Clinical trials: Adult Depression
Blunted Emotion in Major Depressive Disorder
Lumateperone Added to Antidepressant Therapy in Adults With Major Depressive Disorder Experiencing Emotional Blunting
The purpose of this study is to evaluate whether or not adding lumateparone to current antidepressant treatment in adults with major depressive disorder experiencing blunted emotion will reduce or eliminate the blunted emotion as…
- Trial name
- NCT07824206
- Testing
- lumateparone 42 mg once daily, lumateparone
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Future Options Research, LLC
Anxiety Disorders and Symptoms, Depression, Anxiety
Emotion Regulation Therapy for Clinical Worry and Rumination
The present project aims to broaden our understanding of neural mechanisms which may underlie change in symptoms occurring over the course of Emotion Regulation Therapy.
- Conditions
- Anxiety Disorders and Symptoms, Depression, Anxiety, Generalized Anxiety Disorder, Emotional Dysfunction
- Trial name
- ERT (NCT04060940)
- Testing
- Emotion Regulation Therapy: 8-session version, Emotion Regulation Therapy: 16-session version
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Douglas Mennin
Major Depressive Disorder
Study Evaluating Long-Term Safety of Desvenlafaxine Succinate Sustained Release With Japanese Adult Subjects in Major Depressive Disorder (MDD)
The primary objective of this study is to evaluate the long-term safety of desvenlafaxine succinate sustained release tablets during 10-month open-label treatment of Japanese subjects with major depressive disorder (MDD).
- Trial name
- NCT00831415
- Testing
- desvenlafaxine succinate sustained release tablets
- Where
- 17 sites in Japan
- Volunteers
- 304 people
- Sponsor
- Pfizer
Post COVID-19
Pulmonary and Extrapulmonary Impacts of COVID-19 on Young Adults
When the literature search is conducted, it is seen that there are many studies examining the effects of COVID-19 disease on individuals in various disease groups (MS, stroke, Parkinson, COPD, asthma, etc.) and age groups (adult…
- Trial name
- PEPICov (NCT05282043)
- Testing
- Evaluation of Pulmonary and Extrapulmonary Impacts of COVID-19 on Young Adults
- Where
- Turkey (Türkiye)
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Istanbul Arel University
Cognitive Decline, Osteoarthritis
Healthy Body & Mind Program for Older Adults Living With Osteoarthritis and Cognitive Decline
The goal of this pilot randomised clinical trial is to compare a 12-week Healthy Body \& Mind Program to usual care in older adults living with cognitive decline and osteoarthritis.
- Trial name
- NCT06070818
- Testing
- Healthy Body & Mind Program
- Where
- Australia
- Volunteers
- 20 people
- Sponsor
- The University of New South Wales
Brain Fog, Cognitive Impairment
Cognitive Task-Based Walking Effects on Cognition, Mood, Sleep, and Quality of Life in Older Adults With Brain Fog
This randomized controlled trial aims to investigate the effects of cognitive task-based walking exercise on cognitive function, depressive symptoms, sleep quality, and quality of life in older adults experiencing brain fog.
- Conditions
- Brain Fog, Cognitive Impairment, Geriatric Population
- Trial name
- NCT07396779
- Testing
- Cognitive Task-Based Walking Exercise, Walking-Only Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Medipol University
Major Depressive Disorder, Depression
Buprenorphine Used With Treatment Resistant Depression in Older Adults
The investigators are conducting a research study to learn about the safety and benefit of using a medication called buprenorphine for patients with difficult to treat depression.
- Trial name
- IRLGreyB (NCT02181231)
- Testing
- venlafaxine XR, buprenorphine
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Washington University School of Medicine
Depression, Sleep Quality
Effect of Music Activities on Depression and Sleep Quality in Frail Older Adults
This study aims to examine the effects of music activities on depression and sleep quality among frail older adults, and to develop a standardized music activity protocol suitable for use in adult day care centers.
- Conditions
- Depression, Sleep Quality, Frailty
- Trial name
- NCT07049445
- Testing
- Music Activity Program
- Where
- Taiwan
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- National Chung Hsing University
Major Depressive Disorder, Generalized Anxiety Disorder
The Modular Protocol for Mental Health (MPMH)
Currently, our best psychological treatments for anxiety and mood disorders only focus on individual diagnoses. So, there are separate treatments for Panic Disorder, or Depressive Disorder, or Social Anxiety, etc.
- Conditions
- Major Depressive Disorder, Generalized Anxiety Disorder, Posttraumatic Stress Disorder, Social Anxiety Disorder
- Trial name
- MPMH (NCT03143634)
- Testing
- The Modular Protocol for Mental Health, Treatment-as-usual
- Where
- United Kingdom
- Volunteers
- 43 people
- Sponsor
- Medical Research Council Cognition and Brain Sciences Unit
Cardiorespiratory Failure
Mobile Coping Skills Training to Improve Cardiorespiratory Failure Survivors' Psychological Distress
This is a pilot randomized clinical trial involving adult survivors of cardiorespiratory failure treated in intensive care units (ICUs) that is designed to test the acceptability, feasibility, and clinical impact of a coping…
- Trial name
- Blueprint (NCT04329702)
- Testing
- Coping skills training mobile app with call from CST therapist, Coping skills training mobile app only
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Duke University
Depression
Omega-3 Fatty Acids for Treating Adults With Major Depression
This study will test the effectiveness of two different kinds of omega-3 fatty acid dietary supplements in treating the symptoms of major depression.
