Clinical trials: Adult Depression
COVID-19, Cardiorespiratory Failure
Lift Mobile Mindfulness for COVID-19 Distress Symptoms
This is a randomized clinical trial (RCT) nested within the NIH PETAL Network's COVID cohort study (BLUE CORAL [Biology and Longitudinal Epidemiology: COVID Observational Study]) of patients hospitalized for COVID-19-related…
- Trial name
- LIFTCOVID (NCT04581200)
- Testing
- Lift
- Where
- 4 sites in United States
- Volunteers
- 56 people
- Sponsor
- Duke University
Depression in Adolescence, Depression in Adults
Neuro-affective Response to Light in Depressed Adolescents and Young Adults
The goal of this neuroimaging pilot study is to understand developmental differences in the impact of therapeutic wavelength light (blue light) versus a non-therapeutic wavelength (red light) on emotional brain function in…
- Trial name
- NCT05712772
- Testing
- Blue Light, Red Light
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Pittsburgh
Cachexia, Depression
Computerized Questionnaires in Assessing Symptoms, Pain, Depression, and Physical Function in Patients With Metastatic and/or Advanced Locoregional Cancer
RATIONALE: A computer-based system for assessing symptoms may be effective for patients with metastatic or advanced cancer. PURPOSE: This clinical trial is studying how well computerized questionnaires work in assessing symptoms…
- Conditions
- Cachexia, Depression, Pain, Unspecified Adult Solid Tumor, Protocol Specific
- Trial name
- NCT00972634
- Testing
- computer-assisted intervention, questionnaire administration, assessment of therapy complications
- Where
- Norway
- Volunteers
- 1,051 people
- Sponsor
- Norwegian University of Science and Technology
Depressive Disorder, Major Depressive Disorder, Suicidal Ideation
Evaluation of a Multi-Layered Digital Phenotyping, Digital Safety Plan, and Pharmacogenomic Intervention for Suicide Prevention in Adults With Depression
The goal of this clinical trial is to learn if a multi-layered digital and pharmacogenomic intervention works to prevent suicide re-attempts in adults with depression.
- Conditions
- Depressive Disorder, Major Depressive Disorder, Suicidal Ideation, Suicide, Attempted, Suicide Prevention
- Trial name
- SMARTomicS (NCT07885722)
- Testing
- Digital Monitoring (Active/Passive EMA), Ecological Momentary Intervention (EMI) via Digital Safety Plan, Pharmacogenetic-Guided Care and Therapeutic Drug Monitoring
- Where
- Spain
- Volunteers
- 525 people
- Sponsor
- Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz
Anxiety, Depression
Chatbot Intervention for Anxiety and Depressive Symptoms in Young Adults
This clinical trial compares the effects of using an artificial intelligence based therapy chatbot and a self-help book to lower anxiety and depressive symptoms.
- Trial name
- NCT05762939
- Testing
- Chatbot, Control (book)
- Where
- Poland
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- University of Social Sciences and Humanities, Warsaw
Anxiety Depression (Mild or Not Persistent)
Clinical Trials to Evaluate Neurophysiological and Neuropsychological Effects of a Mindfulness-based Intervention
Depression and anxiety are conditions with a high prevalence in the world population and youth are no exception. In developing countries it is reported that given the conditions of social disadvantage, anxiety and depression are…
- Trial name
- PRESENTE-IA (NCT06618339)
- Testing
- Mindfulness-based intervention
- Where
- Mexico
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Universidad Autonoma de Baja California
Depression
Extension Study of the Safety and Efficacy of Armodafinil Treatment as Adjunctive Therapy in Adults With Major Depression Associated With Bipolar I Disorder
The primary objective of this study is to evaluate the safety and tolerability of long term (6 months) armodafinil treatment as adjunctive therapy to mood-stabilizing medications in adults with bipolar I disorder.
- Trial name
- NCT01121536
- Testing
- Armodafinil
- Where
- 158 sites in United States, Argentina and 15 more
- Volunteers
- 867 people
- Sponsor
- Cephalon
Major Depressive Disorder
Study Evaluating DVS-233 SR In Adult Outpatients With Major Depressive Disorder
Primary Objective: To compare the efficacy and safety of DVS-233 SR versus placebo treatment in reducing the relapse rate of depressive symptoms in subjects with major depressive disorder (MDD), and to compare the percentages of…
- Trial name
- NCT00075257
- Testing
- DVS-233 SR
- Volunteers
- 603 people
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Depressive Disorder
Efficacy of Acceptance and Commitment Therapy on Serum GDF-15 Levels in Older Adults With and Without Depression: a Non-randomized Intervention Study
In a world where the population is aging, strategies are required that promote physical, social and mental health in these age groups.
- Trial name
- ACT GDF-15 (NCT06195436)
- Testing
- Acceptance and Commitment Therapy for people with and without depression
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universidad de Colima
Depression Disorder
The Effects of Chiropractic on Adults With Depression
The goal of this clinical trial is to evaluate the feasibility of the study design in preparation for a future clinical trial examining chiropractic care for adults with mild to moderate depression.
- Trial name
- DEP (NCT07260045)
- Testing
- Chiropractic Care
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Life University
Major Depressive Disorder
Genecept Assay™ vs. Treatment-as-Usual to Evaluate Efficacy of Assay-Guided Treatment in Adults With MDD
In this randomized clinical trial, subjects will be assigned to either an assay-guided treatment condition (AGT) or a treatment-as-usual condition (TAU).
