Clinical trials: Advanced Age
Aging
Acute Passive Heating in Healthy Older Adults
Aging is associated with a decline in cardiovascular health, cognitive function and losses in muscle strength, with half or more of those over age 65 suffering from two or more comorbidities (e.g., heart disease, type 2…
- Trial name
- NCT05622747
- Testing
- Passive heating
- Where
- United Kingdom
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University of Portsmouth
Conditions Influencing Health Status
Clinical Applications of a Smart Physical Examination System for the Health Management in Elderly
Aging usually results in a decline in motor function. However, the elderly tend to refuse the regular health examination because of travel issues or lack of self-health awareness.
- Trial name
- NCT03858660
- Testing
- No intervention
- Where
- Taiwan
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Alzheimer's Disease
A Multiple Ascending Dose Study of BPN14770 in Healthy Young and Elderly Male or Female Subjects
This is a randomized, double-blind (Investigator and subject-blinded) placebo-controlled, multiple, ascending-dose study to evaluate the safety, tolerability, and pharmacokinetic profile of BPN14770 in healthy young and elderly…
- Trial name
- NCT02840279
- Testing
- BPN14770
- Where
- United States
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Tetra Discovery Partners
Mild Cognitive Impairment
The Influence of Oral Vibrational Stimulation on Cognitive Function of Elderly Individuals
The purpose of this study is to investigate the effect of oral vibratory stimulus on the brain activity and cognitive function of elderly people with non-dementia subjects (cognitive normal, mild cognitive impairment)
- Trial name
- OVSCF (NCT02332525)
- Testing
- Oral Vibrational Stimulation
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Seoul National University Bundang Hospital
Influenza, Vaccination Coverage
Communication Intervention to Improve Influenza Vaccination Rates Among Elderly in Can Tho
This study evaluates the effectiveness of a multi-component community-based communication intervention to increase influenza vaccination rates among adults aged above 65 years in Can Tho City, Vietnam.
- Conditions
- Influenza, Vaccination Coverage, Health Communication
- Trial name
- CIVECT (NCT07508189)
- Testing
- Multi-component Health Communication Package
- Where
- Vietnam
- Volunteers
- 1,237 people, healthy volunteers welcome
- Sponsor
- Can Tho University of Medicine and Pharmacy
Healthy Volunteers, Norovirus
Long-Term Immunogenicity of the Norovirus GI.1/GII.4 Bivalent Virus-like Particle (VLP) Vaccine (NoV Vaccine) in Adults
The purpose of this study is to evaluate descriptively the long-term immunogenicity of at least 1 NoV vaccine administration.
- Trial name
- NCT03039790
- Testing
- NoV Vaccine
- Where
- 11 sites in United States, Belgium
- Volunteers
- 528 people, healthy volunteers welcome
- Sponsor
- Takeda
Electroencephalography, Aging
Relationship Between Bispectral Index, EEG Features, and Propofol Effect-site Concentration in Young and Elderly Patients.
The aim of this study is to describe the BIS values and electroencephalographic patterns during total intravenous anesthesia with propofol-remifentanyl, in patients from 18 to 85 years.
- Conditions
- Electroencephalography, Aging, Propofol, Depth of Anesthesia
- Trial name
- NCT04774120
- Testing
- Propofol
- Where
- Chile
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Pontificia Universidad Catolica de Chile
Surgery
Effectiveness of Animation-Based Education Given to Elderly Patients Undergoing Coronary Artery Bypass Graft Surgery
It was conducted to measure the effectiveness of animation-based training given to elderly patients who will undergo coronary artery bypass graft surgery on the patients' pain, fear, anxiety and self-care management.
- Trial name
- NCT06928025
- Testing
- Preoperative Education
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Ayşegül Sena Pirgaip Yavuz
Balance
Effects of Game-based Virtual Reality Intervention on Senior Fitness, Fall Prevention and Balance Function Among Older Adults
The purpose of this study is to explore the effectiveness between game-based virtual reality intervention and conventional health education in improving older adults' balance knowledge, and let them know how to prevent falling.
- Trial name
- NCT05779189
- Testing
- Game-based virtual reality (Game), Conventional health education
- Where
- Taiwan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University
Cognition
Daily Egg Consumption and Cognitive Function in Older Adults
The purpose of this study is to test the effects of provisioning twelve eggs weekly, incorporated into breakfast meals, on composite scores of executive functioning and memory using the CNSVS computerized test platform in older…
- Trial name
- NCT05460624
- Testing
- Egg-containing breakfast, Typical American-style breakfast excluding eggs
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Indiana University
Diabetes Mellitus, Type 2, Insulin Resistance
The Aging Endocrine Pancreas: Characterization of the Entero-insular Axis Physiology in the Elderly
Like most endocrine axes, the entero-insular axis is expected to go through an age-related physiological deterioration, what might contribute to special features of the elderly onset type 2 diabetes in comparison to middle-age.
