Clinical trials: Adipose Tissue Inflammation
Coronary Artery Disease, Atherosclerosis
Measuring Athlete's Risk of Cardiovascular Events 3 (MARC-3)
Regular endurance exercise is widely known to improve cardiovascular health and reduce the risk of heart disease. Yet several imaging studies have shown that male endurance athletes have a higher prevalence of coronary artery…
- Trial name
- MARC-3 (NCT07625488)
- Where
- 2 sites in Netherlands
- Volunteers
- 250 people
- Sponsor
- Radboud University Medical Center
Heart Failure With Preserved Ejection Fraction, Obesity
Adipose Tissue Inflammation in HFpEF
To evaluate the role of adipose tissue inflammation in patients with heart failure with preserved ejection fraction (HFpEF). Patients undergoing coronary artery bypass grafting with HFpEF and without heart failure will be…
- Trial name
- SLIM-HFpEF (NCT04886713)
- Testing
- Adipose and myocardial tissue sampling, Cardiac magnetic resonance imaging, Cardiopulmonary exercise testing
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- Heart Center Leipzig - University Hospital
Inflammation, Obesity
Systemic and White Adipose Tissue Inflammatory Profile in Lean Versus Obese Individuals
This study will compare the systemic and white adipose tissue inflammatory profile of individuals who are classified as lean and obese.
- Conditions
- Inflammation, Obesity, Inflammatory Response, Cardiovascular Risk Factor
- Trial name
- NCT04078776
- Testing
- No intervention
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Loughborough University
Metabolic Syndrome, Obesity
Acute Effects of Glucose Dependent Insulinotropic Polypeptide (GIP) on Subcutaneous Adipose Tissue
This clinical, randomized, cross-over study in obese healthy subjects aimed to analyse the acute effects of the incretin hormon Glucose Dependent Insulinotropic Polypeptide (GIP) on metabolic parameters and gene expression in…
- Conditions
- Metabolic Syndrome, Obesity, Insulin Sensitivity
- Trial name
- NCT00774488
- Testing
- Glucose dependent insulinotropic polypeptide (GIP)
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- German Institute of Human Nutrition
Spinal Stenosis, Ligamentum Flavum Hypertrophy
Cytokines, Neuroplasticity Modulators, and Biomarkers in Spinal Canal Stenosis and Endoscopic Decompression
Research Rationale and Study Design Lumbar spinal stenosis (LSS) is a common degenerative musculoskeletal disorder characterized by narrowing of the spinal canal, often leading to pain and disability.
- Trial name
- NCT07232836
- Testing
- Endoscopic Spinal Canal Decompression
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- Poznan University of Physical Education
Overweight, Obese
Angiotensin II Blockade and Inflammation in Obesity
Overweight and obesity, which afflicts ~65% of the U.S. population and more than 1 billion people worldwide, increases the risk of developing hypertension.
- Conditions
- Overweight, Obese, Prehypertension, Hypertension
- Trial name
- ARB (NCT01684748)
- Testing
- Olmesartan medoxomil
- Volunteers
- 20 people
- Sponsor
- Virginia Polytechnic Institute and State University
Hypogonadism, Metabolic Syndrome
Testosterone Replacement in Metabolic Syndrome and Inflammation
Hypogonadism (HG) frequently complicates the Metabolic Syndrome (MetS), whether testosterone replacement (TRT) is beneficial has not been clearly ascertained.
- Conditions
- Hypogonadism, Metabolic Syndrome, Obesity, Erectile Dysfunction
- Trial name
- TERMSINFAT (NCT01123278)
- Testing
- Testosterone
- Where
- 2 sites in Italy
- Volunteers
- 82 people
- Sponsor
- University of Roma La Sapienza
Obesity, Morbid, Bariatric Surgery Candidate
Adipose Tissue Inflammation in Individuals Undergoing Bariatric Surgery
A growing body of work done over the past few decades has established that adipose tissue as an active endocrine organ which secretes a wide range of metabolic and immunological factors collectively called "adipokines (1)."…
- Trial name
- NCT03419273
- Testing
- bariatric surgery
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Fat Consumption, Inflammatory Markers
Preoperative Dietary Fat Consumption and Baseline Inflammatory Markers
This single-center, prospective pilot study will examine dietary fat consumption and its relationship with inflammatory markers before surgery and the incidence of perioperative neurocognitive disorders in older surgical…
- Trial name
- D&D (NCT07442981)
- Testing
- Inflammatory markers test in blood prior to surgery, Inflammatory markers test in CSF (cerebrospinal fluid), MOCA test
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Ohio State University
Inflammation, Obesity
Impact of High-fat Meals Varying in Fatty Acid Composition on Adipose and Systemic Metabolic-inflammatory Responses
Cardiometabolic disorders are a leading cause of death worldwide. Replacing saturated fatty acids (SFA) with unsaturated fatty acids is recommended as a way of lowering cardiometabolic disease risk.
