Clinical trials: Adrenergic Beta-Receptor Blockader
Primary Open Angle Glaucoma, Intraocular Pressure
Effects of Forskolin on Intraocular Pressure in Glaucomatous Patients Under Treatment With Either Beta-blockers or Prostaglandins Eye Drops
Elevated intraocular pressure is still the main risk factor for development and progression of glaucoma. Several drugs exist on the market that may decrease IOP in glaucomatous patients.
- Trial name
- NCT00863811
- Where
- Italy
- Sponsor
- Sooft Italia
Glaucoma, Open-Angle, Ocular Hypertension
Phase 1-2 Evaluation of OT-730 Eye Drops in Reducing the Intraocular Pressure in Patients With Ocular Hypertension or Open-Angle Glaucoma
The purpose of this study is to evaluate the safety and potential efficacy of a new drug, OT-730 ophthalmic solution (eye drops), in reducing intraocular pressure in the eyes of patients with open angle glaucoma or ocular…
- Trial name
- NCT00753168
- Testing
- OT-730 ophthalmic solution, timolol maleate ophthalmic solution
- Where
- 5 sites in United States
- Volunteers
- 48 people
- Sponsor
- Othera Pharmaceuticals
Hereditary Angioedema (HAE)
Open-label, Single-arm Study to Assess the Pharmacokinetics, Safety, and Tolerability of a Single Subcutaneous Dose of Icatibant in Healthy Japanese Volunteers
This is a single-dose study to evaluate the pharmacokinetics, safety, and tolerability of icatibant administered to adult Japanese subjects.
- Trial name
- NCT02045264
- Testing
- Icatibant (30 mg)
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Shire
Hypersensitivity
Coreg and HSRs-Updated Analysis
A cluster of reports of hypersensitivity reactions among patients who switched from carvedilol (immediate release formulation, referred to hereafter as carvedilol) to carvedilol extended release was received during the initial…
- Trial name
- NCT01316952
- Testing
- Carvedilol immediate release only, Carvedilol extended release only, Long acting β-blockers
- Volunteers
- 1 people
- Sponsor
- GlaxoSmithKline
Stable Angina, Hypertension
Achievement of Goal Resting Heart Rate on B-blockers in Patients With Stable Angina and Hypertension
This is a multicenter survey of Russian data on target heart rate achievement in patients with stable angina and arterial hypertension who are currently treated with beta-blockers for at least 2 months and with no dose change for…
- Trial name
- Athena (NCT01321242)
- Where
- 6 sites in Russia
- Volunteers
- 400 people
- Sponsor
- AstraZeneca
Chronic Heart Failure
Association Between Genetic Polymorphism of Beta-adrenergic Receptor and Effects of Bisoprolol in Korean Heart Failure Patients.
At present, there is some clinical data for different functional response to beta-blockers associated with beta-adrenergic receptor polymorphisms.
- Trial name
- ABBA (NCT01104558)
- Testing
- Bisoprolol
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Heart Failure
REBEAT Resynchronisation and Beta-Blocker European Trial
This protocol will evaluate the effect of cardiac resynchronization therapy (CRT) combined with beta-blocker therapy in patients with symptomatic heart failure in whom beta-blocker therapy was either not tolerated or could not be…
- Trial name
- NCT00305526
- Testing
- Contak Renewal (CRT-D)
- Where
- 3 sites in Italy, Switzerland
- Volunteers
- 354 people
- Sponsor
- Guidant Corporation
Hypertension
A Study of the Efficacy and Safety of Nebivolol Added to Existing Antihypertensive Treatment in Patients With Hypertension
The purpose of this study was to contrast the efficacy and safety of 3 dose levels of nebivolol vs. placebo, when added to a patient's existing antihypertensive medication(s) for 3 months, in patients with mild to moderate…
- Trial name
- NCT00200434
- Testing
- Nebivolol
- Where
- United States
- Volunteers
- 600 people
- Sponsor
- Mylan Bertek Pharmaceuticals
Ocular Hypertension, Glaucoma
Tolerance and Effect on Intraocular Pressure After Administration of SYL040012
The purpose of this study is to determine whether SYL040012 is safe for the treatment of ocular hypertension and glaucoma.
- Trial name
- NCT00990743
- Testing
- SYL040012
- Where
- Spain
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Sylentis, S.A.
Heart Failure, Congestive
Enoximone Plus Extended-Release Metoprolol Succinate in Subjects With Advanced Chronic Heart Failure
Beta-blocker medications have been shown to improve heart function and prolong the lives of patients with chronic heart failure (CHF).
