Clinical trials: Adolescent Substance Use
Substance Use
Drug Abuse Prevention Among Girls Through a Mother-Daughter Intervention
The purpose of this study is to determine a computer- and family-based drug abuse prevention program is able to reduce drug use among early adolescent girls.
- Trial name
- NCT01236248
- Testing
- Prevention
- Where
- United States
- Volunteers
- 916 people, healthy volunteers welcome
- Sponsor
- Columbia University
Violence, Substance Use
Using Re-inforcement Learning to Automatically Adapt a Remote Therapy Intervention (RTI) for Reducing Adolescent Violence Involvement
This study will use a randomized control trial (RCT) design to administer two versions of a multisession remote behavioral intervention for youth seeking Emergency Department care for a violent injury with the goal to reduce…
- Conditions
- Violence, Substance Use, Criminal Behavior, Violence in Adolescence
- Trial name
- NCT04850274
- Testing
- Remote Therapy Intervention (RTI), Artificial Intelligence Remote Therapy Intervention
- Where
- 4 sites in United States
- Volunteers
- 584 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Vaping, Adolescent
Nicotine and Cannabis Vape Labeling Experiment - Spring 2025
This study assesses how the ways in which nicotine and cannabis vaping devices are labeled impact use susceptibility, anticipated effects, and health harm.
- Conditions
- Vaping, Adolescent, Electronic Cigarette Use, Nicotine
- Trial name
- EPIC/ADVANCE (NCT06919276)
- Testing
- Vaping Device Labeling
- Where
- United States
- Volunteers
- 3,048 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Alcohol Use, Underage, Substance Use
Strategies: Motivational Interviewing/Psychoeducation
The goal of this research program is to implement and evaluate complementary interventions designed to address underage alcohol, marijuana, tobacco and other drug use and abuse among Native American youth residing in and around…
- Conditions
- Alcohol Use, Underage, Substance Use, Underage Drinking
- Trial name
- NCT03458299
- Testing
- Motivational Interviewing, Psychoeducation
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Pacific Institute for Research and Evaluation
Alcohol or Other Drugs Use
Brief Substance Use Intervention for Youth in Teen Court
Youth involved in the juvenile justice system have multiple problems, including an earlier onset of alcohol and drug use and higher rates of alcohol and drug use than their peers in the general population.
- Trial name
- NCT01464554
- Testing
- Usual care, Project Free Talk
- Where
- United States
- Volunteers
- 193 people, healthy volunteers welcome
- Sponsor
- RAND
Nicotine Dependence
Extended Cessation Treatment for Teen Smokers
This study is designed to test the efficacy of an extended smoking cessation program for teen smokers. We hypothesize that teen smokers randomized to extended treatment will have a higher abstinence rate at 52 week follow-up than…
- Trial name
- Nicoteens (NCT00459953)
- Testing
- Extended treatment
- Where
- United States
- Volunteers
- 141 people, healthy volunteers welcome
- Sponsor
- Stanford University
Substance Use Disorders
CDP-choline Treatment in ATS Users
This study is a 12-week, randomized, double-blind, placebo-controlled trial of cytidine-5'-diphosphate choline in amphetamine-type stimulants-using adolescents.
- Trial name
- NCT02630069
- Testing
- CDP-choline, Supportive psychotherapy
- Where
- South Korea
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Ewha Womans University Mokdong Hospital
Relationship, Family (Foster), Substance Use Prevention
A Trial of Connecting to Promote Foster Teen Well-Being
This study evaluates the efficacy of a self-directed parenting program called Connecting in reducing risk of substance use and other risky behaviors in young foster teens (ages 11-15).
- Trial name
- NCT03157895
- Testing
- Connecting
- Where
- United States
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- University of Washington
Adolescent Problem Behavior, Truancy; Unsocialized
Substance Use Interventions for Truant Adolescents
This study evaluates a brief motivation-building intervention for parents and teens to reduce truancy and substance use. It is hypothesized that the motivational intervention will result in better outcomes compared to an…
- Conditions
- Adolescent Problem Behavior, Truancy; Unsocialized, Marijuana Abuse, Truancy; Socialized
- Trial name
- GOALS (NCT03655574)
- Testing
- Motivational + Family Check-up (MET+FCU), Psychoeducation
- Where
- 2 sites in United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Brown University
Adverse Childhood Experiences, Family Functioning
The THRIVE Study: Teaching Healthy Regulation in Individuals & Vulnerable Environments
The goal of this 2-arm randomized control trial is to determine the impact of a community health worker delivered coaching intervention, GRIT, on preventing the early initiation of regular use of alcohol and cannabis among…
- Trial name
- NCT06821035
- Testing
- Garnering Resilience in Traumatized youth and families (GRIT), Digital Citizenship Curriculum (DCC)
- Where
- United States
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- University of California, Irvine
Substance Use (Drugs, Alcohol), Substance Use Risk
Options for Navigating Talking About Risk and Adolescent Choices
This study will examine the effectiveness of ON-TRAC (Options for Navigating Talking about Risk and Adolescent Choices), which is an online substance use prevention program that also teaches emotion regulation skills.
