Clinical trials: Advanced Life Support, open to volunteers
Chronic Kidney Disease (Stages 4 and 5), Health Related Quality of Life
Symptom Monitoring With Supported Feedback in Advanced Chronic Kidney Disease
Patient-reported outcome measures (PROMs) are validated tools to reliably measure outcomes highly prioritized by patients, such as health-related quality of life (HRQOL) and symptoms, but the current clinical impact of PROMs is…
- Trial name
- NCT07186218
- Testing
- Electronic patient-reported outcome measure (ePROM) for symptom monitoring
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Massachusetts General Hospital
Cardiac Arrest (CA), Cardiopulmonary Resuscitation (CPR)
The OXY-VENT Study
Effective ventilation during cardiopulmonary resuscitation is essential but can be difficult to achieve consistently. Current practice relies on visible chest rise to guide ventilation volume, although this may not always…
- Trial name
- OXY-VENT (NCT07870551)
- Testing
- Ventilation Feedback Device (Active), Control (Recording-Only)
- Where
- Netherlands
- Volunteers
- 515 people
- Sponsor
- Jeroen van Eijk
Skill Performance, Knowledge
Standard Two-Day Advanced Life Support (ALS) Versus One Day Recertification Course
this study aims to compare the effectiveness of a one-day versus two-day ALS recertification course in terms of knowledge retention, practical skills performance, participant satisfaction, and confidence.
- Trial name
- NCT07358741
- Where
- Egypt
- Volunteers
- 158 people, healthy volunteers welcome
- Sponsor
- National Hepatology & Tropical Medicine Research Institute
Cardiac Arrest (CA), Cardiopulmonary Arrest
A Randomized Controlled Study of the NEURESCUE Device as an Adjunct to Advanced Cardiac Life Support
The NEURESCUE device is the first intelligent balloon catheter for aortic balloon occlusion (ABO), an emergency technique that supercharges blood flow to the heart and brain within one minute from deployment.
- Trial name
- ARISE RCT (NCT06793033)
- Testing
- Advanced Cardiac Life Support (ACLS), Aortic balloon occlusion (ABO)
- Where
- 2 sites in Germany
- Volunteers
- 84 people
- Sponsor
- neurescue
Cardiac Arrest (CA), Pediatric Cardiac Arrest (Simulated)
Augmented Reality-Cardiopulmonary Resuscitation Support for Pediatric Resuscitation
This study evaluates whether an augmented reality cardiopulmonary resuscitation feedback system (AR-CPR) can support health care providers in delivering high-quality chest compressions during pediatric cardiac arrest.
- Conditions
- Cardiac Arrest (CA), Pediatric Cardiac Arrest (Simulated), Cardiopulmonary Resuscitation (CPR)
- Trial name
- AR-CPR (NCT07778823)
- Testing
- AR-CPR
- Where
- 8 sites in United States, Canada
- Volunteers
- 252 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Heart Failure, Advanced Heart Failure
REACTION-VAD Trial: Remote Exercise Training Via Telemedicine in Patients With Long-Term Ventricular Assist Devices
Current international guidelines recommend that patients with a heart pump (left ventricular assist device, LVAD) participate in supervised exercise cardiac rehabilitation programs.
- Conditions
- Heart Failure, Advanced Heart Failure, Left Ventricular Assist Device, LVAD
- Trial name
- REACTION-VAD (NCT07611188)
- Testing
- Remote Physical Conditioning Program (Telerehabilitation), Usual care. No Remote Monitoring.
- Where
- 10 sites in Spain
- Volunteers
- 78 people
- Sponsor
- Puerta de Hierro University Hospital
Advanced Cardiac Life Support Education
Effects of Two-Tier Test-Based Virtual Reality Instruction on ACLS Outcomes Among Clinical Nurses
This study aims to evaluate the effects of two-tier test-based virtual reality (VR) instruction on Advanced Cardiac Life Support (ACLS) learning outcomes among clinical nurses.