- Trial name
- NCT02634177
- Testing
- Assay-guided treatment (AGT), Treatment-as-usual (TAU)
- Where
- 23 sites in United States
- Volunteers
- 305 people
- Sponsor
- Genomind, LLC
Depression, Alcoholism
Suicidal Behavior in Patients Diagnosed With Bipolar Disorder
The purpose of this study is to learn the environmental and psychological factors that impact suicidality in patients diagnosed with Bipolar Disorder.
- Conditions
- Depression, Alcoholism, Drug Abuse
- Trial name
- NCT02604277
- Testing
- Interpersonal and Social Rhythm Therapy (ISRT), Bipolar-Specific Cognitive Behavioral Therapy (CBT), Mindfulness-Based Stress Reduction (MBSR)
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- Emory University
Caregivers, Brain Injury
OSCAR - An Internet-based Supportive Coaching for Informal Caregivers of Adult Individuals With an Acquired Brain Injury
This is an intervention study for informal caregivers of adult patients with an acquired brain injury (stroke, traumatic brain injury or cerebral haemorrhage).
- Trial name
- NCT01112969
- Testing
- Internet-based supportive coaching OSCAR, Waiting-list control group (TAU)
- Where
- Switzerland
- Volunteers
- 40 people
- Sponsor
- University of Bern
Autism Spectrum Disorder, Depression, Anxiety
Transdiagnostic Group Behavioral Activation for Autistic Adults
The purpose of this study is to evaluate the feasibility, acceptability and effectiveness of a telehealth Group Behavioral Activation Therapy (GBAT) for autistic adults.
- Conditions
- Autism Spectrum Disorder, Depression, Anxiety, Anxiety, Anger
- Trial name
- GBAT (NCT04788212)
- Testing
- Group Behavioral Activation Therapy for Autism Spectrum Disorder
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Rutgers, The State University of New Jersey
Depressive Disorder, Major
A Study of Seltorexant Compared to Quetiapine XR as Adjunctive Therapy to Antidepressants in Adult and Elderly Participants With Major Depressive Disorder With Insomnia Symptoms Who Have Responded Inadequately to Antidepressant Therapy
The purpose of this study is to assess the efficacy of seltorexant compared with quetiapine extended-release (XR) as adjunctive therapy to an antidepressant drug in treatment response in participants with major depressive…
- Trial name
- NCT04513912
- Testing
- Seltorexant, Quetiapine XR
- Where
- 175 sites in United States, Argentina and 13 more
- Volunteers
- 757 people
- Sponsor
- Janssen Research & Development, LLC
Depression - Major Depressive Disorder, Behavioral Activation
VR-Based Behavioral Activation in Adults
Study Overview This study aims to evaluate the effectiveness of a newly developed Virtual Reality (VR) behavioral activation software program for individuals experiencing symptoms of depression.
- Conditions
- Depression - Major Depressive Disorder, Behavioral Activation, Virtual Reality Therapy, Behavioral Inhibition
- Trial name
- VR-Dep (NCT07703397)
- Testing
- Virtual Reality Behavioral Activation Software, Waitlist Control and Psychoeducation
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- KTO Karatay University
Anxiety, Depression
Mindfulness-based Cognitive Therapy to Improve Emotional Wellbeing and Glycaemic Control in Diabetes
Type 1 and 2 diabetes are challenging conditions to manage. Anxiety and depression are common among this group and are associated with poorer diabetes control.
- Conditions
- Anxiety, Depression, Diabetes
- Trial name
- MILESTONE (NCT02600091)
- Testing
- Mindfulness-Based Cognitive Therapy
- Where
- United Kingdom
- Volunteers
- 29 people
- Sponsor
- University of Aberdeen
Cancer, Quality of Life
The PRISM Intervention: a Multi-site Randomized Controlled Trial for Adolescents and Young Adults With Advanced Cancer
Multi-Site Randomized Controlled Trial testing the efficacy of the Promoting Resilience in Stress Management (PRISM) intervention among Adolescents and Young Adults with Advanced Cancer
- Conditions
- Cancer, Quality of Life, Anxiety, Depression
- Trial name
- PRISM-AC (NCT03668223)
- Testing
- Promoting Resilience in Stress Management (PRISM)
- Where
- 5 sites in United States
- Volunteers
- 269 people
- Sponsor
- Dana-Farber Cancer Institute
Institutional Older Adults
Senior Elastic Band (SEB) on Institutional Elders
The goals of this research project are: 1) to develop and evaluate the safety and feasibility of the Senior Elastic Band (SEB) exercise program for elderly residents in long term care facilities, 2) to evaluate the long-term…
- Trial name
- SEB (NCT02165150)
- Testing
- Wheelchair-bound Senior Elastic Band exercise program
- Where
- Taiwan
- Volunteers
- 127 people
- Sponsor
- Kaohsiung Medical University
Major Depressive Disorder
Efficacy Study of Vortioxetine on Cognitive Dysfunction in Adult Patients With Major Depressive Disorder
Major Depressive Disorder (MDD) is a severe and common psychiatric disorder. Although MDD primarily involves mood disturbances, patients also usually present alterations in cognitive function (attention, memory, executive…
- Trial name
- FOCUS (NCT01422213)
- Testing
- Vortioxetine (Lu AA21004)
- Volunteers
- 598 people
- Sponsor
- H. Lundbeck A/S
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