- Conditions
- Substance Use (Drugs, Alcohol), Substance Use Risk, Substance Use, Emotion Regulation
- Trial name
- ON-TRAC (NCT06754527)
- Testing
- ON-TRAC
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Rhode Island Hospital
Diet Modification, Substance Use Disorders
The Impact of a Parenting Intervention on Latino Youth Health Behaviors
The purpose of this study is to test if a parenting program can be used to prevent substance use among Latino youth and at the same time promote healthy eating.
- Conditions
- Diet Modification, Substance Use Disorders, Diabetes Mellitus Risk, Cardiovascular Risk Factor
- Trial name
- FPNG+ (NCT03517111)
- Testing
- Nutrition/substance use prevention, Substance use prevention only, Academic success program
- Where
- United States
- Volunteers
- 844 people, healthy volunteers welcome
- Sponsor
- Arizona State University
Cannabis Use
A Hybrid Effectiveness-Implementation Trial of a School-Based Teen Marijuana Checkup
A hybrid effectiveness-implementation trial that is designed to assess the effectiveness of an intervention (The Teen Marijuana Check-Up) when delivered in real world settings.
- Trial name
- TMCU5 (NCT03111667)
- Testing
- Teen Marijuana Check Up, Treatment as Usual, Gold Standard Coaching
- Where
- United States
- Volunteers
- 264 people, healthy volunteers welcome
- Sponsor
- University of Washington
Mental Health Wellness 1
Evaluation of the Healthy Relationships Plus Program for Youth
Adolescent risk behaviours, such as violence and substance use, are prevalent public health concerns in Canada. Further, these behaviours often co-occur, and are associated with poor mental health.
- Trial name
- NCT02140099
- Testing
- Healthy Relationships Plus Program (HRPP), Control Condition (Classroom Activities)
- Where
- Canada
- Volunteers
- 238 people, healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health
Healthy Participants
Prevention of Hazardous Use of Alcohol with Danish High School Students (Our Choice)
The trial 'Our Choice' examines the effect of two prevention interventions targeting school, parent, and student levels at Danish high schools.
- Trial name
- NCT06018389
- Testing
- Structural only, Structural+Group MI
- Where
- Denmark
- Volunteers
- 3,100 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Substance Use, Adolescent Behavior
Acceptability and Feasibility Study of the Program "Yo Se Lo Que Quiero" (Unplugged)
Substance use and drug related disorders are important public health problems. Alcohol and illicit drug use account for 5.4% of the total burden of disease and the peak has been found in early adulthood (between ages 20 and 30…
- Trial name
- YSLQQ-Pilot (NCT04566627)
- Testing
- "Yo Sé Lo Que Quiero" programl
- Where
- Chile
- Volunteers
- 1,214 people, healthy volunteers welcome
- Sponsor
- Universidad de los Andes, Chile
Substance Use
Technology-Based Prevention for Adolescents in Primary Care
Adolescent substance use, sexual assault, and sexual risk behaviors pose a great public health concern, and subsequently there is also a great need to prevent these behaviors and experiences.
- Trial name
- NCT03489434
- Testing
- Intervention
- Where
- United States
- Volunteers
- 123 people, healthy volunteers welcome
- Sponsor
- Georgia State University
Substance Use
Feasibility of Peer-mentor Delivered Substance Use Brief Intervention for Adolescents in Kenya
Adolescent substance use is prevalent in Kenya and in the US, and is associated with significant negative health and social outcomes.
- Trial name
- NCT05545904
- Testing
- Substance use brief intervention (BI), substance use education intervention
- Where
- Kenya
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Moi University
Suicide, Surveillance
Southwest Hub for American Indian Youth Suicide Prevention Research
1. To use a SMART design to evaluate which of four sequences of New Hope (NH), Elders Resilience (ER) and Case Management (CM) have the greater effects on immediate and longer-term suicidal ideation (primary outcome) and…
- Conditions
- Suicide, Surveillance, Mental Health, Substance Use
- Trial name
- NCT03543865
- Testing
- New Hope (NH), Elders Resilience (ER), Case Management (CM)
- Where
- United States
- Volunteers
- 304 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Nicotine Dependence, Nicotine Use Disorder
Combined Pharmaco/Behavior Therapy in Adolescent Smokers
In the current proposal, we intend to study the efficacy of bupropion SR with or without combined contingency management (CM) among adolescent cigarette smokers.
- Trial name
- NCT00330187
- Testing
- Bupropion SR, Contingency Management
- Where
- United States
- Volunteers
- 134 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina