Clinical trials: Adjuvant Drug Therapy
Pancreatic Cancer Resectable
Personalized Tumor Neoantigen MRNA Therapy Adjuvant Treatment for Postoperative Pancreatic Cancer.
This study is a single-center, open-label clinical study to evaluate the feasibility and safety of personalized tumor neoantigen mRNA therapy (iNeo-Vac-R01) in combination with PD-1 antibody and standard chemotherapy regimen as…
- Trial name
- NCT06888674
- Testing
- individualized anti-tumor new antigen iNeo-Vac-R01 injection, Gemcitabine + Capecitabine, Sintilimab injection
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Zhejiang University
Pancreatic Cancer
mFOLFIRINOX as Adjuvent Chemotherapy in Treating Chinese Pancreatic Cancer Patients
Although FOLFIRINOX regimen was recently presented to be effective as adjuvant chemotherapy for resectable pancreatic cancer in selected patients who have good physical condition, there is still insufficient evidence on this…
- Trial name
- NCT04084496
- Testing
- Folfirinox
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Sun Yat-sen University
Non-small Cell Lung Cancer, Stage II-IIIA
Evaluate the Efficacy and Safety of Serplulimab Plus Chemotherapy in Neoadjuvant and Adjuvant Treatment of Resectable NSCLC (ECTOP-1013)
This is a clinical trial from Eastern Cooperative Thoracic Oncology Project (ECTOP), numbered as ECTOP-1013. The purpose of this neoadjuvant and adjuvant study is to evaluate the efficacy and safety of Serplulimab and…
- Conditions
- Non-small Cell Lung Cancer, Stage II-IIIA, Immunotherapy, Neoadjuvant Therapy
- Trial name
- NCT05775796
- Testing
- Serplulimab and Chemotherapy
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Fudan University
Breast Cancer, Adenocarcinoma of Breast
Adjuvant Chemotherapy With Epirubicin, CMF, and Weekly Docetaxel or Weekly Paclitaxel in Patients With Resected High-risk Breast Cancer
This study was a transnational pooled analysis of biological material from patients with resected high risk breast cancer who had received adjuvant chemotherapy with epirubicin and cyclophosphamide followed by weekly docetaxel or…
- Trial name
- NCT04829890
- Volunteers
- 89 people
- Sponsor
- Hellenic Cooperative Oncology Group
Malignant Melanoma, Adjuvant Drug Therapy
Complementary Vaccination With Dendritic Cells Pulsed With Autologous Tumor Lysate in Resected Stage III and IV Melanoma Patients.
This phase II, randomized, open-label trial aims to assess whether the vaccination increase RFS in disease free melanoma patients after surgery.
- Conditions
- Malignant Melanoma, Adjuvant Drug Therapy, Vaccin Therapy
- Trial name
- ACDC (NCT02718391)
- Testing
- Autologous Dendritic Cell vaccine
- Where
- 2 sites in Italy
- Volunteers
- 12 people
- Sponsor
- Istituto Romagnolo per lo Studio dei Tumori Dino Amadori IRST S.r.l. IRCCS
Non-small Cell Lung Cancer Stage I
Adjuvant Chemotherapy for High-Risk Pathologic Stage I Non-Squamous NSCLC
Brief Summary The goal of this clinical trial is to evaluate the effect of postoperative adjuvant chemotherapy (ACT) in patients with stage I non-squamous non-small cell lung cancer (NSCLC) after curative resection.
- Trial name
- NCT07250360
- Testing
- Adjuvant chemotheapy
- Volunteers
- 2,072 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Rectal Cancer, Adjuvant Chemoradiotherapy
Observational Study on the Patients With Rectal Cancer
The aim of this observational study is to retrospectively collect current survival data for 3995 primary rectal cancer patients who were extracted from 5097 rectal cancer patients admitted in Cancer Hospital, Chinese Academy of…
- Conditions
- Rectal Cancer, Adjuvant Chemoradiotherapy, Neoadjuvant Chemoradiotherapy, Adjuvant Chemotherapy
- Trial name
- NCT02312284
- Where
- China
- Volunteers
- 3,995 people
- Sponsor
- Chinese Academy of Medical Sciences
Breast Cancer
Estrogen Priming to Increase the Efficacy of Adjuvant Chemotherapy in Operable Breast Cancer
One of the basic principles of cancer chemotherapy is that these drugs act exclusively or mainly on cells in cycle. Estrogens have been shown to increase the fraction of breast cancer cells in cycle.