- Trial name
- NCT07862322
- Testing
- Two-Tier Test-Based Virtual Reality Instruction, Traditional Interactive Virtual Reality Instruction
- Where
- Taiwan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Taoyuan General Hospital
Head and Neck Squamous Cell Carcinoma, Locally Advanced Rectal Cancer
Galenos 2 Immunonutrition in Head and Neck, Lung, and Rectal Cancer Patients
GALENOS 2 is a single-arm, single-center, phase II interventional study designed to evaluate the effects of a galenic immunonutrition dietary supplement in patients with head and neck squamous cell carcinoma, locally advanced…
- Conditions
- Head and Neck Squamous Cell Carcinoma, Locally Advanced Rectal Cancer, Lung Cancer
- Trial name
- GALENOS 2 (NCT07514754)
- Testing
- Galenic Immunonutrition Formula
- Where
- Italy
- Volunteers
- 52 people
- Sponsor
- Fondazione del Piemonte per l'Oncologia
Head and Neck Squamous Cell Carcinoma, Locally Advanced Rectal Cancer
GALENOS 1 in Head and Neck, Lung, and Rectal Cancer Patients
GALENOS 1 is a prospective observational study designed to explore longitudinal changes in nutritional status and body composition in patients with head and neck squamous cell carcinoma, locally advanced rectal cancer, and lung…
- Conditions
- Head and Neck Squamous Cell Carcinoma, Locally Advanced Rectal Cancer, Lung Cancer
- Trial name
- GALENOS 1 (NCT07511413)
- Where
- Italy
- Volunteers
- 110 people
- Sponsor
- Fondazione del Piemonte per l'Oncologia
MDS, AML, Adult
Quality of Life-Guided Transfusion in Refractory MDS or AML
Patients with refractory myelodysplastic syndromes (MDS) or acute myeloid leukemia (AML) in exclusive palliative care frequently receive red blood cell transfusions based on hemoglobin thresholds, despite limited evidence of…
- Conditions
- MDS, AML, Adult, Anemia
- Trial name
- Q-TRANS (NCT07328191)
- Testing
- Red blood cell transfusions based on EQ-5D-5L questionnaire
- Where
- France
- Volunteers
- 52 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Cardiac Arrest
In-hospital Cardiopulmonary Resuscitation With Balloon Occlusion of the Descending Aorta
This study will test if a sustained Return of Spontaneous Circulation (ROSC) in patients with cardiac arrest is more frequent when patients receive advanced cardiac life support (ACLS) alone or when they receive ACLS plus a…
- Trial name
- CPReboa (NCT07434726)
- Testing
- resuscitative endovascular occlusion of the aorta (REBOA), Advanced Cardiac Life Support (ACLS)
- Where
- Switzerland
- Volunteers
- 98 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Cardiac Arrest (CA)
Does Increasing the Compression Pause From 3 to 5 Seconds in Mechanical Compression Devices Increase Ventilation Success Rate and Return of Spontaneous Circulation?
To give chest compressions during cardiopulmonary resuscitation (CPR), mechanical chest compression devices can be used. During synchronous 30:2 CPR, the standard setting on these devices leave an automated 3-second chest…
- Trial name
- LUCASVP (NCT06824961)
- Testing
- 5-second ventilation pause duration during mechanical CPR, 3-second ventilation pause duration during mechanical CPR
- Where
- 2 sites in Netherlands
- Volunteers
- 692 people
- Sponsor
- Amsterdam UMC, location VUmc
Traumatic Injuries, Prehospital Emergency Care
Study of Pre Hospital Management of Polytrauma Patients by Medical Teams From a Department in the Parisian Region
To study the impact of prehospital management duration by SMUR teams in the Essonne department (91) on early patient mortality (within 24 hours) and to analyze the procedures performed on scene.
