, Inflammatory Response
- Trial name
- EXODYA (NCT03386461)
- Testing
- Exercise training, omega 3 supplementation
- Where
- Czechia
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Charles University, Czech Republic
Breast Lesions, Breast Cyst
Survey of Optical Values of the Breast Using Radiation-Free Pressure-Free Optical Scanning
The purposes of this study is to establish normal optical values of breast tissue in the general population. This will allow for establishing normals for breast composition, and is expected to be useful in the classification of…
- Conditions
- Breast Lesions, Breast Cyst, Early-Stage Breast Cancer, Benign Growth, Breast
- Trial name
- NCT00671385
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Spectros Corporation
Growth Hormone Deficiency
Adipose Tissue and Circulating Markers of Inflammation in GH Deficiency and Changes With GH Therapy
In order to examine the effect of GH on adipose tissue inflammation, this study will examine adipose tissue and serum inflammation in patients with GH deficiency before and after GH therapy.
- Trial name
- NCT03225755
- Testing
- Growth hormone
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Columbia University
Obesity
mTOR and Adipose Tissue Inflammation
The target of rapamycin complex 2 (TORC2) is an evolutionarily conserved serine/threonine protein kinase that controls growth and metabolism.
- Trial name
- NCT02881697
- Testing
- Adipose tissue sampling
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Insulin Resistance, Obesity
Adipose Tissue Response to Overfeeding in Insulin Resistance-Prone vs. Insulin Sensitive Humans
Obesity has become an epidemic worldwide. Data from our laboratory and others demonstrate that most of the excess morbidity from obesity is related to insulin resistance (IR).
- Trial name
- NCT02084641
- Testing
- Over feeding
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Stanford University
Tethered Spinal Cord, Including Thickened Filum, Lipomas, Myelomeningocele and Meningocele
Inflammatory Response in Children Suffering From Tethered Cord
Embryologic phenomenons that lead to dysraphisms are known, but pathophysiology remains questioned. It is supposed not to be a simple mechanistic dysfunction, and other biological phenomenons are implied in spinal cord damaging.
- Trial name
- TETHERIC (NCT07611058)
- Testing
- CSF sampling during surgery
- Where
- France
- Volunteers
- 32 people
- Sponsor
- University Hospital, Lille
Coronary Heart Disease
Adipose Tissue and Inflammation in Coronary Heart Disease
The aims of the present project are to study possible differences in inflammatory gene expression and protein secretion in various compartments of adipose tissue being exposed during open cardiac surgery in patients with coronary…
- Trial name
- ATICH (NCT02760914)
- Where
- Norway
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital