Clinical trials: Advanced
Response to Toxin, Toxicity
Two-week Course Versus Conventionally Fractionated Chemoradiotherapy in Rectal Cancer
The investigators compare two-week course of chemoradiation (33 Gy in 10 fractions with oral capecitabine) and conventional chemoradiation (50.4 Gy in 28 fractions with 5-FU and leucovorin) in this randomized trial.
- Conditions
- Response to Toxin, Toxicity, Recurrence
- Trial name
- NCT02484040
- Testing
- Two-week course of radiation
- Where
- South Korea
- Volunteers
- 370 people, healthy volunteers welcome
- Sponsor
- Jong Hoon Lee
Gingival Recession
Clinical Evaluation of Two Different Surgical Techniques With PRF in the Treatment of Multiple Gingival Recessions
This prospective clinical study aims to evaluate and compare the effectiveness of coronally advanced flap (CAF) and tunnel techniques, both combined with platelet-rich fibrin (PRF), in the treatment of multiple Miller Class I-II…
- Trial name
- NCT06986525
- Testing
- CAF with PRF, Tunnel with PRF
- Where
- Turkey (Türkiye)
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Pamukkale University
Advanced Cardiac Life Support
Comparing the Outcomes of Virtual Reality Based Serious Gaming and Lecture Based Training for Advanced Life Support
The hypothesis of this study is to reveal whether virtual reality(VR) based Advanced Life Support(ALS) serious game module can replace classroom-based ALS lecture, which is part of existing ALS training protocol in addition to…
- Trial name
- NCT05798910
- Testing
- ALS VR (VR based serious gaming module for advanced life support training), Lecture based training for advanced life support
- Where
- Turkey (Türkiye)
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Acibadem University
Dental Plaque, Dental Plaque Accumulation
Effect of Different Products to Support Plaque Control During Daytime
The goal of this clinical trial is to test if the additional use of different commercially available products for a better breath and plaque reduction, taken during daytime between morning and evening tooth brushing, can reduce…
- Conditions
- Dental Plaque, Dental Plaque Accumulation, Mouthwashes, Chewing Gum
- Trial name
- NCT07382310
- Testing
- Oral B Pro-Health Multi-Protection Mouth Rinse refreshing mint without alcohol (0.07% CPC), Listerine Total Care mouth rinse without alcohol, Colgate total advanced pro-shield mouth rinse without alcohol (0.075% CPC)
- Where
- Australia
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- King Abdullah University Hospital
Musculoskeletal Pain Disorder, Spinal Pain
Single Session Compared to Multiple Sessions of Education and Exercise for Older Adults With Spinal Pain in an Advanced Practice Physiotherapy Model of Care
Objectives: To assess the effectiveness and cost-effectiveness of a single session compared to multiple sessions of education and exercise for older adults with spinal pain treated conservatively in an advanced practice…
- Trial name
- NCT04868591
- Testing
- Single session of education and exercise provided by an advanced practice physiotherapist., Multiple session of education and exercise provided by an advanced practice physiotherapist.
- Where
- Canada
- Volunteers
- 109 people, healthy volunteers welcome
- Sponsor
- Ciusss de L'Est de l'Île de Montréal
Advanced Solid Tumor
Phase I Study to Evaluate the Effect of LDE225 on the Pharmacokinetics of Bupropion and Warfarin in Patients
This is a multi center, open-label study to evaluate the drug-drug interaction of LDE225 on the PK of bupropion and warfarin patients with advanced solid tumors.
- Trial name
- NCT01769768
- Testing
- LDE225, Wafarin, Bupropion
- Where
- 13 sites in United States
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- Novartis Pharmaceuticals
Fatty Liver Disease
Prevalence of Advanced Fibrosis in Patients Living With HIV
Monocentric, cross-sectional study to define the prevalence of advanced fibrosis in an HIV infected outpatient population. Follow-up over 10 years to assess clinical relevance.
- Trial name
- FLASH (NCT04066608)
- Where
- 2 sites in Germany
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Johannes Gutenberg University Mainz
Childhood Leukemia
Advanced Translational Research on Childhood Leukemia
Prognosis of children with leukemia, the most common pediatric cancer, has improved markedly. Yet, relapse still occurs in 15-40% of patients with a probability of survival of <50%, which is unlikely to be boosted by…
- Trial name
- NCT04478006
- Testing
- RNA-seq, whole exon sequencing, Cytogenetics test
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Small Vessel Disease of Diabetes Mellitus
Validating Imaging Biomarkers of Small Vessel Disease in Diabetic Individuals Using Advanced MRI Techniques.
To develop a set of biomarkers for imaging of small vessel disease in diabetic individuals using advanced MRI techniques. With this the investigators want to document progression of disease both radiologically and clinically.
- Trial name
- NCT03754608
- Testing
- MRI including cf-MRI, DTI, ASL and CVR.
- Where
- United States
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Yale University
Hearing Impairment, Deafness
RoboHear™ Device: Advanced Haptic Technology That Allows the Deaf to Understand Speech
Pilot study to test the feasibility of translating the English language into haptics (touch sensations)
- Trial name
- NCT03966144
- Testing
- RoboHear Device
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Arkansas
Resuscitation, Cardiac Arrest (CA)
Comparison of Different Chest Compression Techniques in Infant Resuscitation
In this prospective, single-center, randomized, self-controlled crossover manikin simulation study, participitants performed 2 minutes of single-rescuer CPR (30:2 compression-to-ventilation ratio) with each of the four techniques…
- Trial name
- NCT07698340
- Testing
- Two-Finger (2F) Technique, Three-Finger (3F) Technique, Heel-of-One-Hand (HOH) Technique
- Where
- Turkey (Türkiye)
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- Ankara City Hospital Bilkent
Colon Cancer
Screening and Risk Factors of Colon Neoplasia
The investigators propose a screening population-based study to systematically evaluate the accuracy and clinical relevance of sDNA testing as a potential alternative to colonoscopy screening.
- Trial name
- NCT01647776
- Testing
- Stool DNA Test, biopsies of rectal and colon mucosa, Questionnaires
- Where
- United States
- Volunteers
- 3,315 people, healthy volunteers welcome
- Sponsor
- Case Comprehensive Cancer Center
Healthy
Bioequivalence Study of Loperamide Hydrochloride 2 mg and Simethicone 125 mg Tablet Under Fasting Conditions
The objective of this study is to compare the relative bioavailability of Loperamide HCl 2 mg and simethicone 125 mg tablets (Ranbaxy) with that of Imodium® Advanced caplets (McNeil) in healthy subjects under fasting condition
- Trial name
- NCT00778115
- Testing
- Loperamide HCl 2 mg and simethicone 125 mg tablets
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Ranbaxy Laboratories Limited
Injury;Sports
Optimizing Football Training: Integrating Portable Force Plates for Advanced Performance Analysis
Optimizing Football Training at Multan Sports Complex: Integrating Portable Force Plates for Advanced Performance Analysis," aims to enhance football training through innovative technology. Under the supervision of Dr.
- Trial name
- NCT06437808
- Testing
- Training with Portable Force Plates Integration, Standard Training
- Where
- Pakistan
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Superior University
Keratoconus, Corneal Cross-Linking
Surface Ablation With Corneal Cross Linking in Mild Keratoconus
Interventional and comparative prospective study: Sixty-nine eyes (38 patients) suffering from keratoconus (stages 1-2 Amsler-Krumeich classification) will be divided into four groups.
- Trial name
- NCT05176171
- Testing
- Photorefractive Keratectomy with Corneal Cross-Linking
- Where
- Iran
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Shahid Beheshti University
Advanced Colorectal Cancer
Second-line Surufatinib Combined With Chemotherapy in Advanced CRC
A phase II, muti-cohort study to assess the efficacy and safety of Surufatinib combined with chemotherapy as a second-line treatment in patients with advanced CRC
- Trial name
- NCT04734249
- Testing
- Surufatinib(HMPL-012)
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Fujian Cancer Hospital
Post-traumatic Stress Disorder
An Advanced Digital Phenotype System Among People Suffering From Post-traumatic Stress Disorder
Psychiatric diagnosis is based mainly on questioning the patient and subjective impression rather than a quantitative assessment.
- Trial name
- NCT03788278
- Testing
- BioBeat
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Nadav Goldental
Root Coverage
The Evaluation Clinical Results of Coronally Advanced Flap With Platelet Rich Fibrin
The aim of this study was to evaluate the clinical outcomes of platelet- rich fibrin and coronally advanced flap technique in the treatment of multiple gingival recessions in comparison with connective tissue graft technique.
- Trial name
- NCT04942821
- Testing
- Platelet rich fibrin and coronally advanced flap, Connective tissue graft and coronally advanced flap
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Marmara University
Gingival Recession
Platelet Rich Fibrin on Root Coverage of Gingival Recessions
Several surgical techniques and various adjunctive agents have been used to covered Gingival Recession (GR) and promote clinical outcomes.
- Trial name
- NCT04248049
- Testing
- Platelet rich fibrin
- Where
- Colombia
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Universidad Antonio Nariño
Esophageal Cancer
Study of Anti-PD-1 Antibody SHR-1210 Plus Apatinib vs SHR-1210 as Second-Line Treatment of Advanced Esophageal Squamous Cell
The purpose of this study is to observe and evaluate the efficacy and safety of Anti-PD-1 antibody SHR-1210 plus apatinib versus SHR-1210 as second-line treatment of advanced esophageal squamous cell.
- Trial name
- NCT05049681
- Testing
- Camrelizumab, Apatinib
- Volunteers
- 234 people, healthy volunteers welcome
- Sponsor
- Feng Wang