- Conditions
- Traumatic Injuries, Prehospital Emergency Care, Early Mortality
- Trial name
- DELTA-91 (NCT07414186)
- Where
- France
- Volunteers
- 400 people
- Sponsor
- Centre Hospitalier Sud Francilien
Cancer, Physical Symptom Distress
Supportive Clinic for Patients Living With Advanced and Metastatic Cancers
To conduct a feasibility trial to examine the feasibility and acceptability of conducting a randomized controlled trial that evaluates the effect of the survivorship care intervention on patient-reported outcomes, defined as…
- Trial name
- NCT06465511
- Testing
- Supportive clinic, Control: Self-management
- Where
- 5 sites in Hong Kong
- Volunteers
- 68 people
- Sponsor
- The University of Hong Kong
Dementia Caregivers, End of Life Decision Making
A Culturally Adapted Decision Aid Intervention to Support Chinese American Dementia Caregivers in Feeding-Related Decisions
Family caregivers of people with dementia have to decide between tube feeding and hand feeding when persistent eating problems arise.
- Conditions
- Dementia Caregivers, End of Life Decision Making, Advanced Dementia
- Trial name
- NCT07370311
- Testing
- Chinese version of Making Choices Feeding Options for Patients with Dementia Decision Aid
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Yaolin Pei
Advanced Heart Failure, Mechanical Circulatory Support
Palliative Care Intervention to Improve Health Related Quality of Life for Patients on Long-Term LVAD Support
Background: While left ventricular assist device (LVAD) therapy improves survival in patients with advanced heart failure (AHF), unique LVAD-related burdens may impact health-related quality of life (HRQoL).
- Conditions
- Advanced Heart Failure, Mechanical Circulatory Support, Left Ventricular Assist Device, Palliative Care
- Trial name
- PALL-VAD (NCT07445932)
- Testing
- Palliative care intervention
- Where
- 2 sites in United States
- Volunteers
- 90 people
- Sponsor
- Medstar Health Research Institute
Malignant Neoplasm, Home Care Services
SupporTive Care At Home Research for Patients With Advanced Cancer (STAHR-cancer)
To test the effects of home-based care on unplanned hospitalization within 6 months among advanced cancer patients with decreased performance status.
- Conditions
- Malignant Neoplasm, Home Care Services, Quality of LIfe, Unplanned Hospitalization
- Trial name
- HOMECARE (NCT05636384)
- Testing
- Home-based care
- Where
- 6 sites in South Korea
- Volunteers
- 396 people
- Sponsor
- Seoul National University Hospital
Chestcompressionadequacy
Assessment of Cardiopumonary Resuscitation (CPR) Competency Post ALS Course
to assess chest compression competency in healthcare providers following ALS training to identify areas for improvement and ensure high-quality CPR delivery.
- Trial name
- NCT07085832
- Testing
- Education (ALS provider course) in Egypt
- Where
- 2 sites in Egypt
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- National Hepatology & Tropical Medicine Research Institute
Adaptive Support Condition, Standard Training Condition
EDA-Based Adaptive Support in VR ALS Training
This randomized controlled study aims to investigate the effects of an electrodermal activity (EDA)-based adaptive support system on performance during virtual reality (VR)-based advanced life support (ALS) training.
- Trial name
- NCT07650019
- Testing
- EDA-Based Adaptive Support System, Standard VR-Based Training
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Acibadem University
Non-Small Cell Lung Cancer, Carcinoma, Non-Small-Cell Lung
Acupuncture and Laser Acupuncture for Advanced Non-Small Cell Lung Cancer
This three-arm randomized controlled clinical trial evaluates the clinical efficacy and safety of needle acupuncture and laser acupuncture compared with placebo (sham) laser acupuncture as supportive care for patients with…
- Trial name
- NCT07879768
- Testing
- Needle Acupuncture, Laser Acupuncture
- Where
- Taiwan
- Volunteers
- 90 people
- Sponsor
- China Medical University, Taiwan