Clinical trials: Adverse Childhood Experiences
Psychological Trauma
To Repeat or Not to Repeat - Preventing Intergenerational Transfer of Adverse Childhood Experiences
The main aim of the study is to examine patients' and therapists' experiences with prenatal psychotherapy provided to pregnant women with adverse childhood experiences and how this may influence intergenerational transmission of…
- Trial name
- NCT04528589
- Testing
- prenatal psychotherapy
- Where
- Norway
- Volunteers
- 23 people
- Sponsor
- University Hospital, Akershus
Adverse Childhood Experiences, Child Development
Testing a Scalable Model For ACEs-Related Care Navigation
The study is a randomized controlled trial of a telephone-based care coordination system for families who experienced Adverse Childhood Events (ACEs).
- Trial name
- NCT05567250
- Testing
- Behavioral: Telephone-based ACEs care coordination
- Where
- United States
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Child Development
Caregiver Adverse Childhood Experiences (ACEs) in Pediatric Primary Care
This longitudinal study will evaluate if increased caregiver awareness of their own ACEs through provider-led discussions will lead to improved child health via fewer emergency department, urgent care visits and missed primary…
- Trial name
- NCT05013138
- Testing
- Training for ACEs and study procedures, Training on study procedures
- Where
- United States
- Volunteers
- 181 people
- Sponsor
- Emory University
Adverse Childhood Experience, Endothelial Function (FMD)
Probing the Role of Mitochondrial Oxidative Stress in Impaired Vascular Function Among Young Adults With Early Life Adversity
Adverse childhood experiences (ACEs) represent highly stressful events in the first 18 years of life that include abuse, neglect, and household and community-level dysfunction.
- Conditions
- Adverse Childhood Experience, Endothelial Function (FMD), Endothelial Injury, Mitochondrial Function
- Trial name
- PROMISE (NCT07244809)
- Testing
- Mitoquinone mesylate (MitoQ)
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Life Change Events, Loneliness
Me and the Others: Expectations and Evaluation of Social Relationships
Chronic and pervasive loneliness has been identified as an important factor in the relationship between adverse childhood experiences (ACE) (e.g. abuse and neglect) and mental disorders.
- Trial name
- NCT03764566
- Testing
- Questionnaires
- Where
- Germany
- Volunteers
- healthy volunteers welcome
- Sponsor
- Central Institute of Mental Health, Mannheim
Preschool Age Children, Preschool Education
The Building Resilience Program: Examining Self-Regulation, Behavior, and Resilience in Under-Resourced Preschoolers With ACEs
# Brief Summary The goal of this clinical trial is to learn if a occupational therapy-led trauma-informed care intervention can improve resilience, self-regulation, coping skills, and emotional health in preschoolers ages 2-4…
- Conditions
- Preschool Age Children, Preschool Education, Adverse Childhood Experience, Mental Health
- Trial name
- NCT07170605
- Testing
- Mental health, positive coping strategies promoting self-regulation and adaptive skills, Standard care/School Readiness Condition
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Cleveland State University
Parent-Child Relations, Maternal Behavior
A Randomized Controlled Trial to Improve Mother-Infant Synchrony Among Women With Childhood Adversity
Childhood adversity affects almost two-thirds of the US population, is a major risk factor for the leading causes of disease and increases US economic health burdens.
- Conditions
- Parent-Child Relations, Maternal Behavior, Infant Behavior
- Trial name
- NCT04818112
- Testing
- ATVV, Attention control
- Where
- 2 sites in United States
- Volunteers
- 262 people, healthy volunteers welcome
- Sponsor
- University of Arizona
Adverse Childhood Experiences
The FACE Self-help App for Fostering Resilience
The FACE self-help app is an online intervention for young adults with Adverse Childhood Experiences (ACEs). It was developed based on well-established cognitive-behavioural therapy principles.
- Trial name
- NCT05824182
- Testing
- FACE self-help App
- Where
- Switzerland
- Volunteers
- 167 people, healthy volunteers welcome
- Sponsor
- Jeannette Brodbeck
Overweight and Obesity
An App-based Mindfulness Intervention for Sexual Minority Women With a History of Early Life Adversities (ELA)
Sexual minority women (SMW) in mid-age are at significantly higher risk for obesity, which is associated with greater vulnerability to cardiovascular disease, diabetes, cancer, and mortality.
- Trial name
- NCT05201391
- Testing
- "Eat Right Now" (ERN) mobile application
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Brown University
Mental Health Outcomes, Adverse Childhood Experiences
School Violence Exposure as an Adverse Childhood Experience
This study hypothesize that school safety strategies may contribute to poor mental health and distress among various school populations and proposes the following research questions to be answered through this study: 1.