- Trial name
- NCT00193726
- Testing
- Tab Premarin (Ethinyl estradiol)
- Where
- India
- Volunteers
- 273 people
- Sponsor
- Sudeep Gupta
Breast Cancer
ACCELERATE: Doxorubicin and Cyclophosphamide Followed by Paclitaxel With Pegfilgrastim and Darbepoetin Alfa Support for the Treatment of Women With Breast Cancer
This is a study of dose dense doxorubicin/cyclophosphamide (AC) followed by paclitaxel (Taxol; T) with pegfilgrastim (Neulasta) and darbepoetin alfa support in the adjuvant breast cancer setting.
- Trial name
- NCT00261313
- Testing
- Neulasta, Aranesp
- Volunteers
- 80 people
- Sponsor
- Amgen
Gastric Cancer Stage III
Adjuvant Chemotherapy in Combination With Camrelizumab for Stage III Gastric Cancer (FOCUS-02)
This study is a prospective, single arm, multi-center phase II clinical trial. The primary study objective is to evaluate the safety of tegafur gimeracil oteracil potassium capsule plus oxaliplatin and Camrelizumab as adjuvant…
- Trial name
- NCT04515615
- Testing
- Camrelizumab, Oxaliplatin, Tegafur gimeracil oteracil potassium capsule
- Where
- 4 sites in China
- Volunteers
- 52 people
- Sponsor
- Yu jiren
Esophageal Cancer
Adjuvant Chemotherapy With Paclitaxel and Cisplatin in Lymph Node-Positive Adjuvant Chemotherapy in the Treatment of the Lymph Node Positive Thoracic Esophageal Squamous Cell Carcinoma
Esophageal cancer is a highly aggressive malignancy with a poor overall outcome. Five year survival rate after radical esophagectomy is modest at about 40%.The patients with regional lymph node metastases have worse outcome than…
- Trial name
- NCT02461043
- Testing
- paclitaxel; cisplatin, radiation
- Where
- China
- Volunteers
- 386 people
- Sponsor
- Chinese Academy of Medical Sciences
Stage IIIB(N2) Non-small Cell Lung Cancer, Stage IIA Non-small Cell Lung Cancer
Pembrolizumab and Chemotherapy Neoadjuvant/Adjuvant of NSCLC
This study is to evaluate the efficacy and safety of neoadjuvant pembrolizumab plus chemotherapy following by pembrolizumab adjuvant in stage IIA-IIIB (N2) NSCLC participants without sensitizing EGFR/ALK mutation.
- Conditions
- Stage IIIB(N2) Non-small Cell Lung Cancer, Stage IIA Non-small Cell Lung Cancer, Stage IIB Non-small Cell Lung Cancer, Stage IIIA Non-small Cell Lung Cancer
- Trial name
- NCT05894889
- Testing
- Pembrolizumab 200 mg IV infusion
- Where
- 2 sites in China
- Volunteers
- 70 people
- Sponsor
- Peking University
Ovarian Cancer Stage IV
PEMBRO With Chemo in Neo Adj Treatment of Ovarian Cancer .
There are several data suggesting that pembrolizumab and bevacizumab may be synergistic. Enhanced tumor angiogenesis is commonly associated with absence of tumor-infiltrating T cells in patients.
- Trial name
- NEOPEMBROV (NCT03275506)
- Testing
- Pembrolizumab Injectable Product - Chemotherapy - Bevacizumab, Chemotherapy - Bevacizumab
- Where
- 22 sites in France
- Volunteers
- 91 people
- Sponsor
- ARCAGY/ GINECO GROUP
Astrocytoma, Astrocytic Tumors
Impact of IDH Mutation and Adjuvant Chemo(radio)therapy on Survival Outcome in Grade II/III Astrocytoma
This study looked at a type of brain tumor called astrocytoma and how specific genetic changes like IDH mutations affect patients outcomes.