- Trial name
- NCT00517036
- Testing
- EPA omega-3 fatty acid, DHA omega-3 fatty acid
- Where
- United States
- Volunteers
- 196 people
- Sponsor
- Cedars-Sinai Medical Center
Depression
Dose-Response Effect Exercise and Depression
The present study aims to address gaps in the literature by evaluating the objectively measured dose-response relationship between exercise and depression symptoms; examining changes in resting (Brain-derived Neurotrophic Factor)…
- Trial name
- NCT06166095
- Testing
- high-dose, Walking attention control, moderate-dose
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- University of Central Florida
Gut Microbiome, Gastrointestinal Microbiome
A Non-Interventional Pilot Study to Explore the Role of Gut Flora in Disease
This study seeks to correlate microbiome sequencing data with information provided by patients and their medical records.
- Conditions
- Gut Microbiome, Gastrointestinal Microbiome, Autism, Autism Spectrum Disorder
- Trial name
- NCT04031469
- Testing
- There is no intervention in this study
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- ProgenaBiome
Exercise, Smartphone Addiction
The Effects of 8-week Resistance and Aerobic Exercise on Anxiety, Depression, Sleep, Inhibitory Control in Young Adults With Smartphone Overdependence
The purpose of this study is to identify the effects of the resistance exercise and aerobic exercise on depression, anxiety, sleep, inhibitory control in young adult with smartphone overdependence
- Conditions
- Exercise, Smartphone Addiction, Sleep, Inhibition
- Trial name
- NCT06848322
- Testing
- resistance exercise, aerobic exercise
- Where
- South Korea
- Volunteers
- 36 people
- Sponsor
- University of Seoul
Depression
A Ketamine-assisted Group Therapy Intervention for Spanish-speaking Adults With Depression
This is a pilot clinical trial to assess the feasibility, safety, and preliminary efficacy of ketamine-assisted group therapy for Spanish-speaking adults with depression
- Trial name
- NCT06597695
- Testing
- Ketamine-assisted psychotherapy
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Juliana Zambrano, MD, MPH
Major Depressive Disorder
Study Evaluating Desvenlafaxine Succinate Sustained-Release (DVS SR) in Adult Outpatients With Major Depressive Disorder (MDD)
A multicenter, 8-week study to evaluate the efficacy of 2 doses (50 and 100 mg/day) of desvenlafaxine succinate sustained-release (DVS SR) versus placebo in adult outpatients with major depressive disorder.
- Trial name
- NCT01432457
- Testing
- desvenlafaxine succinate sustained-release 50 mg/day, desvenlafaxine succinate sustained-release 100 mg/day
- Where
- 61 sites in United States
- Volunteers
- 924 people
- Sponsor
- Pfizer
Treatment-resistant Depression
A Study to Evaluate the Efficacy, Safety, and Tolerability of Flexible Doses of Intranasal Esketamine Plus an Oral Antidepressant in Adult Participants With Treatment-resistant Depression
The purpose of this study is to compare the efficacy and safety of switching treatment-resistant depression (TRD) subjects from a prior antidepressant treatment (to which they have not responded) to either intranasal esketamine…
- Trial name
- TRANSFORM-2 (NCT02418585)
- Testing
- Esketamine, Duloxetine (Oral Antidepressant), Escitalopram (Oral antidepressant)
- Where
- 48 sites in United States, Czechia and 3 more
- Volunteers
- 236 people
- Sponsor
- Janssen Research & Development, LLC
Depressive Symptoms, Mild Traumatic Brain Injury
Digital Therapeutic for Depression After Head Injury in Current and Former US Military Personnel
The Center for Neuroscience and Regenerative Medicine (CNRM) Clinical Trials Unit has developed the first cognitive-behavioral therapy (CBT) digital therapeutic (DTx) mobile application to counteract depressive symptoms in…
- Trial name
- NCT05147506
- Testing
- CNRM DTx, Psychoeducation Comparison
- Where
- United States
- Volunteers
- 113 people
- Sponsor
- Henry M. Jackson Foundation for the Advancement of Military Medicine
Depression Disorders, Depression - Major Depressive Disorder
Comparing the Efficacy of Heated Yoga and Sauna as a Treatment for Depression
This project explores whether heated yoga, sauna, and a mindfulness app reduce depressive symptoms
- Conditions
- Depression Disorders, Depression - Major Depressive Disorder, Depression Disorder, Depression Chronic
- Trial name
- SHINE (NCT07082998)
- Testing
- heated yoga, sauna, mindfulness app
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Massachusetts General Hospital
Grief, Depressive Symptoms
Accelerated Resolution Therapy for Complicated Grief
This study will examine whether accelerated resolution therapy (ART) is effective for the treatment of prolonged and complicated grief and associated psychological trauma among older adult hospice caregivers who have experienced…
- Conditions
- Grief, Depressive Symptoms, Trauma, Psychological
- Trial name
- NCT03484338
- Testing
- Accelerated Resolution Therapy
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- University of South Florida
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