Clinical trials: Adults With Overweight and Obesity
Prediabetes or Overweight, Obesity Type 2 Diabetes Mellitus
Real-World Outcomes of Tirzepatide in Pakistani Adults With Obesity, Prediabetes, and Type 2 Diabetes
This is a multicentre, prospective, observational study of the medicine tirzepatide as it is used in routine clinical care in Pakistan.
- Conditions
- Prediabetes or Overweight, Obesity Type 2 Diabetes Mellitus, Obesity & Overweight
- Trial name
- TRIBUTE-PK (NCT07809568)
- Where
- 9 sites in Pakistan
- Volunteers
- 330 people
- Sponsor
- Universiti Sains Malaysia
Obesity
Dietary Intervention With Shop Model - SHOPUS
The objective is to investigate whether New Nordic Diet (NND) versus Average Danish Diet (ADD) in adults (18-65 y) with central obesity and components of the metabolic syndrome can improve body weight loss and risk markers of the…
- Trial name
- SHOPUS (NCT01195610)
- Testing
- Dietary intervention
- Where
- Denmark
- Volunteers
- 181 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Overweight, Obesity
Effect of Different Physical Programs on the Body Composition of Adult Men and Women With an Initial Body Fat >25% and >30%, Respectively.
Compare the Effect of Different Physical Programs on the Body Composition of Adult Women and Men With a Total Body Fat Percentage ≥ 30 % at the Beginning of the Test or BMI ≥25
- Trial name
- NCT03833791
- Testing
- education and modifying diet, education, modifying diet and physical activity prescription
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Universidad de Córdoba
Obesity, Type 2 Diabetes Mellitus (T2DM)
Efficacy and Safety of Semaglutide for Weight Loss in Overweight or Obese Adults in Bangladesh With or Without Type 2 Diabetes Mellitus
The goal of this clinical trial is to learn if semaglutide can help with weight loss in overweight or obese adults in Bangladesh. The study will also look at how safe semaglutide is for these participants.
- Trial name
- NCT06616961
- Testing
- Semaglutide Pen
- Where
- Bangladesh
- Volunteers
- 480 people
- Sponsor
- Popular Medical College Hospital
Obesity, Physical Activity
Lifestyle Intervention on Patients With Overweight or Obesity
This study aims to analyze the effects of a 3-month self-applied online program, focused on promoting healthy lifestyle habits (healthy eating and increased physical activity), on adults with obesity.
- Conditions
- Obesity, Physical Activity, Eating Behavior, Therapeutic Alliance
- Trial name
- LIO (NCT06829862)
- Testing
- Own Doctor Education, Unknown Doctor Education
- Where
- Spain
- Volunteers
- 115 people
- Sponsor
- Cardenal Herrera University
Type II Diabetes Mellitus
Efficacy and Safety of GL0034 in Overweight or Obese Adults With Type II Diabetes Mellitus
This is a phase II, randomized, double-blind, placebo-controlled study to evaluate the efficacy and tolerability of GL0034 among type II diabetes mellitus subjects who are obese or overweight with weight-related comorbidities.
- Trial name
- NCT07282743
- Testing
- GL0034 Dose Level 1, GL0034 Dose Level 2, GL0034 Dose Level 3
- Where
- 21 sites in United States, India
- Volunteers
- 285 people
- Sponsor
- Sun Pharmaceutical Industries Limited
Fatty Liver, Obesity
Study of the Efficacy and Safety of Nicotinamide in Patients With Liver Fibrosis (NICOFIB)
The objective of this clinical trial, a pilot study, is to assess the impact of nicotinamide (NAM) on individuals with hepatic fibrosis.
- Conditions
- Fatty Liver, Obesity, Hepatic Fibrosis, NAFLD
- Trial name
- NICOFIB (NCT06599918)
- Testing
- Nicotinamide
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Adults With Heart Failure, Mild Decrease in Ejection Fraction/Preserved Ejection Fraction, and Obesity
Study on the Efficacy and Safety of HRS-7535 in Patients With Mild Decrease in Ejection Fraction/Preserved Ejection Fraction Heart Failure and Obesity
This is a multicenter, randomized, double-blind, placebo-controlled, parallel design phase II clinical trial, including a screening period of up to 2 weeks, a 36-weeks' treatment period, and a 1-week safety follow-up visit period.
- Trial name
- NCT06820099
- Testing
- HRS-7535 tablet
- Where
- China
- Volunteers
- 225 people
- Sponsor
- Shandong Suncadia Medicine Co., Ltd.
Obesity & Overweight
Effects of a 12-Week Individualized Energy-Restricted Diet on Perceived Stress and Serum Cortisol in Adults With Overweight or Obesity
This prospective interventional study investigated changes in perceived stress, serum cortisol concentrations, body weight, and body composition during a 12-week individualized energy-restricted dietary intervention in adults…
- Trial name
- NCT07873762
- Testing
- Energy-Restricted Mediterranean-Style Diet
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Acibadem University
Prader-Willi Syndrome
Growth Hormone Study in Adults With Prader-Willi Syndrome
The overall objective of this study is to measure the effect of growth hormone (GH) treatment on physical and psychosocial health in adults with Prader-Willi syndrome.
- Trial name
- GAP (NCT04484051)
- Where
- Netherlands
- Volunteers
- 25 people
- Sponsor
- Erasmus Medical Center
Pulmonary Disease, Chronic Obstructive, Obesity Hypoventilation Syndrome
Treatment of Metabolic Alkalosis With Acetazolamide. Effect on the Length of Mechanical Ventilation.