- Conditions
- Astrocytoma, Astrocytic Tumors, Astrocytoma of Brain
- Trial name
- NCT06620926
- Testing
- IDH mutant-type, IDH wild-type
- Where
- Egypt
- Volunteers
- 811 people
- Sponsor
- asmaa salama ibrahim
Breast Cancer
National Surgical Adjuvant Study of Breast Cancer(N-SAS BC) 07 [RESPECT]
To investigate clinical positioning between trastuzumab (Herceptin) monotherapy (H group) and combination therapy of trastuzumab and chemotherapy (H+CT group) based on a randomized controlled trial in women over 70 years with…
- Trial name
- RESPECT (NCT01104935)
- Testing
- trastuzumab monotherapy, trastuzumab and chemotherapy
- Where
- Japan
- Volunteers
- 275 people
- Sponsor
- Comprehensive Support Project for Oncology Research
Pancreatic Cancer
Adjuvant Chemoradiotherapy Versus Chemotherapy for Pancreatic Cancer (ADJUPANC)
In this trial, we aim to compare the outcomes of adjuvant chemoradiotherapy with chemotherapy for patients with resected pancreatic cancer who are at high risk of disease progressions.
- Trial name
- ADJUPANC (NCT06427447)
- Testing
- Adjuvant chemoradiotherapy, Adjuvant chemotherapy
- Where
- China
- Volunteers
- 770 people
- Sponsor
- Changhai Hospital
Tongue Neoplasms, Squamous Cell Carcinoma
Role of Neo-adjuvant Chemotherapy in Tongue Preservation in Locally Advanced Squamous Cell Carcinoma of Oral Tongue
Patients enrolled for the study, who are eligible for NACT, will undergo a pre-treatment workup comprising of Evaluation Under Anesthesia (EUA) for tumor Mapping and tissue biopsy along with a PET-CT scan.
- Conditions
- Tongue Neoplasms, Squamous Cell Carcinoma, Anterior Tongue Squamous Cell Carcinoma
- Trial name
- NCT02985255
- Testing
- Docetaxel, Cisplatin, 5FU
- Where
- India
- Volunteers
- 30 people
- Sponsor
- HealthCare Global Enterprise Ltd.
Nasopharyngeal Carcinoma
Neoadjuvant and Adjuvant Tislelizumab for Nasopharyngeal Carcinoma
To estimate the efficacy and safety of tislelizumab for stage IVA locally advanced nasopharyngeal carcinoma combined with induction chemotherapy and concurrent chemoradiotherapy, followed by maintenance therapy
- Trial name
- NCT05448885
- Testing
- Tislelizumab
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Diabetic Nephropathies, Diabetic Kidney Disease
Efficacy, Safety and Response Predictors of Adjuvant Astragalus Therapy for Diabetic Kidney Disease
This add-on open-label randomised controlled pragmatic trial aims to: 1. evaluate the effect of add-on astragalus treatment on type 2 diabetic patients with stage 2 to 3 chronic kidney disease and macroalbuminuria. 2.
- Trial name
- READY (NCT03535935)
- Testing
- Astragalus Powder, Routine medical care (active comparator)
- Where
- 2 sites in Hong Kong
- Volunteers
- 118 people
- Sponsor
- The University of Hong Kong
Gallbladder Cancer
Adjuvant Chemotherapy vs no Chemotherapy for Patients With GallBllader Carcinoma
Carcinoma of the gallbladder is the commonest malignancy of the biliary tract. Higher incidence has been noted in Chile, Mexico and Southwest American Indians.[1] It is the third most common malignancy in India.[2] The disease…
- Trial name
- NCT02778308
- Testing
- Gemcitabine + Cisplatin
- Where
- India
- Volunteers
- 100 people
- Sponsor
- Govind Ballabh Pant Institute of Postgraduate Medical Education and Research
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