Clinical trials: Adult Periodontitis
Chronic Periodontitis
Efficacy of Locally Delivred 1.2% Rosuvastatin Gel in Chronic Periodontitis
BACKGROUND: Chronic periodontitis (CP) is an inflammatory condition affecting tooth supporting tissues and alveolar bone that surround the tooth leading to formation of deepend gingival sulcus that is highly prone to pathologic…
- Trial name
- NCT02283515
- Testing
- Rosuvastatin
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Government Dental College and Research Institute, Bangalore
Chronic Periodontitis
Platelet Rich Fibrin+1% Alendronate in Treatment of Chronic Periodontitis
The present study is designed to evaluate the combined efficacy of Platelet Rich Fibrin (PRF) and 1% Alendronate (ALN) with open flap debridement (OFD) in treatment of intrabony defects in chronic periodontitis patients.
- Trial name
- NCT02518152
- Testing
- Open flap debridement (OFD), OFD with Platelet rich fibrin (PRF), OFD with Platelet rich fibrin (PRF)+1% Alendronate
- Where
- India
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Government Dental College and Research Institute, Bangalore
Chronic Periodontitis, Type2 Diabetes
1.2% Rosuvastatin Subgingivally Delivered In Chronic Periodontitis With Type 2 Diabetes Mellitus
The purpose of the present study was to evaluate the effects of subgingival delivery of 1.2% Rosuvastatin (RSV) gel as an adjunct to scaling and root planing in chronic periodontitis (CP) with Type 2 diabetes mellitus patients.
- Trial name
- NCT02985099
- Testing
- SRP plus Rosuvastatin gel
- Where
- India
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Government Dental College and Research Institute, Bangalore
Chronic Periodontitis
Comparison of Moxifloxacin With Ciprofloxacin/Metronidazole on Patients With Chronic Periodontitis
The purpose of this study is to assess the clinical and microbiological effectiveness of the moxifloxacin compared with the combination ciprofloxacin - metronidazole, when used as adjunctive therapy to scaling and root planning…
- Trial name
- NCT00805558
- Testing
- moxifloxacin, Ciprofloxacin plus metronidazole
- Where
- Colombia
- Volunteers
- 76 people
- Sponsor
- Facultad Nacional de Salud Publica
Generalized Chronic Periodontitis, Vitamin D Deficiency
Effects of Vitamin D Supplementation During a Non-surgical Treatment of Generalized Chronic Periodontitis
The subjects participating in the trial will be randomly allocated to either the group receiving the treatment under investigation (scaling and root planning (SRP) accompanied by administration of vitamin D) or to a group…
- Trial name
- Protocol01 (NCT03162406)
- Testing
- Vitamin D3
- Where
- Belgium
- Volunteers
- 30 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Periodontitis, Periodontitis, Adult
Clinical and Microbiological Evaluation of Laser Therapy in the Treatment of Periodontal Disease in Stages III and IV
The aim of this clinical trial is to evaluate photodynamic therapy and photobiomodulation in the periodontitis treatment. To evaluate the clinical and microbiological response of conventional periodontal treatment associated with…
- Trial name
- NCT06426550
- Testing
- Antimicrobial photodynamic therapy and 0.005% methylene blue (PDT), Photobiomodulation with a red laser (PBM-RL), Saline solution
- Where
- Brazil
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Universidade Federal Fluminense
Periodontal Disease
Characterizing Gingival and Periodontal Ligament Fibroblasts Reaction to Infection With the Bacteria Porphyromonas Gingivalis
Porphyromonas gingivalis is one of the major bacteria involved in the formation and progression of chronic periodontitis. Pathogens invading the gingiva face the host's innate immune system at first and later on the acquired…
- Trial name
- NCT01599091
- Testing
- Specimens collection
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Hadassah Medical Organization
Periodontitis, Adult, Mouthwash
Evaluation of Coconut Oil Mouth Rinse on Periodontal Parameters
This study was based on testing a new natural mouthwash with coconut oil and xylitol as active agents to a placebo rinse on new periodontal parameters
- Trial name
- NCT07175090
- Testing
- Coconut oil
- Where
- Kosovo
- Volunteers
- 120 people
- Sponsor
- University of Pristina
Diabetes Mellitus, Chronic Periodontitis
Effects of Omega-3 Plus Low-dose Aspirin as Adjunct to Periodontal Debridement for Chronic Periodontitis in Diabetics
Therefore, the aim of this study is to investigate the effectiveness of daily supplementation of omega-3 polyunsaturated fatty acids and low-dose aspirin as adjunct therapy to one-stage full-mouth periodontal ultrasonic…
- Trial name
- NCT02800252
- Testing
- 3g omega-3 plus 100mg aspirin daily for 60 days, omega-3 plus aspirin before periodontal therapy
- Where
- Brazil
- Volunteers
- 75 people
- Sponsor
- Universidade Estadual Paulista Júlio de Mesquita Filho
Chronic Periodontitis, Type 2 Diabetes
Diabetes and Periodontal Therapy Trial
The primary aim of the study is to determine if non-surgical periodontal therapy (scaling and root planing and supportive periodontal therapy) is efficacious compared to delayed therapy in reducing elevated glycosylated…
- Trial name
- DPTT (NCT00997178)
- Testing
- Non-surgical periodontal therapy, Delayed non-surgical periodontal therapy
- Where
- 8 sites in United States
- Volunteers
- 514 people
- Sponsor
- Stony Brook University
Periodontal Diseases, Periodontitis
Effect of Iodine Deficiency on Periodontitis
The goal of this observational study is to compare urine iodine levels of participants with/without periodontitis. The main question it aims to answer is there a relationship between iodine levels of urine and periodontitis.