- Conditions
- Inflammation, Obesity, Inflammatory Response, Cardiovascular Diseases
- Trial name
- NCT03712579
- Testing
- SFA-Rich Meal, MUFA-Rich Meal
- Where
- United Kingdom
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Loughborough University
Long COVID, Insulin Resistance
Obesity, Insulin Resistance, and PASC: Persistent SARS-CoV-2
The investigators are studying the pathophysiologic links between obesity, insulin resistance (IR), adipose tissue infection, and post-acute sequelae of COVID-19 (PASC).
- Conditions
- Long COVID, Insulin Resistance, Insulin Sensitivity
- Trial name
- NCT05833217
- Testing
- Adipose Tissue Biopsy, Steady State Plasma Glucose (SSPG) Test
- Where
- 2 sites in United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Stanford University
Obesity, Vascular Dysfunction
DNA Methylation and Vascular Function
The main objective is to examine DNA hypomethylation as an underlying mechanism for the increased production of inflammatory cytokines and the impaired vascular function in obese individuals and as a potential target for…
- Trial name
- NCT03527420
- Testing
- Exercise training
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
Healthy
Obesity and Adipose Tissue Inflammation in Pregnant Mothers
To date very little research has been conducted on pregnant mothers. Research shows that mothers with obesity and gestational diabetes have children who have a higher risk of later developing obesity and diabetes compared to…
- Trial name
- NCT03412981
- Testing
- pregnant mothers
- Where
- 2 sites in United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Obesity, Metabolic Diseases
Fibrosis a New Pathological Actor in Adipose Tissue
Adipose tissue (AT) has specific alterations in obesity in particular increased fibrosis amount compared to lean subjects. Fibrosis amount measured by immunohistochemistry on adipose biopsies appears to to predict weight loss…
- Conditions
- Obesity, Metabolic Diseases, Fibrosis, Body Weight
- Trial name
- fibrota (NCT01655017)
- Testing
- biopsy
- Where
- 2 sites in France
- Volunteers
- 281 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Musculoskeletal Diseases, Inflammation
Effects Of Vitamin D On Bone, Muscle, And Adipose Tissue In Obese Subjects
Obesity has emerged as a risk factor in the onset of bone, muscle and adipose tissue impairments that are further aggravated by vitamin D deficiency. A link of an active bone-muscle-adipose axis is represented by Wnt pathway.
- Conditions
- Musculoskeletal Diseases, Inflammation, Sarcopenic Obesity
- Trial name
- DON3 (NCT06508242)
- Testing
- Cholecalciferol
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- Fondazione Policlinico Universitario Campus Bio-Medico
Obesity
Fish Oils and Adipose Inflammation Reduction
This study is a clinical trial designed to assess whether fish oil treatments are effective in the prevention of obesity-related fat tissue (adipose) inflammation.
- Trial name
- FAIR (NCT02010359)
- Testing
- Lovaza
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Inflammation
Effects of a Short Term Caloric Restriction on T Cell Activation in Fat
Overweight and obesity are major problems and their complications such as cardiovascular disease and type 2 diabetes mellitus pose great burdens on healthcare systems.
- Trial name
- NCT02473835
- Testing
- Calorie restriction, Activity monitoring, Diet monitoring
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Bath
Severe Obesity, Morbid Obesity
Sleep and Immune Response in Severe Obese Patients Undergoing Bariatric Surgery.
Obesity is a major public health problem in developed and developing countries, causing a range of respiratory and metabolic changes. There is a strong correlation between obesity and cardiorespiratory sleep disorders.
- Trial name
- NCT02409160
- Testing
- Standard Roux-en-Y gastric bypass
- Where
- 3 sites in Brazil
- Volunteers
- 17 people
- Sponsor
- Centro Universitário de Anapolis
Diabetes Mellitus, Type 2, Diabetes Mellitus, Type II
Effect of Liraglutide (Victoza) on Inflammation in Human Adipose Tissue and Blood
The objective of this study is to test the hypothesis that liraglutide (commonly known as Victoza) can promote an anti-inflammatory macrophage phenotype in human adipose tissue and blood, thereby reducing localized and systemic…
- Conditions
- Diabetes Mellitus, Type 2, Diabetes Mellitus, Type II, Diabetes Mellitus, Adult-Onset, Inflammation
- Trial name
- NCT02650206
- Testing
- Victoza (liraglutide) with dietician monitoring
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Stanford University
Asthma, Allergies and Obesity
The Relation Between Obesity, Adipose Tissue Content of Fatty Acids and Systemic and Airway Inflammation
Obesity has been recognized as a risk factors for developing asthma. In a cohort of 5384 children aged 15-17, we aim to: 1. To investigate the association of asthma prevalence at age 15-17 with body mass index (BMI) at age 15-17…
- Trial name
- NCT01229787
- Where
- Cyprus
- Volunteers
- 5,384 people, healthy volunteers welcome
- Sponsor
- Cyprus International Institute for Environment and Public Health