The purpose of this study is to analyze whether the treatment of metabolic alkalosis with acetazolamide in intubated patients with chronic obstructive pulmonary disease (COPD) or with obesity hypoventilation syndrome (OHS)…
- Conditions
- Pulmonary Disease, Chronic Obstructive, Obesity Hypoventilation Syndrome, Metabolic Alkalosis
- Trial name
- TRAMA (NCT01499485)
- Testing
- Acetazolamide
- Where
- 8 sites in Spain
- Volunteers
- 140 people
- Sponsor
- Hospital Son Llatzer
Time Restricted Feeding
The Effects of Early and Late Time-Restricted Feeding on Body Composition
A randomized controlled trial to determine the effectiveness of either morning or evening time-restricted feeding on body composition in sedentary, breakfast eating overweight and obese adults.
- Trial name
- NCT04000516
- Testing
- Time restricted feeding
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Texas Tech University
Critical Illness, Obesity
Indirect Calorimetry Guided Energy Provision in Critically Ill Patients With Obesity
The DIRECT trial is a prospective, multi-centre, two arm parallel feasibility pilot randomised controlled trial. The primary aim is to determine the feasibility of using repeat indirect calorimetry measurements to direct energy…
- Trial name
- DIRECT (NCT06053216)
- Testing
- Indirect calorimetry, Indirect calorimetry (Standard care nutrition arm)
- Where
- 5 sites in Australia, New Zealand
- Volunteers
- 60 people
- Sponsor
- Australian and New Zealand Intensive Care Research Centre
Neuromuscular Diseases, Obesity (Disorder)
Gait Analysis Parameter and Upper Limb Evaluation in Adult Patients With Neurological or Metabolic Pathology
The ActiLiège-Adult study is a prospective, longitudinal, observational study designed to collect natural history data on adult patients with neurological or metabolic diseases affecting movement.
- Conditions
- Neuromuscular Diseases, Obesity (Disorder), Myotonic Dystrophy 1, Myasthenic Syndrome
- Trial name
- Acti-Adult (NCT07136844)
- Testing
- Syde, Dynamometric measurements of muscle strength, The 6-minute walk test (6MWT)
- Where
- Belgium
- Volunteers
- 300 people
- Sponsor
- Centre Hospitalier Universitaire de Liege
Type 2 Diabetes Mellitus (T2DM), Sarcopenia
HMB Plus Vitamin D to Preserve Muscle in Older Adults Starting Semaglutide
This randomized, double-blind, placebo-controlled trial will evaluate whether daily calcium beta-hydroxy-beta-methylbutyrate (calcium-HMB) plus vitamin D3 preserves muscle mass, physical function, and resting metabolism in adults…
- Conditions
- Type 2 Diabetes Mellitus (T2DM), Sarcopenia, Obesity, Muscle Loss
- Trial name
- PRESERVE-HMB (NCT07760948)
- Testing
- Calcium-HMB Plus Vitamin D3
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Vanderbilt University Medical Center
Schizophrenia
Early and Short Psycho-educational Lifestyle Intervention
People with severe mental illness have an increased risk of somatic comorbidities such as metabolic syndrome, obesity, hypertension, dyslipidemia and diabetes mellitus, which induce an increased risk of early mortality, mainly…
- Trial name
- HYVIE (NCT02657941)
- Testing
- Motivational group, educational group
- Where
- France
- Volunteers
- 10 people
- Sponsor
- Hôpital le Vinatier
Obesity
A Study to Learn About Safety and Effects of Once-monthly Treatment With Berobenatide in Adults With Obesity Disease in Japan (VESPER-JM)
The purpose of this clinical study is to learn about safety and effects of berobenatide (PF-08653944) in adults with obesity disease, a condition in which a person has too much body fat, which can harm their health and increase…
- Trial name
- NCT07794774
- Testing
- Berobenatide
- Where
- 28 sites in Japan
- Volunteers
- 197 people
- Sponsor
- Pfizer
Overweight , Obesity
Two-Week Stair-Climbing Exercise Snacks and Metabolic Health in Adults With Overweight or Obesity: A Pilot Study
This pilot study will evaluate whether brief bouts of stair climbing performed throughout the day for two weeks can improve metabolic health, cardiovascular fitness, and other health-related outcomes in adults with overweight or…
- Trial name
- NCT07849439
- Testing
- Stair-Climbing Exercise Snacks
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- St. Louis University
Weight Loss
Oral VK2735 for Weight Management in Adults With Type 2 Diabetes Mellitus Phase 3 (SUNRISE 2)
This study is one of two planned Phase 3 studies to support the weight management indication for VK2735 Oral in obese (BMI ≥ 30 kg/m2) or overweight (BMI ≥ 27 kg/m2) adults with Type 2 Diabetes Mellitus.
- Trial name
- NCT07868939
- Testing
- VK2735 Oral
- Volunteers
- 560 people
- Sponsor
- Viking Therapeutics, Inc.
Obesity
Effects of XW003 Versus Liraglutide on Body Weight of Adult Participants With Obesity
XW003 is an acylated human glucagon-like peptide 1 (GLP-1) analogue and is being developed for type 2 diabetes mellitus (T2DM) and obesity management.
- Trial name
- NCT05111912
- Testing
- XW003, Saxenda
- Where
- Australia
- Volunteers
- 206 people
- Sponsor
- Sciwind Biosciences APAC CO Pty. Ltd.