- Conditions
- Mental Health Outcomes, Adverse Childhood Experiences, Perceived School Safety, Educational Outcomes
- Trial name
- NCT06153316
- Testing
- School shooting incident
- Where
- United States
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- Teachers College, Columbia University
Hunger, Child Development
Building Wealth and Health Network: A Microfinance/TANF Demonstration Project
The goals of the The Building Wealth and Health Network (The Network) are to develop and rigorously test an asset building model that will build financial, social and human capital through asset building, financial education and…
- Conditions
- Hunger, Child Development, Social Isolation
- Trial name
- NCT02577705
- Testing
- Self Empowerment Groups, Financial Empowerment, Matched Savings
- Where
- United States
- Volunteers
- 145 people, healthy volunteers welcome
- Sponsor
- Center for Hunger-Free Communities
Temporomandibular Disorder, Temporomandibular Joint Dysfunction
Trauma Exposure and Childhood Trauma in Temporomandibular Joint Disorders
Temporomandibular disorder is a multifactorial condition that involves the temporomandibular joint, masticatory muscles, and surrounding structures and is influenced by biological, psychological, and social factors.
- Conditions
- Temporomandibular Disorder, Temporomandibular Joint Dysfunction, Trauma Exposure, Childhood Traumas
- Trial name
- NCT07292103
- Where
- Turkey (Türkiye)
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Gulseren Demir Karakilic
Perinatal Depression
Perinatal Depression and Adverse Childhood Experiences: Prevention Trial
The goal of this clinical trial is to evaluate the impact of ROSE in individuals with adverse childhood experiences. The main question it aims to answer is, compared to enhanced treatment as usual, does the delivery of ROSE…
- Trial name
- PPD-ACE (NCT05795114)
- Testing
- Reach Out, Stand Strong, Essentials for New Mothers (ROSE) Program
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- Northwestern University
Internet-Based Intervention
Evaluation of the First Pathways Game on Parent-child Interactions and Development for Vulnerable Children
Children's brains develop quickly in the first three years of life and are particularly sensitive to their environment. Adverse experiences, such as exposure to abuse and neglect, can increase children's risk for behavioral…
- Trial name
- NCT04902404
- Testing
- First Pathways Game
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- University of Calgary
Suicide, Trauma
Integrated Suicide & Trauma Therapy for Suicide Risk
The investigators have developed a novel suicide intervention, Integrated Suicide and Trauma Therapy (ISTT). ISTT combines Brief-Skills for Safer Living (Brief-SfSL)-a promising method to enhance coping skills and reduce…
- Conditions
- Suicide, Trauma, Major Depressive Disorder
- Trial name
- ISTT (NCT05613972)
- Testing
- Integrated Suicide and Trauma Therapy
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Unity Health Toronto
Stress, Childhood Obesity
Healing Experiences of Adversity Among Latinos (HEALthy4You)
Healing Experiences of Adversity Among Latinos (HEALthy4You) is a project funded by the California Initiative for the Advancement of Precision Medicine ("Advancing a Precision Population Health Approach to ACEs to Reduce Health…
- Trial name
- NCT05676281
- Testing
- Healthy Together (Control), Healthy Together + Promotora Support, Healthy Together + Parenting Training
- Where
- 2 sites in United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Child Abuse, Child Neglect
Child-Parent Psychotherapy - a Feasibility Study for Children in Foster Care
Children in foster care have an increased risk of exposure to adverse experiences during childhood and across the lifespan. In current studies of interventions children in foster care are often excluded, or they are too few to be…
- Conditions
- Child Abuse, Child Neglect, Post-Traumatic Stress Disorder in Children, Parent-Child Relations
- Trial name
- NCT04519229
- Testing
- Child-Parent Psychotherapy
- Where
- Sweden
- Volunteers
- 20 people
- Sponsor
- Kronoberg County Council
Child Abuse
Calling All Dads! Evaluation of APAs ACT Program: Engaging Fathers to Prevent Adverse Childhood Experiences
The goal of this observational study is to assess the American Psychological Association's ACT Raising Safe Kids program with male caregivers.
- Trial name
- CAD (NCT06075446)
- Testing
- ACT Raising Safe Kids
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Georgia State University
Mental Health Issue, Adverse Childhood Experience
Chinese Community Sample of Hierarchical Model of Psychopathology
By validating Hierarchy Model of psychopathology(HiTOP) in Chinese community samples, this study aims for illumating the problem of diagnostic heterogeneity and high comorbidity within existing psychiatric classification systems…
- Trial name
- NCT06105970
- Testing
- No intervention
- Where
- China
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- Shanghai Mental Health Center
Substance-Related Disorders, Adverse Childhood Experiences
Evaluating an Adverse Childhood Experience-Targeting Advocate Model of a Substance Use Prevention Program
Primary Objective: Conduct a rigorous evaluation of a prevention-based intervention designed to mitigate the harms of adverse childhood experiences (ACEs) exposure and prevent future ACEs, substance use, and overdose within 36…
- Trial name
- NCT06236100
- Testing
- Strengthening Families Program + Family Advocate, Strengthening Families Program
- Where
- United States
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- RTI International