- Trial name
- NCT00077948
- Testing
- Enoximone, Metoprolol succinate
- Where
- 2 sites in United States
- Volunteers
- 175 people
- Sponsor
- Gilead Sciences
Hypertension
Effect Of Carvedilol Versus Metoprolol On Glycemic Control In Patients With Type II Diabetes And Hypertension
Evaluation of the effect of two different antihypertensive treatments on control of glucose in Type II diabetic patients with high blood pressure
- Trial name
- NCT00060931
- Testing
- carvedilol, metoprolol
- Where
- 119 sites in United States
- Volunteers
- 501 people
- Sponsor
- GlaxoSmithKline
Healthy Subjects
Clinical Study to Investigate Safety and Effects on Heart Rate, Blood Pressure, and Pharmacokinetic Interactions of ACT-334441
The aim of the study is to investigate the safety of the concomitant administration of ACT-334441 with cardiovascular drugs.
- Trial name
- NCT02479204
- Testing
- ACT-334441 2 mg, ACT-334441 4 mg, Atenolol
- Where
- France
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Viatris Innovation GmbH
Infantile Hemangioma
Study in Infants With Infantile Hemangioma to Compare Propranolol Gel to Placebo
There is an unsatisfied medical need for a first-line treatment of localized uncomplicated proliferating Infantile Hemangioma with a good benefit/risk profile.
- Trial name
- NCT01512173
- Testing
- propranolol gel
- Where
- 17 sites in France, Poland and 1 more
- Volunteers
- 82 people
- Sponsor
- Pierre Fabre Dermatology
Hypertension
Dosing Study of the Effects of Nebivolol on Blood Pressure in Black Patients With Mild to Moderate Hypertension
The purpose of this study was to determine if nebivolol is superior to placebo for the treatment of elevated blood pressure in Black patients with mild to moderate hypertension.
- Trial name
- NCT00145236
- Testing
- Nebivolol
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Mylan Bertek Pharmaceuticals
Hypertension
A Study of the Safety and Efficacy of Nebivolol in Hypertensive Patients
A study to determine the safety, efficacy and superiority of nebivolol to placebo for the treatment of elevated blood pressure in patients with mild to moderate hypertension.
- Trial name
- NCT00200473
- Testing
- Nebivolol
- Where
- United States
- Volunteers
- 800 people
- Sponsor
- Mylan Bertek Pharmaceuticals
Hypertension
Study to Evaluate Symptoms in Patients Treated With Nebivolol or Metoprolol Extended-release (ER) for Hypertension
The purpose of this study was to compare the tolerability of nebivolol to metoprolol ER in a general population of patients with mild to moderate hypertension receiving hydrochlorothiazide (HCTZ)
- Trial name
- NCT00547300
- Testing
- Metoprolol ER, Nebivolol
- Where
- 24 sites in United States
- Volunteers
- 49 people
- Sponsor
- Forest Laboratories
Pulmonary Disease, Chronic Obstructive
Optimising the Propranolol Block Model
Optimising the propranolol block model
- Trial name
- NCT00549120
- Testing
- Propranolol, Salbutamol, Ipratropium
- Where
- United Kingdom
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Heart Failure
Study to Assess the Safety of BAY1067197 in Stable Heart Failure Patients on Standard Therapy Including ß-blocker
This is a study to investigate the safety and tolerability of the partial A1 agonist BAY1067197 in patients with chronic heart failure.
- Trial name
- NCT01945606
- Testing
- BAY1067197 (treatment 2)
- Where
- Netherlands
- Volunteers
- 11 people
- Sponsor
- Bayer
Chronic Hypertension
To Determine Blood Pressure Interaction Between TC-5214 and Anti-Hypertensive Medications (Calcium Channel Blockers, Beta Blockers, and ACE Inhibitors) in Patients With Chronic Hypertension
This is a two part study. Part 1 will determine determine if administration of TC-5214 has an effect on sitting blood pressure in patients with chronic hypertension.
- Trial name
- NCT01403922
- Testing
- TC-5214
- Where
- 4 sites in United States, Germany and 1 more
- Volunteers
- 80 people
- Sponsor
- AstraZeneca
Hypertension
A Study of the Safety and Efficacy of Long-Term Nebivolol Use in Hypertensive Patients
The study was conducted to determine the long-term safety and efficacy of nebivolol in patients with mild to moderate hypertension. This was an extension of the Phase III dose ranging studies NEB 202, 302 and 305.
- Trial name
- NCT00200499
- Testing
- Nebivolol
- Where
- United States
- Volunteers
- 845 people
- Sponsor
- Mylan Bertek Pharmaceuticals