Clinical trials: Adolescents With Obesity
PCOS (Polycystic Ovary Syndrome) of Bilateral Ovaries, Obese
Role of Semaglutide in Restoring Ovulation in Youth and Adults With Polycystic Ovary Syndrome
Girls and women 12-35 years old with obesity and polycystic ovarian syndrome who are on or off metformin, will receive a glucagon like peptide-1 receptor agonist intervention for 10 months to induce metabolic changes, weight loss…
- Trial name
- RESTORE (NCT05819853)
- Testing
- Semaglutide Injectable Product (Wegovy and/or Ozempic)
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Colorado, Denver
Prader-Willi Syndrome
Effects of Exenatide on Overweight Adolescents With Prader-Willi Syndrome
Prader-Willi Syndrome (PWS) is one of the most common genetic causes of obesity. Obesity is a major source of morbidity and mortality in this population.
- Trial name
- NCT01444898
- Testing
- Exenatide
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Children's Hospital Los Angeles
Type 1 Diabetes Mellitus, Obesity
The COCCOS Study: a Transition Program for Young Persons With Chronic Conditions
A study is undertaken to examine the feasibility of the newly developed transition program in adolescents with type 1 diabetes, asthma and obesity in a multicentric setting.
- Conditions
- Type 1 Diabetes Mellitus, Obesity, Asthma
- Trial name
- COCCOS (NCT07145671)
- Testing
- Transition program
- Where
- Belgium
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Universiteit Antwerpen
Obesity
Effectiveness of Adapted Basketball Programs in Adolescents With Obesity (ABBA)
This study aims to evaluate the effects of different basketball training programs on adolescents with obesity. The objective is to assess how these programs influence body weight, physical fitness, motivation to exercise, and…
- Trial name
- ABBA (NCT07046871)
- Testing
- 1. Intervention Name (Arm 1) Name: Adapted Basketball Program with Video Support Type: Behavioral Description: A 7-week basketball intervention for adolescents with obesity, combining pedagogically a, ADAPT Adapted Basketball Program
- Where
- Tunisia
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University of Sfax
Childhood Obesity, Pediatric Obesity
A Trial of an Integrated Clinic-community Intervention in Children and Adolescents With Obesity (Hearts and Parks)
The investigators propose a randomized controlled effectiveness trial to evaluate the integrated clinic-community model of child obesity treatment as compared with routine primary care.
- Conditions
- Childhood Obesity, Pediatric Obesity, Quality of Life, Cardiovascular Risk Factor
- Trial name
- NCT03339440
- Testing
- Hearts & Parks
- Where
- 3 sites in United States
- Volunteers
- 327 people, healthy volunteers welcome
- Sponsor
- Duke University
Obesity
Level Up! (The Combined and Independent Effects of Exercise Training and Dietary Enhancement on Cardiometabolic Health in Adolescents With Obesity)
The goal of this clinical trial is to determine whether adding structured exercise training and a structured fruit and vegetable dietary program to standard multidisciplinary obesity care improves cardiometabolic health in…
- Trial name
- NCT06848478
- Testing
- Exercise Intervention, Nutritional Intervention
- Where
- 2 sites in United States
- Volunteers
- 120 people
- Sponsor
- Arkansas Children's Hospital Research Institute
Obesity, Childhood
Evaluating a Telemedicine-based Intensive Treatment Program for Children and Adolescents With Obesity
The study objective is to evaluate whether a novel telemedicine-based intensive treatment program for children with obesity is superior to standard on-site care.
- Trial name
- NCT05700409
- Testing
- Intensive lifestyle consultations
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Sheba Medical Center
Adolescent Obesity
Fructose-induced Hepatic De Novo Lipogenesis in Adolescents With Obesity
In the U.S., dietary fructose has increased in parallel with the increase in obesity and may promote the development of diabetes and other chronic diseases.
- Trial name
- NCT03567837
- Testing
- Fructose + Glucose Beverage
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- The Rogosin Institute
Obesity
A Family-Based Weight Loss Intervention for Youth With Intellectual Disability
The purpose of this randomized controlled trial is twofold. First, to examine the efficacy of a 24-session, 6-month family-based behavioral intervention (FBBI) - as compared to a waitlist FBBI group, which later receives the same…
- Trial name
- HealthU (NCT02033642)
- Testing
- Family Based Behavioral Intervention, Maintenance
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University of Massachusetts, Boston
Obesity
Overweight, Quality of Life and Psychological Difficulties in Teenagers
Obesity is a major public heath issue. It may have various impacts on a patient's life by causing psychological problems, altering a patient's quality of life,etc.