- Trial name
- NCT00843479
- Where
- Brazil
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Campinas, Brazil
Mild Cognitive Impairment (MCI), Moderate Cognitive Impairment
Comparative Effects of Integrated Versus Sequential Approaches to Dual-Task Training in Elderly With Mild to Moderate Cognitive Impairment
Mild and Moderate cognitive impairment is a condition characterized by a noticeable decline in cognitive abilities, including memory and thinking skills, which is greater than expected for an individual's age but does not…
- Trial name
- nill (NCT07775079)
- Testing
- Integrated Dual-Task Training, Sequential Dual-Task Training
- Where
- Pakistan
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Shifa Tameer-e-Millat University
Telemedicine
Smartphone Applications to Improve Lifestyles in Olders Over 65 Years
This is a randomized controlled clinical trial performed in urban primary care centers in Salamanca (Spain). Its objective is to evaluate the effect of an intervention based on the use of new information and communication…
- Trial name
- EVIDENT-Age (NCT03574480)
- Testing
- Intervention (training in use of a Smartphone application), Control (Advice on healthy diet and physical activity recommendations)
- Where
- Spain
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Fundacion para la Investigacion y Formacion en Ciencias de la Salud
Influenza, Immunization
Influenza Immunization in Adults Over Age 75
The immune system is the part of the body that protects against infection. The immune system often doesn't work as effectively as people get older.
- Conditions
- Influenza, Immunization, Older Adults, Over Age 75
- Trial name
- NCT02200276
- Testing
- Influenza
- Where
- United States
- Volunteers
- 1,025 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Muscle Protein Synthesis, Muscle Atrophy
Exogenous Ketosis During Bed Rest in Older Adults
The goal of this randomized, double-blind, parallel group interventional study is to evaluate the effect of ketone bodies on healthy older adults (65-85 y) during 5 days of bed rest.
- Conditions
- Muscle Protein Synthesis, Muscle Atrophy, Insulin Sensitivity, Mitochondrial Function
- Trial name
- KBR (NCT05679596)
- Testing
- ketone monoester (R)-3-hydroxybutyl (R)-3- hydroxybutyrate
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- McGill University
Mild Cognitive Impairment (MCI), Subjective Cognitive Decline (SCD)
LETHE-AT: a Personalized Multidomain Lifestyle Intervention for Individuals at Increased Risk of Memory Impairment.
The goal of this clinical trial is to learn whether a hybrid multidomain lifestyle program can prevent cognitive decline and reduce dementia risk in community-dwelling adults in mid- to late life who are at increased risk of…
- Trial name
- LETHE-AT (NCT07376135)
- Testing
- A tailored hybrid multidomain lifestyle intervention group, Self-guided multimodal lifestyle advice group
- Where
- 3 sites in Austria
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
None Volunteer
Measurement and Determinants of Diet Quality in Older Adults
The goal of this observational study is to learn about dietary quality and barriers to healthy eating among older adults who participate in the Los Angeles County Food Rx Produce Distribution Program.
- Trial name
- NCT07780708
- Where
- United States
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Alzheimer's Disease
Evaluation of the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of E2609 in Healthy Subjects and an Elderly Cohort
The purpose of this study is to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of E2609 when administered as single doses to healthy adult volunteers and healthy elderly subjects.
- Trial name
- NCT01294540
- Testing
- Drug: E2609
- Where
- United States
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- Eisai Inc.
Healthy
Effects of Milk Powder Intervention on Body Composition and Physical Performance in Middle-aged and Older Adults
This study aims to conduct a 24-week intervention involving formula milk powder for middle-aged and elderly individuals, assessing its impact on body composition and physical performance in comparison to interventions using…
- Trial name
- NCT06429410
- Testing
- fortified formula milk powder, formula milk powder, regular milk powder
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Huilian Zhu
Influenza
CSL H1N1 Influenza Vaccine Administered at Two Dose Levels in Adult and Elderly Populations
The purpose of this study is to assess the safety and immune response (body's defense against disease) to an experimental H1N1 influenza vaccine in healthy adult and elderly populations.
- Trial name
- NCT00943488
- Testing
- Inactivated H1N1 Vaccine
- Where
- 4 sites in United States
- Volunteers
- 408 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
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