- Conditions
- Periodontal Diseases, Periodontitis, Iodine Deficiency, Periodontitis, Adult
- Trial name
- NCT05724251
- Testing
- healthy, periodontitis
- Where
- Turkey (Türkiye)
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- Ataturk University
Chronic Periodontitis
The Effect of Zinc on the Gingival Crevicular Fluid Level of Total Oxidant Capacity in Type 2 Diabetic Patients
To evaluate the effect of systemic administration of zinc on the gingival crevicular fluid level of total oxidant capacity in controlled Type-2 diabetic patients with stage-II and III periodontitis after non-surgical periodontal…
- Trial name
- NCT03923829
- Testing
- Zinc Sulfate, scaling and root planing
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Cairo University
Chronic Periodontitis
Effect of Scaling and Root Planing Along With Topical Application of Commercially Available Curcuma Longa Gel on Superoxide Dismutase and Malondialdehyde Levels in Saliva of Chronic Periodontitis Patients
Periodontitis is initiated by microbial biofilm but its progression is mediated by an abnormal host response to biofilm microorganisms.
- Trial name
- NCT02442453
- Testing
- Topical application of curenext gel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Tatyasaheb Kore Dental College
Chronic Periodontitis
Dose and Duration of Metronidazole and Amoxicillin for Treatment of Chronic Periodontitis
The aim of this study was to compare the clinical and microbiological outcomes of different dosages of metronidazole (MTZ) and of the duration of the systemic administration of MTZ and amoxicillin as adjunct to scaling and root…
- Trial name
- NCT02735395
- Testing
- Scaling and root planing (SRP), Metronidazole 250 (7 days), Metronidazole 400 (7 days)
- Where
- Brazil
- Volunteers
- 110 people
- Sponsor
- University of Guarulhos
Chronic Periodontitis
Locally Delivered Metformin and Aloe Vera for Treatment of Intrabody Defects in Chronic Periodontitis
Metformin (MF), a biguanide group of anti-diabetic drug has been shown to enhance osteoblasts differentiation and inhibit osteoclast differentiation in vitro, thus may exhibit a favorable effect on alveolar bone.
- Trial name
- NCT03204071
- Testing
- Aloevera, Metformin
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Government Dental College and Research Institute, Bangalore
Chronic Periodontitis
Simvastatin Gel With Perforated Resorbable Membranes in Treatment of Intrabony Defects in Chronic Periodontitis
Modified perforated membrane (MPM) is considered as a modality that could enable participation of periosteal cells and gingival stem cells which could improve the outcomes of guided tissue regeneration more than the use of the…
- Trial name
- NCT03419429
- Testing
- Simvastatin, EDTA, Occlusive membrane
- Volunteers
- 40 people
- Sponsor
- Ain Shams University
Periodontitis, Adult
Utilization of a Periodontal Endoscope in Nonsurgical Periodontal Therapy
The purpose of this study was to compare the clinical outcomes of teeth deep cleaning or scaling and root planing (SRP) using a periodontal endoscope (Perioscopy®) versus traditional SRP using magnifying loupes for up to twelve…
- Trial name
- NCT05293301
- Testing
- Use of Periodontal Endoscope (Perioscopy®) to enhance visualization while performing teeth deep cleaning, Use of traditional loupes to enhance magnification to enhance visualization while performing teeth deep cleaning
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Louisiana State University Health Sciences Center in New Orleans
Aggressive Periodontitis, Chronic Periodontitis
Analysis of Osteoimmune Interactions Linking Inflammation and Bone Destruction in Aggressive Periodontitis
Periodontitis are inflammatory diseases characterized by the destruction of the tooth-supporting bone due to increased bone resorption by osteoclasts (OCLs).
- Trial name
- PAG (NCT01993368)
- Testing
- flow cytometry
- Where
- France
- Volunteers
- 8 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Chronic Periodontitis, Hyaluronic Acid
Hyaluronic Acid 0.2% Application Enhanced Chronic Periodontitis Treatment in Non-surgical Phase
Background: Chronic periodontitis is one of the most common causes of tooth loss and is rather common in the population. Treating chronic periodontitis remains a challenge for dental practitioners.
- Trial name
- NCT04675385
- Testing
- 0.2% hyaluronic acid gel
- Where
- Vietnam
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University of Medicine and Pharmacy at Ho Chi Minh City
Periodontitis
Effect of Injectable Platelet-Rich Fibrin (i-PRF) in Initial Treatment of Chronic Periodontitis
Current treatments of periodontitis have limited efficacy since they fail to suppress microorganisms satisfactorily over time. The aim of present study was to investigate whether there are differences between initial treatment of…
- Trial name
- EIPRFITCP (NCT04178590)
- Testing
- SRP + Injectable Platelet-Rich Fibrin
- Where
- Serbia
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Belgrade