- Trial name
- QOL-ADOB (NCT02417909)
- Testing
- questionnaires about quality of life
- Volunteers
- 173 people, healthy volunteers welcome
- Sponsor
- Lille Catholic University
Metabolic Dysfunction-Associated Fatty Liver Disease, Obesity, Adolescent
Effect of L-citrulline and HIIT on Arterial Stiffness, Body Composition, and Lipid Profile in Adolescents with Steatosis Associated with Metabolic Dysfunction (MASLD)
Obesity and metabolic dysfunction-associated steatotic liver disease (MASLD) accelerate the appearance of arterial stiffness due to inflammatory and oxidative stress mechanisms producing increased vascular tone and increasing the…
- Conditions
- Metabolic Dysfunction-Associated Fatty Liver Disease, Obesity, Adolescent, Arterial Stiffness
- Trial name
- NCT05778266
- Testing
- L-citrulline, Carboxymethyl cellulose, High Intensity Intervals Training
- Where
- Mexico
- Volunteers
- 43 people
- Sponsor
- Universidad de Guanajuato
MASLD - Metabolic Dysfunction-Associated Steatotic Liver Disease, Obesity
Effect of Ketone Esters on Liver Fat Content and Metabolic Function
The goal of this clinical trial is to determine whether ingestion of a ketone ester drink helps improve liver health and blood glucose control.
- Conditions
- MASLD - Metabolic Dysfunction-Associated Steatotic Liver Disease, Obesity, Overweight (BMI > 25)
- Trial name
- JV (NCT07097506)
- Testing
- bis-octanoyl (R)-1,3-butanediol (C8 ketone di-ester)
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Bipolar Youth Treated With Second-generation Antipsychotics
SGA-induced Metabolic Syndrome in Bipolar Youth
The investigators tested the hypothesis that long-chain omega-3 (LCn-3) fatty acid supplementation will attenuate the adverse cardiometabolic effects of second-generation antipsychotics exposure in first-episode adolescent manic…
- Trial name
- NCT01858948
- Testing
- Omega, Quetiapine fumarate
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- University of Cincinnati
Children, Only, Behavior, Eating
School Lunch Salad Bars and Fruit and Vegetable Consumption
The investigators propose an efficacy study (i.e., do salad bars work under controlled conditions in naturalistic settings) to test whether introducing salad bars in elementary, middle, and high schools that have never had salad…
- Conditions
- Children, Only, Behavior, Eating, School, Obesity
- Trial name
- NCT03283033
- Testing
- New salad bar, Marketing
- Where
- United States
- Volunteers
- 7,491 people, healthy volunteers welcome
- Sponsor
- Arizona State University
Obesity and Overweight, Obese Adolescents
Mitigation of Cardiovascular Disease Risks in Children With Extreme Obesity
The goal of this clinical trial is to learn if the drug semaglutide changes markers of disease risk as it relates to weight in children ages 12-15 years old who are obese (class 2 or 3).
- Conditions
- Obesity and Overweight, Obese Adolescents, Weight Management, Weight Loss
- Trial name
- MODERN (NCT06967389)
- Testing
- Ozempic®
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- John Bauer
Obesity, Morbid
Effectiveness Gastric Balloon in Obese Adolescents
Assess the effectiveness of utilization of endoscopically placed intra-gastric balloon in obese and morbid obese adolescents combined with behavioral support for weight loss and health optimization.
- Trial name
- NCT04209842
- Testing
- gastric balloon
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Stanford University
Type 2 Diabetes Mellitus, Obesity
Type 2 Diabetes and the Brain in Adolescents
This study evaluates differences in brain function and cognitive performance in adolescents with type 2 diabetes (T2D) compared to non diabetic controls (both obese and lean) and correlates these changes with obesity, insulin…
- Conditions
- Type 2 Diabetes Mellitus, Obesity, Pediatric Obesity, Insulin Resistance
- Trial name
- NCT03461510
- Testing
- Hyperglycemic clamp, Hyperinsulinemic Euglycemic clamp
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Nemours Children's Clinic
Bipolar Disorder
Metformin for Overweight & OBese ChILdren and Adolescents With BDS Treated With SGAs
A prospective, large, pragmatic, randomized trial to study the impact of METFORMIN and healthy lifestyle intervention (LIFE) vs.
- Trial name
- MOBILITY (NCT02515773)
- Testing
- Metformin, healthy lifestyle intervention (LIFE)
- Where
- 29 sites in United States
- Volunteers
- 1,565 people
- Sponsor
- Melissa Delbello
Obesity Prevention, Pediatric Obesity
Relationship Between Eating Patterns, Body Composition and the Detection of Fatty Liver in Children and Adolescents With Trisomy 21: LiverTy Project
Childhood obesity is a growing public health issue affecting millions of children worldwide, increasing the risk of metabolic and cardiovascular diseases in adulthood.
- Conditions
- Obesity Prevention, Pediatric Obesity, Trisomy 21, Down Syndrome (Trisomy 21)
- Trial name
- LiverTy (NCT06888570)
- Testing
- To evaluate fat liver content in the cases/controls population.
- Where
- Spain
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- IMDEA Food
Prader Willi Syndrome, Childhood Obesity
Family-based Intervention for Youth With Prader-Willi Syndrome: The Active Play at Home Study
Compared to other children, those with disability have additional challenges to being physically active. Prader-Willi Syndrome (PWS) is a genetic form of childhood obesity that is characterized by hypotonia, growth hormone…
- Trial name
- APAH (NCT02058342)
- Testing
- Active Play at Home
- Where
- 2 sites in United States
- Volunteers
- 115 people
- Sponsor
- California State University, Fullerton